Benzimidazoles
Cayman Chemical Albendazole sulfon 10mg
A GPR52 antagonist (IC50 0 63 UM) reduces mHTT protein levels in STHdhQ7/Q111 cells in a concentration-dependent manner reduces apoptosis induced by growth factor deprivation in primary striatal neurons isolated from HdhQ7/Q140 mice decreases striatal levels of soluble and insoluble mHTT as well as increases the latency to fall in the rotarod test in the HdhQ140 mouse model of Huntingtons disease at 5 mg/kg
Cayman Chemical Omeprazole sulfIde 1g
A colorimetric substrate whose amino acids YVAD have been shown to be a preferred cleavage site for caspase-1 and -4
Sigma Aldrich Fine Chemicals Biosciences Pantoprazole sodium hydrate >=98% (HPLC) | 718635-09-7 | 50MG
Pantoprazole sodium hydrate >=98% (HPLC) | Purity: >=98% (HPLC) | 718635-09-7 | 50MG
Albendazole Oxide 54029-12-8 50mg
Albendazole Oxide (CAS 54029-12-8) is a small-molecule inhibitor targeting beta-tubulin It is designed to inhibit beta-tubulin polymerization in parasites thereby disrupting cytoplasmic microtubule structure and interfering with glucose metabolic pathways Albendazole Oxide exerts its biological activity primarily through inhibition of beta-tubulin polymerization In both in vitro and in vivo studies Albendazole Oxide demonstrates anti-parasitic activity with reported IC50 values typically ranging from nanomolar to micromolar concentrations depending on the parasite species and assay system Based on these pharmacological properties Albendazole Oxide holds research potential in the exploration of anti-parasitic pharmacodynamics notably for studies involving Echinococcus spp and other parasitic infections
Cayman Chemical Omeprazole sulfIde-d3 1mg
A pre-mRNA splicing modulator corrects aberrant splicing in a SPREADD using HeLa cells expressing IKBKAP with an IVS20 6TC point mutation restores the modification of cytoplasmic tRNAs with uridine in the wobble position in primary human fibroblasts from patients with FD to the same level as in primary human fibroblasts from carriers of the FD mutation at 2 UM increases the levels of correctly spliced PARK7 mRNA in neural precursor cells differentiated from fibroblasts of patients with the homozygous PARK7 c.192GC exonic splicing mutation in combination with phenylbutyric acid intratumoral administration decreases tumor volume and increases survival and the number of tumor-infiltrating CD8 T cells in an MC-38 murine colon carcinoma model
Fenbendazole 43210-67-9 10mM (in 1mL DMSO)
Fenbendazole (CAS 43210-67-9) is a small-molecule inhibitor targeting microtubule polymerization It is designed to bind tubulin and disrupt microtubule dynamics thereby impairing cytoskeletal integrity and protein homeostasis Fenbendazole exerts its biological activity primarily through microtubule destabilization and disruption of proteasomal function triggering the unfolded protein response (UPR) pathway In various cancer cell lines fenbendazole demonstrates cytotoxic and anti-proliferative activity with reported IC50 values generally ranging from approximately 0 5 to 5 M Based on these pharmacological properties fenbendazole holds research potential in antiparasitic therapy and cancer drug repurposing studies
Selleck Chemical LLC Omeprazole Sodium
Omeprazole Sodium is the sodium salt form of omeprazole which is a proton pump inhibitor and suppresses gastric acid secretion Omeprazole Sodium is a metabolism-dependent inhibitor (MDI) of CYP2C19
eMolecules Medchem Express / Omeprazole sulfide-d3 / 1mg / 713706661 / HY-141776S / / 922730-98-1 / [null] / 332.440 / C17H19N3O2S
Medchem Express / Omeprazole sulfide-d3 / 1mg / 713706661 / HY-141776S / / 922730-98-1 / [null] / 332.440 / C17H19N3O2S
Cayman Chemical Omeprazole sulfon-d3 500ug
An antiviral guanosine analog has activity against multiple laboratory and clinical isolate strains of HSV-1 HSV-2 and VZV in a plaque reduction assay (IC50s 0.4-3.1 g/ml) inhibits HSV-1 and HSV-2 replication (IC99s 0.4 and 0.7 g/ml respectively) and DNA synthesis (IC50 0.04 g/ml) in MRC-5 cells reduces the severity of skin lesions caused by HSV-1 in guinea pigs and mice prevents development of HSV-2-induced genital lesions in guinea pigs infected intravaginally
Sigma Aldrich Fine Chemicals Biosciences Omeprazole solid500MG
Omeprazole is a benzimidazole derivative a weak base and is lipophilic in nature. This compound is pH sensitive and does not exists in its original form at low pH.
Albendazole 54965-21-8 100mg
Albendazole (CAS 54965-21-8) is a small-molecule inhibitor targeting tubulin It is designed to disrupt microtubule assembly thereby impairing cellular cytoskeletal function and parasite viability Albendazole exerts its biological activity primarily through binding to tubulin and inhibiting microtubule polymerization In tumor cell-based assays Albendazole demonstrates antiproliferative activity and induces cell cycle arrest autophagy and apoptosis with reported IC50 values typically ranging from 0 1 to 1 M depending on cell line and experimental conditions Based on these pharmacological properties Albendazole holds research potential in studies of parasitic infections microtubule dynamics tumor cell proliferation angiogenesis and programmed cell death
Selleck Chemical LLC Albendazole Oxide S1836-50mg
Albendazole Oxide (Ricobendazole Albendazole sulfoxide) is a tubulin polymerization or assembly inhibitor used for the treatment of a variety of parasitic worm infestations
Selleck Chemical LLC Albendazole S1640-1g
Albendazole is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations
Cayman Chemical 4-hydroxy Omeprazole sulfide
An alkaloid and a toxin reduces sciatic nerve stimulation-induced CMAPS in isolated lizard extensor digitorum longus muscle (IC50 156 UM) induces neuromuscular impairment in mice at 85 mg/kg induces lethality in mice (LD50 113 mg/kg)