Trigonelline is an alkaloid with potential antidiabetic activity. It acts as a potent Nrf2 inhibitor, blocking Nrf2-dependent proteasome activity and enhancing apoptosis in pancreatic cancer cells. It also exhibits anti-HSV-1, antibacterial, and antifungal activities, and induces ferroptosis.
- Potential antidiabetic activity
- Potent Nrf2 inhibitor
- Enhances apoptosis in pancreatic cancer cells
- Antimicrobial properties (anti-HSV-1, antibacterial, antifungal)
- Induces ferroptosis
- Cardioprotective activity by rescuing H9c2 cell morphology and attenuating H2O2 induced cell deaths