Benzoxazines
TARGETMOL CHEMICALS INC DECURSIN 10MG
Also available in 1 mg 5 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. 1. Decursin (Decursinol angelate) is able to attenuate kainic acid-induced seizures and could have potential as an antiepileptic drug. 2. Decursin exhibits hepatoprotective effects potentially by inhibiting the TGF-(beta)1 induced NOX activation and Smad signaling. 3. Decursin has anti-cancer activity mediated suppression of the PKC(alpha) MAPK and NF-(kappa)B pathways in MCF-7 cells. 4. Decursin exhibits cytotoxicity against various human cancer cells and to possess anti-amnesic activity in vivo through the inhibition of AChE activity. purity: 97%
TARGETMOL CHEMICALS INC NESBUVIR 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Nesbuvir is a selective hepatitis C virus (HCV) nonstructural protein 5B (NS5B) RNA-dependent polymerase inhibitor.Nesbuvir has an IC50 of 9 nM against hepatocellular carcinoma cells containing 1b HCV replicons. purity: 98%
![Amsbio LLC Fibronectin (FN1) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI1G2]](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502563528.png-250.jpg)
Amsbio LLC Fibronectin (FN1) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI1G2]
Fibronectin (FN1) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI1G2]
TARGETMOL CHEMICALS INC FA16 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. FA16 is a selective metabolically stable ferroptosis inducer with an IC50 value of 1.26 uM.FA16 is a derivative of 2-(trifluoromethyl)benzimidazole.FA16 inhibits the cystine/glutamate inverse transporter protein (system Xc-)-mediated exchange of intracellular glutamate for extracellular cystine.FA16 significantly inhibited tumor growth in a HepG2 xenograft tumor model. HepG2 xenograft tumor model significantly inhibited tumor growth.
Medchemexpress LLC Zilovertamab vedotin | 98.6% | 1 MG
Zilovertamab vedotin is an antibody-drug conjugate for preclinical cancer research that combines a humanized anti-ROR1 monoclonal antibody with the cytotoxic payload monomethyl vedotin. It is supplied as a lyophilized powder for experimental use.
- targets receptor tyrosine kinase-like orphan receptor 1 (ROR1)
- contains monomethyl vedotin cytotoxic payload
- suitable for in vitro and in vivo research
- high reported purity (98.61%)
- documentation available: certificate of analysis and safety data sheet
Cell Signaling Technology Phospho-Syk Tyr525/526 C87C
Phospho-Syk (Tyr525/526) (C87C1) Rabbit mAb (APC Conjugate) 100 ul
AdipoGen 5-CFDA
Chemical. CAS 79955-27-4. Formula C25H16O9. MW 460.39. Synthetic. Carboxyfluorescein diacetate CFDA, which was originally used to measure intracellular pH but was soon adapted for use as a cell viability indicator. Upon hydrolysis by intracellular nonspecific esterases, CFDA forms carboxyfluorescein. As compared with fluorescein, carboxyfluorescein contains extra negative charges and is therefore better retained in cells CFDA is moderately permeant to most cell membranes, with uptake greater at pH 6.2 than at pH 7.41. CFDA has been used as a viability probe with a variety of cells, including bacteria, fungi e.g. Saccharomyces cerevisiae, spermatozoa, natural killer NK cells and tumor cells.
AdipoGen 7-Azido-4-methylcoumarin
Chemical. CAS 95633-27-5. Formula C10H7N3O2. MW 201.18. Synthetic 7-Azido-4-methylcoumarin is a highly sensitive and selective fluorogenic H2S probe. The aromatic azide moiety of AzMC is selectively reduced in the presence of H2S, producing the fluorescent 7-amino-4-methylcoumarin AMC with a concomitant increase in fluorescence with lambdaex = 365 nm and lambdaem = 450 nm. It is a photoaffinity labeling probe for the substrate binding site of human sulfotransferase 1A1 SULT1A1. 7-Azido-4-methylcoumarin is a tool for monitoring the activity of pyridoxal-5-phosphate PLP-dependent enzymes e.g. cystathionine beta-synthase CBS, cystathionine gamma-lyase CGL and tryptophan synthase TS and to identify novel cystathionine beta-synthase CBS inhibitors and activators.
TARGETMOL CHEMICALS INC GEFITINIB-BASED PROTAC 3 10MG
Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. Gefitinib-based PROTAC 3 conjugating an EGFR binding element to a VHL ligand via a linker induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells respectively[1]. purity: 98%
TARGETMOL CHEMICALS INC NAPABUCASIN 50MG
Also available in 5 mg 10 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Napabucasin (BBI608) is an orally available Stat3 and Y cell stemness inhibitor. purity: 99%
Cell Signaling Technology AQP4 (D1F8E) XP(R) Rabbit mAb (Alexa Fluor(R) 647 Conjugate) 100 ul
AQP4 (D1F8E) XP(R) Rabbit mAb (Alexa Fluor(R) 647 Conjugate) 100 ul
Cell Signaling Technology IL2-R-alpha/CD25 PC61.5 Rat
IL2-R-alpha/CD25 (PC61.5) Rat mAb (PerCP-Cy5.5(R) Conjugate) 100 ug
Cell Signaling Technology PIP4K2C (E7P3S) Rabbit mAb (Alexa Fluor(R) 488 Conjugate) 100 ul
PIP4K2C (E7P3S) Rabbit mAb (Alexa Fluor(R) 488 Conjugate) 100 ul
TARGETMOL CHEMICALS INC PALATRIGINE 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. Palatrigine (BW-A 256C) is a compound with angiotensin-converting enzyme inhibitory and beta-adrenergic receptor blocking properties. purity: 98%