Diterpenoids
Medchemexpress LLC Resiniferatoxin | 57444-62-9 | MFCD00135927 | 50 MG
Resiniferatoxin is a selective agonist of the transient receptor potential vanilloid 1 (TRPV1) receptor. It can be isolated from the Euphorbia resinifera plant. Resiniferatoxin eliminates TRPV1+ primary sensory afferents and blunts cardiac sympathetic afferent reflex for a relatively long period. It causes extremely prolonged channel opening and calcium influx, leading to cytotoxicity to TRPV1-positive pain fibers or cell bodies.
- Selective agonist of the transient receptor potential vanilloid 1 (TRPV1) receptor
- Isolated from the Euphorbia resinifera plant
- Eliminates TRPV1+ primary sensory afferents
- Blunts cardiac sympathetic afferent reflex
- Causes prolonged channel opening and calcium influx
- Leads to cytotoxicity to TRPV1-positive pain fibers or cell bodies
Medchemexpress LLC Resiniferatoxin | 57444-62-9 | 5 MG
Resiniferatoxin is a selective agonist of the transient receptor potential vanilloid 1 (TRPV1) receptor. It can be isolated from the Euphorbia resinifera plant. This compound eliminates TRPV1+ primary sensory afferents and blunts cardiac sympathetic afferent reflex for a relatively long period.
- Selective agonist of TRPV1 receptor
- Isolated from Euphorbia resinifera plant
- Eliminates TRPV1+ primary sensory afferents
- Blunts cardiac sympathetic afferent reflex
- For research use only
![Medchemexpress LLC 1H-Indole-2,3-dione, 5-chloro-1-[(2,5-dichlorophenyl)methyl]-, 3-(O-acetyloxime) | 668467-91-2 | 98.93% | 397.64 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000384533-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 1H-Indole-2,3-dione, 5-chloro-1-[(2,5-dichlorophenyl)methyl]-, 3-(O-acetyloxime) | 668467-91-2 | 98.93% | 397.64 | 25 MG
LDN-57444 is a reversible, competitive, and site-directed inhibitor of ubiquitin C-terminal hydrolase L1 (UCH-L1), with an IC50 of 0.88 μM and a Ki of 0.40 μM. It also suppresses UCH-L3 activity, with an IC50 of 25 μM.
- Inhibits 70% of Uch activity in hippocampal slices of mouse brain at 5 μM for 1 hour.
- Does not further reduce potentiation in APP/PS1 slices or in wt slices exposed to 200 nM Aβ at 5 μM for 2 hours.
- Inhibits ubiquitin-proteasome activity dose-dependently in SK-N-SH cells at 25-100 μM.
- Induces apoptotic cell death, causes endoplasmic reticulum stress, and results in expression of spliced XBP-1 (XBP-1s, 48KD) in SK-N-SH cells at 50 μM.
- Blocks the beneficial effect of V-Uch-L1 and worsens contextual conditioning performance in mice when administered at 0.4 mg/kg (i.p.) and exposed to the context at 1, 7, 14, and 21 days after training.
![Medchemexpress LLC 1H-Indole-2,3-dione, 5-chloro-1-[(2,5-dichlorophenyl)methyl]-, 3-(O-acetyloxime) | 668467-91-2 | 98.9% | 397.64 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000387735-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 1H-Indole-2,3-dione, 5-chloro-1-[(2,5-dichlorophenyl)methyl]-, 3-(O-acetyloxime) | 668467-91-2 | 98.9% | 397.64 | 1 ML
LDN-57444 is a reversible, competitive, and site-directed inhibitor of ubiquitin C-terminal hydrolase L1 (UCH-L1) with an IC50 of 0.88 μM and a Ki of 0.40 μM. It also suppresses UCH-L3 activity, with an IC50 of 25 μM.
- Inhibits UCH-L1 with high potency (IC50 of 0.88 μM, Ki of 0.40 μM) and suppresses UCH-L3 activity (IC50 of 25 μM).
- Inhibits 70% of Uch activity in hippocampal slices of mouse brain at 5 μM for 1 hour.
- Inhibits ubiquitin-proteasome activity dose-dependently (25-100 μM) in SK-N-SH cells.
- Induces apoptotic cell death, causes endoplasmic reticulum stress, and results in expression of spliced XBP-1 in SK-N-SH cells at 50 μM.
- Blocks the beneficial effect of V-Uch-L1 and worsens contextual conditioning performance in mice at 0.4 mg/kg (intraperitoneal injection).
- Purity: 98.93%.
