Diterpenoids
![Medchemexpress LLC 1H-Indole-2,3-dione, 5-chloro-1-[(2,5-dichlorophenyl)methyl]-, 3-(O-acetyloxime) | 668467-91-2 | 98.9% | 397.64 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000387735-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 1H-Indole-2,3-dione, 5-chloro-1-[(2,5-dichlorophenyl)methyl]-, 3-(O-acetyloxime) | 668467-91-2 | 98.9% | 397.64 | 1 ML
LDN-57444 is a reversible, competitive, and site-directed inhibitor of ubiquitin C-terminal hydrolase L1 (UCH-L1) with an IC50 of 0.88 μM and a Ki of 0.40 μM. It also suppresses UCH-L3 activity, with an IC50 of 25 μM.
- Inhibits UCH-L1 with high potency (IC50 of 0.88 μM, Ki of 0.40 μM) and suppresses UCH-L3 activity (IC50 of 25 μM).
- Inhibits 70% of Uch activity in hippocampal slices of mouse brain at 5 μM for 1 hour.
- Inhibits ubiquitin-proteasome activity dose-dependently (25-100 μM) in SK-N-SH cells.
- Induces apoptotic cell death, causes endoplasmic reticulum stress, and results in expression of spliced XBP-1 in SK-N-SH cells at 50 μM.
- Blocks the beneficial effect of V-Uch-L1 and worsens contextual conditioning performance in mice at 0.4 mg/kg (intraperitoneal injection).
- Purity: 98.93%.
TARGETMOL CHEMICALS INC 7-Epi 10-desacetyl paclitaxel
7-Epi 10-desacetyl paclitaxel (10-Deacetyl-7-epipaclitaxel) shows IC50 values of 0.085 nM, against HeLa cells. Purity 98.05%
Medchemexpress LLC Docetaxel (standard) | 114977-28-5 | 99.9% | C43H53NO14 | 5 MG
Docetaxel (Standard) is the analytical standard of Docetaxel, intended for research and analytical applications. Docetaxel (RP-56976) acts as a microtubule depolymerization inhibitor with an IC50 of 0.2 μM. It attenuates the effects of bcl-2 and bcl-xL gene expression, arrests the cell cycle at G2/M, and induces cell apoptosis, demonstrating anti-cancer activity.
- Serves as a grade of analytical standard, providing a reference standard for assays
- Commonly utilized in qualitative, quantitative, and methodological research experiments, including techniques such as HPLC, GC, and MS
Medchemexpress LLC Paclitaxel-d5 | 1129540-33-5 | 1129540-33-5 | 99.9% | C47H46D5NO14 | 1 MG
Paclitaxel-d5 is a deuterium-labeled Paclitaxel, a natural antineoplastic agent that works by stabilizing tubulin polymerization. This product is strictly for research purposes and is not intended for patient use. Deuteration, the process of incorporating stable heavy isotopes into drug molecules, is primarily employed as a tracer for quantitation during the drug development process and can impact the pharmacokinetic and metabolic profiles of drugs.
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Stabilizes tubulin polymerization
- For research use only
Medchemexpress LLC Paclitaxel (Standard) | 33069-62-4 | 99.9% | C₄₇H₅₁NO₁₄ | 5 MG
Paclitaxel (Standard) is an analytical standard of Paclitaxel, a naturally occurring antineoplastic agent that stabilizes tubulin polymerization, causing mitotic arrest and apoptotic cell death, and also induces autophagy. This compound serves as a reference standard for various research applications.
- Analytical standard for research and analytical applications
- Stabilizes tubulin polymerization
- Induces mitotic arrest and apoptotic cell death
- Induces autophagy
- Reference standard for assays
- Used in HPLC, GC, and MS experiments
- White to off-white solid appearance
- Molecular weight is 853.91
- Derived from Taxaceae family plants (*Taxus chinensis*)
Medchemexpress LLC Paclitaxel | 33069-62-4 | MFCD00869953 | 99.9% | 853.91 g/mol | C47H51NO14 | 10 MG
Paclitaxel (Standard) is an analytical reference standard of paclitaxel for research and analytical applications. Paclitaxel is a naturally occurring antineoplastic agent that stabilizes tubulin polymerization and can cause mitotic arrest, apoptotic cell death, and autophagy. Provided in a 10 mg reference pack with high-purity material suitable for method development and quantitative assays.
- Analytical standard intended for research and analytical applications.
- High purity: 99.88%.
- Suitable for HPLC and LC-MS method development and validation.
- Mechanism: stabilizes tubulin polymerization and induces apoptosis.
- Molecular formula C47H51NO14 and molecular weight 853.91 g/mol.
