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Filtered Search Results
Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000656231 DFHBI-BI 5MG
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![Medchemexpress LLC 4-[4-[(dimethylamino)methyl]-3,5-dimethoxyphenyl]-2-methyl-2,7-naphthyridin-1(2H)-one | 1883429-21-7 | >98.0% | 353.4 Da | C20H23N3O3 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000214347.png-250.jpg)
Medchemexpress LLC 4-[4-[(dimethylamino)methyl]-3,5-dimethoxyphenyl]-2-methyl-2,7-naphthyridin-1(2H)-one | 1883429-21-7 | >98.0% | 353.4 Da | C20H23N3O3 | 10 MG
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BI-7273 is a selective, cell-permeable small-molecule inhibitor of the BRD9 bromodomain that also inhibits BRD7 with lower potency. It binds BRD9 with a reported Kd of ~15 nM and an AlphaScreen IC50 of 19 nM, while BRD7 AlphaScreen IC50 is reported as 117 nM. Reported CAS number is 1883429-21-7 and molecular weight is 353.4 Da. It is used as a research tool in epigenetic and leukemia studies.
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(CCCC)c1cnc(OCC)nc1 | 500mg | 525916542](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502454290.PNG-250.jpg)
eMolecules 1025746-10-4 | 2-Ethoxy-5-(tributylstannyl)pyrimidine | Synthonix - Stock | MFCD09025789 | 413.193 | C18H34N2OSn | 97.000 | CCCC[Sn](CCCC)(CCCC)c1cnc(OCC)nc1 | 500mg | 525916542
2-Ethoxy-5-(tributylstannyl)pyrimidine | Synthonix - Stock | 1025746-10-4 | MFCD09025789 | 413.193 | C18H34N2OSn | 97.000 | CCCC[Sn](CCCC)(CCCC)c1cnc(OCC)nc1 | 500mg | 525916542
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Aobchem AOBCHEM
5000872752 7- BENZYLOXY -2-NAPHTHOIC ACID
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eMolecules 74133-20-3 | ChemScene | 4-Methoxynicotinonitrile | 1g | 582648154 | CS-0142298 | MFCD06661870 | 134.138 | C7H6N2O
ChemScene | 4-Methoxynicotinonitrile | 1g | 582648154 | CS-0142298 | 74133-20-3 | MFCD06661870 | 134.138 | C7H6N2O
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Apexbio Technology LLC BI-847325 1207293-36-4 25mg
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BI-847325 (CAS 1207293-36-4) is a dual inhibitor targeting MEK1/2 and Aurora kinases with reported IC50 values of 25 nM and 4 nM against MEK1 and MEK2 and 3 nM 25 nM and 15 nM against Aurora A B and C respectively By inhibiting these kinases BI-847325 disrupts the MAPK/ERK and cell cycle signaling pathways that regulate cell proliferation and survival In cellular assays it demonstrates nanomolar EC50 values for inhibition of pERK and pHH3 in KRAS- and BRAF-mutant cancer cell lines and potently suppresses proliferation across a wide range of tumor cell models In xenograft studies it fully blocks tumor growth in BRAF- and KRAS-mutant cancer models This compound is utilized in research on kinase-targeted cancer therapies
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Synnovator Inc 3- 2-AMINO-5- NAPHTHALEN-2-YL
3-(2-Amino-5-(naphthalen-2-yl)pyridin-3-yl)acrylic acid
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Medchemexpress LLC 6-(5-methoxymethyl-pyridin-3-yl)-3,4-dihydro-2H-naphthyridine-1-carboxylic acid amide | 1633009-87-6 | 99.2% | 298.34 | C16H18N4O2 | 25 MG
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The compound is a small-molecule, highly selective aldosterone synthase (CYP11B2) inhibitor with nanomolar potency, used in biochemical and pharmacological research to probe aldosterone synthesis and CYP11B2-mediated pathways. It exhibits reported IC50 values of 2.1 nM for CYP11B2 and 310 nM for CYP11B1, and is supplied as a high-purity solid for laboratory studies.
- Highly selective aldosterone synthase inhibitor with nanomolar potency (CYP11B2 IC50 ≈ 2.1 nM).
