Naphthalenes

Polycyclic aromatic hydrocarbon compounds that consist of ten carbon atoms and eight hydrogen atoms fused into two benzene rings; it is the simplest polycyclic aromatic hydrocarbon.

Search Within Results

571 – 585 of 4,901 results

571

Apexbio Technology LLC BI-7273 1883429-21-7 5mg

BI-7273 (CAS 1883429-21-7) is a selective small-molecule inhibitor targeting the bromodomains of BRD9 and BRD7 with reported IC50 values of 19 nM and 117 nM respectively BRD9 is a component of the SWI/SNF chromatin remodeling complex implicated in the proliferation of acute myeloid leukemia (AML) cells BI-7273 demonstrates effective disruption of BRD9 function in vitro and also engages BRD7 due to high sequence homology between their bromodomains Biochemical assays indicate negligible activity against BET family bromodomains even at high concentrations In vivo oral administration in mouse models shows dose-dependent systemic exposure BI-7273 is currently utilized as a chemical probe in preclinical studies investigating BRD9/BRD7 modulation in hematological malignancies

Pricing & Availability

572

Medchemexpress LLC Xaliproden hydrochloride | 90494-79-4 | 98.4% | 417.89 | 1 ML

Xaliproden hydrochloride (SR57746A) is a potent, selective, and orally active agonist of the 5-HT1A receptor, showing high affinity for 5-HT1A specific binding sites in the rat hippocampus (IC50=3 nM). It is also a selective antagonist of the dopamine D2 receptor, with moderate affinity (IC50=0.1-1 μM). Xaliproden hydrochloride exhibits anti-depression and anti-anxiety effects and may have therapeutic potential for the research of neurodegenerative diseases.

Potent, selective, and orally active 5-HT1A receptor agonist
High affinity for 5-HT1A specific binding sites (IC50=3 nM)
Selective antagonist of the dopamine D2 receptor
Moderate affinity for D2 receptor (IC50=0.1-1 μM)
Exhibits anti-depression and anti-anxiety effects
May have therapeutic potential for neurodegenerative disease research

Pricing & Availability

573

Apexbio Technology LLC MK-571 115104-28-4 5mg

MK-571 (CAS 115104-28-4) also known as L-660711 is a selective antagonist of the leukotriene D4 (LTD4) receptor a G protein-coupled receptor activated by cysteinyl leukotrienes involved in inflammatory responses MK-571 demonstrates high affinity for the LTD4 receptor with reported Ki values of 0 22 nM in guinea pig lung and 2 1 nM in human lung membranes It effectively antagonizes LTD4- and LTE4-induced contractions in guinea pig and human airway tissues as indicated by pA2 values ranging from 8 5 to 10 5 In vivo MK-571 reduces airway hyperresponsiveness and leukocyte infiltration in animal models of pulmonary inflammation Additionally MK-571 acts as a specific inhibitor of multidrug resistance protein 1 (MRP1) supporting its use in studies of leukotriene signaling and drug transport mechanisms

Pricing & Availability

574

Medchemexpress LLC BI-4142 | 2682003-36-5 | 96.5% | 521.57 | 25 MG

BI-4142 is a potent, highly selective, and orally active HER2 inhibitor with an IC50 of 5 nM. It demonstrates antiproliferative activity against tumor cells and inhibits tumor growth and oncogenic signaling in animal models. The compound exhibits good permeability and no PgP-mediated efflux liability in the CaCo-2 assay.

Potent, highly selective, and orally active HER2 inhibitor
IC50 of 5 nM against HER2
Inhibits tumor growth and oncogenic signaling
Displays good permeability and no PgP-mediated efflux liability
Inhibits HER2-dependent cell lines and downstream signaling
Target: EGFR, JAK/STAT Signaling, Protein Tyrosine Kinase/RTK
Soluble in DMSO at 100 mg/mL (191.73 mM)

Pricing & Availability

575

Medchemexpress LLC Adapalene | 106685-40-9 | 99.9% | C28H28O3 | 100 MG

Adapalene is a third-generation synthetic retinoid widely used for acne research. It acts as a potent RAR agonist, with AC50s of 2.3 nM for RARβ, 9.3 nM for RARγ, and 22 nM for RARα. This compound also non-competitively inhibits the enzymatic activity of GOT1 and exhibits anti-tumor activity.

