Azepines
Medchemexpress LLC Carbamazepine 10,11 epoxide-d10 | 1219804-16-6 | 99.0% | 262.33 | 1 MG
Carbamazepine 10,11 epoxide-d10 is a deuterium labeled version of Carbamazepine 10,11 epoxide, intended for research use. It serves as a valuable tool in quantitative analysis for various scientific applications.
- Functions as a tracer
- Suitable as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Carbamazepine 10,11-epoxide | 36507-30-9 | 99.1% | 252.27 | 25 MG
Carbamazepine 10,11-epoxide is an orally active metabolite of Carbamazepine. This compound exhibits an anticonvulsant effect and is suitable for research related to seizures.
- Orally active metabolite
- Anticonvulsant effect
- Suitable for research of seizures
Apexbio Technology LLC Eslicarbazepine acetate 236395-14-5 10mM (in 1mL DMSO)
Eslicarbazepine acetate (CAS 236395-14-5) is an orally administered anticonvulsant prodrug that undergoes rapid first-pass hydrolysis to yield eslicarbazepine its pharmacologically active metabolite Eslicarbazepine predominantly modulates neuronal excitability by stabilizing the inactivated state of voltage-gated sodium channels thereby reducing sustained repetitive neuronal firing associated with seizure activity While approved for adjunctive treatment in partial-onset seizures eslicarbazepine acetate is frequently utilized in research to investigate the pathophysiology of epileptic disorders and to study sodium channel-mediated neuronal signaling
Apexbio Technology LLC Oxcarbazepine 28721-07-5 50mg
Oxcarbazepine (CAS 28721-07-5) is a small molecule that modulates voltage-gated sodium channels a critical target in neuronal excitability studies It impedes the association of [3H]batrachotoxin ([3H]BTX) with sodium channels demonstrating an IC50 of 160 M and restricts sodium ion influx as indicated by inhibition of 22Na uptake into rat brain synaptosomes with an IC50 of approximately 100 M These properties make oxcarbazepine valuable for investigating sodium channel function and regulation in neuropharmacology and for exploring mechanisms underlying neuronal signaling and excitotoxicity
Cayman Chemical CarbamazepIn 50g
A sodium channel inhibitor; preferentially inhibits inactivated Nav1.7 and Nav1.3 channels (IC50s = 406 and 900 µM, respectively) over resting (closed) Nav1.7 and Nav1.3 channels in whole-cell patch-clamp assays using HEK293 cells (IC50s = 1,584 and 2,464 µM, respectively); inhibits sodium currents in a rat sciatic nerve patch-clamp assay ex vivo at 100 µM; reduces dopamine levels in the striatum and hippocampus, as well as L-DOPA levels in the striatum, in rats at 100 mg/kg; reduces amphetamine-induced hyperactivity in mice at 0.5% w/w in the diet; reduces immobility time in the forced swim test in mice at 0.75% w/w in the diet
Medchemexpress LLC Conduritol B epoxide | 6090-95-5 | MFCD00077326 | 99.9% | 162.14 g/mol | C6H10O5 | 1 ML
Conduritol B epoxide is an irreversible covalent inhibitor of acid β-glucosidase (GCase) used to block GCase activity in biochemical and cellular studies. It is supplied in solid form and as a 10 mM solution in DMSO for convenient preparation and dosing in research assays.
- Irreversible covalent inhibitor of acid β-glucosidase (GCase).
- Useful for biochemical and cellular assays investigating lysosomal function.
- Available as solid and as a 10 mM solution in DMSO for convenience.
- High reported purity and defined molecular weight for reproducible results.
- Stable under recommended storage conditions to preserve activity.
Medchemexpress LLC (1R,2R)-N1,N2-dibenzylcyclohexane-1,2-diamine | 143443-23-6 | MFCD29919494 | 97.7% | 294.44 g/mol | C20H26N2 | 500 MG
(1R,2R)-N1,N2-dibenzylcyclohexane-1,2-diamine is a chiral diamine intermediate used in organic synthesis and medicinal chemistry. The (1R,2R) stereochemistry and dibenzyl substitution make it useful as a building block for asymmetric synthesis and for preparing biologically active compounds.
