Unsubstituted Phenols
Apexbio Technology LLC Ko 143 461054-93-3 25mg
Ko 143 (CAS 461054-93-3) is a selective inhibitor of the breast cancer resistance protein (BCRP/ABCG2) an ATP-binding cassette transporter implicated in multidrug resistance in cancer cells By targeting BCRP Ko 143 effectively blocks BCRP-mediated drug efflux as demonstrated by an EC90 of 26 nM in cell-based assays This compound exhibits over 200-fold selectivity for BCRP compared to P-glycoprotein and MRP1 In vitro Ko 143 reverses BCRP-mediated resistance to chemotherapeutics such as topotecan and mitoxantrone enhancing their potency up to tenfold in relevant cancer cell lines Ko 143 has been used in murine models to increase systemic exposure of BCRP substrates supporting its utility in studying drug resistance mechanisms and improving chemotherapeutic efficacy in preclinical research
Medchemexpress LLC Agi-41998 | 2377492-26-5 | 99.9% | C22H16BrF3N4O2 | 100 MG
AGI-41998 is a potent and orally active inhibitor of methionine adenosyltransferase 2A (MAT2A) that effectively penetrates the blood-brain barrier. It exhibits inhibitory activities against MAT2A and S-adenosyl methionine (SAM), and can significantly inhibit the proliferation of HCT-116 cells and tumor growth.
- Potent and orally active MAT2A inhibitor
- Effectively penetrates the blood-brain barrier
- Exhibits inhibitory activities against MAT2A and SAM in HCT-116 MTAP-null cells (IC50s of 22 nM and 34 nM)
- Can significantly inhibit the proliferation of HCT-116 cells and tumor growth
- Can be used to study the role of SAM regulation in the central nervous system (CNS) and colon cancer
Medchemexpress LLC (E/Z)-4-Hydroxytamoxifen (Afimoxifene) | 68392-35-8 | 99.62% | 387.51 | 100 MG
(E/Z)-4-Hydroxytamoxifen (Afimoxifene) is a racemic compound comprised of (Z)-4-Hydroxytamoxifen and (E)-4-Hydroxytamoxifen isomers. It functions as a selective estrogen receptor modulator, exhibiting both estrogenic and antiestrogenic properties. It is also an active metabolite of Tamoxifen. The compound shows promise for research related to cyclical mastalgia, including breast pain, tenderness, and nodularity.
- Functions as a selective estrogen receptor modulator
- Exhibits both estrogenic and antiestrogenic properties
- Active metabolite of tamoxifen
- Acts as an agonist of the G protein-coupled estrogen receptor (GPER) with relatively low affinity (100-1000 nM)
- Shows promise for research related to cyclical mastalgia, including breast pain, tenderness, and nodularity
Medchemexpress LLC Isosilybin B | 142796-22-3 | 1 MG
Isosilybin B is a flavonolignan isolated from Silybum marianum that demonstrates anticancer activity, particularly against prostate cancer. Its mechanisms involve regulating cell cycle proteins and promoting apoptosis.
- Regulates cell cycle-related proteins (cyclins, Cdk4, Cdk2, Cdc25A).
- Activates caspases (caspase-9 and caspase-3) to promote apoptosis.
- Reduces androgen receptor (AR) and prostate-specific antigen (PSA) levels.
- Exhibits cytotoxicity in Huh-7 cells with an IC50 of 27 μM.
- Induces G1 arrest and increased cell death in LNCaP and 22Rv1 prostate cancer cells.
Medchemexpress LLC ML-109 | 1186649-91-1 | 99.0% | 523.58 | 50 MG
ML-109 is identified as a potent and full agonist of the thyroid stimulating hormone receptor (TSHR), exhibiting an EC50 of 40 nM. While being surprisingly stable under neutral and basic conditions with a half-life of approximately 16 hours, it degrades at lower pH levels, with a half-life of about 3 hours. It shows no activity at FSHR or LHCGR.
