Biotin and derivatives
Medchemexpress LLC DBCO-N-bis(PEG4-NHS ester) | 2639395-38-1 | 96.2% | 995.03 g/mol | C49H62N4O18 | 10 MG
DBCO-N-bis(PEG4-NHS ester) is a PEG-based bifunctional linker that contains a dibenzocyclooctyne (DBCO) group and two PEG4-NHS ester reactive ends. It is designed for click chemistry applications, enabling strain-promoted alkyne-azide cycloaddition (SPAAC) for protein modification, labeling, and use as a linker in conjugate syntheses.
- Contains two PEG4-NHS ester groups and one DBCO group.
- Enables strain-promoted alkyne-azide cycloaddition (SPAAC) reactions.
- Suitable for protein modification and labeling applications.
- Molecular weight 995.03 g/mol; formula C49H62N4O18.
- Purity approximately 96.2%.
- Available in small quantities (for example, 10 mg) for laboratory use.
- Storage: pure form -20 °C (long-term); in solvent -80 °C (recommended for extended storage).
Medchemexpress LLC AF647-NHS ester triTEA | 407627-61-6 | 99.7% | 1259.66 | 50 MG
AF647-NHS ester is an analogue of Alexa Fluor 647 (AF647). It features an excitation wavelength (λex) of 635 nm for conventional fluorescence detection and 620 nm for instantaneous detection. This compound's NHS ester group enables covalent binding to molecules containing amino groups, such as proteins and antibodies.
- Fluorescent properties suitable for various detection methods.
- Reactive NHS ester group for covalent attachment to amino groups.
- Enables labeling of proteins, antibodies, and other biomolecules.
- Excitation at 635 nm (conventional) and 620 nm (instantaneous).
- Available in multiple quantities for research needs.
Medchemexpress LLC NHS-modified monomethyl auristatin F (TFA salt) | 1404073-10-4 | 96.0% | 1051.32 g/mol | C55H86N8O12 | 10 MG
NHS-Modified MMAF TFA is an NHS-activated derivative of monomethyl auristatin F provided as the trifluoroacetic acid (TFA) salt and used as a drug-linker intermediate for preparing antibody-drug conjugates (ADCs).
- NHS-activated ester for efficient conjugation to primary amines
- Provided as the TFA salt for isolation and handling
- Intended as a drug-linker intermediate for ADC synthesis
- Molecular formula C55H86N8O12; molecular weight 1051.32 g/mol
- Commonly supplied in a 10 mg pack size
Apexbio Technology LLC Sulfo-NHS-Biotin Kit (90-180 kDa) 3samples
Sulfo-NHS-Biotin labeling is widely utilized in biochemical research to covalently conjugate biotin molecules to free amino groups on protein molecules primarily lysine residues and N-terminal amines The reaction proceeds via activated ester intermediates forming stable amide bonds that facilitate subsequent detection or purification using streptavidin-biotin affinity interactions This labeling method is routinely applied to diverse protein samples particularly immunoglobulin G and other antibodies (molecular weight 90-180 kDa) enabling downstream applications such as immunoassays Western blotting immunoprecipitation and flow cytometry analyses Commonly the labeled proteins are purified rapidly by spin-based filtration to eliminate unreacted small molecules improving purity and yield
Medchemexpress LLC Sulfo-NHS-Acetate | 152305-87-8 | 98.0% | C6H7NO7S | 50 MG
Sulfo-NHS-Acetate is an alkyl chain-based PROTAC linker. It is utilized in the synthesis of PROTACs, which are molecules designed to degrade target proteins by exploiting the intracellular ubiquitin-proteasome system. PROTACs consist of two ligands connected by a linker: one binds to an E3 ubiquitin ligase, and the other to the target protein.
- Alkyl chain-based PROTAC linker
- Used in the synthesis of PROTACs
- PROTACs exploit the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Apexbio Technology LLC Biotin-16-dCTP 200ul (5 mM)
Biotin-16-dCTP is a biotinylated derivative of deoxycytidine triphosphate (dCTP) designed for enzymatic incorporation into nucleic acids during polymerase-mediated processes Structurally it consists of a dCTP core conjugated via a 16-atom spacer arm to a biotin moiety facilitating effective interaction with streptavidin This specific biotin-streptavidin binding affinity enables applications in nucleic acid labeling detection and affinity purification protocols PCR experiments indicate that biotin-16-dCTP incorporation by Taq polymerase can reach approximately 90% substitution without considerable reduction in amplification yield demonstrating greater polymerase compatibility compared to biotin-16-dUTP analogues
Medchemexpress LLC m-PEG11-acid | 2280998-74-3 | 98.0% | 544.63 | C24H48O13 | 100 MG
m-PEG11-acid is a monomethyl-capped polyethylene glycol (PEG) linker containing 11 ethylene glycol units. It is supplied as a non-cleavable, hydrophilic spacer for use in antibody-drug conjugate (ADC) synthesis and proteolysis-targeting chimera (PROTAC) linker construction.
- Monomethyl-capped polyethylene glycol linker with 11 ethylene glycol units.
- Non-cleavable design suitable for stable conjugation.
