Lactams
Medchemexpress LLC Thalidomide-4-O-C12-NH2 hydrochloride | 95.6% | 494.02 | C25H36ClN3O5 | 10 MG
Thalidomide-4-O-C12-NH2 hydrochloride is a thalidomide-derived cereblon ligand provided as the hydrochloride salt for use in chemical biology and medicinal chemistry applications. It functions as a CRBN E3 ligase recruiter for targeted protein degradation and is intended for use in PROTAC and ligand-linker conjugation studies. Store protected from light at recommended temperatures.
Medchemexpress LLC Thalidomide-5-O-C5-NH2 hydrochloride | 2761385-94-6 | 395.84 | C18H22ClN3O5 | 10 MG
Thalidomide-5-O-C5-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand provided as the hydrochloride salt for use in chemical biology research. It is designed for incorporation into ligand-linker conjugates and PROTAC constructs to recruit CRBN and enable targeted protein degradation. The material is supplied as a research-grade powder with recommended cold, light-protected storage conditions.
TARGETMOL CHEMICALS INC HKI-357 5MG
Also available in 1 mL, 1 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. HKI-357 is an irreversible dual inhibitor of EGFR and ERBB2 (IC50s 34 nM and 33 nM), effectively suppressing EGFR autophosphorylation (at Y1068), as well as AKT and MAPK phosphorylation. Purity 98.31%
Medchemexpress LLC Thalidomide 4-chloro | 244057-36-1 | MFCD30188071 | 96.0% | 292.68 g·mol⁻¹ | C13H9ClN2O4 | 1 G
Thalidomide 4-chloro is a chlorinated thalidomide derivative that functions as a cereblon (E3 ligase) ligand and E3 ligase activator. It is used in PROTAC development and as a synthetic building block for further derivatization via substitution at the 4-chloro position. The compound is supplied as a solid and is characterized for research applications.
- Molecular formula: C13H9ClN2O4.
- Molecular weight: 292.68 g·mol⁻¹.
- CAS number: 244057-36-1.
- Appearance: solid (powder).
- Purity: 96.0%.
- Intended use: E3 ligase (cereblon) ligand for PROTAC design and derivatization.
- Storage: powder -20 °C (3 years) or 4 °C (2 years); in solvent -80 °C (6 months) or -20 °C (1 month).
Medchemexpress LLC Thalidomide 4-chloro | 244057-36-1 | MFCD30188071 | >98.0% | 292.68 | C13H9ClN2O4 | 5 G
Thalidomide 4-chloro is a chlorinated thalidomide derivative that functions as an E3 ligase (cereblon) ligand/activator for research use. It is commonly used as a synthetic building block in PROTAC design and for studies involving CRBN recruitment, where the 4-chloro group can be substituted to create derivatives.
- Functions as an E3 ligase (cereblon) ligand for biochemical studies.
- Useful for PROTAC design and cereblon recruitment assays.
- Enables further derivatization via substitution at the 4-chloro position.
- Available in laboratory pack sizes suitable for synthesis and screening.
- Analytical data and a product datasheet are available for reference.
Apexbio Technology LLC Thalidomide 50-35-1 10mM (in 1mL DMSO)
Thalidomide (CAS 50-35-1) is a small-molecule inhibitor targeting the CRBN-DDB1-Cul4A E3 ubiquitin ligase complex It is designed to modulate ubiquitination pathways thereby regulating protein degradation cellular proliferation and immune signaling Thalidomide exerts its biological activity primarily through inhibition of the CRBN-DDB1-Cul4A complex In cell-based studies thalidomide demonstrates inhibitory activity with reported IC50 values ranging from approximately 1 M to 100 M depending on the assay and cell line Based on these pharmacological properties thalidomide holds research potential in the fields of immune regulation angiogenesis inhibition and cancer biology particularly in studies of hematological malignancies such as multiple myeloma
Medchemexpress LLC Thalidomide-C2-amido-C2-COOH | 2353496-84-9 | 98.5% | C19H20N4O7 | 10MG
Thalidomide-C2-amido-C2-COOH is a thalidomide-derived cereblon (CRBN) ligand-linker conjugate for research use. Supplied as a powder, it is intended as a building block for design and synthesis of PROTAC degraders and other molecules that recruit the CRBN E3 ubiquitin ligase.
- Incorporates a cereblon-binding thalidomide moiety for E3 ligase recruitment.
- Contains a short C2-amido-C2-COOH linker for conjugation to target ligands.
- High purity (98.5%) suitable for synthetic and analytical work.
- Molecular formula and weight provided to support design calculations.
- Soluble in DMSO for preparation of concentrated stock solutions.
- Powder form allows long-term frozen storage for stability.
![eMolecules Medchem Express / Thalidomide-4-O-C6-NH2 (hydrochloride) / 5mg / 599150703 / HY-135250B / / 2245697-88-3 / [null] / 409.870 / C19H24ClN3O5](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502484194.JPG-250.jpg)
eMolecules Medchem Express / Thalidomide-4-O-C6-NH2 (hydrochloride) / 5mg / 599150703 / HY-135250B / / 2245697-88-3 / [null] / 409.870 / C19H24ClN3O5
Medchem Express / Thalidomide-4-O-C6-NH2 (hydrochloride) / 5mg / 599150703 / HY-135250B / / 2245697-88-3 / [null] / 409.870 / C19H24ClN3O5