Acyl bromides
Apexbio Technology LLC Tiotropium Bromide hydrate 139404-48-1 50mg
Tiotropium Bromide hydrate is a small-molecule antagonist targeting muscarinic acetylcholine receptors (mAChRs) It is designed to competitively inhibit mAChRs thereby modulating airway smooth muscle contraction and mediating bronchodilation Tiotropium Bromide hydrate exerts its biological activity primarily through competitive antagonism at mAChRs resulting in relaxation of airway smooth muscle Based on these pharmacological properties Tiotropium Bromide hydrate holds research potential in respiratory pharmacology particularly for investigating mechanistic pathways in chronic obstructive pulmonary disease (COPD) receptor-ligand interactions and pulmonary pharmacodynamics associated with airway obstruction
Medchemexpress LLC Pinaverium bromide | 53251-94-8 | 99.7% | 591.42 | 100 MG
Pinaverium bromide is an L-type calcium channel blocker that selectively targets the gastrointestinal tract. It is effective in relieving pain, diarrhea, and intestinal discomfort, offering therapeutic benefits without significant adverse effects in patients with Irritable Bowel Syndrome (IBS). It is intended for research use only.
- Selectively blocks L-type calcium channels
- Relieves pain, diarrhea, and intestinal discomfort
- Provides therapeutic efficacy for Irritable Bowel Syndrome (IBS)
- Exhibits good safety profile with no significant adverse effects
- Inhibits neutrophil migration and ROS production
- Reduces expression of inflammatory cytokines (IL-1β, IL-6, TNF-α)
- Increases survival rate and reduces lung and liver injury in LPS-induced animal models
Medchemexpress LLC 3',5'-Di-O-benzoyl-2'-deoxy-2'-fluoro-2'-methyluridine | 863329-65-1 | 99.4% | 468.43 | 250 MG
3',5'-Di-O-benzoyl-2'-deoxy-2'-fluoro-2'-methyluridine is a drug intermediate for the synthesis of various active compounds.
TARGETMOL CHEMICALS INC Pipecuronium bromide 10MG
Also available in 1 mg, 5 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Pipecuronium bromide (RGH-1106) is a selective and potent nAChR antagonist that also acts as a non-depolarising steroidal neuromuscular blocker, causing muscle relaxation, often in conjunction with antibiotics. Purity 100%
Medchemexpress LLC Roslin 2 bromide | 29574-21-8 | 99.0% | C13H19BrN4 | 1 MG
Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator that exhibits anticancer effects. It functions by binding to FAK, thereby disrupting the interaction between FAK and p53.
- Decreases cancer cell viability and clonogenicity in a p53-dependent manner.
- Increases p53 transcriptional activity, which is inhibited by FAK, using p21, Mdm-2, and Bax-promoter targets.
- Leads to increased expression of p53 targets: p21, Mdm-2, and Bax proteins.
- Significantly reduces tumor growth, disrupts the FAK and p53 complex, and up-regulates p21 in HCT116 p53+/+ xenografts (not in HCT116 p53-/- xenografts).
![Medchemexpress LLC Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium, 13-[(2-fluorophenyl)methyl]-5,6-dihydro-9,10-dimethoxy- | 1390654-28-0 | 98.8% | 524.38 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000437181-Logo.png-250.jpg){kind=logo}
Medchemexpress LLC Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium, 13-[(2-fluorophenyl)methyl]-5,6-dihydro-9,10-dimethoxy- | 1390654-28-0 | 98.8% | 524.38 | 10 MG
Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium, 13-[(2-fluorophenyl)methyl]-5,6-dihydro-9,10-dimethoxy- | 1390654-28-0 | 98.8% | 524.38 | 10 MG
Apexbio Technology LLC Aclidinium Bromide 320345-99-1 10mM (in 1mL DMSO)
Aclidinium Bromide (CAS 320345-99-1) is a long-acting muscarinic antagonist (LAMA) that selectively inhibits muscarinic acetylcholine receptors In binding assays it demonstrates high affinity for M1 M5 receptor subtypes with Ki values of 0 10 0 21 nM Functional studies reveal greater potency at endogenous M2 and M3 receptors with EC50 values of 17 4 nM and 5 3 nM respectively In vivo aclidinium bromide produces a concentration-dependent inhibition of acetylcholine-induced bronchoconstriction (EC50 2 5 23 1 g/mL in anesthetized guinea pigs) and suppresses pilocarpine-induced salivation in rats (EC50 38 g/kg) This compound is widely utilized in respiratory research for evaluating airway smooth muscle modulation via muscarinic receptor antagonism
Medchemexpress LLC NCT-506 | 2231098-99-8 | 99.95% | 478.54 | 1 ML
NCT-506 is an orally bioavailable aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitor with an IC50 of 7 nM. It is intended for research use only.
- Inhibits ALDH1A1, hALDH1A3, and hALDH2 with IC50s of 0.007±0.001, 16.4±3.99, and 21.5 μM, respectively.
- Decreases cell viability with an EC50 of 45.6 μM in OV-90 cells (3D culture) after 6 days.
- Inhibits MIA PaCa-2, OV-90, and HT-29 cells in aldefluor cell-based assays.
- Shows enhanced inhibitory effects when combined with Paclitaxel in SKOV-3-TR cells.
TARGETMOL CHEMICALS INC Tiotropium bromide 100MG
Also available in 1 mL, 10 mg, 25 mg, 50 mg, 500 mg and bulk. Please contact Fisher for quotes. Tiotropium bromide (BA679 BR) is a long-acting, 24 hour, anticholinergic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD). Tiotropium is a muscarinic receptor antagonist, on topical application it acts mainly on M3 muscarinic receptors located in the airways to produce smooth muscle relaxation, thus producing a bronchodilatory effect. Purity 99.09%
Cayman Chemical N4-benzoyl-2-DeoxycytIdIn 50g
A building block; has been used in the synthesis of nucleosides and nucleotides with anticancer activity, as well as oligonucleotides
eMolecules AstaTech / 3-IODO-5-NITROBENZOTRIFLUORIDE / 0.25g / 721956217 / 35508 / 95.000 / 41253-01-4 / MFCD03412248 / 317.006 / C7H3F3INO2
AstaTech / 3-IODO-5-NITROBENZOTRIFLUORIDE / 0.25g / 721956217 / 35508 / 95.000 / 41253-01-4 / MFCD03412248 / 317.006 / C7H3F3INO2
Apexbio Technology LLC Umeclidinium bromide 869113-09-7 5mg
Umeclidinium bromide (CAS 869113-09-7) is a potent and long-acting antagonist of muscarinic acetylcholine receptors (mAChRs) displaying high affinity for subtypes M1 M5 with Ki values of 0 16 nM 0 15 nM 0 06 nM 0 05 nM and 0 13 nM respectively It selectively targets mAChRs without observable activity at unrelated receptors or channels such as / opioid receptors sodium channels or dopamine transporters In cell-based assays using CHO cells expressing recombinant human mAChRs umeclidinium inhibits acetylcholine-induced calcium flux with pA2 values between 9 6 and 10 6 for M1 M3 receptors In murine models it reverses acetylcholine-driven bronchoconstriction Umeclidinium bromide is broadly applied in research focused on pulmonary disease mechanisms and drug development