Cayman Chemical Paclitaxel Neurochemicals
A potent disruptor of microtubules used as a chemotherapeutic compound; inhibits growth of cervical (HeLa), lung (A549), breast (MCF-7), colon (HT-29), ovarian (OVG-1), and pancreatic (PC-Sh) carcinomas with IC50 values ranging from 2.5-7.5 nM; induces mitotic arrest and initiates apoptosis of cancer cells through multiple mechanisms
AdipoGen Docetaxel
Chemical. CAS 114977-28-5. Formula C43H53NO14. MW 807.88. Synthetic. Anticancer agent. Semisynthetic analog of taxol paclitaxel. Inhibits microtubule disassembly and inhibits cell replication. Binds to and stabilizes the beta−tubulin subunit of microtubules, preventing depolymerization of the mitotic spindle thus leading to cell cycle arrest at G2/M and apoptosis. This cytotoxic activity has been widely exploited in suppressing oncogenic proliferation. Displays potent and broad antineoplastic properties, used mainly for the treatment of breast, ovarian, and non-small cell lung cancer. Also inhibits pro-angiogenic factors such as vascular endothelial growth factor VEGF and displays immunomodulatory and pro-inflammatory properties by inducing various mediators of the inflammatory response. Also studied for use as a radiation-sensitizing agent.
Medchemexpress LLC Resiniferatoxin | 57444-62-9 | 5 MG
Resiniferatoxin is a selective agonist of the transient receptor potential vanilloid 1 (TRPV1) receptor. It can be isolated from the Euphorbia resinifera plant. This compound eliminates TRPV1+ primary sensory afferents and blunts cardiac sympathetic afferent reflex for a relatively long period.
- Selective agonist of TRPV1 receptor
- Isolated from Euphorbia resinifera plant
- Eliminates TRPV1+ primary sensory afferents
- Blunts cardiac sympathetic afferent reflex
- For research use only
![Medchemexpress LLC 1H-Indole-2,3-dione, 5-chloro-1-[(2,5-dichlorophenyl)methyl]-, 3-(O-acetyloxime) | 668467-91-2 | 98.93% | 397.64 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000384533-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 1H-Indole-2,3-dione, 5-chloro-1-[(2,5-dichlorophenyl)methyl]-, 3-(O-acetyloxime) | 668467-91-2 | 98.93% | 397.64 | 25 MG
LDN-57444 is a reversible, competitive, and site-directed inhibitor of ubiquitin C-terminal hydrolase L1 (UCH-L1), with an IC50 of 0.88 μM and a Ki of 0.40 μM. It also suppresses UCH-L3 activity, with an IC50 of 25 μM.
- Inhibits 70% of Uch activity in hippocampal slices of mouse brain at 5 μM for 1 hour.
- Does not further reduce potentiation in APP/PS1 slices or in wt slices exposed to 200 nM Aβ at 5 μM for 2 hours.
- Inhibits ubiquitin-proteasome activity dose-dependently in SK-N-SH cells at 25-100 μM.
- Induces apoptotic cell death, causes endoplasmic reticulum stress, and results in expression of spliced XBP-1 (XBP-1s, 48KD) in SK-N-SH cells at 50 μM.
- Blocks the beneficial effect of V-Uch-L1 and worsens contextual conditioning performance in mice when administered at 0.4 mg/kg (i.p.) and exposed to the context at 1, 7, 14, and 21 days after training.
Medchemexpress LLC Resiniferatoxin | 57444-62-9 | 10 MM 1 ML
Resiniferatoxin is a selective agonist of the transient receptor potential vanilloid 1 (TRPV1) receptor. It can be isolated from the Euphorbia resinifera plant. It eliminates TRPV1+ primary sensory afferents and blunts cardiac sympathetic afferent reflex for a relatively long period. It is for research use only.
- Selective agonist for the transient receptor potential vanilloid 1 (TRPV1) receptor.
- Can be isolated from the Euphorbia resinifera plant.
- Eliminates TRPV1+ primary sensory afferents.
- Blunts cardiac sympathetic afferent reflex for a relatively long period.
- Causes prolonged channel opening and calcium influx, leading to cytotoxicity in TRPV1-positive pain fibers or cell bodies.
- For research use only.
Medchemexpress LLC Phytol | 150-86-7 | 1 ML
Phytol ((E)-Phytol) is an orally active diterpenoid alcohol extracted from chlorophyll. It exhibits antioxidant, anti-inflammatory, anti-schistosomiasis, and antibacterial activities. It is intended for research use only and not for sale to patients.
- Exhibits antioxidant activity
- Shows anti-inflammatory properties
- Possesses anti-schistosomiasis activity
- Demonstrates antibacterial activities
- Reduces motor activity and causes death in worms
- Inhibits osteoclast differentiation and oxidative stress
- Reduces parasite numbers in mice infected with C. mansoni
- Improves anemia and oxidative brain damage in Plasmodium berghei infected mice
Medchemexpress LLC Tanshinone IIA (Dan Shen ketone) | 568-72-9 | 99.78% | 294.34 | 5 MG
Tanshinone IIA is a primary component found in the root of Salvia miltiorrhiza Bunge. It may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2, and has anti-tumor effects including inhibiting tumor cell proliferation, disrupting the tumor cell cycle, promoting tumor cell apoptosis, and inhibiting tumor cell invasion and transfer.
- Has antiproliferative activity against various cell lines
- Protects rat myocardium-derived H9C2 cells against apoptosis
- Blocks the PI3K/Akt/mTOR pathway in gastric carcinoma AGS cells