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A fungal metabolite with fungicidal activity; active against the plant pathogenic fungus F. graminearum; has been used as a substrate in the determination of PON1 activity; has been used in the chemiluminescent detection of HRP release from liposomes; an intermediate in the synthesis of the near-infrared lipid droplet probe LD-2
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Pinolenic acid is a PUFA found in Korean pine (Pinus orientalis) and maritime pine (Pinus pinaster) seed oils. Both oils have been found to have lipid-lowering properties. A diet containing maritime pine seed oil (MPSO) lowered HDL and ApoA1 levels in transgenic mice expressing human ApoA1. MPSO was found to diminish cholesterol efflux in vitro.{14273} Korean pine seed oil supplements may help in obesity by reduction of appetite. People taking this oil had an increase in the satiety hormones CCK and GLP-1 and a reduced desire to EAt.{14280} The activity of the oil is attributed to pinolenic acid. Pinolenic acid is not converted to arachidonic acid metabolically and can reduce arachidonic acid levels in the phosphatidylinositol fraction of Hep-G2 cells from 15.9% to 7.0%.{8724}
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13(Z)-Docosenoic acid is a 22-carbon monounsaturated fatty acid. It is found predominantly in canola oil.{8144} 13(Z)-Docosenoic acid is metabolized to oleic acid in vivo. Diets rich in 13(Z)-docosenoic acid were shown to cause heart lipidosis in experimental animals.{7786,8145} The C-1 amide of docosenoic acid has been identified as one of the anandamide-related neurotransmitters associated with sleep.{1317}
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A cyclohexenecarboxylic acid; an intermediate in the biosynthesis of aromatic amino acids in plants and microorganisms; a precursor in the synthesis of oseltamivir; decreases lipid droplet accumulation in HepG2 cells and 3T3-L1 adipocytes at 80 µM; increases the levels of phosphorylated AMPK and decreases the levels of MID1IP1 in HepG2 and 3T3-L1 adipocytes at 40 µM; decreases inflammation and demyelination in a mouse model of EAE at 50-200 mg/kg and reduces symptom progression at 100 mg/kg
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