Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC TD-0212 TFA 10mM | 10MM 1ML
TD-0212 TFA is an orally active dual pharmacology angiotensin II type 1 receptor (AT1) antagonist and neprilysin (NEP) inhibitor with a pKi of 8 9 for AT1 and a pIC50 of 9 2 for NEP[1]
Medchemexpress LLC Galnon (TFA) | 1217448-19-5 | MFCD06798339 | 98.9% | 792.84 g·mol⁻¹ | C42H47F3N4O8 | 25 MG
Galnon TFA is a selective, non-peptide agonist of the galanin receptors GAL1 and GAL2, with reported Ki values of 11.7 μM (GAL1) and 34.1 μM (GAL2). It is used in in vitro and in vivo research to study galanin receptor pharmacology and has demonstrated anticonvulsant and anxiolytic effects.
- Selective galanin receptor agonist with reported Ki values (GAL1 = 11.7 μM, GAL2 = 34.1 μM).
- Non-peptide small-molecule ligand suitable for receptor pharmacology studies.
- Demonstrated anticonvulsant and anxiolytic activity in preclinical studies.
- Supplied at high purity (98.88%) for research use.
- Available in small research-scale quantities, including 25 mg.
Medchemexpress LLC Mambalgin 1 TFA | 95.7% | 6554.54 | 100 UG
Mambalgin 1 TFA is a selective ASIC1a inhibitor with IC50 values of 192 nM for human ASIC1a and 72 nM for the ASIC1a/1b dimer. It binds to closed/inactive channels and exhibits selectivity for ASIC1a over ASIC2a, ASIC3, TRPV1, P2X2, 5-HT3, Nav1.8, Cav3.2, and Kv1.2 channels. It has been shown to increase the latency of withdrawal response in mouse tail-flick and paw-flick tests. This product is for research use only.
- Selective ASIC1a inhibitor
- Binds to closed/inactive channels
- Increases latency of withdrawal response in mouse tail-flick and paw-flick tests
- For research use only
Medchemexpress LLC KLD-12 TFA | 95.22% | 1467.79 | 5 MG
KLD-12 TFA is the TFA salt form of KLD-12, a 12-residue self-assembling peptide. It is used in tissue engineering and, when combined with SDF-1 self-assembled polypeptide, enhances chondrogenic differentiation of bone marrow stromal cells (BMSCs). The hydrogel form can fill full-thickness osteochondral defects in situ and improve cartilage repair. In vivo, it promotes bone regeneration at the fracture site in a dose-dependent manner.
- Enhances chondrogenic differentiation of bone marrow stromal cells
- Forms self-assembled polypeptide with SDF-1
- Improves survival of bone marrow stromal cells
- Promotes osteogenic differentiation of bone marrow stromal cells and cell migration via Wnt/β-catenin pathway
- Promotes bone regeneration at the fracture site
Medchemexpress LLC Parasin I TFA | 219552-69-9 | 99.8% | 2114.33 | 5 MG
Parasin I (TFA) is a 19-amino acid histone H2A-derived peptide isolated from the skin of the catfish, exhibiting antimicrobial activity. It is intended for research use only and not for patient administration.
- 19-amino acid histone H2A-derived peptide
- Isolated from the skin of catfish
- Shows antimicrobial activity
- White to off-white solid appearance
- Sequence: Lys-Gly-Arg-Gly-Lys-Gln-Gly-Gly-Lys-Val-Arg-Ala-Lys-Ala-Lys-Thr-Arg-Ser-Ser
- Initial source: Animals, the skin mucus of wounded catfish
Medchemexpress LLC ADWX 1 TFA | 98.4% | 4071.85 | 1 MG
ADWX 1 TFA is a novel peptide inhibitor that is potent and selective for Kv1.3 with an IC50 value of 1.89 pM. It inhibits Kv1.3 channel activity to specifically suppress both initial calcium signaling and NF-κB activation. This compound has demonstrated the ability to ameliorate experimental autoimmune encephalomyelitis (EAE) in rat models and is useful for studying T cell-mediated autoimmune diseases.
- Potent and selective Kv1.3 inhibitor with an IC50 of 1.89 pM
- Inhibits Kv1.3 channel activity
- Suppresses initial calcium signaling and NF-κB activation
- Ameliorates experimental autoimmune encephalomyelitis (EAE) in rat models
- Useful for studying T cell-mediated autoimmune diseases
![Medchemexpress LLC L-Prolinamide, N,N-bis(phenylmethyl)glycyl]-4-[4-[[4-[[(phenylmethyl)amino]phosphonomethyl] | 99.87% | 1323.35 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000384391-logo.png-250.jpg){kind=logo}
Medchemexpress LLC L-Prolinamide, N,N-bis(phenylmethyl)glycyl]-4-[4-[[4-[[(phenylmethyl)amino]phosphonomethyl] | 99.87% | 1323.35 | 25 MG
L-Prolinamide, N,N-bis(phenylmethyl)glycyl]-4-[4-[[4-[[(phenylmethyl)amino]phosphonomethyl] | 99.87% | 1323.35 | 25 MG
Medchemexpress LLC DX600 (TFA) | 99.2% | 3074.33 (free acid) | 5 MG
DX600 TFA is a selective ACE2 specific inhibitor with a KD of 1.3 nM, and it does not cross-react with ACE. This compound exacerbates diabetes-induced cardiovascular dysfunction and increases cardiac and renal NOX activity. It is intended for research use only.
