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Azobenzenes

Organic compounds that consist of two phenyl rings linked by a nitrogen - nitrogen double bond (N=N); also known as aryl azo compounds.

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1

Medchemexpress LLC Eln318463 racemate | 851599-82-1 | >98% | C19H20BrClN2O3S | 50 MG
SDP

ELN318463 racemate is a selective γ-secretase inhibitor, demonstrating differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase. It shows significant selectivity for PS1 with EC50s of 12 nM and 656 nM for PS1 and PS2, respectively. This compound acts as a classic γ-secretase inhibitor, inhibiting Aβ production with 75- to 120-fold selectivity over Notch signaling in cells.

  • Amyloid precursor protein (APP) selective γ-secretase inhibitor
  • Differentially inhibits presenilin (PS1) and PS2-comprised γ-secretase
  • 51-fold more selective for PS1
  • Demonstrates 75- to 120-fold selectivity for inhibiting Aβ production
  • Displaces an active site-directed inhibitor in the presence of a substrate
  • Achieves brain levels up to 2.7 μM at 100 mg/kg dose

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2

Medchemexpress LLC Nav1.1 activator 1 | 2332897-85-3 | 99.0% | 440.46 | 50 MG
SDP

Nav1.1 activator 1 | 2332897-85-3 | 99.0% | 440.46 | 50 MG

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3

Medchemexpress LLC 1-(3-fluorophenyl)-5-methylpyridin-2(1H)-one | 848353-85-5 | 99.8% | 50 MG
SDP

Fluorofenidone (AKF-PD) is an orally active small-molecule research compound with reported anti-fibrotic, antioxidant, and anti-inflammatory effects. Supplied as a purified analytical standard suitable for in vitro and in vivo studies and commonly provided as a 50 mg pack.

  • Orally active small molecule with anti-fibrotic and anti-inflammatory activity.
  • Demonstrated cellular effects (e.g., NIH/3T3 IC50 ~2.75 mM) and in vitro activity in lung and cancer cell lines.
  • Shows protective effects in rodent models of lung injury, cholestasis, and fibrosis.
  • High purity suitable for analytical and preclinical research applications.
  • Molecular formula C12H10FNO; molecular weight 203.21 g/mol.

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4

Medchemexpress LLC 1-(3,4-dihydroxy-5-nitrophenyl)-2-phenylethanone | 274925-86-9 | MFCD09954136 | 99.9% | 273.24 | C14H11NO5 | 50 MG
SDP

Nebicapone is a reversible catechol-O-methyltransferase (COMT) inhibitor provided as a solid research compound for in vitro and in vivo studies. It is used to study COMT-mediated metabolism of L-DOPA and related pharmacology, and is supplied with characterization data and storage recommendations for experimental stability.

  • Reversible COMT inhibitor for research use.
  • Reported purity 99.9%.
  • Molecular weight 273.24 g/mol.
  • Physical form solid powder.
  • High solubility in DMSO (≥100 mg/mL) and formulated in vivo solubility ≥2.5 mg/mL in 10% DMSO/40% PEG300/5% Tween-80/45% saline.
  • Recommended storage 4°C protected from light; in solution store at -80°C up to 6 months or -20°C up to 1 month.

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5

Medchemexpress LLC N-cycloheptyl-6,7-dimethoxy-2-(4-piperidin-1-ylpiperidin-1-yl)quinazolin-4-amine | 864289-85-0 | 100.0% | 467.65 g/mol | C27H41N5O2 | 50 MG
SDP

C-021 is a small-molecule antagonist of CC chemokine receptor 4 (CCR4) developed for research applications; it blocks CCR4-mediated signaling and functional chemotaxis, with low-nanomolar activity in binding and cell-based assays.

  • Potent CCR4 antagonist with low-nanomolar binding activity.
  • Prevents CCL22-derived [35S]GTPγS binding to CCR4 (IC50 18 nM) and inhibits functional chemotaxis (human 140 nM, mouse 39 nM).
  • Molecular formula C27H41N5O2; molecular weight 467.65 g/mol.
  • High purity (~99.95%).
  • Solid form with recommended storage: powder -20°C (long term) or 4°C (short term); in solvent store at -80°C.
  • Intended for research use only; not for human use.

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6

Medchemexpress LLC Urea, N-[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N' | 1166393-85-6 | 98.6% | 445.52 | 50 MG
SDP

PF-4618433 is a potent and selective PYK2 inhibitor, with an IC50 of 637 nM. It may be suitable for the research of osteoporosis, craniofacial and appendicular skeletal defects, and for targeted bone regeneration.

  • Potent and selective PYK2 inhibitor with an IC50 of 637 nM.
  • Promotes osteogenesis of hMSC cultures, increasing alkaline phosphatase (ALP) activity and mineralization.
  • Enhances osteoblast proliferation.
  • Enhances calcium deposition.
  • Increases cell proliferation activity in murine bone marrow-derived mesenchymal stem cells (BMSC).

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