Benzoxadiazoles

Medchemexpress LLC NBD-14270 | 2411819-82-2 | 99.53% | 425.43 | 1 ML

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NBD-14270, a pyridine analogue, is a potent HIV-1 entry antagonist with an IC50 of 180 nM against 50 HIV-1 Env-pseudotyped viruses. It binds to HIV-1 gp120 and demonstrates potent antiviral activity, with low cytotoxicity (CC50>100 μM).

• Potent HIV-1 entry antagonist
• IC50 of 180 nM against 50 HIV-1 Env-pseudotyped viruses
• Binds to HIV-1 gp120
• Demonstrates potent antiviral activity
• Low cytotoxicity (CC50>100 μM)

Medchemexpress LLC Nbd-14270 | 2411819-82-2 | 99.5% | 425.43 | 100 MG

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NBD-14270, a pyridine analogue, is a potent HIV-1 entry antagonist. It binds to HIV-1 gp120 and shows potent antiviral activity.

• Potent HIV-1 entry antagonist with an IC50 of 180 nM against 50 HIV-1 Env-pseudotyped viruses.
• Binds to HIV-1 gp120.
• Low cytotoxicity (CC50>100 μM).
• Anti-HIV-1 activity (IC50=0.16 μM) and Cytotoxicity (CC50=109.3 μM) in single-cycle (TZM-bl Cells) assay.
• Does not induce toxicity in the U87-CD4-CXCR4 cell line at doses used for assay.

Medchemexpress LLC Nbd-14270 | 2411819-82-2 | 99.5% | 425.43 | 50 MG

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NBD-14270, a pyridine analogue, is a potent HIV-1 entry antagonist. It binds to HIV-1 gp120 and demonstrates significant antiviral activity. This compound exhibits low cytotoxicity with a CC50 >100 μM, making it suitable for various research applications.

• Potent HIV-1 entry antagonist with IC50 of 180 nM against 50 HIV-1 Env-pseudotyped viruses
• Binds to HIV-1 gp120
• Exhibits potent antiviral activity
• Low cytotoxicity (CC50 > 100 μM)
• Anti-HIV-1 activity (IC50=0.16 μM) in single-cycle (TZM-bl cells) assay
• No induced toxicity in U87-CD4-CXCR4 cell line at assay doses

Medchemexpress LLC NBD-amine | 10199-91-4 | 96.7% | 50 MG

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NBD-amine is a fluorogenic amine used as a fluorescent probe and reagent. It fluoresces weakly in water and strongly in organic solvents, membranes, and other hydrophobic environments, and is supplied as a powder with demonstrated solubility in DMSO.

• Fluorogenic amine that increases fluorescence in hydrophobic environments.
• CAS number 10199-91-4; molecular weight 180.12 g·mol⁻¹; formula C6H4N4O3.
• Purity 96.7% as supplied.
• Soluble in DMSO (≈31.25 mg/mL); hygroscopic DMSO affects solubility.
• Storage: powder -20°C (stable up to 3 years) or 4°C (2 years); in solvent -80°C (6 months) or -20°C (1 month).
• Available in multiple package sizes including 50 MG.

Medchemexpress LLC 7-Fluorobenzofurazan-4-sulfonic acid ammonium | 84806-27-9 | 98.96% | 50 MG

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7-Fluorobenzofurazan-4-sulfonic acid ammonium is a fluorescent label that can be utilized for detecting dissolved thiol-disulfide, such as Cys and GSH. It is intended for research use only and not for patient use.

• Fluorescent label: can be used for detecting dissolved thiol-disulfide (e.g., Cys, GSH).
• Purity: 98.96%.
• Appearance: solid.
• Color: light yellow to yellow.
• Emission (Em): 495.
• Excitation (Ex): 478.
• Solubility: soluble in DMSO (250 mg/mL) and H2O (≥ 50 mg/mL).
• Storage: 4°C, sealed storage, away from moisture and light. In solvent: -80°C for 6 months; -20°C for 1 month (sealed storage, away from moisture and light).