Diterpenoids
Selleck Chemical LLC Paclitaxel S1150-100mg
Paclitaxel is a microtubule polymer stabilizer with IC50 of 0 1 pM in human endothelial cells Paclitaxel can cause both mitotic arrest and apoptotic cell death Paclitaxel also induces autophagy
Apexbio Technology LLC Docetaxel 114977-28-5 10mM (in 1mL DMSO)
Docetaxel (CAS 114977-28-5) is a semisynthetic taxane derivative originally isolated from the European yew (Taxus baccata) As an antineoplastic agent docetaxel disrupts microtubule dynamics by stabilizing tubulin polymerization resulting in cell cycle arrest at mitosis and subsequent apoptosis In both in vitro and in vivo studies docetaxel demonstrates pronounced cytotoxic activity against diverse tumor types such as breast lung ovarian head and neck and gastric cancers Research particularly highlights its enhanced potency against ovarian cancer cell lines compared to paclitaxel cisplatin and etoposide indicating substantial research value in oncology programs
Medchemexpress LLC Resiniferatoxin | 57444-62-9 | MFCD00135927 | 50 MG
Resiniferatoxin is a selective agonist of the transient receptor potential vanilloid 1 (TRPV1) receptor. It can be isolated from the Euphorbia resinifera plant. Resiniferatoxin eliminates TRPV1+ primary sensory afferents and blunts cardiac sympathetic afferent reflex for a relatively long period. It causes extremely prolonged channel opening and calcium influx, leading to cytotoxicity to TRPV1-positive pain fibers or cell bodies.
- Selective agonist of the transient receptor potential vanilloid 1 (TRPV1) receptor
- Isolated from the Euphorbia resinifera plant
- Eliminates TRPV1+ primary sensory afferents
- Blunts cardiac sympathetic afferent reflex
- Causes prolonged channel opening and calcium influx
- Leads to cytotoxicity to TRPV1-positive pain fibers or cell bodies
![Medchemexpress LLC 1H-Indole-2,3-dione, 5-chloro-1-[(2,5-dichlorophenyl)methyl]-, 3-(O-acetyloxime) | 668467-91-2 | 98.9% | 397.64 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000388040-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 1H-Indole-2,3-dione, 5-chloro-1-[(2,5-dichlorophenyl)methyl]-, 3-(O-acetyloxime) | 668467-91-2 | 98.9% | 397.64 | 5 MG
1H-Indole-2,3-dione, 5-chloro-1-[(2,5-dichlorophenyl)methyl]-, 3-(O-acetyloxime) | 668467-91-2 | 98.9% | 397.64 | 5 MG
AdipoGen Resiniferatoxin high purity
Chemical. CAS 57444-62-9. Formula C37H40O9. MW 628.72. Isolated from Euphorbia resinifera. Highly potent TRPV1 agonist. Resiniferatoxin RTX is a phorbol-related diterpene ester analog of capsaicin. RTX is a highly potent transient receptor potential vanilloid 1 TRPV1 agonist Ki=43pM and acts as a selective modulator of primary afferent neurons. TRPV1 or vanilloid receptor 1 is a non-selective cation channel that is involved in the detection and transduction of nociceptive stimuli. TRPV1 is expressed in the plasma membrane of sensory neurons and stimulation by RTX causes this ion channel to become permeable to cations, especially calcium. The influx of cations causes the neuron to depolarize, transmitting signals similar to those that would be transmitted if the innervated tissue were being burned or damaged. This stimulation is followed by desensitization and analgesia, in part because the nerve endings die from calcium overload.
Medchemexpress LLC Resiniferatoxin | 57444-62-9 | 5 MG
Resiniferatoxin is a selective agonist of the transient receptor potential vanilloid 1 (TRPV1) receptor. It can be isolated from the Euphorbia resinifera plant. This compound eliminates TRPV1+ primary sensory afferents and blunts cardiac sympathetic afferent reflex for a relatively long period.
- Selective agonist of TRPV1 receptor
- Isolated from Euphorbia resinifera plant
- Eliminates TRPV1+ primary sensory afferents
- Blunts cardiac sympathetic afferent reflex
- For research use only
![Medchemexpress LLC 1H-Indole-2,3-dione, 5-chloro-1-[(2,5-dichlorophenyl)methyl]-, 3-(O-acetyloxime) | 668467-91-2 | 98.93% | 397.64 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000384533-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 1H-Indole-2,3-dione, 5-chloro-1-[(2,5-dichlorophenyl)methyl]-, 3-(O-acetyloxime) | 668467-91-2 | 98.93% | 397.64 | 25 MG
LDN-57444 is a reversible, competitive, and site-directed inhibitor of ubiquitin C-terminal hydrolase L1 (UCH-L1), with an IC50 of 0.88 μM and a Ki of 0.40 μM. It also suppresses UCH-L3 activity, with an IC50 of 25 μM.
- Inhibits 70% of Uch activity in hippocampal slices of mouse brain at 5 μM for 1 hour.
