Lactams
Medchemexpress LLC Thalidomide-propargyne-PEG2-COOH | 2797619-65-7 | 98.7% | 428.39 g/mol | C21H20N2O8 | 5 MG
Thalidomide-Propargyne-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate combining a thalidomide-derived cereblon ligand with a PEG2 linker terminating in a propargyl carboxylic acid. It is intended for PROTAC construction and click-chemistry applications, providing an alkyne handle for downstream conjugation.
- Contains terminal propargyl (alkyne) group for copper-catalyzed azide-alkyne cycloaddition.
- Incorporates a PEG2 linker to improve solubility and provide appropriate spacer length.
- Acts as a cereblon ligand to recruit CRBN for targeted protein degradation strategies.
- High purity suitable for research and synthetic applications.
- Available in small pack sizes for efficient use in medicinal chemistry workflows.
Medchemexpress LLC N-Me-thalidomide 4-fluoride | 2244520-92-9 | MFCD34563580 | 99.4% | 290.25 g/mol | C14H11FN2O4 | 1 G
N-Me-Thalidomide 4-fluoride is a research-grade small molecule ligand for E3 ligase used in chemical biology and PROTAC development. It functions as a building block in the synthesis of targeted degraders and related small-molecule tools. Supplied for laboratory research use only.
- Ligand for E3 ligase.
- Useful building block for synthesis of targeted degraders and anti-inflammatory agents.
- High reported purity (99.41%).
- Molecular formula C14H11FN2O4; molecular weight 290.25 g/mol.
- Available in research pack sizes suitable for small-scale synthesis.
Medchemexpress LLC Thalidomide-4-O-C10-NH2 hydrochloride | 00-00-0 | 95.6% | C23H32ClN3O5 | 10MG
Thalidomide-4-O-C10-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand formulated as a hydrochloride salt for use in PROTAC design and related biochemical research. Supplied as a solid with reported high purity, it is intended for small-scale laboratory studies and compound linking applications.
- Hydrochloride salt form for improved stability
- High purity suitable for research applications
- Molecular formula C23H32ClN3O5 and molecular weight 465.97
- Available in small packaging sizes for synthesis and screening
- Solid form for convenient handling and storage
Medchemexpress LLC Thalidomide-NH-PEG2-COOH | 2412056-45-0 | MFCD34368531 | ≥95.0% | 433.41 g/mol | C20H23N3O8 | 5 MG
Thalidomide-NH-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon (CRBN) ligand with a short PEG2 carboxylic acid linker. It is designed as a building block for PROTAC (proteolysis targeting chimera) synthesis and related chemical biology research. For research use only.
- Provides CRBN engagement via a thalidomide-derived ligand.
- Contains a PEG2 spacer terminating in a carboxylic acid for linker conjugation.
- Suitable as a building block for PROTAC synthesis and E3 ligase recruitment studies.
- Characterized by analytical data, including HPLC, LC-MS, and NMR files.
- Available in small research-scale quantities for medicinal chemistry applications.
Medchemexpress LLC 4-bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione | 2093536-12-8 | 99.6% | 337.13 g/mol | C13H9BrN2O4 | 100 MG
Thalidomide-4-Br is a brominated thalidomide analog used as a research reagent and cereblon/E3 ligase ligand. It is employed in PROTAC development and in studies of inflammation, tumor biology, and neurology. The compound is supplied as a solid with high reported purity and should be stored cold according to handling recommendations.
- Useful as an E3 ligase and cereblon ligand in PROTAC design and degradation studies.
- Applicable to research in inflammation, tumor biology, and neurology.
- Provided as an off-white to gray solid in multiple pack sizes suitable for screening and synthesis.
- High reported purity (99.6%).
- Stable when stored cold; follow recommended powder and solvent storage conditions.
- Available in solution format for screening, for example 10 mM in DMSO.
![Medchemexpress LLC 7-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}heptanoic acid | 2169266-69-5 | MFCD32063464 | 99.3% | C20H22N2O7 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000261970.png-250.jpg)
Medchemexpress LLC 7-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}heptanoic acid | 2169266-69-5 | MFCD32063464 | 99.3% | C20H22N2O7 | 10MG
Thalidomide-O-C6-COOH is a thalidomide-based cereblon (CRBN) E3 ligase ligand-linker conjugate terminating in a six-carbon carboxylic acid. It is used as a building block in PROTAC synthesis and chemical biology research, providing a convenient carboxylic acid handle for linker attachment and efficient recruitment of CRBN.
- Used in PROTAC design to recruit cereblon (CRBN) E3 ligase.
- Thalidomide-based ligand with a six-carbon carboxylic acid linker.
- High purity, 99.3% (reported).
- Soluble ≥100 mg/mL in DMSO.
- Off-white to light yellow solid suitable for synthesis.
- Molecular formula C20H22N2O7; molecular weight 402.40 g·mol⁻1.
- Storage recommendations provided for powder and solutions to maintain stability.
Medchemexpress LLC Thalidomide-O-C2-acid | 2369068-42-6 | 95.0% | C16H14N2O7 | 10MG
Thalidomide-O-C2-acid is an E3 ligase ligand-linker conjugate that pairs a thalidomide-derived cereblon ligand with a two-carbon linker. It is designed as a research building block for proteolysis targeting chimera (PROTAC) construction and targeted protein degradation studies, and is supplied with analytical data supporting its identity and purity.
- Contains a thalidomide-derived cereblon ligand for CRBN recruitment.
- Includes a short two-carbon linker suitable for conjugation.
