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Biotin and derivatives

Organic heterocyclic compounds and derivatives that consist of a ureido ring and a tetrahydrothiophene ring; ureido contains the radical: NH2CONH−, and tetrahydrothiophene is a five-membered ring consisting of four carbon atoms and a sulfur atom.

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1

Medchemexpress LLC Biotin-PEG7-amine | 1334172-76-7 | 98.0% | C26H50N4O9S | 50 MG
SDP

Biotin-PEG7-amine is a PEG-based PROTAC linker. It is utilized in the synthesis of PROTACs, which are molecules designed to exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. PROTACs achieve this by connecting two different ligands via a linker, one binding to an E3 ubiquitin ligase and the other to a target protein.

  • PEG-based PROTAC linker
  • Used in the synthesis of PROTACs
  • Exploits intracellular ubiquitin-proteasome system
  • Selectively degrades target proteins

ENCOMPASS_PREFERRED
2

Medchemexpress LLC Biotin-sar-oh | 154024-76-7 | 315.39 | C13H21N3O4S | 1 G
SDP

Biotin-sar-oh is a cleavable antibody-drug conjugate (ADC) linker bearing a biotin functionality, used in the synthesis of antibody-drug conjugates and probe development.

  • Cleavable ADC linker for conjugation and release strategies.
  • Biotinylated for affinity capture and detection.
  • Molecular formula: C13H21N3O4S; molecular weight: 315.39.
  • Available pack sizes: 250 mg and 1 g.
  • CAS number: 154024-76-7.

ENCOMPASS_PREFERRED
3

Medchemexpress LLC Biotin-PEG7-amine | 1334172-76-7 | 98.0% | C26H50N4O9S | 25 MG
SDP

Biotin-PEG7-amine is a PEG-based PROTAC linker used in the synthesis of Proteolysis Targeting Chimeras (PROTACs). PROTACs function by exploiting the intracellular ubiquitin-proteasome system to selectively degrade target proteins, by connecting an E3 ubiquitin ligase ligand to a target protein ligand via a linker.

  • PEG-based PROTAC linker
  • Used in the synthesis of PROTACs
  • Exploits the ubiquitin-proteasome system
  • Selectively degrades target proteins
  • For research use only

ENCOMPASS_PREFERRED
4

Medchemexpress LLC Biotin-PEG7-amine | 1334172-76-7 | MFCD21363308 | 98.0% | C26H50N4O9S | 10MG
SDP

Biotin-PEG7-amine is a PEG-based biotinylation reagent containing a seven-unit polyethylene glycol spacer terminating in a primary amine. It is used as a linker in PROTAC synthesis and for bioconjugation to introduce a biotin tag for affinity capture and detection.

  • PEG7 spacer improves solubility and reduces steric hindrance.
  • Terminal primary amine enables coupling to activated carboxyl groups or NHS esters.
  • Biotin tag allows efficient affinity capture using streptavidin or avidin systems.
  • Compatible with standard peptide- and small-molecule coupling chemistries.
  • High purity supports synthetic and analytical applications.

ENCOMPASS_PREFERRED
5

Medchemexpress LLC 1H-Thieno[3,4-d]imidazole-4-pentanamide, N-(23-amino-3,6,9,12,15,18,21-heptaoxatricos-1-yl) hexahydro-2-oxo- | 1334172-76-7 | 98.0% | C26H50N4O9S | 100 MG
SDP

Biotin-PEG7-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. These molecules contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

  • PEG-based PROTAC linker
  • Used in the synthesis of PROTACs
  • Contains ligands for E3 ubiquitin ligase and target proteins
  • Exploits intracellular ubiquitin-proteasome system
  • Selectively degrades target proteins

ENCOMPASS_PREFERRED