(R)-Terazosin is an active R-enantiomer of Terazosin and a potent α1-adrenoceptor antagonist. It exhibits Ki values of 6.51 nM, 1.01 nM, and 1.97 nM for α1a, α1b, and α1d-adrenoceptor, respectively.
- Potent α1-adrenoceptor antagonist
- Low affinity for α2a, α2B, and α2c-adrenoceptors
- Useful probe in understanding the functional role of adrenoceptor subtypes
- Weaker antagonist at α2B sites than its enantiomer for differentiating pharmacological effects
- Powder stable for 3 years at -20°C and 2 years at 4°C
- In solvent, stable for 2 years at -80°C and 1 year at -20°C
- Soluble in DMSO