Lactams
Medchemexpress LLC (S)-Thalidomide | 841-67-8 | MFCD00210219 | 99.52% | 258.23 | 50 MG
(S)-Thalidomide is the S-enantiomer of Thalidomide. It exhibits immunomodulatory, anti-inflammatory, antiangiogenic, and pro-apoptotic effects. (S)-Thalidomide induces teratogenic effects by binding to cereblon (CRBN).
- It is the S-enantiomer of thalidomide.
- It exhibits immunomodulatory effects.
- It has anti-inflammatory properties.
- It shows antiangiogenic effects.
- It possesses pro-apoptotic effects.
- It binds to cereblon (CRBN).
Medchemexpress LLC Thalidomide-O-PEG4-Boc | 2411681-87-1 | C28H38N2O11 | 25MG
Thalidomide-O-PEG4-Boc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
- Incorporates thalidomide-based cereblon ligand.
- Utilizes a linker in PROTAC technology.
- Contains two different ligands connected by a linker.
- One ligand is for an E3 ubiquitin ligase, and the other is for the target protein.
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Used in PROTAC technology.
Medchemexpress LLC Vh 101 phenol-alkylC6-amine dihydrochloride | 2564467-16-7 | ≥95% | 704.72 | 250 MG
VH 101 phenol-alkylC6-amine dihydrochloride is a functionalized von-Hippel-Lindau (VHL) protein-ligand designed for optimal PROTAC (Proteolysis Targeting Chimeras) functionality. It binds the VHL protein, enabling ubiquitination of target proteins, and the terminal amine on its C6 linker allows conjugation to target ligands for PROTAC synthesis.
- Functionalized VHL protein-ligand.
- Designed for optimal PROTAC functionality.
- Binds VHL protein to recruit E3 ligase.
- Enables ubiquitination of target proteins.
- Terminal amine on C6 linker allows conjugation to target ligands.
- Used in PROTAC synthesis against various targets.
Medchemexpress LLC Thalidomide-NH-PEG3-COOH | 2375283-62-6 | 98.9% | 477.46 | 100 MG
Thalidomide-NH-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate. It incorporates a thalidomide-based cereblon ligand and a linker utilized in PROTAC technology. This product is intended for research purposes only.
- Incorporates a thalidomide-based cereblon ligand
- Designed for use in PROTAC technology
- Targets cereblon
- Appears as a white to yellow solid
- Useful in cancer research applications
- Functions as an E3 ligase ligand-linker conjugate
- Involved in autophagy and apoptosis studies
- Acts as an inhibitor
Medchemexpress LLC 2,6-piperidinedione, 3-(1,3-dihydro-5-iodo-1-oxo-2H-isoindol-2-yl) | 2291364-01-5 | MFCD32853043 | 98.0% | 370.14 g·mol⁻¹ | C13H11IN2O3 | 1 G
Deoxy-thalidomide-5-iodine is a thalidomide analogue used as an E3 ligase ligand in PROTAC research and cereblon-targeting studies. Supplied as a high-purity solid, it is commonly used as a building block for synthesis of degraders and chemical probes.
- High purity suitable for research (98.0%).
- Chemical formula C13H11IN2O3.
- Molecular weight 370.14 g·mol⁻¹.
- Useful as an E3 ligase (cereblon) ligand in PROTAC design.
- Solid form for ease of handling and storage.
- Store protected from light at refrigerated temperatures; in solvent: -80°C (6 months), -20°C (1 month).
Medchemexpress LLC Thalidomide-4-OH | 5054-59-1 | MFCD03699892 | 99.9% | 274.23 g/mol | C13H10N2O5 | 5 G
Thalidomide-4-OH is a 4-hydroxylated thalidomide derivative that serves as a cereblon (CRBN) ligand for targeted protein degradation research. It is commonly used as a building block in PROTAC design and medicinal chemistry studies and is supplied as a solid for laboratory research use only.
- Acts as a cereblon (CRBN) ligand suitable for PROTAC synthesis.
- 4-hydroxyl substitution enables linker attachment for conjugation.
- High purity supports reproducible conjugation and biological assays.
- Solid form allows convenient storage and handling.
- Useful for ligand optimization and E3 ligase recruitment studies.
Medchemexpress LLC Vh 101 phenol-alkylc6-amine dihydrochloride | 2564467-16-7 | 704.72 | 50 MG
VH 101 phenol-alkylC6-amine dihydrochloride is a functionalized von-Hippel-Lindau (VHL) protein-ligand. This compound is suitable for PROTAC synthesis.
- Functionalized von-Hippel-Lindau (VHL) protein-ligand
- Can be used for PROTAC synthesis
Medchemexpress LLC Thalidomide-CH2NH2 hydrochloride | 444287-40-5 | 98.1% | 323.73 | 50 MG
Thalidomide-CH2NH2 hydrochloride is a Thalidomide analogue featuring a primary amine, which is a versatile group that may participate in many reactions. It is for research use only.
- Features a primary amine
- Versatile group that may participate in many reactions
- For research use only
Medchemexpress LLC 2,6-piperidinedione, 3-(1,3-dihydro-5-iodo-1-oxo-2h-isoindol-2-yl)- | 2291364-01-5 | MFCD32853043 | 98.0% | 370.14 g/mol | C13H11IN2O3 | 25 MG
Deoxy-thalidomide-5-iodine is a thalidomide analog bearing an iodine substituent at the 5-position used as a cereblon-binding ligand in PROTAC and targeted protein degradation research. Supplied as a colored solid with high reported purity, it is intended for chemical biology and linker-conjugation workflows.
- Thalidomide-derived cereblon ligand suitable for PROTAC design.
- High reported purity (98.0% by NMR) for research applications.
- Blue to blue-green solid physical form for easy handling.
- Molecular formula C13H11IN2O3 and molecular weight 370.14 g/mol.
- Suitable for linker attachment and synthesis of bifunctional degraders.