Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC RI(dl)-2 TFA | 98.0% | 1 MG
RI(dl)-2 TFA is a potent and selective RAD51-mediated D-loop formation inhibitor.
- Potent and selective RAD51-mediated D-loop formation inhibitor with an IC50 of 11.1 μM.
- Does not influence RAD51 binding to ssDNA.
- Inhibits homologous recombination (HR) activity in human cells (IC50 of 3.0 μM).
Medchemexpress LLC Ile-AMS TFA | 219931-45-0 | MFCD31619268 | 98.6% | 572.52 g/mol | C18H27F3N8O8S | 10 MG
Ile-AMS TFA is the trifluoroacetic acid (TFA) salt of an aminoacyl-sulfamoyl adenosine analogue that inhibits isoleucyl-tRNA synthetase and displays potent antiparasitic activity (P. falciparum ABS IC50 = 1.19 nM). Intended for laboratory research use only.
- Purity 98.55%.
- Molecular weight 572.52 g/mol; chemical formula C18H27F3N8O8S.
- Soluble in water (≈100 mg/mL); ultrasonic assistance may be required.
- Recommended storage: sealed, away from moisture; in solvent -80°C (6 months) or -20°C (1 month).
- Available in small research quantities, including a 10 mg package.
- Used as a tool compound for studies of aminoacyl-tRNA synthetase inhibition and antiparasitic research.
Medchemexpress LLC TD-0212 TFA 10mM | 10MM 1ML
TD-0212 TFA is an orally active dual pharmacology angiotensin II type 1 receptor (AT1) antagonist and neprilysin (NEP) inhibitor with a pKi of 8 9 for AT1 and a pIC50 of 9 2 for NEP[1]
Medchemexpress LLC Spantide I (TFA) | 99.32% | 5 MG
Spantide I TFA is a substance P analog and a selective NK1 receptor antagonist. It has Ki values of 230 nM for NK1 and 8150 nM for NK2 receptors. This compound can reduce type 1 cytokines and enhance type 2 cytokine IL-10 in infected corneas, which leads to a significant reduction in corneal perforation. It is for research use only, not for sale to patients.
- Substance P analog
- Selective NK1 receptor antagonist
- Reduces type 1 cytokines
- Enhances type 2 cytokine IL-10
- Reduces corneal perforation
Medchemexpress LLC Damgo tfa | 950492-85-0 | 99.5% | 627.61 | 1 ML
DAMGO TFA is a selective μ-opioid receptor (μ-OPR) agonist, exhibiting a Kd of 3.46 nM for native μ-OPR. It significantly reduces the activation of neuronal Akt and ERK1/2 by CXCL12 and inhibits CXCL12-promoted neuronal survival without down-regulating CXCR4 protein expression. This compound also effectively inhibits the prostaglandin E2 (PGE2) induced increase in a tetrodotoxin-resistant voltage-gated Na+ current (TTX-R INa). In vivo studies show DAMGO TFA produces significant anti-injury and long-lasting analgesic effects in male Sprague-Dawley rats.
- Selective μ-opioid receptor agonist
- Exhibits Kd of 3.46 nM for native μ-OPR
- Reduces activation of neuronal Akt and ERK1/2
- Inhibits CXCL12-promoted neuronal survival
- Does not down-regulate CXCR4 protein expression
- Inhibits prostaglandin E2 induced increase in TTX-R INa
- Produces anti-injury effects
- Provides long-lasting analgesic effects
Medchemexpress LLC Ampreloxetine trifluoroacetate | 1227056-85-0 | 98.3% | 5 MG
Ampreloxetine trifluoroacetate (TFA) is the trifluoroacetate salt of ampreloxetine, an orally active norepinephrine and serotonin (5-HT) uptake inhibitor investigated for research into neurogenic orthostatic hypotension. Supplied as a white to off-white solid with high purity for laboratory research use only.
- High purity (98.3%) suitable for research applications.
- Trifluoroacetate salt form to improve stability and solubility properties.
- Molecular weight 435.36 g/mol; formula C20H19F6NO3.
- Available in small research pack sizes (e.g., 5 MG) for assay development and preclinical studies.
- Intended for laboratory research use only; not for human or animal therapeutic use.
Medchemexpress LLC Thanatin TFA | 99.7% | 2433.92 | 1 MG
Thanatin TFA is an inducible cationic antimicrobial peptide that exhibits broad-spectrum activity against both Gram-negative and Gram-positive bacteria, as well as various species of fungi. It operates by competitively replacing divalent cations from the bacterial outer membrane, leading to its disruption. It shows potent inhibitory effects on the growth of NDM-1-producing *E. coli* and *K. pneumoniae* strains.
