Biotin and derivatives
Medchemexpress LLC Aeide-C1-NHS ester | 824426-32-6 | 98.0% | C6H6N4O4 | 100 MG
Aeide-C1-NHS ester is an alkyl/ether-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an Azide group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. It is also capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Alkyl/ether-based PROTAC linker.
- Used in the synthesis of PROTACs.
- Click chemistry reagent.
- Contains an Azide group for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne groups.
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups.
- PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Medchemexpress LLC ATRA-biotin | 2226143-93-5 | >98.43% | C36H55N3O4S | 50 MG
ATRA-biotin, also known as Biotin-ATRA-conjugate, is a biotin-conjugated derivative of All-Trans Retinoic Acid (ATRA). This compound serves as a valuable tool for tracking ATRA within cellular environments or specific tissues, enabling researchers to investigate its distribution and interactions.
- Biotin-conjugated derivative of All-Trans Retinoic Acid (ATRA)
- Used to track ATRA in cells or a given tissue
- Targets RAR/RXR, PPAR, Endogenous Metabolite, and Autophagy pathways
- Soluble in DMSO at 100 mg/mL
- Demonstrates biocompatibility in cell viability assays
Medchemexpress LLC Bis-PEG21-NHS ester | 2221948-98-5 | 98.0% | 1237.34 g/mol | C54H96N2O29 | 25 MG
Bis-PEG21-NHS ester is a PEG/alkyl/ether-based linker used in the synthesis of PROTACs and as a cleavable linker for antibody-drug conjugates (ADCs). It is supplied as a solid with high purity and defined storage recommendations.
- PEG/alkyl/ether-based linker
- Cleavable linker suitable for ADC synthesis
- Used in the construction of PROTAC molecules
- High purity (98.0%)
- Molecular weight 1237.34 g/mol
- CAS number 2221948-98-5
- Powder storage: -20°C for long-term stability
Medchemexpress LLC TCO-PEG12-NHS ester | 2185016-39-9 | MFCD00012569 | 95.0% | 866.99 | C40H70N2O18 | 10 MG
TCO-PEG12-NHS ester is a PEG-based linker reagent consisting of a trans-cyclooctene (TCO) group connected through a 12-unit polyethylene glycol (PEG12) spacer to an N-hydroxysuccinimide (NHS) ester. It enables efficient amine coupling and rapid tetrazine click chemistry, and is used as a cleavable linker in ADC and PROTAC synthesis for bioconjugation applications.
- Provides a TCO functional group for rapid click reactions.
- PEG12 spacer improves solubility and reduces steric hindrance.
- NHS ester enables efficient coupling to primary amines.
- Suitable for ADC and PROTAC linker construction and general bioconjugation.
- Supplied in small research-scale quantities for conjugation workflows.
Medchemexpress LLC Biotin-TEG-ATFBA | 1264662-85-2 | MFCD13184978 | 99.1% | 663.68 | C27H37F4N7O6S | 10 MG
Biotin-TEG-ATFBA is a biotin-labeled click chemistry reagent containing a perfluorophenylazide group. Upon photolysis it forms a stable azene intermediate that participates in insertion and cycloaddition reactions, enabling bioconjugation and linker construction for research applications. The compound is supplied as a solid with high purity and is intended for laboratory use.
eMolecules 1353016-71-3 | Medchem Express | DBCO-NHS ester | 10mg | 515744338 | HY-42973 | MFCD24386367 | 402.406 | C23H18N2O5
Ambeed | tert-Butyl 10-bromodecanoate | 100mg | 603089553 | A944295 | 1644575-06-3 | 307.272 | C14H27BrO2
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Medchemexpress LLC PC azido-PEG3-NHS carbonate ester | 1802907-96-5 | MFCD29052189 | 98.7% | 640.60 | C26H36N6O13 | 10 MG
PC Azido-PEG3-NHS carbonate ester is a photocleavable linker used to attach an azido-terminated PEG3 spacer to primary amines on proteins, amine-modified oligonucleotides, and other amine-containing molecules via an NHS carbonate ester, enabling bioorthogonal click chemistry and light-triggered release.
- Photocleavable linker for light-triggered release
- Labels primary amines on proteins and oligonucleotides
- Installs azido-terminated PEG3 spacer via NHS carbonate chemistry
- Enables copper-catalyzed azide-alkyne click reactions
- High purity suitable for bioconjugation (≈98.7%)
- Soluble in DMSO at ≥116.67 mg/mL
- Store at -20 °C in pure form for long-term stability
Medchemexpress LLC Biotin-X-NTA | 856661-92-2 | 98.1% | 715.98 | 5 MG
Biotin-X-NTA is a reagent used for detecting histidine-tagged proteins immobilized on nitrocellulose membranes.
