Diterpenoids
eMolecules Tanshinone i | 568-73-0 | MFCD00210563 | 1g
Combi-Blocks, Inc. | Tanshinone i | 1g | 603145422 | QC-9410 | 95.000 | 568-73-0 | MFCD00210563 | 276.291 | C18H12O3
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool
Selleck Chemical LLC Paclitaxel S1150-1g
Paclitaxel is a microtubule polymer stabilizer with IC50 of 0 1 pM in human endothelial cells Paclitaxel can cause both mitotic arrest and apoptotic cell death Paclitaxel also induces autophagy
TARGETMOL CHEMICALS INC Docetaxel 500MG
Also available in 1 g, 1 mL, 25 mg, 50 mg, 100 mg, 200 mg and bulk. Please contact Fisher for quotes. Docetaxel (RP-56976), a semi-synthetic analog of paclitaxel, is a microtubule depolymerization inhibitor (IC50=0.2 uM) that attenuates the effects of bcl-2 and bcl-xL gene expression and exhibits apoptosis-inducing, anti-tumor activity. Purity 99.1%
TARGETMOL CHEMICALS INC Aphidicolin 1MG
Aphidicolin, an antibiotic derived from the mold Cephalosporium aphidicola, is a potent inhibitor of DNA (deoxyribonucleic acid) synthesis, effectively hindering the proliferation of herpes simplex virus[2]. It targets DNA polymerase alpha and delta, disrupting mitotic cell division by affecting DNA polymerase activity[1]. Additionally, aphidicolin enhances apoptosis when combined with arabinosyl nucleosides in a human promyelocytic leukemia cell line[3].
Apexbio Technology LLC Phytol 150-86-7 100g
Phytol is a naturally occurring diterpene alcohol derived from chlorophyll metabolism serving as an activator for retinoid X receptors (RXRs) RXRs are nuclear hormone receptors implicated in transcriptional regulation and cellular differentiation through ligand-dependent signaling pathways involving vitamins and hormones Phytol activates RXRs displaying Ki values ranging from 2 3 to 67 2 M In mammals phytol is metabolized to phytanic acid a reaction regulated by peroxisome proliferator-activated receptor (PPAR ) Additionally phytol interacts with GABA A receptors exhibiting sedative and anxiolytic properties and has been investigated as an antischistosomal candidate in animal models
TARGETMOL CHEMICALS INC Tanshinone I 25MG
Also available in 5 mg, 10 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Tanshinone I (Tanshinone A), an active principle isolated from the herbal medicine Salvia miltiorrhiza, displays cytotoxicity against tumor cells. Purity 98.58%
Medchemexpress LLC Topoisomerase IIα-in-8 | 1251578-67-2 | 314.32 | C15H15FN6O | 1 MG
Topoisomerase IIα-IN-8 is a research-grade small-molecule inhibitor of human DNA topoisomerase IIα reported as a weak inhibitor (IC50 = 462 ± 38.0 μM). It is supplied as a powder for laboratory use, has molecular formula C15H15FN6O and molecular weight 314.32 g·mol-1, and is provided with downloadable product and safety documentation. For research use only.
- Weak inhibitor of human DNA topoisomerase IIα (IC50 = 462 ± 38.0 μM).
- Shows limited antiproliferative activity (GI50 > 100 μM in HEK293 and HT-29 cells).
- Supplied as a powder with specified storage recommendations for powder and solutions.
- Molecular formula C15H15FN6O; molecular weight 314.32 g·mol-1.
- Datasheet and safety data sheet available for handling and purity details.
Apexbio Technology LLC Paclitaxel (Taxol) 33069-62-4 100mg
Paclitaxel (Taxol) is a diterpenoid alkaloid initially isolated from the bark of Taxus brevifolia It exhibits antitumor activity primarily by disrupting microtubule dynamics Mechanistically paclitaxel binds tubulin and promotes microtubule polymerization thus stabilizing microtubules and inhibiting their depolymerization This mechanism impairs normal mitotic spindle formation arrests cells in G2-M phase of the cell cycle and induces apoptotic cell death Paclitaxel is extensively employed in biomedical research for investigating antineoplastic mechanisms and testing therapeutic interventions targeting various cancers such as ovarian breast head and neck and lung carcinoma
Apexbio Technology LLC Paclitaxel (Taxol) 33069-62-4 10mM (in 1mL DMSO)
Paclitaxel (Taxol) is a diterpenoid alkaloid initially isolated from the bark of Taxus brevifolia It exhibits antitumor activity primarily by disrupting microtubule dynamics Mechanistically paclitaxel binds tubulin and promotes microtubule polymerization thus stabilizing microtubules and inhibiting their depolymerization This mechanism impairs normal mitotic spindle formation arrests cells in G2-M phase of the cell cycle and induces apoptotic cell death Paclitaxel is extensively employed in biomedical research for investigating antineoplastic mechanisms and testing therapeutic interventions targeting various cancers such as ovarian breast head and neck and lung carcinoma