Diterpenoids
Medchemexpress LLC Paclitaxel | 33069-62-4 | MFCD00869953 | 100.0% | 853.91 g·mol⁻¹ | C47H51NO14 | 10 MG
Paclitaxel is a microtubule-stabilizing antineoplastic reagent used in biological research to inhibit mitosis and induce apoptosis. It is supplied as a solid for preparation of experimental stock solutions and is commonly used in cell culture, in vivo studies, and assay development.
- Stabilizes tubulin polymerization and induces mitotic arrest.
- Used for cell culture, in vivo tumor models, and assay development.
- Supplied as a solid powder suitable for dissolution in DMSO or other organic solvents.
- Storage recommendations: protect from light; solids at 4°C; solutions at -20°C (short term) or -80°C (long term).
- Analytical identity confirmed by LC-MS; batch-specific purity reported by certificate of analysis.
Apexbio Technology LLC Phytol 150-86-7 250g
Phytol is a naturally occurring diterpene alcohol derived from chlorophyll metabolism serving as an activator for retinoid X receptors (RXRs) RXRs are nuclear hormone receptors implicated in transcriptional regulation and cellular differentiation through ligand-dependent signaling pathways involving vitamins and hormones Phytol activates RXRs displaying Ki values ranging from 2 3 to 67 2 M In mammals phytol is metabolized to phytanic acid a reaction regulated by peroxisome proliferator-activated receptor (PPAR ) Additionally phytol interacts with GABA A receptors exhibiting sedative and anxiolytic properties and has been investigated as an antischistosomal candidate in animal models
Medchemexpress LLC (5E,9E,13E)-Teprenone | 3796-63-2 | 99.9% | 100 MG
(5E,9E,13E)-Teprenone is an isomer with antiulcer activity. It induces the transcriptional activation of HSP genes, which may enhance gastric mucosal defense under stress conditions.
- Antiulcer activity.
- Induces transcriptional activation of heat shock protein protein genes.
- May increase gastric mucosal defense at conditions of stress.
- Available in various quantities.
- Purity of 99.9%.
Medchemexpress LLC Tanshinone I | 568-73-0 | MFCD00210563 | 98.8% | 276.29 g/mol | C18H12O3 | 10 MG
Tanshinone I is a natural diterpenoid research standard used as a phospholipase inhibitor and analytical reference for biochemical and preclinical studies. It inhibits human type IIA secreted phospholipase A2 (sPLA2) (IC50 = 11 μM) and rabbit cytosolic phospholipase A2 (cPLA2) (IC50 = 82 μM), and is supplied as a high-purity solid for laboratory use.
- Natural diterpenoid research standard for biochemical assays.
- Inhibits sPLA2 (human type IIA) and cPLA2 (rabbit) with reported IC50 values.
- High purity suitable for analytical and research applications.
- Supplied as a solid for flexible formulation and storage.
- Commonly used in studies of inflammation and cardiovascular pathways.
Medchemexpress LLC Docetaxel | 114977-28-5 | 99.9% | 807.88 | C43H53NO14 | 10 MG
Docetaxel (standard) is an analytical reference of the chemotherapeutic agent docetaxel supplied for research and analytical applications. It acts as a microtubule depolymerization inhibitor that arrests cells at G2/M and promotes apoptosis. The product is provided in small vial sizes for laboratory workflows and is accompanied by supporting documentation (SDS, COA).
- High purity suitable for analytical applications.
- Molecular weight 807.88.
- CAS number 114977-28-5 for unambiguous identification.
- Available in multiple small vial sizes for flexibility in experiments.
- Intended for research and analytical use only.
Medchemexpress LLC Docetaxel Standard | 114977-28-5 | C43H53NO14 | 25MG
Docetaxel (RP-56976) is a microtubule depolymerization inhibitor with an IC50 of 0.2 μM. It attenuates the effects of bcl-2 and bcl-xL gene expression, arrests the cell cycle at G2/M, and leads to cell apoptosis. Docetaxel exhibits anti-cancer activity.
- Microtubule depolymerization inhibitor
- Attenuates bcl-2 and bcl-xL gene expression
- Arrests cell cycle at G2/M
- Leads to cell apoptosis
- Exhibits anti-cancer activity
![Medchemexpress LLC Sodium 1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-2-sulfonate | 69659-80-9 | MFCD09028094 | 99.8% | 396.4 g/mol | C19H17NaO6S | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000295618.png-250.jpg)
Medchemexpress LLC Sodium 1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-2-sulfonate | 69659-80-9 | MFCD09028094 | 99.8% | 396.4 g/mol | C19H17NaO6S | 10 MG
Tanshinone IIA sulfonate sodium is the sodium sulfonate derivative of tanshinone IIA. It is a water-soluble small molecule reported to inhibit store-operated Ca2+ entry (SOCE) and is used in research on cardiovascular disorders and calcium-signaling pathways.
- Water-soluble sodium sulfonate derivative suitable for aqueous assays.
- Reported inhibitor of store-operated Ca2+ entry (SOCE).
- Applicable to cardiovascular and calcium-signaling research models.
- Characterized chemical identifiers: formula C19H17NaO6S and molecular weight 396.4 g/mol.
