Formic Acid
Formic acid (HCOOH) is naturally-occurring, flammable, corrosive, organic, and the simplest carboxylic acid. Used as a hydride ion source in synthetic organic chemistry, a mobile phase component in HPLC, a preservative/antibacterial agent in agriculture, etc.
Formic or methanoic acid (CAS: 64-18-6; PubChem ID: 284) is a colorless organic acid with the formula HCOOH. At ambient temperatures, it has a strong, penetrating odor, like acetic acid. Used in chemical synthesis as an intermediate, this simple carboxylic acid is miscible in water and most organic solvents and is somewhat hydrocarbon-soluble.
Formic acid occurs naturally in the venom of some ants and bees. Formate, the conjugate base of formic acid, also occurs naturally in bodily fluids following methanol poisoning.
Formic acid is a source of hydride ion in synthetic organic chemistry, as in the Eschweiler-Clarke and Leuckart-Wallach reactions. It is also a useful component of the mobile phase in reversed-phase high-performance liquid chromatography (RP-HPLC) for peptides, proteins, and intact viruses.
Although formic acid is easily metabolized and eliminated, it can have toxic effects. Methanol metabolism produces formic acid and formaldehyde, which are responsible for the optic nerve damage that results from methanol poisoning. Chronic exposure in humans may cause kidney damage and skin allergies in some people.
In diluted forms, formic acid and formate esters are used as artificial flavorings and perfume additives. In higher concentrations, formic acid is flammable, and skin and eye contact with concentrated liquid or vapors is dangerous.
In agriculture, formic acid is used as a preservative and antibacterial agent and by beekeepers to kill mites. It is useful in leather tanning, textile dyeing and finishing, and in rubber production. Formic acid replaces mineral acids in limescale removers and other cleaning products.
Sigma Aldrich Fine Chemicals Biosciences SIGMA ALDRICH FINE CHEMICALS BIOSCIENCES
NC3924754 SIGMA FORMIC ACID 98 - 100
Medchemexpress LLC Zelavespib formic | 97.4% | 558.39 | 25 MG
Zelavespib formic (PU-H71 formic) is a potent Hsp90 inhibitor with an IC50 value of 51 nM for Hsp90 in MDA-MB-468 cells. It is intended for research use only.
- Potent Hsp90 inhibitor
- Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO
- Available in various solid forms (5 mg, 10 mg, 25 mg, 50 mg, 100 mg)
- Also available in solution form (10 mM * 1 mL in DMSO)
- Cited in 12 publications
- Related to various compound screening libraries and small molecules
- Clinical trials listed for Metastatic Breast Cancer, Accelerated Phase MPN, Blast Phase MPN, Metastatic Solid Tumor, Lymphoma, Myeloproliferative Neoplasms (MPN), Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (Post-PV MF), Post-Essential Thrombocythemia Myelofibrosis (Post-ET MF)
Medchemexpress LLC LCC-12 (formic) | 3029253-76-4 | 99.9% | 460.57 | 1 MG
LCC-12 formic is a dimer of metformin that targets mitochondrial copper(II), leading to a decrease in the NAD(H) pool and modulation of inflammatory responses. It reduces inflammation in mouse models of bacterial and viral infections and serves as a tool for investigating metabolic diseases through its effects on cell plasticity and epigenetic programming.
- Targets mitochondrial copper(II)
- Leads to a decrease in the NAD(H) pool
- Modulates inflammatory responses
- Reduces inflammation in mouse models of bacterial and viral infections
- Serves as a tool for investigating metabolic diseases
- Affects cell plasticity and epigenetic programming
Medchemexpress LLC CBI1 formic | 461.40 | 50 MG
CBI1 formic is a covalent BAX inhibitor that selectively derivatizes BAX at C126. It inhibits BAX activation by triggering ligands or point mutagenesis, and also blocks t-2-hex lipidation and oligomerization of BAX. CBI1 formic is effective in inhibiting BAX activation induced by BH3 ligands, F116A mutagenesis or t-2-hex.
- Covalent BAX inhibitor
- Selectively derivatizes BAX at C126
- Inhibits BAX activation by triggering ligands or point mutagenesis
- Blocks t-2-hex lipidation and oligomerization of BAX
- Inhibits BAX activation induced by BH3 ligands, F116A mutagenesis or t-2-hex
- Available in 50 mg quantity
Medchemexpress LLC SJ1008030 formic | 97.7% | 919.96 | 5 MG
SJ1008030 formic is a JAK2 PROTAC that selectively degrades JAK2. It inhibits MHH-CALL-4 cell growth with an IC50 of 5.4 nM and can be used for leukemia research.
