Commonly in liquid form and available in various chemical compositions, solvents are substances that dissolve solutes to form solutions. The amount and type of solute that a solvent can dissolve is dependent upon temperature and polarity.
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An L-type calcium channel blocker induces morphological and growth defects in wild-type C. elegans and those with hypoexpression of egl-19 inhibits L-type calcium channels in chick ciliary neurons increases TRAIL-induced cytotoxicity and synergistically enhances caspase-8 and caspase-3 activation in a concentration-dependent manner in H1299 lung adenocarcinoma cells decreases Survivin expression in A549 cells
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An L- and T-type calcium channel inhibitor inhibits hamster Cav1 2a and human Cav3 2 (IC50s 1 8 and 350 nM respectively) inhibits L- and T-type calcium channels and fetal bovine serum-induced hypertrophy in isolated mouse cardiomyocytes increases survival in a mouse model of acute myocardial infarction induced by ligation of the left coronary artery at 200 mg/kg inhibits SARS-CoV-2 Mpro (IC50 38 5 UM)
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An LTB4 receptor antagonist (Ki 2 UM) inhibits chemotaxis and calcium flux by LTB4 in isolated human neutrophils (IC50s 10 and 7 UM respectively) inhibits bronchoconstriction induced by LTB4 in rats by 46
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An LTB4 receptor antagonist (Ki 2 UM) inhibits chemotaxis and calcium flux by LTB4 in isolated human neutrophils (IC50s 10 and 7 UM respectively) inhibits bronchoconstriction induced by LTB4 in rats by 46
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A TRPA1 antagonist (IC50 0.131 UM in a calcium mobilization assay) selective for human TRPA1 over human TRPV1 and TRPV4 rat TRPV1 TRPV3 and TRPM8 and a panel of 40 additional targets at 10 UM reduces the number of AITC-induced tail flinches in rats at 10 and 30 mg/kg
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A CCR4 receptor antagonist inhibits CCL22-induced calcium flux (IC50 31 6 nM) inhibits CCL22- and CCL17-mediated chemotaxis of Th2 cells (IC50 501 2 nM) reduces alveolitis and leukocyte infiltration in lungs of antigen-challenged ovalbumin sensitized rats in a dose-dependent manner (0 07-2 5 mg/kg p o )
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A diterpene with diverse biological activities a TRPV3 activator (EC50 16 UM for inducing calcium influx in HEK293 cells expressing TRPV3) inhibits IKBa degradation in TNF-a-stimulated HeLa cells at 60-140 UM reduces amyloid-B (25-35) peptide-induced apoptosis increases in MDA levels and the production of ROS reduces paw edema in a mouse model of hind paw inflammation at 50 mg/kg has anxiolytic and antidepressant-like activity in mice
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An agonist of FPR1 and FPR2 induces calcium flux in CHO cells expressing human FPR2 Ga15 and aequorin (EC50 0.044 UM) and in CHO-K1 cells expressing either human FPR1 human FPR2 mouse Fpr1 or mouse Fpr2 Ga16 and aequorin in a concentration-dependent manner inhibits fMLP- or IL-8-induced neutrophil migration (IC50s 0.64 and 0.24 UM respectively) reduces PGE2- and LTB4-induced ear swelling in mice at 50 mg/kg
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Vitamin D plays an important role in calcium homeostasis and metabolism Vitamin D3 and vitamin D2 are two forms of vitamin D in human body both of which only a few foods contain The deficiency of vitamin D in human body can cause a threat of diseases such as osteomalacia rickets and diabetes 25-OH Vitamin D2 and 25-OH Vitamin D3 as vitamin D metabolites are measured in human serum to evaluate vitamin D level Vitamin D supplements are considered as an effective way to treat or to prevent the diseases
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Vitamin D plays an important role in calcium homeostasis and metabolism Vitamin D3 and vitamin D2 are two forms of vitamin D in human body both of which only a few foods contain The deficiency of vitamin D in human body can cause a threat of diseases such as osteomalacia rickets and diabetes 25-OH Vitamin D2 and 25-OH Vitamin D3 as vitamin D metabolites are measured in human serum to evaluate vitamin D level Vitamin D supplements are considered as an effective way to treat or to prevent the diseases
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