Lactams
Medchemexpress LLC Thalidomide-O-C6-COOH | 2169266-69-5 | 99.29% | 50 MG
Thalidomide-O-C6-COOH is a synthesized E3 ligase ligand-linker conjugate. It incorporates a Thalidomide-based cereblon ligand and a linker, which is used in PROTAC (Proteolysis-Targeting Chimera) technology. This compound is intended for research use only.
- Utilizes the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Composed of two different ligands connected by a linker
Medchemexpress LLC Thalidomide-iodo | 2509137-01-1 | MFCD31735039 | 98.0% | 384.13 g/mol | C13H9IN2O4 | 250 MG
Thalidomide-iodo is an iodinated derivative of thalidomide that functions as an E3 ligase activator for chemical biology and medicinal chemistry research. It is supplied as a solid research reagent and can be used as a synthetic building block for further derivatization via substitution of the iodine atom.
- Iodinated thalidomide derivative suitable for E3 ligase activation studies.
- Useful as a synthetic building block for iodine substitution and derivatization.
- High purity (≥98.0%) appropriate for research applications.
- Molecular weight 384.13 g/mol; formula C13H9IN2O4.
- CAS number 2509137-01-1 for unambiguous identification.
Medchemexpress LLC VH 101 phenol-alkylC6-amine dihydrochloride | 2564467-16-7 | 704.72 | 100 MG
VH 101 phenol-alkylC6-amine dihydrochloride is a functionalized von-Hippel-Lindau (VHL) protein-ligand that can be used for PROTAC synthesis.
- Functionalized von-Hippel-Lindau (VHL) protein-ligand
- Can be used for PROTAC synthesis
Medchemexpress LLC Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride | 2341841-02-7 | 99.3% | 410.81 | 25 MG
Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a linker. This compound is suitable for designing PROTACs.
- Incorporates a cereblon (CRBN) ligand for E3 ubiquitin ligase
- Contains a linker
- Suitable for designing PROTACs
- Relevant to cancer targeted therapy, cancer metabolism, and metastasis
- Related to PROTAC research
- Involved in autophagy studies
- Used in apoptosis research
- Applicable to E3 ligase ligand-linker conjugates
Medchemexpress LLC Thalidomide-Piperazine-PEG3-COOH | 2797619-63-5 | 99.89% | 546.57 | 25 MG
A synthesized ligand-linker conjugate is described as incorporating a cereblon ligand and a linker often employed in protein degradation technology. This conjugate is intended for research applications only and not for patient use.
- Synthesized conjugate.
- Incorporates a cereblon ligand.
- Utilizes a linker as part of protein degradation technology.
- Composed of two distinct ligands joined by a linker.
- One ligand targets an E3 ubiquitin ligase.
- The other ligand targets a specific protein.
- Leverages the intracellular ubiquitin-proteasome system.
- Aims for selective degradation of target proteins.
- For research purposes only.
eMolecules 1061605-21-7 | Thalidomide-O-C1-acid | Broadpharm332.268 | C15H12N2O7 | 98.000 | OC(=O)COc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 | 1g | 550804650
Thalidomide-O-C1-acid | Broadpharm | 1061605-21-7332.268 | C15H12N2O7 | 98.000 | OC(=O)COc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 | 1g | 550804650
Medchemexpress LLC Thalidomide-NH-C5-NH2 hydrochloride | 2375194-03-7 | 99.9% | 394.85 | 250 MG
Thalidomide-NH-C5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. It is for research use only and not sold to patients.
- Targets cereblon.
- Utilizes PROTAC technology for selective degradation of target proteins.
- Soluble in DMSO at 250 mg/mL (633.15 mM) with ultrasonication.
- In vivo dissolution protocols available for clear solutions.
- Ships at room temperature in continental US.
- Solid storage at -20°C, sealed, away from moisture and light.
- Storage in solvent at -80°C for 6 months or -20°C for 1 month.
