Benzodiazepines
Medchemexpress LLC Coelenterazine | 55779-48-1 | 98.59% | 423.46 | 50 MG
Coelenterazine is a luminescent enzyme substrate for apoaequorin and Renilla luciferase. It has been utilized as the bioluminescence donor in bioluminescence resonance energy transfer (BRET) for detecting protein-protein interactions. Additionally, it serves as a superoxide anion-sensitive chemiluminescent probe for the chemiluminescent detection of peroxynitrite (Ex/Em = 429/466 nm).
- Luminescent enzyme substrate for apoaequorin and Renilla luciferase
- Used as a bioluminescence donor in BRET to detect protein-protein interactions
- Superoxide anion-sensitive chemiluminescent probe
- Can be used in chemiluminescent detection of peroxynitrite (Ex/Em = 429/466 nm)
Medchemexpress LLC Clozapine N-oxide (dihydrochloride) | 2250025-93-3 | 99.7% | 415.74 | 100 MG
Clozapine N-oxide dihydrochloride is a major metabolite of Clozapine and acts as an agonist for human muscarinic designer receptors (DREADDs). It activates the DREADD receptors hM3Dq and hM4Di. This compound cannot cross the blood-brain barrier. Clozapine, its parent compound, is a potent dopamine antagonist and a selective muscarinic M4 receptor agonist with an EC50 of 11 nM.
- Major metabolite of Clozapine
- Activates human muscarinic designer receptors (DREADDs) hM3Dq and hM4Di
- Cannot cross the blood-brain barrier
- Clozapine is a potent dopamine antagonist and selective muscarinic M4 receptor agonist
- Appearance: Solid
- Color: Light yellow to yellow
Medchemexpress LLC Clozapine N-oxide | 34233-69-7 | MFCD00210190 | >99.8% | 342.82 | 25 MG
Clozapine N-oxide is a major metabolite of Clozapine and acts as an agonist for human muscarinic designer receptors (DREADDs). It activates the DREADD receptors hM3Dq and hM4Di. Notably, Clozapine N-oxide does not cross the blood-brain barrier. Clozapine, its parent compound, is a potent dopamine antagonist and a potent and selective muscarinic M4 receptor agonist (EC50=11 nM).
- Activates the DREADD receptors hM3Dq and hM4Di.
- Does not cross the blood-brain barrier.
- Major metabolite of clozapine.
- Parent compound clozapine is a potent dopamine antagonist.
- Parent compound clozapine is a selective muscarinic M4 receptor agonist.
Alkali Scientific Coelenterazine, Native, 10 Milligrams
Coelenterazine Native is a bioluminescent substrate used in biochemical assays to measure luciferase activity. This 10mg reagent triggers the emission of light in the presence of luciferase enzymes, enabling precise and sensitive detection of enzymatic activity. Coelenterazine Native is commonly used in gene expression assays, cellular signaling studies, and immunological tests. It is especially valuable for in vivo and in vitro imaging where real-time monitoring of biological processes is required. Researchers use this substrate to study enzyme kinetics, protein-protein interactions, and other cellular functions that require high sensitivity and low background noise. The reagent is essential for a wide range of assays in molecular and cell biology.