Lactams
Medchemexpress LLC Thalidomide-5-NH2-C8-NH2 (TFA) | 2097509-49-2 | 514.49 g/mol | C23H29F3N4O6 | 10 MG
Thalidomide-5-NH2-C8-NH2 (TFA) is a thalidomide-derived intermediate provided as the trifluoroacetic acid salt for research use and compound synthesis. It is intended for laboratory applications only and should be handled using appropriate safety procedures; store sealed at -20°C away from moisture and light. In solvent, recommended storage is -80°C for up to 6 months or -20°C for up to 1 month.
- Salt form: trifluoroacetic acid (TFA) salt.
- Suitable for compound synthesis and as a building block.
- Molecular formula: C23H29F3N4O6.
- Molecular weight: 514.49 g/mol.
- Storage: sealed at -20°C; in solvent -80°C (6 months) or -20°C (1 month).
- Intended for research use only; not for human or clinical use.
Medchemexpress LLC Thalidomide-5-O-C14-NH2 hydrochloride | 97.7% | 522.08 g/mol | C27H40ClN3O5 | 10 MG
Thalidomide-5-O-C14-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied for research use in targeted protein degradation and PROTAC development. It is provided as a small-quantity, high-purity solid suitable for conjugation through linkers to build bifunctional degraders and other CRBN-recruiting constructs.
- High purity of 97.7%.
- Molecular weight 522.08 g/mol and chemical formula C27H40ClN3O5.
- White to off-white solid appearance.
- Storage recommendations: -20 °C; in solvent: -80 °C (6 months) or -20 °C (1 month), protect from light, store under nitrogen.
- Suitable for use as a CRBN-recruiting ligand in PROTAC synthesis.
![Chemscene ChemScene | tert-Butyl 6-amino-3-azabicyclo[3.1.0]hexane-3-carboxylate | 250MG | CS-0088547 | 0.98 | 208837-83-6| MFCD09040607 | 198.26](https://assets.fishersci.com/TFS-Assets/CCG/product-images/CS-0088547.JPG-250.jpg)
Chemscene ChemScene | tert-Butyl 6-amino-3-azabicyclo[3.1.0]hexane-3-carboxylate | 250MG | CS-0088547 | 0.98 | 208837-83-6| MFCD09040607 | 198.26
ChemScene | tert-Butyl 6-amino-3-azabicyclo[3.1.0]hexane-3-carboxylate | 250MG | CS-0088547 | 0.98 | 208837-83-6| MFCD09040607 | 198.26
Medchemexpress LLC 2-(2,6-dioxopiperidin-3-yl)-4,5-difluoroisoindoline-1,3-dione | 2222115-19-5 | >98.0% | 294.21 g/mol | C13H8F2N2O4 | 1 G
Thalidomide-4,5-F is a fluorinated analogue of thalidomide used as a cereblon (CRBN) E3 ligase ligand in research. It promotes ubiquitinylation of target proteins and can be derivatized via substitution at the fluorine positions. Supplied as a powder with high reported purity for use in chemical biology and medicinal chemistry studies.
- Fluorinated thalidomide analogue enabling derivatization via fluorine substitution
- Acts as a cereblon (CRBN) E3 ligase ligand for targeted protein ubiquitination
- Promotes ubiquitinylation of proteins in biochemical assays
- High reported purity (≥98.0%) suitable for research use
- Powder form compatible with synthetic and analytical workflows
- Molecular formula C13H8F2N2O4 and molecular weight 294.21 g/mol
Medchemexpress LLC Thalidomide-pyrrolidine hydrochloride | 2616553-35-4 | 98.0% | 335.74 g/mol | C15H14ClN3O4 | 25 MG
Thalidomide-pyrrolidine hydrochloride is an E3 ligase ligand (compound 18) used as a cereblon (CRBN) ligand in the synthesis of PROTAC degraders and other bifunctional molecules. It is supplied as an off-white to gray solid with high purity for research use.
- High purity: 98.0%.
- Molecular weight: 335.74 g/mol.
- Molecular formula: C15H14ClN3O4.
- CAS number: 2616553-35-4.
- Physical form: off-white to gray solid.
- Storage: store dry and keep cool; in solution store at -80°C (2 years) or -20°C (1 year).
- Applications: used as an E3 ligase ligand for PROTAC synthesis.
Chemscene ChemScene | 3-Amino-2,6-piperidinedione | 1G | CS-0020118 | 0.98 | 2353-44-8| MFCD11506223 | 128.13
ChemScene | 3-Amino-2,6-piperidinedione | 1G | CS-0020118 | 0.98 | 2353-44-8| MFCD11506223 | 128.13
Medchemexpress LLC (S)-thalidomide-4-oh | 2357105-36-1 | 98.0% | 274.23 g/mol | C13H10N2O5 | 50 MG
(S)-Thalidomide-4-OH is the S-enantiomer of thalidomide-4-OH, a thalidomide-derived cereblon ligand used in chemical biology and medicinal chemistry. Supplied as a solid research reagent, it is commonly used to recruit CRBN in PROTAC design and as a building block for medicinal chemistry.