- Inhibits rhACE2 activity.
- Decreases NR 8383 cell growth and increases TNF-a and IL-6 content.
- Exacerbates diabetes-induced cardiovascular dysfunction.
- Increases thrombus weight in a thrombosis model.
- Increases cardiac and renal NOX activity.
Medchemexpress LLC Thymocartin TFA 25mg | 25MG
Thymocartin TFA is the TFA salt form of Thymocartin (HY-105025) Thymocartin TFA inhibits apoptosis of peripheral blood lymphocytes in HIV infected individuals Thymocartin TFA is potential for immunodeficiency diseases research[1 [2
Medchemexpress LLC Fn-439 TFA | 124168-73-6 | MFCD00237459 | 99.8% | 604.58 g·mol⁻¹ | C25H35F3N6O8 | 5 MG
FN-439 TFA is the trifluoroacetic acid salt of FN-439, a selective small-molecule inhibitor of collagenase-1 (matrix metalloproteinase). It inhibits collagenase-1 with an IC50 of 1 μM and is supplied as a research reagent for in vitro studies of cancer and inflammatory processes.
- Selective collagenase-1 inhibitor with reported IC50 of 1 μM.
- High purity (99.81%) suitable for biochemical assays.
- Trifluoroacetic acid salt form to aid solubility in aqueous systems.
- Supplied in research-scale quantities (e.g., five mg) for assay development.
- Intended for in vitro research applications; not for human use.
Medchemexpress LLC OS-2966 1mg | 1mg
OS-2966 is a humanized antibody expressed in CHO cells targeting Integrin b1/ITGB1/CD29 OS-2966 carries a huIgG1 type heavy chain and a hu type light chain with a predicted molecular weight (MW) of 145 5 kDa The isotype control for OS-2966 can be referenced as Human IgG1 kappa Isotype Control (HY-P99001)
Medchemexpress LLC Frakefamide TFA 25mg | 25MG
Frakefamide TFA is a potent analgesic that acts as a peripheral active -selective receptor agonist Frakefamide is unable to penetrate the blood-brain-barrier and enter the central nervous system[1 [2
Medchemexpress LLC Boc-Met-Leu-Phe (trifluoroacetate) | 00-00-0 | MFCD00037435 | 99.5% | 623.68 g/mol | C27H40F3N3O8S | 1 ML
Boc-MLF TFA is a Boc-protected tripeptide (Boc-Met-Leu-Phe as the trifluoroacetate salt) used as a formyl peptide receptor (FPR) antagonist for receptor pharmacology and cell signaling studies. It is supplied as a 10 mM solution in DMSO (1 mL) or as a dry powder and is offered with high reported purity for research applications.
- Acts as a formyl peptide receptor (FPR) antagonist.
- Inhibits formyl peptide receptor like 1 (FPRL1) at higher concentrations.
- Available as a 10 mM solution in DMSO (1 mL) or as dry powder formats.
- High reported purity suitable for biochemical assays (~99.5%).
- Contains Boc-protected Met-Leu-Phe sequence as the trifluoroacetate salt.
Medchemexpress LLC 3-amino-4-(3-hexylphenylamino)-4-oxobutyl phosphonic acid | 909725-62-8 | 98.2% | 456.39 g/mol | C18H28F3N2O6P | 1 ML
W146 TFA is the trifluoroacetic acid salt of W146, a selective antagonist of the sphingosine-1-phosphate receptor 1 (S1PR1). It is supplied as a ready-to-use 10 mM solution in DMSO and as solid material for research applications, and is used in in vitro pharmacology and signaling studies to probe S1PR1-mediated pathways.
- Selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1).
- Reported EC50 of 398 nM.
- Supplied as 10 mM solution in DMSO (1 mL) and in multiple solid masses.
- Chemical identifiers: CAS 909725-62-8, formula C18H28F3N2O6P, MW 456.39 g/mol.
- Intended for research use only; not for human or clinical use.
Medchemexpress LLC Thymocartin TFA 5mg | 5MG
Thymocartin TFA is the TFA salt form of Thymocartin (HY-105025) Thymocartin TFA inhibits apoptosis of peripheral blood lymphocytes in HIV infected individuals Thymocartin TFA is potential for immunodeficiency diseases research[1 [2