- Selectively degrades JAK2.
- Inhibits MHH-CALL-4 cell growth with an IC50 of 5.4 nM.
- Degrades JAKs, GSPT1, and IKZF1 in a dose-dependent manner.
- Dose-dependently degrades JAK2 and GSPT1 protein in xenograft bone marrow SJBALL021415 cells.
- Indicates inhibition of the JAK-STAT signaling pathway.
- Suitable for leukemia research.
Medchemexpress LLC Ivaltinostat formic | 98.3% | 473.56 | 5 MG
Ivaltinostat formic is an orally active, potent pan-HDAC inhibitor that contains a hydroxamic acid moiety. It inhibits the deacetylation of histone H3 and tubulin, and induces the accumulation of p53. This compound promotes p53-dependent transactivation and enhances the expression of MDM2 and p21 (Waf1/Cip1) proteins. It also enhances the sensitivity of Gemcitabine-resistant cells to Gemcitabine and 5-Fluorouracil, inducing apoptosis and exhibiting anti-tumor effects. This product is intended for research use only.
- Potent pan-HDAC inhibitor
- Inhibits deacetylation of histone H3 and tubulin
- Induces p53 accumulation and p53-dependent transactivation
- Enhances MDM2 and p21 (Waf1/Cip1) protein expression
- Increases sensitivity of Gemcitabine-resistant cells to chemotherapy
- Induces apoptosis and demonstrates anti-tumor effects
- Attenuates oxidative stress and inflammatory cytokines
Medchemexpress LLC CBI1 formic | 461.40 | 25 MG
CBI1 formic is a covalent BAX inhibitor. It selectively derivatizes BAX at C126 and inhibits BAX activation induced by triggering ligands or point mutagenesis. CBI1 formic also blocks t-2-hex lipidation and oligomerization of BAX.
- Covalent BAX inhibitor.
- Selectively derivatizes BAX at C126.
- Inhibits BAX activation by triggering ligands or point mutagenesis.
- Blocks t-2-hex lipidation and oligomerization of BAX.
- Inhibits BAX activation induced by BH3 ligands, F116A mutagenesis, or t-2-hex.
eMolecules Oakwood Chemicals Formic Acid ACS Grade 4kg 480143865 093996 0 000 64-18-6 MFCD00003297 46 025 CH2O2
Oakwood Chemicals Formic Acid ACS Grade 4kg 480143865 093996 0 000 64-18-6 MFCD00003297 46 025 CH2O2
Medchemexpress LLC Formic acid ammonium salt | 540-69-2 | MFCD00013103 | 98.5% | 63.06 | CH5NO2 | 1mL
Formic acid ammonium salt is an endogenous metabolite
Medchemexpress LLC OAB-14 | 2140911-49-3 | 99.2% | 518.73 | 1 ML
OAB-14 is a derivative of Bexarotene that improves Alzheimer's disease-related pathologies and cognitive impairments. It works by increasing β-amyloid clearance and ameliorating the dysfunction of the endosomal-autophagic-lysosomal pathway in APP/PS1 transgenic mice. OAB-14 has no significant effect on body weight or liver toxicity after acute and chronic treatment.
- Improves Alzheimer's disease-related pathologies and cognitive impairments
- Increases β-amyloid clearance
- Ameliorates dysfunction of the endosomal-autophagic-lysosomal pathway
- Promotes microglia phagocytosis
- Attenuates downstream pathological events of Aβ accumulation
- Restores autophagy flux via the AMPK/mTOR pathway
- Enhances lysosomal activity and reduces Aβ accumulation in lysosomes
eMolecules Oakwood Chemical Formic Acid ACS Grade 1kg 736631842 093996 0 000 64-18-6 MFCD00003297 46 025 CH2O2
Oakwood Chemical Formic Acid ACS Grade 1kg 736631842 093996 0 000 64-18-6 MFCD00003297 46 025 CH2O2
Sigma Aldrich Fine Chemicals Biosciences Formic acid >=95%, FCC, FG | 64-18-6 | MFCD00003297 |
Formic acid >=95%, FCC, FG | Purity: >=95% | Mol Wt: 46.03 | 64-18-6 | MFCD00003297 |