Halomethanes
Medchemexpress LLC N-(4-((4-isopropylpiperazin-1-yl)sulfonylphenyl)-5-pentafluorophenyl)nicotinamide | 1803003-65-7 | 99.9% | 513.54 | 5 MG
RN-1665 is an orally active TRPV4 antagonist that exhibits excellent selectivity for related TRP receptors such as TRPV1, TRPV3, and TRPM8. RN-1665 is a TRPV4 probe for focus screens, with IC50s of 0.26 μM and 0.39 μM for hTRPV4 and rTRPV4 from human and rat, respectively.
- IC50 for human TRPV4 is 0.26 μM.
- IC50 for rat TRPV4 is 0.39 μM.
- Antagonist activity at human TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 minutes.
- Antagonist activity at rat TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 minutes.
- Pharmacokinetic analysis has been performed in Wistar rats.
Medchemexpress LLC Vilagletistat | 1542132-88-6 | 99.8% | 528.60 | C26H36N6O6 | 10 MG
Vilagletistat (ZED-1227) is a small-molecule, orally active transglutaminase 2 (TG2) inhibitor supplied for research use. It is provided as a high-purity powder in multiple package sizes and includes storage and stability guidance for powder and solutions.
- High purity: reported 99.82% typical; example batch 99.97%.
- CAS number 1542132-88-6.
- Molecular formula C26H36N6O6 and molecular weight 528.60 g·mol^-1.
- Available package sizes from 1 mg to 100 mg; larger quantities available by quote.
- Storage: powder -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months) or -20°C (1 month).
eMolecules ChemScene / 4-Chloro-2-fluorobenzothioamide / 250mg / 572194186 / CS-0114061 / 0.000 / 1343722-88-2 / MFCD17290209 / 189.630 / C7H5ClFNS
ChemScene / 4-Chloro-2-fluorobenzothioamide / 250mg / 572194186 / CS-0114061 / 0.000 / 1343722-88-2 / MFCD17290209 / 189.630 / C7H5ClFNS
eMolecules 6,7-Dibromobenzo(1,4)dioxan | 25812-80-0 | MFCD00463506 | 1g
Combi-Blocks | 6,7-Dibromobenzo(1,4)dioxan | 1g | 117543164 | OT-1148 | 97.000 | 25812-80-0 | MFCD00463506 | 293.942 | C8H6Br2O2
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Medchemexpress LLC Myrcene (β-Myrcene) | 123-35-3 | 136.23 | 5 G
Myrcene (β-Myrcene) is an aromatic compound that inhibits TNFα and NF-κB activity. It possesses anti-invasive action, inhibits the cell cycle, and induces apoptosis in cancer cells. Additionally, Myrcene demonstrates strong blood protection effects, anti-inflammation, and anti-inflammatory activity.
- Inhibits TNFα and NF-κB activity
- Possesses anti-invasive properties
- Inhibits the cell cycle
- Induces apoptosis in cancer cells
- Demonstrates strong blood protection effects
- Anti-inflammation and anti-inflammatory activities
Sigma Aldrich Fine Chemicals Biosciences Iodomethane contains copper as stabilizer, ReagentPlus(R), 99% | 74-88-4 | MFCD00001073 | 4X100G
Iodomethane contains copper as stabilizer, ReagentPlus(R), 99% | Purity: 99% | Mol Wt: 141.94 | 74-88-4 | MFCD00001073 | 4X100G
Medchemexpress LLC Demethylzeylasteral | 107316-88-1 | 480.59 | 20 MG
Demethylzeylasteral | 107316-88-1 | 480.59 | 20 MG
eMolecules AstaTech / 5-(4-CHLOROBENZAMIDO)-2-ETHOXYBENZENE-1-SULFONYL CHLORIDE / 0.1g / 721754411 / AB1324 / 95.000 / 680617-88-3 / MFCD03424955 / 374.230 / C15H13Cl2NO4S
AstaTech / 5-(4-CHLOROBENZAMIDO)-2-ETHOXYBENZENE-1-SULFONYL CHLORIDE / 0.1g / 721754411 / AB1324 / 95.000 / 680617-88-3 / MFCD03424955 / 374.230 / C15H13Cl2NO4S
Medchemexpress LLC MPP+ (iodide) | 36913-39-0 | 99.96% | 297.14 | 25 MG
MPP+ iodide is a toxic metabolite of the neurotoxin MPTP. It causes symptoms of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in the substantia nigra. The compound is taken up by the dopamine transporter into dopaminergic neurons, where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. It is also a high-affinity substrate for the serotonin transporter (SERT).
- Toxic metabolite of neurotoxin MPTP
- Causes Parkinson's disease symptoms in animal models
- Selectively destroys dopaminergic neurons in the substantia nigra
- Taken up by the dopamine transporter
- Exerts neurotoxic action on mitochondria by affecting complex I of the respiratory chain
- High-affinity substrate for the serotonin transporter (SERT)
eMolecules AstaTech / (S)-3-(CBZ-AMINO)BUTANOIC ACID / 0.25g / 308517972 / 62368 / 97.000 / 83509-88-0 / MFCD08277048 / 237.255 / C12H15NO4
AstaTech / (S)-3-(CBZ-AMINO)BUTANOIC ACID / 0.25g / 308517972 / 62368 / 97.000 / 83509-88-0 / MFCD08277048 / 237.255 / C12H15NO4
eMolecules AstaTech / 5-(CHLOROMETHYL)FURAN-2-CARBALDEHYDE / 0.25g / 296379227 / F11818 / 95.000 / 1623-88-7 / MFCD02181084 / 144.550 / C6H5ClO2
AstaTech / 5-(CHLOROMETHYL)FURAN-2-CARBALDEHYDE / 0.25g / 296379227 / F11818 / 95.000 / 1623-88-7 / MFCD02181084 / 144.550 / C6H5ClO2
Medchemexpress LLC Inaxaplin (VX-147) | 2446816-88-0 | 99.4% | C21H18F3N3O3 | 10MG
Inaxaplin (VX-147) is an orally active small-molecule inhibitor of apolipoprotein L1 (APOL1) channel function, developed for research into APOL1-mediated kidney disease. It is supplied for laboratory research as a high-purity solid or as a DMSO solution.
Cell Signaling Technology ZNF366 (E5O9G) Rabbit mAb (ChIP Formulated) 20 ul
ZNF366 (E5O9G) Rabbit mAb (ChIP Formulated) 20 ul
eMolecules ChemScene / 5-(Trifluoromethyl)pyridazin-3-amine / 50mg / 582640721 / CS-W022265 / 0.000 / 1211591-88-6 / MFCD20726836 / 163.103 / C5H4F3N3
ChemScene / 5-(Trifluoromethyl)pyridazin-3-amine / 50mg / 582640721 / CS-W022265 / 0.000 / 1211591-88-6 / MFCD20726836 / 163.103 / C5H4F3N3
Medchemexpress LLC CCL4 Human 100ug
CCL4 Protein Human is a small cytokine of the CC chemokine subfamily that binds to the CCR5 chemokine receptor on the cell surface promotes leukocyte aggregation under various inflammatory conditions and contributes to immune protection against human immunodeficiency virus type 1 CCL4 Protein Human is a recombinant human CCL4 (A24-N92) expressed by E coli[1]