- Provides a hydrophilic spacer to improve solubility and reduce steric hindrance.
- Commonly used in ADC and PROTAC linker synthesis.
- Molecular weight approximately 544.63 g/mol.
- High purity, specified at 98.0%.
- Available in small-scale packaging suitable for research (100 MG).
Medchemexpress LLC M-PEG-NHS ester | 92451-01-9 | 98.0% | (C2H4O)nC7H9NO5 | 50 MG
M-PEG-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Peg-based protac linker
- Used in the synthesis of protacs
- Protacs contain two different ligands connected by a linker
- Features a ligand for an E3 ubiquitin ligase and another for the target protein
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC 1,2-distearoyl-sn-glycero-3-phosphoethanolamine N-hydroxysuccinimide ester | 1383932-86-2 | MFCD29267127 | 95.0% | 945.21 g/mol | C49H89N2O13P | 25 MG
DSPE-NHS is an NHS-activated phospholipid (1,2-distearoyl-sn-glycero-3-phosphoethanolamine N-hydroxysuccinimide ester) used to introduce a reactive NHS ester at liposome or nanoparticle surfaces for covalent conjugation to primary amines on proteins, peptides, and other amine-containing molecules. It self-assembles into lipid bilayers and is commonly used for antibody labeling, liposome functionalization, and nanoparticle surface modification in research applications.
- Reactive NHS ester for efficient amine coupling.
- Self-assembles into lipid bilayers for membrane incorporation.
- Enables stable amide bond formation with proteins and peptides.
- Suitable for liposome and nanoparticle surface modification.
- Available in multiple laboratory-scale package sizes for research use.
Medchemexpress LLC Nhs-PEG2-SS-PEG2-NHS | 580.63 | C22H32N2O12S2 | 50 MG
NHS-PEG2-SS-PEG2-NHS is a cleavable, homobifunctional polyethylene glycol (PEG) linker containing a central disulfide bond and two N-hydroxysuccinimide (NHS) activated esters. It is intended for bioconjugation and use as an antibody-drug conjugate (ADC) linker in research settings.
- Molecular formula: C22H32N2O12S2.
- Molecular weight: 580.63.
- Contains a reducible disulfide (cleavable) linker between PEG2 units.
- Homobifunctional with two NHS activated esters for amine coupling.
- Supplied in small laboratory quantity suitable for research use.
- Storage: store sealed at -20°C, protect from moisture; in solution, recommended storage at -80°C up to 6 months or -20°C up to 1 month.
Apexbio Technology LLC NHS-SS-11-Biotin(Synonyms: Sulfo-NHS-SS-Biotin, EZ-Link NHS-SS-Biotin, NHS-SS-D-Biotin, N-Hydroxysuccinimidyl-SS-Biotin), 5mg, CAS: 142439-92-7.
NHS-SS-11-Biotin (CAS 142439-92-7) is an amine-reactive biotinylation reagent commonly used in biochemical research Structurally it possesses an N-hydroxysuccinimide (NHS) ester group that covalently reacts with primary amines of target proteins or biomolecules forming stable amide bonds and releasing sulfo-NHS This reagent features a cleavable disulfide linker and an extended spacer arm of approximately 24 3 enhancing probe accessibility to avidin or streptavidin conjugates It is utilized extensively for reversible biotinylation affinity purification or labeling studies in proteomics and cell biology applications
Medchemexpress LLC Bis-PEG25-NHS ester | 2221948-96-3 | MFCD21363290 | 99.8% | 1413.55 | C62H112N2O33 | 25 MG
Bis-PEG25-NHS ester is a PEG/alkyl/ether-based homobifunctional linker containing two N-hydroxysuccinimide (NHS) ester groups, used for conjugation in the synthesis of PROTACs and as a cleavable linker for antibody-drug conjugates (ADCs). It is provided as a hydrophilic solid for use in organic solvents and should be stored sealed at -20°C.
- Contains two amine-reactive NHS ester groups for conjugation.
- PEG spacer increases hydrophilicity and solubility in aqueous media.
- Suitable as a cleavable linker for ADC and PROTAC synthesis.
- Provided as a solid with recommended cold, sealed storage to preserve stability.
Cell Signaling Technology Goat Anti-Mouse IgG1 Antibody
Goat Anti-Mouse IgG1 Antibody (Biotin Conjugate) 1 mg
Medchemexpress LLC N3-peg3-c2-nhs ester | 1245718-89-1 | MFCD23726613 | 99.9% | 344.32 g/mol | C13H20N4O7 | 10 G
Azide-terminated PEG3 NHS ester linker for bioconjugation and click-chemistry labeling. The reagent contains an azide group for copper-catalyzed azide-alkyne cycloaddition (CuAAC) and is compatible with strain-promoted alkyne-azide cycloaddition (SPAAC). It is supplied as a high-purity NHS ester for amine conjugation and includes a three-unit PEG spacer to improve solubility and reduce steric hindrance.
- Azide functional group for click chemistry reactions.
- NHS ester for efficient conjugation to primary amines.
- Three-unit PEG spacer to enhance solubility.
- Noncleavable linker for stable conjugation.
- High purity suitable for research applications.
- Available in laboratory-scale 10 g packaging.