Formic Acid
Formic acid (HCOOH) is naturally-occurring, flammable, corrosive, organic, and the simplest carboxylic acid. Used as a hydride ion source in synthetic organic chemistry, a mobile phase component in HPLC, a preservative/antibacterial agent in agriculture, etc.
Formic or methanoic acid (CAS: 64-18-6; PubChem ID: 284) is a colorless organic acid with the formula HCOOH. At ambient temperatures, it has a strong, penetrating odor, like acetic acid. Used in chemical synthesis as an intermediate, this simple carboxylic acid is miscible in water and most organic solvents and is somewhat hydrocarbon-soluble.
Formic acid occurs naturally in the venom of some ants and bees. Formate, the conjugate base of formic acid, also occurs naturally in bodily fluids following methanol poisoning.
Formic acid is a source of hydride ion in synthetic organic chemistry, as in the Eschweiler-Clarke and Leuckart-Wallach reactions. It is also a useful component of the mobile phase in reversed-phase high-performance liquid chromatography (RP-HPLC) for peptides, proteins, and intact viruses.
Although formic acid is easily metabolized and eliminated, it can have toxic effects. Methanol metabolism produces formic acid and formaldehyde, which are responsible for the optic nerve damage that results from methanol poisoning. Chronic exposure in humans may cause kidney damage and skin allergies in some people.
In diluted forms, formic acid and formate esters are used as artificial flavorings and perfume additives. In higher concentrations, formic acid is flammable, and skin and eye contact with concentrated liquid or vapors is dangerous.
In agriculture, formic acid is used as a preservative and antibacterial agent and by beekeepers to kill mites. It is useful in leather tanning, textile dyeing and finishing, and in rubber production. Formic acid replaces mineral acids in limescale removers and other cleaning products.
Medchemexpress LLC CCT367766 formic | 98.1% | 992.42 g·mol-1 | C50H50ClN7O13 | 5 MG
CCT367766 formic is a heterobifunctional Cereblon-based PROTAC designed to induce targeted degradation of the pirin protein. It is intended for use as a chemical probe in mechanism-of-action studies and target validation, and is provided with analytical characterization data suitable for research applications.
- Cereblon-based PROTAC that degrades pirin.
- Third-generation heterobifunctional degrader for cellular target engagement studies.
- High reported purity of 98.1% for reliable experimental use.
- Characterized by LC-MS, HNMR, COA, and SDS documentation.
- Reported binding affinities: pirin Kd ≈55 nM, CRBN Kd ≈120 nM, IC50 (CRBN-DDB1) ≈490 nM.
- Available in small research quantities suitable for probe studies.
Sigma Aldrich Fine Chemicals Biosciences Formic acid >=95%, FCC, FG | 64-18-6 | MFCD00003297 | 1KG
Formic acid >=95%, FCC, FG | Purity: >=95% | Mol Wt: 46.03 | 64-18-6 | MFCD00003297 | 1KG
eMolecules Oakwood Chemicals Formic Acid ACS Grade 20kg 480143866 093996 0 000 64-18-6 MFCD00003297 46 025 CH2O2
Oakwood Chemicals Formic Acid ACS Grade 20kg 480143866 093996 0 000 64-18-6 MFCD00003297 46 025 CH2O2
eMolecules Oakwood Chemicals Formic Acid 1kg 480142339 080324 0 000 64-18-6 MFCD00003297 46 025 CH2O2
Oakwood Chemicals Formic Acid 1kg 480142339 080324 0 000 64-18-6 MFCD00003297 46 025 CH2O2
Medchemexpress LLC Ammonium formate | 540-69-2 | MFCD00013103 | 98.5% | 63.06 g/mol | CH5NO2 | 50g
Formic acid ammonium salt is an endogenous metabolite
Sigma Aldrich Fine Chemicals Biosciences Formic acid puriss. p.a., ACS reagent, reag. Ph. Eur., >=98% | 64-18-6 | MFCD00003297 | 500ML
Formic acid puriss. p.a., ACS reagent, reag. Ph. Eur., >=98% | Purity: >=98% | Mol Wt: 46.03 | 64-18-6 | MFCD00003297 | 500ML
Medchemexpress LLC DL-01 formic | 2964513-44-6 | 98.5% | 1144.30 g/mol | C56H73N9O15S | 1 MG
DL-01 formic is a drug-linker conjugate intended for research use in the synthesis of antibody-drug conjugates (ADCs). Supplied as a white to light yellow solid, it has high purity and requires ultra-low temperature storage to preserve stability.
- Drug-linker conjugate for antibody-drug conjugate (ADC) synthesis.
- White to light yellow solid physical form.
- Purity approximately 98.5%.
- Molecular weight 1,144.30 g/mol.
- CAS number 2964513-44-6.
- Stored at -80°C and protected from light under inert gas.
- Available in small milligram quantities for research use.