- Reduced off-target activity against CYP11B1 (IC50 ≈ 310 nM).
- Molecular formula C16H18N4O2; molecular weight 298.34 g/mol.
- Purity 99.2% as reported by supplier.
- Supplied as a small solid quantity suitable for in vitro and in vivo research (e.g., 25 mg).
- Characterized in peer-reviewed pharmacology studies for selectivity and pharmacodynamics.
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000431735 BI-27 SUPPLEMENT 50 50ML
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000429175 8-AMINO-2-NAPHTHOL 10G
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![Medchemexpress LLC 5-Pyrimidineacetic acid, 4,6-bis(dimethylamino)-2-[[4-[[4-(trifluoromethyl)benzoyl]amino]phenyl]me | 1093108-50-9 | 99.4% | 501.50 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000437288-Logo.png-250.jpg){kind=logo}
Medchemexpress LLC 5-Pyrimidineacetic acid, 4,6-bis(dimethylamino)-2-[[4-[[4-(trifluoromethyl)benzoyl]amino]phenyl]me | 1093108-50-9 | 99.4% | 501.50 | 100 MG
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BI-671800 is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2), with IC50 values of 4.5 nM and 3.7 nM for PGD2 binding to CRTH2 in hCRTH2 and mCRTH2 transfected cells, respectively. It has potential for the treatment of poorly controlled asthma.
- Highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2).
- Exhibits low nM potency as an antagonist of human or mouse CRTH2 in transfected cells.
- Shows significant inhibition of AHR in mice.
- Effectively blocks edema formation and greatly reduces inflammatory infiltrate and skin pathology.
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Medchemexpress LLC Givinostat hydrochloride monohydrate | 732302-99-7 | 99.6% | 475.97 | 25 MG
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Givinostat hydrochloride monohydrate is a potent HDAC inhibitor, demonstrating IC50 values of 198 nM for HDAC1 and 157 nM for HDAC3. This compound is notable for its ability to penetrate the blood-brain barrier, making it suitable for a range of research applications.
- Potent HDAC inhibitor for HDAC1 and HDAC3
- Penetrates the blood-brain barrier
- Suppresses LPS-induced IL-1β and IL-6 production
- Inhibits JS-1 cell proliferation
- Reduces serum TNFα and IL-1β levels in vivo
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Selleck Chemical LLC Allylthiourea 50mg 109-57-9
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Allylthiourea is a metabolic inhibitor that selective inhibits ammonia oxidation. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
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Apexbio Technology LLC BI-847325 1207293-36-4 50mg
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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BI-847325 (CAS 1207293-36-4) is a dual inhibitor targeting MEK1/2 and Aurora kinases with reported IC50 values of 25 nM and 4 nM against MEK1 and MEK2 and 3 nM 25 nM and 15 nM against Aurora A B and C respectively By inhibiting these kinases BI-847325 disrupts the MAPK/ERK and cell cycle signaling pathways that regulate cell proliferation and survival In cellular assays it demonstrates nanomolar EC50 values for inhibition of pERK and pHH3 in KRAS- and BRAF-mutant cancer cell lines and potently suppresses proliferation across a wide range of tumor cell models In xenograft studies it fully blocks tumor growth in BRAF- and KRAS-mutant cancer models This compound is utilized in research on kinase-targeted cancer therapies
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Medchemexpress LLC Lesogaberan hydrochloride | 2925644-17-1 | 98.0% | 177.54 | C3H10ClFNO2P | 1 ML
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Lesogaberan hydrochloride is a potent, selective GABAB receptor agonist provided as a ready-to-use 10 mM solution in DMSO for research applications. It is intended for use in receptor pharmacology, binding, and functional assays to probe GABAB-mediated signaling.
- Potent and selective GABAB receptor agonist.
- Supplied as a 10 mM solution in DMSO suitable for in vitro assays.
- High purity, typically 98.0%, for reproducible results.
- Molecular weight 177.54 g/mol; CAS number 2925644-17-1.
- Suitable for receptor pharmacology, binding, and functional studies.
- Available in multiple formats for experimental flexibility.
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