Diterpenoids
Cayman Chemical Mulberry leaf Phytol 250g
A degradation product of chlorophyll that is converted to phytanic acid, which can accumulate to toxic levels in a number of metabolic disorders; activates RXRs (Kis range from 2.3-67.2 µM) and promotes the activity of PPAR/RXR heterodimers
Selleck Chemical LLC Nab-Paclitaxel-E1068-1G
Nab-Paclitaxel is a novel solvent-free paclitaxel in which the binding ratio of paclitaxel to human albumin is approximately 1 9 It is an anti-microtubule drug that promotes microtubule aggregation in tubulin dimers and inhibits microtubule depolymerization to stabilize the microtubule system Solutions are unstable and should be fresh-prepared
Sigma Aldrich Fine Chemicals Biosciences Geranylgeranylacetone | 6809-52-5 | MFCD00869547 | 10MG
Geranylgeranylacetone | Purity: >=98% (HPLC) | Mol Wt: 330.55 | 6809-52-5 | MFCD00869547 | 10MG
Sigma Aldrich Fine Chemicals Biosciences Anhydrous Docetaxel European Pharmacopoeia (EP) Reference Standard | 114977-28-5 | MFCD00800737 |
Anhydrous Docetaxel European Pharmacopoeia (EP) Reference Standard | Mol Wt: 807.88 | 114977-28-5 | MFCD00800737 |
Sigma Aldrich Fine Chemicals Biosciences Aphidicolin from Nigrospor5MG
Aphidicolin from Nigrospor5MG
Medchemexpress LLC Aphidicolin | 38966-21-1 | 1 MG
Aphidicolin is an inhibitor of DNA polymerase α and δ, preventing mitotic cell division by interfering with DNA polymerase activity. It is an antibiotic produced by the mold *Cephalosporium aphidicola*, inhibiting cellular deoxyribonucleic acid synthesis and the growth of herpes simplex virus. Aphidicolin also exhibits anti-orthopoxvirus activity and potentiates apoptosis induced by arabinosyl nucleosides in a human promyelocytic leukemia cell line.
- Inhibits DNA polymerase α and δ
- Prevents mitotic cell division
- Interferes with DNA polymerase activity
- Antibiotic produced by *Cephalosporium aphidicola*
- Inhibits cellular deoxyribonucleic acid synthesis
- Inhibits growth of herpes simplex virus
- Exhibits anti-orthopoxvirus activity
- Potentiates apoptosis induced by arabinosyl nucleosides
Medchemexpress LLC Isotanshinone IIA | 20958-15-0 | 5 MG
Isotanshinone IIA is an abietane-type diterpene metabolite that non-competitively inhibits Protein Tyrosine Phosphatase 1B (PTP1B) activity with an IC50 of 11.4 μM. Intended for research use only, this product is an orange to orange-red solid with 98.0% purity. It has a molecular weight of 294.34 and a chemical formula of C19H18O3.
- Non-competitive inhibitor of Protein Tyrosine Phosphatase 1B (PTP1B) activity
- IC50 of 11.4 μM
- 98.0% purity
- Appears as an orange to orange-red solid
- Molecular weight of 294.34
- Chemical formula of C19H18O3
- Classified under Quinones and Naphthalene Quinones
- Powder storage: -20°C for 3 years
- In solvent storage: -80°C for 6 months, -20°C for 1 month
- Soluble in DMSO at 3 mg/mL (10.19 mM)
Medchemexpress LLC Resiniferatoxin | 57444-62-9 | 5 MG
Resiniferatoxin is a selective agonist of the transient receptor potential vanilloid 1 (TRPV1) receptor. It can be isolated from the Euphorbia resinifera plant. This compound eliminates TRPV1+ primary sensory afferents and blunts cardiac sympathetic afferent reflex for a relatively long period.
- Selective agonist of TRPV1 receptor
- Isolated from Euphorbia resinifera plant
- Eliminates TRPV1+ primary sensory afferents
- Blunts cardiac sympathetic afferent reflex
- For research use only
Medchemexpress LLC Docetaxel | 114977-28-5 | 99.9% | 807.88 | C43H53NO14 | 10 MG
Docetaxel (standard) is an analytical reference of the chemotherapeutic agent docetaxel supplied for research and analytical applications. It acts as a microtubule depolymerization inhibitor that arrests cells at G2/M and promotes apoptosis. The product is provided in small vial sizes for laboratory workflows and is accompanied by supporting documentation (SDS, COA).
