Diterpenoids
Sigma Aldrich Fine Chemicals Biosciences Paclitaxel from semisynthetic, >=97% | 33069-62-4 | MFCD00869953 | 1MG
Paclitaxel from semisynthetic, >=97% | Purity: >=97% | Mol Wt: 853.91 | 33069-62-4 | MFCD00869953 | 1MG
Medchemexpress LLC Aphidicolin | 38966-21-1 | 10 MG
Aphidicolin is an inhibitor of DNA polymerase α and δ, preventing mitotic cell division by interfering with DNA polymerase activity. This antibiotic is produced by the mold *Cephalosporium aphidicola*. It inhibits cellular deoxyribonucleic acid synthesis, the growth of herpes simplex virus, and exhibits anti-orthopoxvirus activity. Additionally, Aphidicolin can potentiate apoptosis induced by arabinosyl nucleosides in human promyelocytic leukemia cell lines.
- Inhibits DNA polymerase α and δ.
- Functions as an antibiotic from *Cephalosporium aphidicola*.
- Exhibits antiviral activity against herpes simplex virus and orthopoxvirus.
- Modulates cell cycle, arresting cells at G2 phase.
- Induces apoptosis and inhibits cell proliferation via the p53-GADD45β pathway.
- Aphidicolin glycinate demonstrates anti-tumor activity in murine models.
Apexbio Technology LLC Paclitaxel (Taxol) 33069-62-4 10mM (in 1mL DMSO)
Paclitaxel (Taxol) is a diterpenoid alkaloid initially isolated from the bark of Taxus brevifolia It exhibits antitumor activity primarily by disrupting microtubule dynamics Mechanistically paclitaxel binds tubulin and promotes microtubule polymerization thus stabilizing microtubules and inhibiting their depolymerization This mechanism impairs normal mitotic spindle formation arrests cells in G2-M phase of the cell cycle and induces apoptotic cell death Paclitaxel is extensively employed in biomedical research for investigating antineoplastic mechanisms and testing therapeutic interventions targeting various cancers such as ovarian breast head and neck and lung carcinoma
Sigma Aldrich Fine Chemicals Biosciences Tanshinone IIA >=97% (HPLC) | 568-72-9 | MFCD00238692 | 5MG
Tanshinone IIA >=97% (HPLC) | Purity: >=97% (HPLC) | Mol Wt: 294.34 | 568-72-9 | MFCD00238692 | 5MG
Medchemexpress LLC Nab-Paclitaxel 25mg | 25mg
Nab-Paclitaxel (Nanoparticle albumin-bound Paclitaxel) is an albumin-bound nanoparticle formulation of Paclitaxel (HY-B0015) Nab-Paclitaxel is composed of albumin and the active pharmaceutical ingredient Paclitaxel in which human albumin is used as an excipient to disperse and stabilize particles and carry the main drug Nab-Paclitaxel is a solvent-free taxane with higher response rates and improved tolerability Nab-Paclitaxel displays less toxicity and greater antitumor activity Nab-Paclitaxel is more readily available for tumor cell uptake in three rhabdomyosarcoma seven neuroblastoma cell lines and one ostersarcoma cell line Nab-Paclitaxel can be studied in cancer research for example breast cancer and solid tumors (The product specifications below only indicate the effective content of Paditaxel the actual albumin quality depends on the batch the ratio of each ingredient in this product is Paditaxel albumin -1 7 1 11)[1][2]
Medchemexpress LLC Nab-Paclitaxel 1mg | 1mg
Nab-Paclitaxel (Nanoparticle albumin-bound Paclitaxel) is an albumin-bound nanoparticle formulation of Paclitaxel (HY-B0015) Nab-Paclitaxel is composed of albumin and the active pharmaceutical ingredient Paclitaxel in which human albumin is used as an excipient to disperse and stabilize particles and carry the main drug Nab-Paclitaxel is a solvent-free taxane with higher response rates and improved tolerability Nab-Paclitaxel displays less toxicity and greater antitumor activity Nab-Paclitaxel is more readily available for tumor cell uptake in three rhabdomyosarcoma seven neuroblastoma cell lines and one ostersarcoma cell line Nab-Paclitaxel can be studied in cancer research for example breast cancer and solid tumors (The product specifications below only indicate the effective content of Paditaxel the actual albumin quality depends on the batch the ratio of each ingredient in this product is Paditaxel albumin -1 7 1 11)[1][2]
Medchemexpress LLC (5E,9E,13E)-teprenone | 3796-63-2 | 99.9% | 330.56 g/mol | C23H38O | 10 MG
(5E,9E,13E)-teprenone is a geranylgeranyl-derived small molecule used in research to induce heat shock proteins (HSPs) and to study gastric mucosal protection. Supplied as a high-purity reagent suitable for biochemical and cellular assays.
- High purity (99.9%) suitable for research applications.
- CAS number 3796-63-2 for unambiguous identification.
- Chemical formula C23H38O; molecular weight 330.56 g/mol.
- Supplied as a 10 mg pack for small-scale experiments.
- Recommended storage: 4°C; in solvent: -80°C (6 months) or -20°C (1 month) under nitrogen.
Medchemexpress LLC 7-epi-docetaxel | 153381-68-1 | MFCD15071206 | 98.8% | 807.88 g·mol⁻¹ | C43H53NO14 | 10 MG
7-Epi-docetaxel is an epimeric impurity of docetaxel used as a research compound and microtubule/tubulin inhibitor. Supplied as a solid powder in a 10 mg quantity, it is intended for laboratory research use only and not for human or clinical applications.
- Impurity/epimer of docetaxel used to study tubulin dynamics and cytotoxicity.
- Solid powder formulation suitable for analytical and cell-based research.
- CAS number 153381-68-1 for unambiguous identification.
- Chemical formula C43H53NO14; molecular weight 807.88 g·mol⁻¹.
- High purity (98.8% reported by supplier) for analytical consistency.
- Store powder at -20°C for long term; store solutions at -80°C for long term per handling instructions.
Medchemexpress LLC Isophytol | 505-32-8 | MFCD00048380 | 99.7% | 296.53 g/mol | C20H40O | 500 G
Isophytol is a branched-chain terpene alcohol used as an organic reagent and intermediate in biochemical and life-science research. It is a colorless to light-yellow liquid commonly used in organic synthesis, assay development, and fragrance/intermediate applications.
- High purity, 99.7%.
- Liquid physical form; density ~0.841 g/cm3.
- Molecular weight 296.53 g/mol.
- Suitable for organic synthesis and assay development.
- Available in bulk packaging, including 500 g quantities.
AdipoGen -Aphidicolin
Chemical. CAS 38966-21-1. Formula C20H34O4. MW 338.5. Isolated from Phoma sp. BS 7210. Phytotoxin. Antibiotic. Antiviral and antineoplastic agent. Antileishmanial agent. Reversible inhibitor of eukaryotic nuclear DNA replication. Useful for cell synchronization. Blocks the cell cycle at G1/S phase. Prolongs the half life of DNA methyltransferase. DNA methylation/demethylation modulator. Specific DNA polymerase alpha and delta inhibitor in eukaryotic cells and in some viruses of animal origin. Acts synergistically with vincristine and doxorubicin. Apoptosis inhibitor/inducer.