DOPE-PEG-Mal (MW 2000) is a maleimide-functionalized phospholipid-polyethylene glycol conjugate for preparing liposomes, lipid nanoparticles, and for thiol-specific bioconjugation. The maleimide end group selectively reacts with thiol groups at pH 6.5-7.5 to form stable thioether bonds, enabling surface functionalization of lipid assemblies and attachment of thiol-containing ligands.
- Provides a maleimide functional group for thiol-specific conjugation.
- Facilitates liposome and nanoparticle formulation as an amphiphilic PEG-lipid.
- Average molecular weight of approximately 2000 Da for the PEG spacer.
- Reacts with thiols at pH 6.5-7.5 to form stable thioether bonds.
- Off-white to light yellow solid with recommended cold storage for stability.