- Provided with reported purity and molecular characterization.
- Available in multiple small pack sizes for research-scale synthesis.
- Intended for use as a building block in PROTAC synthesis and chemical biology studies.
- Supplied with an accessible datasheet and safety documentation.
Cayman Chemical ThalIdomIde 25mg
An active enantiomer of (±)-thalidomide; enhances TPA-induced TNF-α production in HL-60 cells from 0.1-100 µM; preincubation of isolated RIR chicken donor blood reduces recipient chicken embryo splenomegaly in a model of graft versus host disease at 10 mg/ml; induces fetal malformations when administered to pregnant female rabbits at 150 mg/kg
Chemscene ChemScene | Thalidomide 5-fluoride | 5G | CS-0127616 | 0.98 | 835616-61-0| MFCD30188075 | 276.22
ChemScene | Thalidomide 5-fluoride | 5G | CS-0127616 | 0.98 | 835616-61-0| MFCD30188075 | 276.22
Apexbio Technology LLC Thalidomide-O-amido-C4-NH2 TFA 1799711-25-3 50mg
Thalidomide-O-amido-C4-NH2 TFA (CAS 1799711-25-3) is a synthetic small molecule composed of a thalidomide-derived cereblon ligand conjugated to a chemical linker This compound selectively binds to cereblon (CRBN) a substrate receptor of the CRL4CRBN E3 ubiquitin ligase complex By facilitating the recruitment of target proteins to the CRBN complex it enables their ubiquitination and subsequent proteasomal degradation Thalidomide-O-amido-C4-NH2 TFA serves as a molecular tool in the development of proteolysis targeting chimeras (PROTACs) and other targeted protein degradation strategies in biomedical research
Medchemexpress LLC Thalidomide-pyrrolidine (hydrochloride) | 2616553-35-4 | 98.0% | 335.74 g/mol | C15H14ClN3O4 | 10 MG
Thalidomide-pyrrolidine hydrochloride is a thalidomide-derived E3 ligase ligand supplied for laboratory research. It serves as a building block for the synthesis of proteolysis targeting chimeras (PROTACs) and related chemical probes. The compound is provided as a solid hydrochloride salt intended for research use only.
- E3 ligase ligand suitable for PROTAC synthesis.
- Hydrochloride salt form for improved stability and handling.
- Off-white to gray solid for solid-phase handling.
- High purity appropriate for research applications.
- Supplied in small pack sizes for synthesis and screening.
![eMolecules (1R,2R,4R)-rel-1-Azabicyclo[2,2,1]heptane-2-carboxylic acid hydrochloride | 921755-46-6 | | 1g](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502168053.JPG-250.jpg)
eMolecules (1R,2R,4R)-rel-1-Azabicyclo[2,2,1]heptane-2-carboxylic acid hydrochloride | 921755-46-6 | | 1g
Synthonix - Stock | (1R,2R,4R)-rel-1-Azabicyclo[2,2,1]heptane-2-carboxylic acid hydrochloride | 1g | 499991381 | A64984 | | 921755-46-6 | | 177.630 | C7H12ClNO2
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eMolecules Building Block Tool
Medchemexpress LLC Thalidomide-4-O-C7-NH2 hydrochloride | 00-00-0 | 99.8% | C20H26ClN3O5 | 10MG
Thalidomide-4-O-C7-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand-linker conjugate provided as the hydrochloride salt for research use in PROTAC development and E3 ligase recruitment studies. It is supplied as a high-purity, well-characterized reagent suitable for biochemical assays, linker conjugation, and medicinal chemistry workflows.
- High purity (99.8%) suitable for research applications.
- Hydrochloride salt form for consistent handling and storage.
- Characterized molecular formula C20H26ClN3O5 and molecular weight 387.43 g/mol.
- Functions as a cereblon (CRBN) E3 ligase ligand for PROTAC design.
- Available in small, lab-scale quantities for screening and synthesis.
- Datasheet and certificate of analysis available from the supplier.
Apexbio Technology LLC Thalidomide 50-35-1 10mM (in 1mL DMSO)
Thalidomide (CAS 50-35-1) is a small-molecule inhibitor targeting the CRBN-DDB1-Cul4A E3 ubiquitin ligase complex It is designed to modulate ubiquitination pathways thereby regulating protein degradation cellular proliferation and immune signaling Thalidomide exerts its biological activity primarily through inhibition of the CRBN-DDB1-Cul4A complex In cell-based studies thalidomide demonstrates inhibitory activity with reported IC50 values ranging from approximately 1 M to 100 M depending on the assay and cell line Based on these pharmacological properties thalidomide holds research potential in the fields of immune regulation angiogenesis inhibition and cancer biology particularly in studies of hematological malignancies such as multiple myeloma
Medchemexpress LLC Thalidomide 4-chloro | 244057-36-1 | MFCD30188071 | >98.0% | 292.68 | C13H9ClN2O4 | 5 G
Thalidomide 4-chloro is a chlorinated thalidomide derivative that functions as an E3 ligase (cereblon) ligand/activator for research use. It is commonly used as a synthetic building block in PROTAC design and for studies involving CRBN recruitment, where the 4-chloro group can be substituted to create derivatives.
- Functions as an E3 ligase (cereblon) ligand for biochemical studies.
- Useful for PROTAC design and cereblon recruitment assays.
- Enables further derivatization via substitution at the 4-chloro position.
- Available in laboratory pack sizes suitable for synthesis and screening.
- Analytical data and a product datasheet are available for reference.