- S-enantiomer of thalidomide-4-OH for stereospecific studies.
- Cereblon (CRBN) ligand for E3 ligase recruitment.
- Suitable building block for PROTAC synthesis and linker chemistry.
- Off-white to light yellow solid; typical pack size 50 mg.
- Reported purity 98.0% and molecular weight 274.23 g/mol.
eMolecules Thalidomide-5-(PEG4-acid) | Broadpharm |549.533 | C25H31N3O11 | 98.000 | OC(=O)CCOCCOCCOCCOCCNC(=O)c1ccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c2c1 | 100mg | 713699648
Thalidomide-5-(PEG4-acid) | Broadpharm |549.533 | C25H31N3O11 | 98.000 | OC(=O)CCOCCOCCOCCOCCNC(=O)c1ccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c2c1 | 100mg | 713699648
Medchemexpress LLC Thalidomide-5-O-C7-NH2 hydrochloride | 98.1% | 423.89 g/mol | C20H26ClN3O5 | 10 MG
Thalidomide-5-O-C7-NH2 hydrochloride is a thalidomide-derived cereblon ligand supplied as the hydrochloride salt for use in chemical biology and targeted protein degradation research. It is designed to be connected to target ligands via a linker to build PROTACs and other CRBN-recruiting constructs, and includes storage recommendations to preserve compound integrity.
- Facilitates cereblon (CRBN) recruitment for targeted degradation studies.
- Hydrochloride salt form for improved handling and stability.
- Compatible with linker conjugation to form PROTAC molecules.
- Provided with documented molecular and storage data to support experimental planning.
- Suitable for research applications requiring characterized E3 ligase ligands.
Medchemexpress LLC Thalidomide-O-amido-C3-PEG3-C1-NH2 | 1799711-29-7 | 99.1% | 648.58 g/mol | C27H35F3N4O11 | 5 MG
Thalidomide-O-amido-C3-PEG3-C1-NH2 is a thalidomide-derived cereblon E3 ligase ligand conjugated to a three-unit PEG linker and a short C3 spacer terminating in an amine. Supplied for research use, it is intended as a linker-ligand building block for PROTAC design and related chemical biology applications.
- Thalidomide-based cereblon ligand for E3 ligase recruitment.
- Three-unit PEG linker and C3 spacer terminating in an amine for conjugation.
- High purity suitable for research applications (~99.1%).
- Available in small pack sizes for discovery work (mg scale).
- Store sealed at 4°C; in solution store at -80°C (6 months) or -20°C (1 month).
- For research use only, not for human use.
Medchemexpress LLC Thalidomide-NH-C6-NH2 hydrochloride | 2375194-37-7 | 99.6% | 50 MG
Thalidomide-NH-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates cereblon ligand and a linker used in PROTAC technology
- For research use only
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
![Medchemexpress LLC Butanoic acid, 4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl | 2308035-51-8 | 98.4% | 417.37 g/mol | C19H19N3O8 | 1 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000244795.png-250.jpg)
Medchemexpress LLC Butanoic acid, 4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl | 2308035-51-8 | 98.4% | 417.37 g/mol | C19H19N3O8 | 1 G
Thalidomide-O-amido-C3-COOH is an E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon ligand with a short carboxylic-acid linker for use in PROTAC design, synthesis, and degradation studies.
- Used as a cereblon E3 ligase ligand in PROTAC design and synthesis.
- High purity (98.4%) suitable for research applications.
- White to off-white solid with molecular weight 417.37 g/mol.
- Contains a carboxylic acid functional handle for conjugation chemistry.
- Available in small lab-scale quantities and supplied with a certificate of analysis.
Medchemexpress LLC Thalidomide-4-O-C6-NH2 hydrochloride | 2245697-88-3 | 98.5% | 409.86 | C19H24ClN3O5 | 5 MG
Thalidomide-4-O-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate supplied as the hydrochloride salt for research use. It is used as a building block in PROTAC dTAG-13, a degrader of FKBP12F36V and BET proteins, and is provided with supporting analytical data and handling documentation.
- Provided as the hydrochloride salt suitable for synthetic applications.
- High purity (98.5% by HPLC) with supporting analytical data.
- Analytical files include data sheet, COA, H NMR, and LCMS.
- Available in multiple pack sizes from milligrams to grams.
- Intended for research use only; not for human or therapeutic use.
Selleck Chemical LLC Brucine sulfate heptahydrate
Brucine is an alkaloid that acts as an antagonist at glycine receptors and paralyzes inhibitory neurons