- High reported purity (≈99.8%) for research applications.
Medchemexpress LLC Resiniferatoxin | 57444-62-9 | 10 MM 1 ML
Resiniferatoxin is a selective agonist of the transient receptor potential vanilloid 1 (TRPV1) receptor. It can be isolated from the Euphorbia resinifera plant. It eliminates TRPV1+ primary sensory afferents and blunts cardiac sympathetic afferent reflex for a relatively long period. It is for research use only.
- Selective agonist for the transient receptor potential vanilloid 1 (TRPV1) receptor.
- Can be isolated from the Euphorbia resinifera plant.
- Eliminates TRPV1+ primary sensory afferents.
- Blunts cardiac sympathetic afferent reflex for a relatively long period.
- Causes prolonged channel opening and calcium influx, leading to cytotoxicity in TRPV1-positive pain fibers or cell bodies.
- For research use only.
Medchemexpress LLC Aphidicolin | 38966-21-1 | MFCD00083214 | 25 MG
Aphidicolin is an inhibitor of DNA polymerase α and δ, which functions by interfering with DNA polymerase activity to prevent mitotic cell division. This antibiotic, originating from the mold Cephalosporium aphidicola, is known for its ability to inhibit cellular deoxyribonucleic acid synthesis and the growth of herpes simplex virus. Furthermore, it demonstrates anti-orthopoxvirus activity and enhances apoptosis when induced by arabinosyl nucleosides in a human promyelocytic leukemia cell line.
- Inhibits DNA polymerase α and δ
- Prevents mitotic cell division
- Functions as an antibiotic
- Inhibits cellular deoxyribonucleic acid synthesis
- Inhibits growth of herpes simplex virus
- Exhibits anti-orthopoxvirus activity
- Potentiates apoptosis induced by arabinosyl nucleosides
- Targets DNA/RNA synthesis, HSV, and apoptosis pathways
- Applied in infection and inflammation/immunology research
Medchemexpress LLC Isotanshinone IIA | 20958-15-0 | 5 MG
Isotanshinone IIA is an abietane-type diterpene metabolite that non-competitively inhibits Protein Tyrosine Phosphatase 1B (PTP1B) activity with an IC50 of 11.4 μM. Intended for research use only, this product is an orange to orange-red solid with 98.0% purity. It has a molecular weight of 294.34 and a chemical formula of C19H18O3.
- Non-competitive inhibitor of Protein Tyrosine Phosphatase 1B (PTP1B) activity
- IC50 of 11.4 μM
- 98.0% purity
- Appears as an orange to orange-red solid
- Molecular weight of 294.34
- Chemical formula of C19H18O3
- Classified under Quinones and Naphthalene Quinones
- Powder storage: -20°C for 3 years
- In solvent storage: -80°C for 6 months, -20°C for 1 month
- Soluble in DMSO at 3 mg/mL (10.19 mM)
Apexbio Technology LLC Docetaxel 114977-28-5 100mg
Docetaxel (CAS 114977-28-5) is a semisynthetic taxane derivative originally isolated from the European yew (Taxus baccata) As an antineoplastic agent docetaxel disrupts microtubule dynamics by stabilizing tubulin polymerization resulting in cell cycle arrest at mitosis and subsequent apoptosis In both in vitro and in vivo studies docetaxel demonstrates pronounced cytotoxic activity against diverse tumor types such as breast lung ovarian head and neck and gastric cancers Research particularly highlights its enhanced potency against ovarian cancer cell lines compared to paclitaxel cisplatin and etoposide indicating substantial research value in oncology programs
Medchemexpress LLC Paclitaxel | 33069-62-4 | MFCD00869953 | 99.9% | 853.91 g/mol | C47H51NO14 | 10 MG
Paclitaxel (Standard) is an analytical reference standard of paclitaxel for research and analytical applications. Paclitaxel is a naturally occurring antineoplastic agent that stabilizes tubulin polymerization and can cause mitotic arrest, apoptotic cell death, and autophagy. Provided in a 10 mg reference pack with high-purity material suitable for method development and quantitative assays.
- Analytical standard intended for research and analytical applications.
- High purity: 99.88%.
- Suitable for HPLC and LC-MS method development and validation.
- Mechanism: stabilizes tubulin polymerization and induces apoptosis.
- Molecular formula C47H51NO14 and molecular weight 853.91 g/mol.
Medchemexpress LLC Isotanshinone IIA | 20958-15-0 | 1 MG
Isotanshinone IIA is an abietane-type diterpene metabolite. It functions as a non-competitive inhibitor of Protein Tyrosine Phosphatase 1B (PTP1B) activity with an IC50 of 11.4 μM. This compound appears as an orange to orange-red solid and is intended for research use only.
- High purity: 98.0%
- IC50: 11.4 μM for PTP1B
- Molecular weight: 294.34
- Chemical formula: C19H18O3
- Appearance: Solid
- Color: Orange to orange-red
- Structure classification: Quinones, Naphthalene Quinones
- Initial source: Plants Leguminosae Samanea saman (Jacq.) Merr., Plants Labiatae
- Solubility in DMSO: 3 mg/mL (10.19 mM)