TARGETMOL CHEMICALS INC Cucurbitacin IIA 10MG
Also available in 1 mg, 5 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. 1. Cucurbitacin IIA (Dihydrocucurbitacin Q1) can induce apoptosis and enhance autophagy , contributes to the anti-inflammatory activity of Cucurbitacin IIA against inflammation-related diseases. 2. Cucurbitacin IIA is a novel class of anti-cancer drug in suppression of cancer cell expansion by disrupting the actin cytoskeleton and directing the cell to undergo PARP-mediated apoptosis through the inhibition of survivin downstream of JAK2/STAT3. Purity 98.62%
Selleck Chemical LLC Cryptotanshinone (Tanshinone C) S2285-1g
Cryptotanshinone (Tanshinone C) is a STAT3 inhibitor with IC50 of 4 6 M in a cell-free assay strongly inhibits phosphorylation of STAT3 Tyr705 with a small effect on STAT3 Ser727 but none against STAT1 nor STAT5 Cryptotanshinone induces ROS-dependent autophagy and mitochondria-mediated apoptosis
Medchemexpress LLC Tanshinone IIA (Dan Shen ketone) | 568-72-9 | 99.78% | 294.34 | 5 MG
Tanshinone IIA is a primary component found in the root of Salvia miltiorrhiza Bunge. It may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2, and has anti-tumor effects including inhibiting tumor cell proliferation, disrupting the tumor cell cycle, promoting tumor cell apoptosis, and inhibiting tumor cell invasion and transfer.
- Has antiproliferative activity against various cell lines
- Protects rat myocardium-derived H9C2 cells against apoptosis
- Blocks the PI3K/Akt/mTOR pathway in gastric carcinoma AGS cells
Medchemexpress LLC Tanshinone I | 568-73-0 | 98.8% | 276.29 | 100 MG
Tanshinone I is an inhibitor of type IIA human recombinant sPLA2 and rabbit recombinant cPLA2. It demonstrates anti-inflammatory activity in rat carrageenan-induced paw oedema and adjuvant-induced arthritis. It is for research use only.
- Inhibits type IIA human recombinant sPLA2 and rabbit recombinant cPLA2
- Shows anti-inflammatory activity in animal models
- For research use only
Medchemexpress LLC Isotanshinone IIA | 20958-15-0 | 1 MG
Isotanshinone IIA is an abietane-type diterpene metabolite. It functions as a non-competitive inhibitor of Protein Tyrosine Phosphatase 1B (PTP1B) activity with an IC50 of 11.4 μM. This compound appears as an orange to orange-red solid and is intended for research use only.
- High purity: 98.0%
- IC50: 11.4 μM for PTP1B
- Molecular weight: 294.34
- Chemical formula: C19H18O3
- Appearance: Solid
- Color: Orange to orange-red
- Structure classification: Quinones, Naphthalene Quinones
- Initial source: Plants Leguminosae Samanea saman (Jacq.) Merr., Plants Labiatae
- Solubility in DMSO: 3 mg/mL (10.19 mM)
Medchemexpress LLC Tanshinone I | 568-73-0 | MFCD00210563 | 98.8% | 276.29 g/mol | C18H12O3 | 10 MG
Tanshinone I is a natural diterpenoid research standard used as a phospholipase inhibitor and analytical reference for biochemical and preclinical studies. It inhibits human type IIA secreted phospholipase A2 (sPLA2) (IC50 = 11 μM) and rabbit cytosolic phospholipase A2 (cPLA2) (IC50 = 82 μM), and is supplied as a high-purity solid for laboratory use.
- Natural diterpenoid research standard for biochemical assays.
- Inhibits sPLA2 (human type IIA) and cPLA2 (rabbit) with reported IC50 values.
- High purity suitable for analytical and research applications.
- Supplied as a solid for flexible formulation and storage.
- Commonly used in studies of inflammation and cardiovascular pathways.
Medchemexpress LLC Dihydrotanshinone I | 87205-99-0 | 278.30 | 50 MG
Dihydrotanshinone I | 87205-99-0 | 278.30 | 50 MG
Apexbio Technology LLC Tanshinone-IIA-sulfonic-sodium
Tanshinone IIA---sulfonic sodium (CAS No 69659-80-9) is a water-soluble derivative of tanshinone IIA primarily used in biomedical research as an anti-inflammatory and anticancer agent Originating from the root of Salvia miltiorrhiza it exerts its effects through modulation of various signaling pathways including NF- B and MAPK leading to apoptosis and reduction of inflammatory responses In vitro activity generally ranges from nanomolar to low micromolar concentrations depending on the assay conditions It is frequently employed in cancer cell lines and inflammatory models to explore its therapeutic potential and mechanisms Animal studies often utilize it to evaluate efficacy and safety as a potential pharmacological agent Experimental concentrations typically depend on the specific research design allowing flexibility for different objectives yet maintaining relevance for drug screening and development purposes