- Potent and full thyroid stimulating hormone receptor (TSHR) agonist
- EC50 of 40 nM for TSHR
- No activity at FSHR or LHCGR
- Stable at neutral and basic conditions (t1/2 of ~16 h)
eMolecules 1384268-04-5 | Medchem Express | SYP-5 | 5mg | 446255902 | HY-100693 | MFCD30534394 | 312.38 | C18H16O3S
ChemScene | Methyl 5-bromo-6-oxo-16-dihydropyridine-2-carboxylate | 250mg | 572233306 | CS-W006157 | 178876-86-3 | MFCD14698125 | 232.033 | C7H6BrNO3
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Medchemexpress LLC HY-111832 5mg Medchemexpress, 1,2,3,6-Tetragalloylglucose CAS:79886-50-3 Purity:>98%
Medchemexpress, HY-111832 5mg 1,2,3,6-Tetragalloylglucose CAS:79886-50-3 1,2,3,6-Tetragalloylglucose is a potent UDP glucuronosyltransferase 1 family, polypeptide A1 (UGT1A1) inhibitor, with a Ki of 1.68 μM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-19620 10mg Medchemexpress, Branaplam CAS:1562338-42-4 Purity:>98%
Medchemexpress, HY-19620 10mg Branaplam CAS:1562338-42-4 Branaplam (LMI070; NVS-SM1) is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC50 of 20 nM for SMN. Branaplam inhibits human-ether-a-go-go-related gene (hERG) with an IC50 of 6.3 μM. Branaplam elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model[2]. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
ILEX LIFE SCIENCES LLC TRYPSIN/EDTA P10-019500 500ML
PAN-Biotech Trypsin 0.25% / EDTA 0.02% in DPBS, w/o: Ca and Mg, w: Phenol red (500 ml). DESCRIPTION: PAN-Biotech Trypsin 0.25% / EDTA 0.02% in PBS, w/o: Ca and Mg, w: Phenol Red is a porcine pancreas-derived enzyme plus EDTA in a PBS solution. Trypsin-EDTA solution is commonly used for the dissociation of anchorage-dependent (adherent) mammalian cells and tissues from culture surfaces. The concentration of trypsin necessary to dislodge cells from their substrate is dependent on the cell type and the age of the culture. Ethylenediaminetetraacetic acid (EDTA), a chelating agent, is often added to trypsin solutions to enhance enzymatic activity by neutralizing calcium and magnesium ions that enhance cell-to-cell adhesion and obscure the peptide bonds on which trypsin acts. LIQUID/POWDER: Liquid. PHENOL RED: With Phenol Red. Ca/Mg CONTENT: Without Ca and Mg. TRYPSIN: 0.25% Trypsin. EDTA: 0.02% EDTA. STERILE: Yes. STORAGE TEMP.: -20°C. MANUFACTURER: PAN-Biotech GmbH (Germany).
![eMolecules 780757-88-2 | ICG-001 | AstaTech548.643 | C33H32N4O4 | 96.000 | Oc1ccc(C[C@@H]2N3[C@H](CN(Cc4cccc5ccccc45)C2=O)N(CCC3=O)C(=O)NCc2ccccc2)cc1 | 0.1g | 290663019](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502171647.JPG-250.jpg)
eMolecules 780757-88-2 | ICG-001 | AstaTech548.643 | C33H32N4O4 | 96.000 | Oc1ccc(C[C@@H]2N3[C@H](CN(Cc4cccc5ccccc45)C2=O)N(CCC3=O)C(=O)NCc2ccccc2)cc1 | 0.1g | 290663019
ICG-001 | AstaTech | 780757-88-2548.643 | C33H32N4O4 | 96.000 | Oc1ccc(C[C@@H]2N3[C@H](CN(Cc4cccc5ccccc45)C2=O)N(CCC3=O)C(=O)NCc2ccccc2)cc1 | 0.1g | 290663019
Selleck Chemical LLC Troxerutin 50mg 7085-55-4
Troxerutin, a natural bioflavonoid isolated from Sophora japonica, has been reported to have many benefits and medicinal properties. Troxerutin, also known as vitamin P4, is a tri-hydroxyethylated derivative of natural bioflavonoid rutins which can inhibit the production of reactive oxygen species (ROS) and depress ER stress-mediated NOD activation. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
eMolecules 28860-95-9 | Medchem Express | Carbidopa | 10mg | 446272480 | HY-B0311 | MFCD02114422 | 226.232 | C10H14N2O4
ChemScene | 3-Bromo-5-methoxypicolinonitrile | 250mg | 632284090 | CS-0150506 | 717843-46-4 | MFCD08062679 | 213.034 | C7H5BrN2O
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Selleck Chemical LLC 2-Methoxybenzoic acid
2-Methoxybenzoic acid (o-Anisic acid) is a flavouring agent
Medchemexpress LLC Cirsimaritin | 6601-62-3 | MFCD00238561 | 50 MG
Cirsimaritin | 6601-62-3 | MFCD00238561 | 50 MG