- Does not further reduce potentiation in APP/PS1 slices or in wt slices exposed to 200 nM Aβ at 5 μM for 2 hours.
- Inhibits ubiquitin-proteasome activity dose-dependently in SK-N-SH cells at 25-100 μM.
- Induces apoptotic cell death, causes endoplasmic reticulum stress, and results in expression of spliced XBP-1 (XBP-1s, 48KD) in SK-N-SH cells at 50 μM.
- Blocks the beneficial effect of V-Uch-L1 and worsens contextual conditioning performance in mice when administered at 0.4 mg/kg (i.p.) and exposed to the context at 1, 7, 14, and 21 days after training.
Medchemexpress LLC Resiniferatoxin | 57444-62-9 | 10 MM 1 ML
Resiniferatoxin is a selective agonist of the transient receptor potential vanilloid 1 (TRPV1) receptor. It can be isolated from the Euphorbia resinifera plant. It eliminates TRPV1+ primary sensory afferents and blunts cardiac sympathetic afferent reflex for a relatively long period. It is for research use only.
- Selective agonist for the transient receptor potential vanilloid 1 (TRPV1) receptor.
- Can be isolated from the Euphorbia resinifera plant.
- Eliminates TRPV1+ primary sensory afferents.
- Blunts cardiac sympathetic afferent reflex for a relatively long period.
- Causes prolonged channel opening and calcium influx, leading to cytotoxicity in TRPV1-positive pain fibers or cell bodies.
- For research use only.
Selleck Chemical LLC LDN-57444
LDN-57444 is a reversible competitive proteasome inhibitor for Uch-L1 with IC50 of 0 88 M 28-fold selectivity over isoform Uch-L3
TARGETMOL CHEMICALS INC Resiniferatoxin 1MG
Resiniferatoxin ((+)-Resiniferatoxin) is a highly potent synthetic TRPV1 agonist that inhibits the production of Th1 cytokines and has anti-inflammatory activity, reducing serum levels of IL-12, INF-gamma, IL-1beta, TNF-alpha, NO, and PGE. Purity 99.12%
Medchemexpress LLC Aphidicolin | 38966-21-1 | 5 MG
Aphidicolin is an inhibitor of DNA polymerase α and δ, which prevents mitotic cell division by interfering with DNA polymerase activity. It is an antibiotic produced by the mold Cephalosporium aphidicola. Aphidicolin inhibits cellular deoxyribonucleic acid synthesis and the growth of herpes simplex virus. It also demonstrates anti-orthopoxvirus activity and enhances apoptosis induced by arabinosyl nucleosides in a human promyelocytic leukemia cell line.
- Inhibits DNA polymerase α and δ
- Prevents mitotic cell division
- Antibiotic from Cephalosporium aphidicola
- Inhibits DNA synthesis and herpes simplex virus growth
- Exhibits anti-orthopoxvirus activity
- Enhances apoptosis
- Selectively kills neuroblastoma cells
- Arrests cell cycle at G2 phase
- Inhibits cell proliferation via p53-GADD45β pathway
- Inhibits Varicella-zoster virus (VZV)
Cayman Chemical -AphIdIcolIn 5mg
A natural tetracyclic diterpene with antiviral activity against herpes simplex; a cell-permeable, reversible inhibitor of DNA replication in eukaryotic cells, specifically blocking the activity of DNA polymerases α, δ, and ε when used at low micromolar levels.
Medchemexpress LLC Aphidicolin | 38966-21-1 | MFCD00083214 | 1 ML
Aphidicolin is an inhibitor of DNA polymerase α and δ, which prevents mitotic cell division by interfering with DNA polymerase activity. It is an antibiotic produced by the mold Cephalosporium aphidicola. Aphidicolin inhibits cellular deoxyribonucleic acid synthesis and the growth of herpes simplex virus. It also demonstrates anti-orthopoxvirus activity and enhances apoptosis induced by arabinosyl nucleosides in a human promyelocytic leukemia cell line.
- Inhibits DNA polymerase α and δ
- Prevents mitotic cell division
- Inhibits cellular deoxyribonucleic acid synthesis
- Inhibits the growth of herpes simplex virus
- Shows anti-orthopoxvirus activity
- Enhances apoptosis induced by arabinosyl nucleosides in human promyelocytic leukemia cells
Sigma Aldrich Fine Chemicals Biosciences Aphidicolin from Nigrospor5MG
Aphidicolin from Nigrospor5MG
Sigma Aldrich Fine Chemicals Biosciences Aphidicolin - CAS 38966-21-1 - Calbiochem Aphidicolin, CAS 38966-21-1, is a cell-permeable antibiotic that acts as a cell synchronization agent. Blocks the cell cycle at early S-phase. | 38966-21-1 | MFCD00083214 | 1MG
Aphidicolin - CAS 38966-21-1 - Calbiochem Aphidicolin, CAS 38966-21-1, is a cell-permeable antibiotic that acts as a cell synchronization agent. Blocks the cell cycle at early S-phase. | Purity: >=98% (TLC) | Mol Wt: 338.48 | 38966-21-1 | MFCD00083214 | 1MG