Alpha-halocarboxylic acids and derivatives
Cayman Chemical W140 trifluoroacetate salt
An inactive enantiomer of W146; binds weakly to S1P1 (Ki = 4.6 µM for the human receptor); has been used as a negative control in the study of S1P1 receptor signaling
Selleck Chemical LLC BIBO 3304 Trifluoroacetate
BIBO 3304 Trifluoroacetate (BIBO-3304 TFA) is a novel neuropeptide Y Y1 receptor (NPY1R) antagonist with IC50 values of 0 38 nM and 0 72 nM for human Y1 receptor and rat Y1 receptor respectively BIBO 3304 shows low affinity for the human Y2 receptor human and rat Y4 receptor as well as for the human and rat Y5 receptor (IC50 values 1000 nM)
Selleck Chemical LLC LIT-001 trifluoroacetate
LIT-001 trifluoroacetate(LIT-001 TFA) is the first nonpeptide oxytocin receptor (OXTR) agonist that improves social interaction in a mouse model of autism
AdipoGen GE23077 A1 B1
Chemical. CAS 752989-46-1, 752989-45-0752989-44-9. Formula C31H51N9O16, C31H49N9O16. MW 805.8803.8. Isolated from Actinomadura sp. Cyclic heptapeptide antibiotic. Potent and selective inhibitor of bacterial RNA polymerase RNAP. Inhibits Gram-positive Bacillus subtilis and Gram-negative Escherichia coli RNAPs with IC50 ~20nM, whereas it is not active on E. coli DNA polymerase or on eukaryotic wheat germ RNAP II IC50 values >100µM. Even though of its potent activity in vitro on purified bacterial RNAPs, it shows a narrow spectrum of antimicrobial activity in vivo on Gram-positive and Gram-negative bacteria, due to lack of memmbrane permeability. Acts at the level of transcription initiation. Binds directly to the bacterial RNA polymerase RNAP active-center i and i1 nucleotide binding sites, preventing the binding of initiating nucleotides and thereby preventing transcription initiation.
Cayman Chemical CAY10729 trifluoroacetate sa
A tetrazole derivative of Cl-amidine; selectively inhibits PAD1 over PAD2, PAD3, and PAD4 (kinact/KI = 162,200, 60,000, 17,500, and 25,400 M-1min-1 for PAD1-4, respectively)
Cayman Chemical W146 trifluoroacetate salt
An S1P1 receptor antagonist (Ki = 77 nM); selective for S1P1 over S1P2, S1P3, and S1P5 (Kis = >10 µM); prevents ligand-induced receptor internalization in CHO cells and inhibits ERK and Akt phosphorylation at 10 µM; increases AMD3100-induced KSL-HSPC entrance into mouse blood circulation from the bone marrow at 5 mg/kg in combination with AMD3100; disrupts the endothelial barrier and induces PMN neutrophil infiltration into the lungs and skin in an ovalbumin-induced mouse model of immune cell-mediated vascular injury at 10 UG intranasally or intradermally
Cayman Chemical W146 trifluoroacetate salt
An S1P1 receptor antagonist (Ki = 77 nM); selective for S1P1 over S1P2, S1P3, and S1P5 (Kis = >10 µM); prevents ligand-induced receptor internalization in CHO cells and inhibits ERK and Akt phosphorylation at 10 µM; increases AMD3100-induced KSL-HSPC entrance into mouse blood circulation from the bone marrow at 5 mg/kg in combination with AMD3100; disrupts the endothelial barrier and induces PMN neutrophil infiltration into the lungs and skin in an ovalbumin-induced mouse model of immune cell-mediated vascular injury at 10 UG intranasally or intradermally
eMolecules Chem-Impex Bromoacetic acid tert-butyl ester 2 5kg 272388278 24435 0 000 5292-43-3 MFCD00000188 195 056 C6H11BrO2
Chem-Impex Bromoacetic acid tert-butyl ester 2 5kg 272388278 24435 0 000 5292-43-3 MFCD00000188 195 056 C6H11BrO2
Cayman Chemical W140 trifluoroacetate salt
An inactive enantiomer of W146; binds weakly to S1P1 (Ki = 4.6 µM for the human receptor); has been used as a negative control in the study of S1P1 receptor signaling
Cayman Chemical FTI276 trifluoroacetate salt
A peptidomimetic inhibitor of FTase (IC50 = 500 pM); selective for FTase over GGTase I (IC50 = 50 nM); inhibits the growth of NIH3T3 cells expressing RasF at 20 µM; reduces tumor growth in a mouse xenograft model using Calu-1 cells that contain a K-Ras oncogenic mutation
Chem-Impex International, Inc. Bromoacetic acid | MFCD00002678 | 25G
Bromoacetic acid, MFCD00002678, 25G
Medchemexpress LLC Odn 2216 sodium | DNA, d(G-sp-G-sp-G-G-G-A-C-G-A-T-C-G-T-C-G-sp-G-sp-G-sp-G-sp-G-sp-G), sodium salt | 50 MG
Odn 2216 sodium | DNA, d(G-sp-G-sp-G-G-G-A-C-G-A-T-C-G-T-C-G-sp-G-sp-G-sp-G-sp-G-sp-G), sodium salt | 50 MG
eMolecules Ambeed / 2-(3-Bromophenyl)acetic acid / 10g / 525119027 / A202848 / / 1878-67-7 / MFCD00004330 / 215.046 / C8H7BrO2
Ambeed / 2-(3-Bromophenyl)acetic acid / 10g / 525119027 / A202848 / / 1878-67-7 / MFCD00004330 / 215.046 / C8H7BrO2
TARGETMOL CHEMICALS INC XMD-17-51 Trifluoroacetate 5MG
Also available in 1 mL, 1 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. XMD-17-51 Trifluoroacetate is a pyrimido-diazepinone compound that regulates protein kinases. Purity 99.65%
eMolecules Chem-Impex Sodium azide 2 5kg 349011797 29961 0 000 26628-22-8 MFCD00003536 65 011 N3Na
Chem-Impex Sodium azide 2 5kg 349011797 29961 0 000 26628-22-8 MFCD00003536 65 011 N3Na