- Chiral diamine with defined (1R,2R) stereochemistry.
- High purity: 97.7% by HPLC (as provided).
- Chemical formula C20H26N2 and molecular weight 294.44 g/mol.
- Suitable as a synthetic intermediate for drug discovery and ligand synthesis.
- Storage recommendations: 4°C, protect from light; in solvent store at -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Carbamazepine (Standard) | 298-46-4 | 99.9% | 25 MG
Carbamazepine (Standard) is the analytical standard of Carbamazepine, intended for research and analytical applications. It is an orally active pressure-sensitive sodium ion channel blocker with an IC50 of 131 μM. This anticonvulsant can be used for research related to epilepsy and neuropathic pain.
- Analytical standard of Carbamazepine
- Orally active pressure-sensitive sodium ion channel blocker (IC50: 131 μM)
- Blocks voltage-gated Na+, Ca2+, and K+ channels
- Acts as an HDAC inhibitor (IC50: 2 μM)
- Can be used for research related to epilepsy and neuropathic pain
- Commonly used in qualitative, quantitative, and methodological research experiments (HPLC, GC, MS)
Cayman Chemical Cel-Based asy Soluble Epox 5ea
An OGA inhibitor (IC50 46 nM) selective for OGA overBhexosaminidase (IC50 >10 UM) and a panel of 277 kinases (IC50s >1 UM for all) increases the levels of O-GlcNAcylated proteins in SH-SY5Y cells (EC50 450 nM)
Selleck Chemical LLC Oxcarbazepine S1391-10mg
Oxcarbazepine (GP47680) inhibits the binding of [3H]BTX to sodium channels with IC50 of 160 M and also inhibits the influx of 22Na into rat brain synaptosomes with IC50 about 100 M
Medchemexpress LLC Carbamazepine 10,11-epoxide | 36507-30-9 | 99.14% | 252.27 | 50 MG
Carbamazepine 10,11-epoxide is an orally active metabolite of Carbamazepine. It has an anticonvulsant effect and can be used for the research of seizures.
- Orally active metabolite
- Has anticonvulsant effect
- Suitable for research of seizures
Medchemexpress LLC (1R,2R)-N1,N2-Dibenzylcyclohexane-1,2-diamine | 143443-23-6 | MFCD29919494 | 97.7% | 294.44 g·mol⁻¹ | C20H26N2 | 250 MG
(1R,2R)-N1,N2-Dibenzylcyclohexane-1,2-diamine is a chiral diamine used primarily as a synthetic intermediate in the preparation of pharmaceutical and fine chemical compounds. It is intended for research and development applications such as route scouting, asymmetric synthesis, and medicinal chemistry studies.
- Chiral diamine with defined (1R,2R) stereochemistry.
- Drug intermediate for synthesis of active pharmaceutical compounds.
- High purity (≈97.7%) suitable for analytical and synthetic use.
- Molecular formula C20H26N2 and molecular weight 294.44 g·mol⁻¹.
- Available in multiple small-scale pack sizes for research use.
Selleck Chemical LLC Eslicarbazepine Acetate S4657-100mg
Eslicarbazepine Acetate (BIA 2093 Zebinix Exalief Stedesa Aptiom) an antiepileptic drug is a dual a dual Inhibitor of -Secretase and voltage-gated sodium channel
Medchemexpress LLC Eslicarbazepine acetate | 236395-14-5 | 99.9% | 500 MG
Eslicarbazepine acetate (BIA 2-093) is an antiepileptic agent that functions as a dual inhibitor of β-Secretase and voltage-gated sodium channels. It is a prodrug that is converted to eslicarbazepine, an active metabolite of oxcarbazepine, sharing an identical mechanism of action. This compound may offer improved tolerability compared to oxcarbazepine by not producing as high peak levels of (S)-(+)-licarbazepine immediately after dosing.
- Functions as an antiepileptic agent
- Dual inhibitor of β-Secretase and voltage-gated sodium channels
- Prodrug activated to eslicarbazepine
- Mechanism of action identical to oxcarbazepine
- May improve tolerability over oxcarbazepine
- Targets beta-secretase and sodium channel pathways
- Involved in neuronal signaling and membrane transporter/ion channel pathways