- High purity suitable for analytical applications.
- Molecular weight 807.88.
- CAS number 114977-28-5 for unambiguous identification.
- Available in multiple small vial sizes for flexibility in experiments.
- Intended for research and analytical use only.
Medchemexpress LLC Aphidicolin | 38966-21-1 | MFCD00083214 | 25 MG
Aphidicolin is an inhibitor of DNA polymerase α and δ, which functions by interfering with DNA polymerase activity to prevent mitotic cell division. This antibiotic, originating from the mold Cephalosporium aphidicola, is known for its ability to inhibit cellular deoxyribonucleic acid synthesis and the growth of herpes simplex virus. Furthermore, it demonstrates anti-orthopoxvirus activity and enhances apoptosis when induced by arabinosyl nucleosides in a human promyelocytic leukemia cell line.
- Inhibits DNA polymerase α and δ
- Prevents mitotic cell division
- Functions as an antibiotic
- Inhibits cellular deoxyribonucleic acid synthesis
- Inhibits growth of herpes simplex virus
- Exhibits anti-orthopoxvirus activity
- Potentiates apoptosis induced by arabinosyl nucleosides
- Targets DNA/RNA synthesis, HSV, and apoptosis pathways
- Applied in infection and inflammation/immunology research
Medchemexpress LLC Paclitaxel (Standard) | 33069-62-4 | 99.9% | C₄₇H₅₁NO₁₄ | 25 MG
Paclitaxel (Standard) is an analytical standard of Paclitaxel, intended for research and analytical applications. It is a naturally occurring antineoplastic agent that stabilizes tubulin polymerization, causing mitotic arrest, apoptotic cell death, and inducing autophagy.
- Used as an analytical standard for qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS.
- Naturally occurring antineoplastic agent.
- Stabilizes tubulin polymerization.
- Causes mitotic arrest and apoptotic cell death.
- Induces autophagy.
TARGETMOL CHEMICALS INC DIHYDROTANSHINONE I 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. Dihydrotanshinone I (DHTS) is a natural compound extracted from Salvia miltiorrhiza Bunge used for treating of cardiovascular diseases. purity: 99%
Medchemexpress LLC Paclitaxel | 33069-62-4 | MFCD00869953 | 100.0% | 853.91 g·mol⁻¹ | C47H51NO14 | 10 MG
Paclitaxel is a microtubule-stabilizing antineoplastic reagent used in biological research to inhibit mitosis and induce apoptosis. It is supplied as a solid for preparation of experimental stock solutions and is commonly used in cell culture, in vivo studies, and assay development.
- Stabilizes tubulin polymerization and induces mitotic arrest.
- Used for cell culture, in vivo tumor models, and assay development.
- Supplied as a solid powder suitable for dissolution in DMSO or other organic solvents.
- Storage recommendations: protect from light; solids at 4°C; solutions at -20°C (short term) or -80°C (long term).
- Analytical identity confirmed by LC-MS; batch-specific purity reported by certificate of analysis.
Cayman Chemical Docetaxel-d9 500ug
An internal standard for the quantification of docetaxel by GC- or LC-MS
AdipoGen Docetaxel
Chemical. CAS 114977-28-5. Formula C43H53NO14. MW 807.88. Synthetic. Anticancer agent. Semisynthetic analog of taxol paclitaxel. Inhibits microtubule disassembly and inhibits cell replication. Binds to and stabilizes the beta−tubulin subunit of microtubules, preventing depolymerization of the mitotic spindle thus leading to cell cycle arrest at G2/M and apoptosis. This cytotoxic activity has been widely exploited in suppressing oncogenic proliferation. Displays potent and broad antineoplastic properties, used mainly for the treatment of breast, ovarian, and non-small cell lung cancer. Also inhibits pro-angiogenic factors such as vascular endothelial growth factor VEGF and displays immunomodulatory and pro-inflammatory properties by inducing various mediators of the inflammatory response. Also studied for use as a radiation-sensitizing agent.