Carfilzomib-d8 is a deuterium-labeled analog of carfilzomib, an irreversible proteasome inhibitor used in research. It serves as a tracer and internal standard for quantitative analysis by NMR, GC-MS, and LC-MS, and is suitable for studies of proteasome inhibition in cell models.
- Deuterium-labeled internal standard for quantitative mass spectrometry and NMR.
- Irreversible proteasome inhibitor activity; reported IC50 ≈ 5 nM in ANBL-6 and RPMI 8226 cells.
- Molecular formula C40H49D8N5O7; molecular weight 727.96 g/mol.
- Typical purity around 98.7% (batch dependent).
- Storage: protect from light; in solvent store at -80 °C up to 6 months, -20 °C up to 1 month.