Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC JPS016 (TFA) | 99.47% | C50H64F3N7O10S | 25 MG
JPS016 (TFA) | 99.47% | C50H64F3N7O10S | 25 MG
Medchemexpress LLC 6bK TFA | 1774353-12-6 | 99.68% | 871.94 | 1 ML
6bK TFA is a potent and selective insulin degrading enzyme (IDE) inhibitor with an IC50 value of 50 nM. It has been shown to increase circulating insulin in high-fat-fed mice. Acute administration of 6bK TFA enhances glucose tolerance to oral glucose, particularly in high-fat-fed mice. This compound is suitable for use in type 2 diabetes research. It is intended for research use only and is not sold to patients.
- Potent and selective insulin degrading enzyme (IDE) inhibitor with an IC50 value of 50 nM.
- Increases circulating insulin in high-fat-fed mice.
- Enhances glucose tolerance to oral glucose.
- Suitable for use in type 2 diabetes research.
- Intended for research use only.
Medchemexpress LLC Gln-AMS TFA | 209543-57-7 | >99.85% | 588.47 | 1 MG
Gln-AMS (TFA) is a type Ia aminoacyl-tRNA synthetase (AARS) inhibitor. It inhibits glutaminyl-tRNA synthetase (GlnRS) with a Ki of 1.32 μM. It is for research use only.
- Type Ia aminoacyl-tRNA synthetase (AARS) inhibitor
- Inhibits glutaminyl-tRNA synthetase (GlnRS) with a Ki of 1.32 μM
Medchemexpress LLC Glutaurine TFA 5mg | 5MG
Glutaurine (Litoralon) TFA containing glutamine and taurine residues is an orally active hormone of the parathyroid Glutaurine (Litoralon) TFA as a hormone is isolated from parathyroid gland oxyphil cells Glutaurine (Litoralon) TFA can be used for the research of antiepileptic and anti-amnesia[1 [2 [3 [4
Medchemexpress LLC Galnon TFA | 1217448-19-5 | MFCD06798339 | 98.9% | 792.84 | C42H47F3N4O8 | 5 MG
Galnon TFA is a selective, non-peptide agonist of galanin receptors GAL1 and GAL2 used in neuroscience research. It binds GAL1 and GAL2 with reported Kis of 11.7 μM and 34.1 μM and has demonstrated anticonvulsant and anxiolytic effects. The compound is supplied as a white to off-white solid with high purity and is soluble in DMSO for in vitro use.
- Selective galanin receptor agonist (GAL1 and GAL2).
- Demonstrated anticonvulsant and anxiolytic activity in preclinical models.
- High purity (98.9%) and white to off-white solid appearance.
- Soluble in DMSO (125 mg/mL); use fresh DMSO and ultrasonic assistance if needed.
- Recommended storage sealed, protected from moisture and light; frozen solution stability varies by temperature.
Strem, An Ascensus Company CAS# 76-05-1. 100g. Trifluoroacetic acid, 99%. MFCD00004169
CAS# 76-05-1. 100g. Trifluoroacetic acid, 99%. MFCD00004169. Molecular Weight: 114.02. Molecular Formula: CF3COOH. Color/form: colorless liq. Strem# 09-7160. http://www.strem.com/catalog/v/09-7160/
Strem, An Ascensus Company CAS# 76-05-1. 500g. Trifluoroacetic acid, 99%. MFCD00004169
CAS# 76-05-1. 500g. Trifluoroacetic acid, 99%. MFCD00004169. Molecular Weight: 114.02. Molecular Formula: CF3COOH. Color/form: colorless liq. Strem# 09-7160. http://www.strem.com/catalog/v/09-7160/
Medchemexpress LLC QL47B TFA | 96.0% | 992.07 | 1 MG
QL47B TFA is a biotinylated analogue of QL47, functioning as a potent inhibitor of BTK with an IC50 value of 1.3 μM. It has demonstrated anti-tumor activity.
- Potent inhibitor of BTK (IC50 value of 1.3 μM)
- Biotinylated analogue
- Exhibits anti-tumor activity
- Available in various pack sizes
- Purity of 96.03%
Medchemexpress LLC Hth-01-091 Tfa | 2000209-42-5 | 98.64% | 499.43 | 1 MG
HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor, with an IC50 of 10.5 nM. It also inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK, and CLK2. This compound can be used for breast cancer research.
- Potent and selective MELK inhibitor.
- Inhibits multiple kinases including PIM1/2/3, RIPK2, DYRK3, smMLCK, and CLK2.
- Suitable for breast cancer research.
![Medchemexpress LLC (2S)-2-amino-3-[(3-fluorophenyl)-(2-phenylmethoxyphenyl)methoxy]propanoic acid; TFA | 00-00-0 | 99.8% | 509.45 g·mol⁻¹ | C25H23F4NO6 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000263712.png-250.jpg)
Medchemexpress LLC (2S)-2-amino-3-[(3-fluorophenyl)-(2-phenylmethoxyphenyl)methoxy]propanoic acid; TFA | 00-00-0 | 99.8% | 509.45 g·mol⁻¹ | C25H23F4NO6 | 5 MG
ALX-1393 TFA is the trifluoroacetate salt of a selective glycine transporter 2 (GlyT2) inhibitor used as a research reagent to investigate glycinergic neurotransmission and nociception. It is supplied as a purified solid for laboratory use and has reported antinociceptive activity in rodent pain models.
- Selective GlyT2 inhibitor for probing glycinergic neurotransmission.
- Research-grade solid suitable for in vitro and in vivo studies.
- High purity (99.83%) supporting reproducible results.
- Molecular formula C25H23F4NO6 and molecular weight 509.45 g·mol⁻¹.
- Store at -20°C to maintain stability and minimize moisture exposure.
Medchemexpress LLC Apstatin trifluoroacetate | 99.4% | 573.56 g/mol | C25H34F3N5O7 | 5 MG
Apstatin TFA is the trifluoroacetate salt of apstatin, a potent aminopeptidase P (APP) inhibitor with reported Ki values of 2.6 μM (rat) and 0.64 μM (human). It has been used in preclinical studies showing cardioprotective effects and is supplied as a solid research compound for biochemical and pharmacological applications.
- Potent aminopeptidase P inhibitor with reported Ki values of 2.6 μM (rat) and 0.64 μM (human).
- Demonstrated cardioprotective effects in preclinical studies.
- Supplied as a solid with reported purity of 99.43%.
- Molecular formula C25H34F3N5O7 and molecular weight 573.56 g/mol.
- Recommended storage: powder -80°C (2 years) or -20°C (1 year); protect from moisture.
- Available in small research pack sizes suitable for preclinical experiments.