Furans
Medchemexpress LLC Methyl 2-furoate | 611-13-2 | MFCD00003236 | 99.9% | 126.11 g·mol⁻1 | C6H6O3 | 100g
Methyl 2-furoate (Methyl furan-2-carboxylate) can be used to synthesize cis-fused 5-oxofuro[2 3-b]furans Methyl 2-furoate is also used in the preparation of sesquiterpene lactones[1]
Medchemexpress LLC TCS PrP Inhibitor 13 25mg | 34320-83-7 | 25MG
TCS PrP Inhibitor 13 an antiprion agent is a cellular prion protein (PrPC) inhibitor TCS PrP Inhibitor 13 as a protease-resistant form of prion protein (PrP-res) accumulation inhibitor shows an IC50 value of 3 nM in both ScN2a and F3 cell lines TCS PrP Inhibitor 13 induces Schwannoma cells apoptosis[1
Medchemexpress LLC SID7970631 | 868224-75-3 | 98.30% | 10 MG
SID7970631 is an isoquinolinone analog that functions as a potent and selective submicromolar SF-1 inhibitor (IC50=255 nM). It can be used for cancer research.
- Potent and selective submicromolar SF-1 inhibitor
- IC50 of 255 nM (SF-1)
- Displays cytotoxic effects on H295R/TR SF-1 cells and SW-13 cells
- Powder storage: -20°C for 3 years, 4°C for 2 years
- In solvent storage: -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC SID7970631 | 868224-75-3 | 98.3% | 50 MG
SID7970631, an isoquinolinone analog, is a potent and selective submicromolar SF-1 inhibitor with an IC50 of 255 nM. It is used for cancer research.
- Potent and selective submicromolar SF-1 inhibitor (IC50 of 255 nM)
- Used for cancer research
- Exhibits a half-maximal cytotoxic effect in CHO-K1 cells
- Dose-dependently inhibits luciferase expression in the SF-1 assay
- Shows cytotoxic effects on H295R/TR SF-1 cells and SW-13 cells
- Molecular weight is 452.46 with the formula C24H24N2O7
- Appears as a white to off-white solid
- Soluble in DMSO at 100 mg/mL
Medchemexpress LLC Nav1.1 activator 1 | 2332897-85-3 | 99.0% | 440.46 | 10 MG
Nav1.1 activator 1 (compound 4) is a highly potent Nav1.1 activator with BBB penetration, which increases the decay time constant (tau) of Nav1.1 currents at 0.03 μM, demonstrating significant selectivity against Nav1.2, Nav1.5, and Nav1.6.
- A valuable Nav1.1 activator for further evaluation of pathophysiological functions of the Nav1.1 channel.
- Has potential for therapeutic treatments of Central Nervous System (CNS) diseases like Dravet syndrome.
- Intraperitoneal administration (30 mg/kg) in mice achieved sufficient brain exposure (193 ng/g 1 hour after administration), corresponding to 13 nM of free brain concentration, comparable to its in vitro potency.
- Capable of penetrating the blood-brain barrier (BBB) in humans.
Medchemexpress LLC 2,4-dihydro-5-(4-nitrophenyl)-2-phenyl-3H-pyrazol-3-one | 34320-83-7 | MFCD00506084 | 99.7% | 281.27 | C15H11N3O3 | 10 MG
TCS PrP Inhibitor 13 is a small-molecule antiprion agent that inhibits cellular prion protein (PrPC) and reduces protease-resistant prion accumulation. It is supplied as a solid for research use and shows potent activity in cellular assays (IC50 3 nM).
- Chemical formula: C15H11N3O3.
- Molecular weight: 281.27.
- Purity: 99.7%.
- Appearance: solid, white to yellow.
- Storage conditions: powder -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months) or -20°C (1 month).
- Reported activity: IC50 3 nM in ScN2a and F3 cells.
- Biological effect: induces apoptosis in schwannoma cells.
Medchemexpress LLC 5-(4-nitrophenyl)-2-phenyl-4H-pyrazol-3-one | 34320-83-7 | 99.7% | 281.3 | C15H11N3O3 | 100 MG
TCS PrP Inhibitor 13 is a research small molecule that inhibits cellular prion protein (PrPC) and reduces accumulation of protease-resistant prion protein (PrP-res). It is employed in cellular studies to evaluate antiprion activity and related effects on cell viability and apoptosis.
- Potent inhibitor with an IC50 of about 3 nM in ScN2a and F3 cells.
- Reported to induce apoptosis in Schwannoma cells.
- High purity (99.72%) suitable for research applications.
- Supplied as a solid powder and as a DMSO solution (10 mM).
- Stable when stored as a powder at -20 °C (up to 3 years) or 4 °C (up to 2 years).
- In-solution storage: -80 °C (up to 6 months) or -20 °C (up to 1 month).