- Fluorescent dye
- Labeling chemistry reagent
- Functional group type biotin dye
- Detects histidine-tagged proteins
- Suitable for nitrocellulose membranes
Sigma Aldrich Fine Chemicals Biosciences Biotin 3-sulfo-N-hydroxysu10MG
Biotinavidin second antibody signal systems involve the conjugation of biotin to a secondary antibody. Once the secondary antibody binds to a target primary antibody in an immunochemical assay the signal is developed by allowing avidin which has been conjugated to an enzyme or signal molecule to bind to the antibody associated biotin molecule.
Medchemexpress LLC EphA2 Human Biotin 20ug
The EphA2 protein is an important member of the ephrin receptor subfamily that mediates developmental events particularly in the nervous system It has a single kinase domain and an extracellular region that binds ephrin-A ligands EphA2 Protein Human (Biotinylated HEK293 His-Avi) is the recombinant human-derived EphA2 protein expressed by HEK293 with C-6 His C-Avi labeled tag
Medchemexpress LLC Azido-PEG6-NHS ester | 2055014-64-5 | 98.0% | 1 G
Azido-PEG6-NHS ester is a cleavable 6 unit PEG ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs). It also functions as a PEG- and Alkyl/ether based PROTAC linker for synthesizing PROTACs. This compound is a click chemistry reagent, featuring an Azide group, which allows it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing Alkyne groups. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Cleavable linker
- PEG linker type
- Alkyl/ether linker type
- Click chemistry reagent
- Contains an azide group
- Participates in copper-catalyzed azide-alkyne cycloaddition reactions
- Undergoes strain-promoted alkyne-azide cycloaddition reactions
- Used in ADC synthesis
- Used in PROTAC synthesis
Medchemexpress LLC Biotin hydrazide | 66640-86-6 | MFCD00078532 | 258.34 g/mol | C10H18N4O2S | 1 ML
Biotin hydrazide is a carbonyl-reactive biotinylation reagent used to label oxidized glycans, glycoproteins, and other carbonyl-containing biomolecules. It is supplied as a solid or as a 10 mM solution in DMSO for use in conjugation, detection, and enrichment workflows.
- Reacts with carbonyl groups to form stable hydrazone linkages.
- Supplied as solid or as a 10 mM solution in DMSO for convenience.
- Enables biotin-based detection and affinity purification workflows.
- Soluble in DMSO and moderately soluble in water, with solubility data provided.
- Stable when stored under recommended temperatures for long-term use.
Medchemexpress LLC NHS-MMAF | 1404073-19-3 | 97.2% | C49H78N6O12 | 10MG
NHS-MMAF is an N-hydroxysuccinimide-activated derivative of monomethyl auristatin F used as a payload intermediate for antibody-drug conjugate (ADC) synthesis. It acts as a tubulin polymerization inhibitor and is intended for research use in ADC linker and conjugation development; it is described in patent WO2012143499 (intermediate 219).
- NHS-activated ester for amine conjugation.
- Suitable for antibody-drug conjugate linker chemistry.
- High reported purity (97.2%).
- Solid, white to off-white appearance for easy handling.
- Soluble in DMSO for reaction setup.
- Serves as a payload precursor for cytotoxic conjugates.
Medchemexpress LLC Biotin-PEG-amine (MW 2000) | 90.0% | 25 MG
Biotin-PEG-amine (MW 2000) is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. This product is intended for research purposes only and is not for patient use. PROTACs utilize two distinct ligands joined by a linker, one targeting an E3 ubiquitin ligase and the other targeting the protein of interest. This mechanism exploits the intracellular ubiquitin-proteasome system to facilitate the selective degradation of target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- For research use only
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
- Appearance: Solid
- Color: White to off-white
Medchemexpress LLC m-PEG1-NHS ester 5g | 1027371-75-0 | 201.18 g/mol | C8H11NO5 | 5 G
m-PEG1-NHS ester is a methoxy-terminated PEG1 N-hydroxysuccinimide ester that provides an activated NHS ester for efficient coupling to primary amines. It is used as a short PEG linker in bioconjugation and PROTAC synthesis to introduce a flexible spacer and enable amide bond formation under mild conditions.
- Provides a methoxy-terminated PEG1 spacer for minimal linker length.
- Contains an active NHS ester for rapid amide coupling to primary amines.
- Suitable for PROTAC linker assembly and general bioconjugation.
- Available in multiple pack sizes for flexible scaling.