Azolines
Medchemexpress LLC VH032 thiol | 2098836-54-3 | 95.9% | 490.64 | 1 ML
VH032 thiol (VHL ligand 6) is a VHL ligand. It binds to pan-BET inhibitor JQ1 via a linker to form PROTAC. VHL is a substrate recognition subunit of two ubiquitously expressed and biologically important Cullin RING E3 ubiquitin ligase complexes. It is also one of the most popular E3 ligases recruited by bifunctional Proteolysis-targeting chimeras (PROTACs) to induce ubiquitination and subsequent proteasomal degradation of a target protein.
- Binds to JQ1 to form PROTACs.
- Recruits VHL E3 ligase for protein degradation.
- Useful in the study of Proteolysis-targeting chimeras.
Medchemexpress LLC M-PEG-thiol | 134874-49-0 | MFCD21363241 | 99.0% | 550 (average) | (C2H4O)nC3H8OS | 250 MG
m-PEG-thiol (MW 550) is a monofunctional methoxy polyethylene glycol terminated with a free thiol (-SH). It has an average molecular weight of 550 Da and is supplied as a solid for research use in surface functionalization, bioconjugation, and nanoparticle modification.
- Provides a terminal thiol for selective conjugation to maleimide or gold surfaces.
- Average molecular weight of 550 Da for controlled PEGylation.
- High purity suitable for research applications (reported ~98.98%).
- Available in lab-scale pack sizes for method development and small-batch experiments.
- Stable when stored sealed and protected from moisture; follow cold storage recommendations for solutions.
Medchemexpress LLC 3-Mercapto-1,2,4-triazole | 3179-31-5 | 98.0% | 101.13 | 250 G
1,2-Dihydro-3H-1,2,4-triazole-3-thione is a biochemical reagent suitable for life science related research. It serves as a biological material or organic compound, intended for research use only and not for patient applications.
- Utilized in a study to design a surface enhanced Raman scattering based probe for fast and accurate detection of DNA markers.
Medchemexpress LLC 2,4-Dimethyl-1H-imidazole-5-carbaldehyde | 68282-52-0 | 99.86% | C6H8N2O | 50 MG
2,4-Dimethyl-1H-imidazole-5-carbaldehyde is a chemical compound that serves as a drug intermediate for the synthesis of various active compounds. It is intended for research use only.
- Used in the synthesis of diverse active compounds.
- High purity for reliable research applications.
- Available in multiple quantities to suit research needs.
- Solid appearance with a light yellow to yellow color.
- Storage recommendations for optimal shelf life.
Medchemexpress LLC 3-Mercapto-1,2,4-triazole | 3179-31-5 | 99.8% | 101.13 | 1 ML
1,2-Dihydro-3H-1,2,4-triazole-3-thione is a biochemical reagent that can be used as a biological material or organic compound for life science related research. It was used in a study to design a surface enhanced Raman scattering based probe for fast and accurate detection of DNA markers.
- Used as a biochemical reagent
- Can be utilized as a biological material or organic compound
- Suitable for life science related research
- Applied in studies for designing surface-enhanced Raman scattering based probes
Medchemexpress LLC 2-amino-5-mercapto-1,3,4-thiadiazole | 2349-67-9 | 99.9% | 133.20 | 1 KG
2-Amino-5-mercapto-1,3,4-thiadiazole is a biochemical reagent that can be used as a biological material or organic compound for life science-related research. It is intended for research use only and not sold to patients.
- Biochemical reagent
- Can be used as a biological material
- Can be used as an organic compound for life science related research
Medchemexpress LLC Thiol-PEG1-acid | 1260092-48-5 | 95.0% | 150.20 g/mol | C5H10O3S | 5 MG
Thiol-PEG1-acid is a short polyethylene glycol linker bearing a thiol (-SH) and a terminal carboxyl (-COOH). It serves as a bifunctional reagent for chemical biology and bioconjugation applications that require a small, hydrophilic spacer with orthogonal reactive handles.
- Contains a reactive thiol (-SH) functional group for selective conjugation.
- Terminal carboxyl group enables amide or ester bond formation with amines or alcohols.
- Short PEG spacer improves solubility and reduces steric hindrance in conjugates.
- Typical purity listed as 95.0%.
- Soluble in DMSO at 100 mg/mL; may require ultrasonic assistance.
- Stable as a pure material at -20°C for up to 3 years; in solution store at -80°C for extended stability.
