Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC F9170 (TFA) | 99.7% | 1983.3 g/mol | 5 MG
F9170 (TFA) is a laboratory chemical with 99.7% purity and a molecular weight of 1983.3 g/mol. It appears as a solid and is stable under recommended storage conditions. This product is intended for research use only and should be handled by suitably qualified and experienced scientists in appropriate facilities.
- Solid appearance
- Stable under recommended storage conditions
- Store powder at -80°C for up to 2 years or -20°C for up to 1 year
- Store in solvent at -80°C for up to 6 months or -20°C for up to 1 month (sealed storage, away from moisture)
- Suitable for shipping at room temperature if less than 2 weeks
- Requires handling in areas with appropriate exhaust ventilation
- Keep container tightly sealed in a cool, well-ventilated area
- Keep away from direct sunlight and sources of ignition
Medchemexpress LLC LL-37 amide (TFA) | 99.34% | 4492.28 | 5 MG
LL-37 amide TFA is a selective agonist of formyl peptide receptor-like FPRL1, effectively inhibiting periodontal pathogens. It exerts bactericidal effects by activating immune cell chemotaxis and disrupting bacterial cell membrane integrity. This peptide also regulates inflammatory responses and promotes angiogenesis. Its amidation modification reduces sensitivity to serum inhibition and improves stability, making it suitable for research on infection-related diseases like periodontal disease, deep tissue injuries, and wound healing.
- Selective agonist of formyl peptide receptor-like FPRL1
- Inhibits periodontal pathogens
- Exerts bactericidal effects
- Regulates inflammatory responses
- Promotes angiogenesis
- Improved stability and resistance to enzymatic degradation
- Useful in research for infection-related diseases and wound healing
- Effective against Gram-positive and Gram-negative bacteria
Medchemexpress LLC Alvespimycin trifluoroacetate | 00-00-0 | MFCD08457919 | 99.0% | 730.77 g/mol | C34H49F3N4O10 | 1 MG
Alvespimycin TFA is the trifluoroacetate salt of 17-DMAG, a small-molecule Hsp90 inhibitor used in research to probe Hsp90 biology, induce client protein degradation, and trigger stress responses in cancer cell models.
- Potent Hsp90 inhibition with low-nanomolar cellular activity.
- Promotes degradation of Hsp90 client proteins, including Her2.
- Induces Hsp70 expression and apoptosis in sensitive cancer cells.
- High purity solid suitable for biochemical and cellular assays.
- Available in small research quantities for dose-response studies.
- Stable when stored sealed at recommended temperatures.
TARGETMOL CHEMICALS INC MM-102 TFA 5MG
Also available in 1 mL, 1 mg, 2 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. MM-102 TFA (HMTase Inhibitor IX TFA) is a potent WDR5/MLL interaction inhibitor with an IC50 of 2.4 nM. This compound prevents the interaction between mixed lineage leukemia 1 (MLL1) and WD Trp-Asp repeat domain 5 (WDR5), inhibiting MLL1 H3K4 histone methyltransferase (HMT) activity and down-regulating H3K4me3, which facilitates the epigenetic reprogramming of porcine somatic cell nuclear transfer embryos. Purity 99.3%
TARGETMOL CHEMICALS INC CYN 154806 TFA 1MG
Also available in 5 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. CYN 154806 TFA is a cyclic octapeptide and an effective selective somatostatin sst2 receptor antagonist. For the recombinant sst2, sst1, sst3, sst4 and sst5 receptors, the pIC50 values are 8.58, 5.41, 6.07, 5.76 and 6.48, respectively. Purity 99.7%