Medchemexpress LLC Thalidomide-NH-C10-COOH | 2428400-33-1 | 97.5% | 100 MG
Thalidomide-NH-C10-COOH (compound 6b) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based CRBN ligand and a linker used in PROTAC technology. It has a molecular weight of 457.52 and the formula C24H31N3O6. It appears as a light yellow to yellow solid. It is for research use only and not sold to patients.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide-based CRBN ligand
- Used in PROTAC technology
- Molecular weight: 457.52
- Formula: C24H31N3O6
- Appearance: Light yellow to yellow solid
- Purity: 97.5%
- Target: Cereblon
- Solubility in DMSO: 50 mg/mL (109.28 mM)
Medchemexpress LLC Thalidomide-NH-CBP/p300 ligand 2 | 2484739-21-9 | 98.6% | 922.03 | 25 MG
Thalidomide-NH-CBP/p300 ligand 2 (P-007) is a PROTAC-based CBP and p300 degrader, as extracted from patent WO2020173440. This compound is intended for research use only.
- Protac-based CBP and p300 degrader
- Extracted from patent WO2020173440
- For research use only
Sigma Aldrich Fine Chemicals Biosciences Pomalidomide >=98% (HPLC) | 19171-19-8 | MFCD12756407 | 25MG
Pomalidomide >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 273.24 | 19171-19-8 | MFCD12756407 | 25MG
Medchemexpress LLC Thalidomide-O-amido-PEG4-azide | 2411681-89-3 | 99.19% | C25H32N6O10 | 100 MG
Thalidomide-O-amido-PEG4-azide is a PEG-based PROTAC linker designed for the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an Azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. It also participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. PROTACs utilizing this linker are engineered to selectively degrade target proteins by exploiting the intracellular ubiquitin-proteasome system.
- PEG-based PROTAC linker
- Click chemistry reagent with Azide group
- Enables CuAAc reactions with alkyne groups
- Facilitates SPAAC reactions with DBCO or BCN groups
- Used in the synthesis of PROTACs
Medchemexpress LLC Thalidomide-5-O-CH2-COOH | 2467425-53-0 | MFCD34186095 | 95.0% | 332.26 g/mol | C15H12N2O7 | 50 MG
Thalidomide-5-O-CH2-COOH is an E3 ligase ligand-linker conjugate used as a cereblon (CRBN) ligand and an intermediate for the synthesis of PROTAC molecules. Supplied as a solid with supplier-characterized purity, it is intended for research applications in targeted protein degradation.
- Acts as a cereblon ligand for targeted protein degradation research.
- Suitable intermediate for PROTAC synthesis and conjugation chemistry.
- Approximately 95.0% purity, characterized by supplier analytical data.
- Solid form, light yellow to brown appearance for easy handling.
- Good solubility in DMSO for in vitro formulation and assays.
- Stable when stored under recommended conditions for long-term use.
Medchemexpress LLC Thalidomide-5-PEG3-NH2 hydrochloride | 2761385-81-1 | 97% | 441.86 | 1 MG
Thalidomide-5-PEG3-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. It has an IC 50 of Cereblon.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide-based cereblon ligand
- Used in PROTAC technology
- Solid form
- White to off-white color
Medchemexpress LLC Thalidomide-O-C6-NHBoc | 2509093-23-4 | 95.99% | C24H31N3O7 | 50 MG
Thalidomide-O-C6-NHBoc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. It is for research use only and not sold to patients. The product appears as an off-white to light yellow solid with a molecular weight of 473.52.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide based cereblon ligand
- Linker used in PROTAC technology
- For research use only
- Appears as an off-white to light yellow solid
- Molecular weight of 473.52
Medchemexpress LLC Thalidomide-5-PEG6-NH2 hydrochloride | 574.02 g/mol | C25H36ClN3O10 | 10 MG
Thalidomide-5-PEG6-NH2 hydrochloride is a thalidomide-derived cereblon ligand designed as a synthetic building block for targeted protein degradation research. The molecule includes a PEG6 linker terminating in a primary amine (hydrochloride salt) that enables conjugation to linkers or target ligands for PROTAC construction. Storage and handling conditions are provided to maintain stability.