- Inducible cationic antimicrobial peptide
- Broad-spectrum activity against Gram-negative and Gram-positive bacteria, and fungi
- Disrupts bacterial outer membrane
- Inhibits NDM-1-producing *E. coli* and *K. pneumoniae* strains
- Strongly cationic with a pI of 10.48
Apexbio Technology LLC 2X hyperfusion plus master mix 10X1ml
Our 2X Hyperfusion Plus Master Mix (With dye) product offers high fidelity strong amplification performance and faster extension speed simultaneously making it suitable for most PCR applications Hyperfusion Plus DNA Polymerase is created by fusing a Pyrococcus-like proofreading polymerase with a DNA binding domain providing increased fidelity and speed Hyperfusion Plus DNA Polymerase owns high fidelity 50 times lower error rate than Taq DNA Polymerase and 6 times lower error compared to Pyrococcus Furious DNA Polymerase Hyperfusion Plus DNA Polymerase exhibits both 5 to 3 polymerase activity and 3 to 5 exonuclease (proofreading) activity producing blunt-ended amplification products rather than A-tailed ends (commonly produced by Taq polymerase) Experimental results demonstrate that our Hyperfusion Plus polymerase can amplify genome fragments as long as 20 1 kb
Medchemexpress LLC QTX125 trifluoroacetate | 2989537-78-0 | 99.9% | 100 MG
QTX125 TFA is the trifluoroacetate salt of QTX125, a potent and highly selective histone deacetylase 6 (HDAC6) inhibitor with reported antitumor activity. Supplied as an off-white to gray solid for research use, it is available in multiple pack sizes and should be stored sealed and protected from moisture.
- Potent and selective HDAC6 inhibitor
- High reported purity and chemical stability
- Provided as a trifluoroacetate salt for improved handling
- Suitable for in vitro and preclinical research applications
- Store sealed, away from moisture; follow cold storage recommendations
Apexbio Technology LLC DTP3 TFA 1809784-29-9 (free-base) 25mg
DTP3 TFA is a small-molecule inhibitor targeting the GADD45 /MKK7 protein-protein interaction complex It is designed to disrupt this interaction thereby modulating downstream NF- B signaling involved in tumor cell survival DTP3 TFA exerts its biological activity primarily by binding directly to MKK7 (KD 64 81 nM) inducing conformational changes that dissociate GADD45 from MKK7 resulting in activation of JNK signaling In cell-based studies DTP3 TFA selectively inhibits proliferation of cancer cell lines with elevated GADD45 expression Based on these pharmacological properties DTP3 TFA holds research potential in the study and therapeutic intervention of cancers including multiple myeloma via disruption of GADD45 /MKK7 signaling
Medchemexpress LLC PD1-PDL1-IN 1 TFA | 2005454-12-4 | >99.5% | 385.38 g/mol | C14H23N7O6 | 1 ML
PD1-PDL1-IN 1 TFA is a small-molecule programmed cell death 1 (PD-1) inhibitor supplied as the trifluoroacetic acid (TFA) salt for research use. It is intended for use as an immune-modulating reagent in PD-1/PD-L1 pathway studies, screening, and preclinical laboratory assays.
- Potent PD-1 inhibition useful for pathway and mechanism studies.
- Supplied as a TFA salt to aid solubility and handling.
- Characterized with published CAS and molecular data for identification.
- Suitable for compound screening and preclinical research applications.
- Available in small research-scale formats for laboratory use.
Medchemexpress LLC 6H05 trifluoroacetate | 2061344-88-3 | 99.0% | 590.14 | C22H31ClF3N3O4S3 | 1MG
6H05 TFA is the trifluoroacetate salt of 6H05, a selective, allosteric inhibitor of the oncogenic mutant K-Ras(G12C) intended for biochemical and cellular research. Supplied as a solid or as a 10 mM DMSO solution, the compound is provided at high purity for assay development and mechanistic studies.
- Selective, allosteric inhibitor of K-Ras(G12C).
- High purity (99.02%).
- Molecular formula C22H31ClF3N3O4S3; molecular weight 590.14.
- Available in small-scale solid quantities and as a 10 mM DMSO solution.
- Suitable for biochemical and cellular assays; for research use only, not for human use.
Medchemexpress LLC Cilengitide TFA | 199807-35-7 | 99.92% | 702.68 | 1 ML
Cilengitide is a potent and selective integrin inhibitor for αvβ3 and αvβ5 receptors, with IC50 values of 4 nM and 79 nM, respectively. It functions as an αvβ3 and αvβ5 integrin receptor antagonist. In cell adhesion studies, it inhibits integrin-mediated binding to vitronectin with IC50s of 0.4 and 0.4 μM in human melanoma M21 or UCLA-P3 human lung carcinoma cell lines. In vitro, concentrations greater than 1 μM show concentration- and time-dependent cytotoxic effects. In nude mice bearing M21-L melanoma tumors, it demonstrates inhibition of tumor growth with reductions in both tumor volume and tumor weight.
- Potent and selective integrin inhibitor for αvβ3 and αvβ5 receptors.
- Inhibits integrin-mediated binding to vitronectin.
- Exhibits cytotoxic effects in vitro at concentrations greater than 1 μM.
- Inhibits tumor growth in melanoma models.
Medchemexpress LLC Pardaxin P5 TFA | ≥96% | 3381.87 (free base) | 5 MG
Pardaxin P5 TFA is the TFA salt form of Pardaxin P5, an antimicrobial peptide that inhibits Escherichia coli with a MIC value of 13 μM. This peptide is for research use only.
- Inhibits Escherichia coli
- Antimicrobial peptide
- Available in solid form
- Molecular weight of 3381.87 (free base)
- Store at -80°C for 2 years (powder) or 6 months (in solvent)