Medchemexpress LLC Thiol-PEG1-acid | 1260092-48-5 | 95.0% | 150.20 g·mol⁻¹ | C5H10O3S | 25 MG
Thiol-PEG1-acid is a short-chain polyethylene glycol derivative with a terminal thiol and carboxylic acid. It functions as a bifunctional linker and short PEG spacer for bioconjugation, surface modification, and click-chemistry applications, providing a reactive thiol for coupling and a carboxyl group for further derivatization. It is supplied as a laboratory reagent with specified storage recommendations.
- Contains reactive thiol (-SH) and carboxyl (-COOH) functional groups.
- Provides a short PEG spacer to minimize steric hindrance.
- Good solubility in DMSO for common bioconjugation workflows.
- Suitable for bioconjugation, surface functionalization, and assay reagent development.
- Stable when stored under recommended conditions noted in the safety data sheet.
Medchemexpress LLC 1H-Benzimidazole, 2-(2-pyridinyl)- | 1137-68-4 | 99.9% | 195.22 | 10 G
2-(2′-Pyridyl)benzimidazole is a potentially tridentate ligand capable of forming stable complexes with various transition metal ions. It functions as an anti-inflammatory agent and effectively inhibits Escherichia coli methionine aminopeptidase, making it suitable for biochemical research. This compound appears as a solid, ranging from pale purple to purple or colorless to light pink and is intended for research use only.
- Functions as an anti-inflammatory agent
- Inhibits Escherichia coli methionine aminopeptidase
- IC50 of 13.3 μM in inhibiting human MetAP2 expressed in Sf9 cells
- Molecular formula: C12H9N3
- Molecular weight: 195.22
- Purity: 99.88%
- Ships at room temperature
- Stable for up to 3 years at room temperature
- Consistent with 1H NMR spectrum and LCMS
Biotium Antibody Labeling Kits Antibody and Protein Labeling Kits Mix n Stain Antibody Labeling Kits CF680 1/EA
Mix-n-Stain CF Dye Nanobody Thiol Labeling Kits are optimized for labeling nanobodies with bright and photostable CF dyes in 2 hours with no purification Kits tolerate common stabilizers Far-red/near-IR CF680 dye has Ex/Em at 681/698 nm One labeling of 5-20 ug Nanobody Thiol per kit
Medchemexpress LLC DOTA-thiol | 865470-67-3 | MFCD11501203 | 98.9% | 463.55 g/mol | C18H33N5O7S | 5 MG
DOTA-thiol is a bifunctional chelator and macrocyclic DOTA derivative used for tumor pre-targeting and radiolabeling research. It provides a thiol functional group for covalent conjugation to peptides, biomolecules, and radionuclides, enabling targeted delivery and imaging studies.
- Bifunctional macrocyclic chelator suitable for radiolabeling.
- Thiol functional group enables covalent conjugation to peptides and biomolecules.
- High purity (98.9%) appropriate for research use.
- Molecular weight 463.55 g/mol and formula C18H33N5O7S.
- Available in research-scale quantities such as 5 MG.
Biotium Antibody Labeling Kits Antibody and Protein Labeling Kits Mix n Stain Antibody Labeling Kits CF647 1/EA
Mix-n-Stain CF Dye Nanobody Thiol Labeling Kits are optimized for labeling nanobodies with bright and photostable CF dyes in 2 hours with no purification Kits tolerate common stabilizers Far-red fluorescent CF647 has Ex/Em at 650/665 nm One labeling of 5-20 ug Nanobody Thiol per kit
Medchemexpress LLC Thiol-PEG-CH2COOH | 95.0% | HS-(CH2-CH2-O)n-CH2COOH | 25 MG
Thiol-PEG-CH2COOH (MW 5000) is a PEG-based PROTAC linker primarily used in the synthesis of PROTACs. PROTACs utilize two different ligands connected by a linker, one for an E3 ubiquitin ligase and the other for the target protein, to exploit the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits intracellular ubiquitin-proteasome system
- Target proteins selectively degraded
- Average molecular weight of 5000
- Purity of 95.0% by NMR
- Appearance is white to off-white solid
Medchemexpress LLC m-PEG-thiol (MW 20000) | 95.0% | 50 MG
m-PEG-thiol (MW 20000) is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. PROTACs operate by connecting two different ligands, one for an E3 ubiquitin ligase and another for a target protein, to exploit the intracellular ubiquitin-proteasome system for selective degradation of target proteins. This product is for research use only and has not been validated for medical applications.
- PEG-based PROTAC linker
- Designed for PROTAC synthesis
- Facilitates selective degradation of target proteins
- Average molecular weight of 20000
- Appears as a white to off-white solid
- Purity of 95.0%