Third-generation synthetic retinoid
Potent RAR agonist for RARβ, RARγ, and RARα
Non-competitive inhibitor of GOT1 enzymatic activity
Exhibits anti-tumor activity
Induces apoptosis and inhibits proliferation in ES-2 cells
Inhibits growth of DLD1 cell-derived xenograft tumors

Pricing & Availability

576

Pfaltz & Bauer Methyl b-Hydroxynaphthoate 99 100G | 883-99-8

Methyl b-Hydroxynaphthoate 99 100G | 883-99-8

Pricing & Availability

577

Ambeed AMBEED

5000868506 7-BROMO-1234-TETRAHYDROISO 1GR

Pricing & Availability

578

Medchemexpress LLC Prmt5-in-1 hydrochloride | 99.51% | 455.29 | 1 ML

PRMT5 IN-1 hydrochloride, a hemiaminal, is a potent and selective inhibitor of protein arginine methyltransferase 5 (PRMT5) with an IC50 of 11 nM for the PRMT5/MEP50 complex. This compound can be converted to aldehydes and reacts with C449 to form covalent adducts under physiological conditions. As a hydrochloride salt, it typically offers enhanced water solubility and stability.

Potent and selective inhibitor of PRMT5.
Exhibits an IC50 of 11 nM for the PRMT5/MEP50 complex.
Inhibits cellular sDMA in Granta-519 cells with an IC50 of 0.012 μM.
Demonstrates antiproliferative activity in Granta-519 cells with an IC50 of 0.06 μM.
Hydrochloride form provides enhanced water solubility and stability.

Pricing & Availability

579

Medchemexpress LLC Clobutinol hydrochloride | 1215-83-4 | 99.86% | 292.24 | 100 MG

Clobutinol hydrochloride is a compound with anti-tussive effects. It influences heart rate and blood pressure, making it suitable for cough-related research.

Has anti-tussive effects.
Influences heart rate and blood pressure.
Used in cough related research.
Functions as a potassium channel inhibitor.

Pricing & Availability

580

Aobchem AOBCHEM

5000864284 1 2-DIFLUORO-4- 2-PROPEN-1-YL

Pricing & Availability

581

Apexbio Technology LLC BI-847325 1207293-36-4 100mg

BI-847325 (CAS 1207293-36-4) is a dual inhibitor targeting MEK1/2 and Aurora kinases with reported IC50 values of 25 nM and 4 nM against MEK1 and MEK2 and 3 nM 25 nM and 15 nM against Aurora A B and C respectively By inhibiting these kinases BI-847325 disrupts the MAPK/ERK and cell cycle signaling pathways that regulate cell proliferation and survival In cellular assays it demonstrates nanomolar EC50 values for inhibition of pERK and pHH3 in KRAS- and BRAF-mutant cancer cell lines and potently suppresses proliferation across a wide range of tumor cell models In xenograft studies it fully blocks tumor growth in BRAF- and KRAS-mutant cancer models This compound is utilized in research on kinase-targeted cancer therapies

Pricing & Availability

582

eMolecules 223418-74-4 | 2-Methoxy-3-(tributylstannyl)pyridine | Synthonix - Stock | MFCD01319029 | 398.178 | C18H33NOSn | 97.000 | CCCC[Sn](CCCC)(CCCC)c1cccnc1OC | 1g | 525920394

2-Methoxy-3-(tributylstannyl)pyridine | Synthonix - Stock | 223418-74-4 | MFCD01319029 | 398.178 | C18H33NOSn | 97.000 | CCCC[Sn](CCCC)(CCCC)c1cccnc1OC | 1g | 525920394

Pricing & Availability

583

Aobchem AOBCHEM

5000866158 1-IODO-4-METHOXYNAPHTHALENE 50

Pricing & Availability

584

Medchemexpress LLC Isoguvacine (hydrochloride) | 68547-97-7 | 99.8% | 163.60 g/mol | C6H10ClNO2 | 100 MG

Isoguvacine hydrochloride is a selective GABAA receptor agonist used in neuroscience research to modulate inhibitory GABAergic signaling. It is supplied as a white to light yellow solid or as a 10 mM solution in DMSO. Intended for laboratory research use only; handle and store according to the product SDS.

Selective GABAA receptor agonist.
High purity (99.8%).
Molecular weight 163.60 g/mol.
Available as solid and 10 mM DMSO solution.
White to light yellow appearance.
Store sealed, away from moisture; follow SDS for solvent storage conditions.

Pricing & Availability

585

Selleck Chemical LLC TA-02

TA-02 is a p38 MAPK inhibitor with IC50 of 20 nM TA-02 especially inhibits TGFBR-2

Pricing & Availability

Naphthalenes

Filtered Search Results

Narrow Results

Apexbio Technology LLC BI-7273 1883429-21-7 5mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Xaliproden hydrochloride | 90494-79-4 | 98.4% | 417.89 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC MK-571 115104-28-4 5mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC BI-4142 | 2682003-36-5 | 96.5% | 521.57 | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Adapalene | 106685-40-9 | 99.9% | C28H28O3 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Prmt5-in-1 hydrochloride | 99.51% | 455.29 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Clobutinol hydrochloride | 1215-83-4 | 99.86% | 292.24 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC BI-847325 1207293-36-4 100mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Isoguvacine (hydrochloride) | 68547-97-7 | 99.8% | 163.60 g/mol | C6H10ClNO2 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Selleck Chemical LLC TA-02 Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More