Other Solvents
Medchemexpress LLC Rel-Ritonavir-d6 | 1217720-20-1 | 98.7% | C37H42D6N6O5S2 | 500 UG
rel-Ritonavir-d6 is the deuterium labeled rel-Ritonavir, a stable isotope of Ritonavir. Ritonavir is an inhibitor of HIV protease, commonly used in the study of HIV infection and AIDS, and also functions as a SARS-CoV 3CLpro inhibitor with an IC50 of 1.61 μM. The incorporation of stable heavy isotopes into drug molecules, such as deuterium in rel-Ritonavir-d6, is largely for quantitation during the drug development process and has shown potential to influence pharmacokinetic and metabolic profiles.
- Deuterium labeled rel-Ritonavir
- Inhibitor of HIV protease
- Used to study HIV infection and AIDS
- SARS-CoV 3CLpro inhibitor
- Functions as a tracer
- Serves as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC 1,1,2,2-tetradeuterioethane-1,2-diol | 2219-51-4 | MFCD00144289 | 99.8% | 66.09 g·mol⁻¹ | C2H2D4O2 | 50mg
Ethylene glycol-d4 is the deuterium labeled Ethylene glycol[1]
Medchemexpress LLC Doxofylline-d6 | 1219805-99-8 | >99.6% | C11H8D6N4O4 | 1 MG
Doxofylline-d6 is the deuterium labeled Doxofylline, an antagonist of the adenosine A1 receptor that also inhibits phosphodiesterase IV.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC 5α-cholestane-d6 | 358731-18-7 | MFCD01861631 | 99.0%
5α-cholestane-d6 | 358731-18-7 | MFCD01861631 | 99.0%
Medchemexpress LLC CK-666 | 442633-00-3 | 99.95% | 296.34 | 1 ML
CK-666 is a cell-permeable actin-related protein Arp2/3 complex inhibitor with an IC50 of 12 μM. It binds to the Arp2/3 complex, stabilizing its inactive state and blocking the movement of the Arp2 and Arp3 subunits into the activated filament-like conformation.
- Cell-permeable
- Arp2/3 complex inhibitor
- Stabilizes the inactive state of the Arp2/3 complex
- Blocks movement of Arp2 and Arp3 subunits into activated filament-like conformation
- Significantly reduces filopodia on cell surface of treated trabecular meshwork (TM) cells.
- Reduces uptake of S-EMs by VSMCs.
- Inhibits S-EMs-induced proliferation of VSMCs.
- Inhibits S-EMs-induced migration of VSMCs.
- Reduces F-actin polymerization in E15.5 fetal mice.
- Reduces F-actin/G-actin ratio in doxycycline-treated iPSC-derived neurons.
Cayman Chemical LthreoSphingosine d18 1
An analog of D-erythro-sphingosine; inhibits PKC in mixed micelle assays with 50% inhibition at 2.2 mol % making it a more potent inhibitor compared to D-erythro-sphingosine or other analogs of shorter alkyl chain length
Medchemexpress LLC Maxacalcitol-d6 | 2070009-38-8 | 99.6% | 424.65 | C26H36D6O4 | 10 MG
Maxacalcitol-d6 is the deuterated form of maxacalcitol (22-oxacalcitriol), a non-calcemic vitamin D3 analog and vitamin D receptor (VDR) ligand used as a labeled reference standard for research. It is supplied as a high-purity solid (99.63%) in a 10 mg pack and is intended for analytical applications including mass spectrometry, pharmacokinetic studies, and VDR pathway research.
- Deuterated internal standard for quantitative mass spectrometry.
- Non-calcemic vitamin D3 analog and VDR ligand.
- High purity (99.63%) suitable for analytical and bioanalytical assays.
- Solid white to off-white form with good stability under recommended storage.
- Supplied in 10 mg packs for laboratory use.
Medchemexpress LLC D18 | 2230218-36-5 | 98.8% | C21H28N6 | 1 MG
D18 is an immune modulator and acts as a TLR7/8 dual agonist. It increases PD-L1 expression through epigenetic regulation, sensitizing tumors to PD-1/PD-L1 blockade. This substance is also an ADC cytotoxin used for the synthesis of ADC HE-S2 (HY-144497) and exhibits strong immune activation and anti-tumor activity, commonly used in cancer research.
- Acts as a TLR7/8 dual agonist
- Increases PD-L1 expression through epigenetic regulation
- Sensitizes tumors to PD-1/PD-L1 blockade
- Utilized as an ADC cytotoxin for ADC HE-S2 synthesis
- Exhibits strong immune activation and anti-tumor activity
- Used in cancer research, including colon cancer
Selleck Chemical LLC MK-2206 2HCl S1078-1g
MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM in cell-free assays respectively no inhibitory activities against 250 other protein kinases observed MK-2206 2HCl induces autophagy and apoptosis in cancer cells Phase 2
Medchemexpress LLC Ethylene glycol-d4 (1,2-ethanediol-d4) | 2219-51-4 | MFCD00144289 | 99.8% | 66.09 g/mol | C2H2D4O2 | 500mg
Ethylene glycol-d4 is the deuterium labeled Ethylene glycol[1]
Medchemexpress LLC L-proline-13C5,15N | 202407-23-6 | MFCD00144671 | 99.6% | 121.09 | 13C5H915NO2 | 25mg
L-Proline-13C5 1-15N is the 13C- and 15N-labeled L-Proline L-Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins
Medchemexpress LLC Acetophenone-d3 | 17537-31-4 | MFCD00064445 | 96.3% | 123.17 | C8H5D3O | 1g
Acetophenone-d3 is the deuterium labeled Acetophenone[1] Acetophenone is an organic compound with simple structure[2]
Medchemexpress LLC Clascoterone-d5 | 95.0% | 407.55 g·mol⁻¹ | C24H29D5O5 | 1mg
Clascoterone-d5 (Cortexolone 17 alpha-propionate-d5) is the deuterated analog of Clascoterone Clascoterone is a topical and peripheral androgen antagonist[1][2][3]
Medchemexpress LLC β-Dihydroequilin-d5 | 275.40 | 1 MG
β-Dihydroequilin-d5 is a deuterium-labeled version of β-Dihydroequilin, intended for research use only. Stable heavy isotopes such as deuterium are incorporated into drug molecules as tracers for quantitative analysis during drug development, with potential impact on pharmacokinetic and metabolic profiles.
- Deuterium-labeled β-Dihydroequilin for research
- Functions as a tracer for quantitative analysis in drug development
- May influence pharmacokinetic and metabolic profiles of drugs
- Stable under recommended storage conditions
- Presented as a solid
Medchemexpress LLC Pentacosane-d52 | 121578-13-0 | 25 MG
Pentacosane-d52 is a deuterium-labeled form of Pentacosane. Pentacosane, found in Curcuma raktakanda extract and Malus domestica essential oil, is known for its anti-cancer activities. The incorporation of stable heavy isotopes, such as deuterium, can significantly influence the pharmacokinetic and metabolic profiles of drug molecules.
- Used as a tracer
- Serves as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Deuteration can impact drug pharmacokinetics and metabolism
- Contains stable heavy isotopes for quantitation during drug development