Lactams
Medchemexpress LLC Thalidomide-NH-C6-NH2 TFA | 2093386-51-5 | 99.8% | 250 MG
Thalidomide-NH-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. This product is for research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates thalidomide-based cereblon ligand
- Used in PROTAC technology
- Purity of 99.8%
- CAS number: 2093386-51-5
- Molecular weight: 486.44
- Chemical formula: C21H25F3N4O6
- Appearance as a solid
- Color ranges from light yellow to yellow
- Targets cereblon
Medchemexpress LLC Thalidomide-piperazine-PEG2-NH2 diTFA | 00-00-0 | 99.7% | C27H33F6N5O10 | 10MG
Thalidomide-Piperazine-PEG2-NH2 diTFA is a synthesized E3 ligase ligand-linker conjugate that incorporates a thalidomide-derived cereblon (CRBN) ligand and a PEG2-piperazine amino linker. Supplied as the bis(trifluoroacetate) salt, it is designed as a building block for assembling heterobifunctional degraders (PROTACs) to recruit CRBN and enable targeted protein degradation.
- Incorporates thalidomide-based cereblon ligand for CRBN recruitment.
- Contains a PEG2-piperazine linker with a terminal primary amine for conjugation chemistry.
- Supplied as the bis(trifluoroacetate) salt to aid handling and solubility.
- High purity suitable for synthesis (99.7%).
- Water solubility up to 50 mg/mL with ultrasonic assistance.
- Store sealed at 4°C, away from moisture.
Medchemexpress LLC Thalidomide-propargyne-PEG3-COOH | 2797649-54-6 | 96.3% | C23H24N2O9 | 10MG
Thalidomide-Propargyne-PEG3-COOH is a thalidomide-derived E3 ligase ligand-linker conjugate featuring a terminal propargyl alkyne and a PEG3 spacer terminating in a carboxylic acid. It is intended as a research reagent for chemical biology and PROTAC synthesis to enable cereblon recruitment and bioorthogonal conjugation in degradation studies.
- Provides a cereblon-binding ligand for CRBN-mediated degradation
- Contains an alkyne handle for copper-catalyzed azide-alkyne cycloaddition
- PEG3 spacer improves solubility and linker flexibility
- Terminal carboxylic acid enables amide coupling and conjugation
- Supplied at research-grade purity suitable for synthesis
Medchemexpress LLC CD3 epsilon Canine 10ug | 10ug
The CD3 protein on lymphocytes is a component of the TCR-CD3 complex and is critical for adaptive immune responses When APC is activated TCR signals transmitted by CD3D CD3E CD3G and CD3Z initiate pathways through ITAM CD3 epsilon Protein Canine (HEK293 Fc) is the recombinant canine-derived CD3 epsilon protein expressed by HEK293 with C-hFc labeled tag
Medchemexpress LLC CD3 epsilon Human 500ug
Recombinant human CD3 epsilon protein produced in HEK293 mammalian cells and supplied as a lyophilized preparation with a C-terminal 6xHis tag, intended for research use in studies of T-cell receptor signaling, binding assays, and related immunological applications. Lot-specific COA provides detailed formulation and buffer information.
- Produced in HEK293 mammalian expression system.
- C-terminal 6xHis tag for detection and purification.
- Lyophilized powder formulation for convenient storage and handling.
- Approximate molecular weight 18-21 kDa by SDS-PAGE.
- Stable at -20 °C for long-term storage; reconstituted stability at 4 °C for one week.
- Lot-specific COA and datasheet available for quality and formulation details.
Medchemexpress LLC CD23/Fc epsilon RII 10ug
CD23 also known as Fc epsilon Receptor II (Fc epsilon RII) is a low-affinity receptor for immunoglobulin E (IgE) and complement receptor 2 (CR2/CD21) CD23 regulates IgE production and B-cell differentiation aiding in IGE-dependent antigen uptake CD23/Fc epsilon RII Protein Rat (HEK293 Fc) is the recombinant rat-derived CD23/Fc epsilon RII protein expressed by HEK293 with N-hFc labeled tag
Medchemexpress LLC NFKBIE/IKB epsilon protein, human (His tag) | 50UG
Recombinant human NFKBIE (IκBε) protein with a His tag, expressed in E. coli and supplied lyophilized for in vitro biochemical and cell-signaling studies of NF-κB regulation. Lyophilized material is provided from a buffered formulation and is stable when stored at recommended temperatures.
- Recombinant human NFKB inhibitor epsilon with a His tag
- Expressed in E. coli and purified for research use
- Sequence length 395 amino acids and approximate mass 57 kDa
- Lyophilized from 50 mM Tris-HCl, 200 mM NaCl, 200 mM arginine, pH 8.0, 10% glycerol
- Store frozen; stable at -20°C for long term and at 4°C for short term after reconstitution
eMolecules 17557-84-5 | 3-Azetidinone Hydrochloride | Accela ChemBio (ASD) | MFCD01861742 | 107.540 | C3H6ClNO | 97.000 | Cl.O=C1CNC1 | 25g | 588340315
3-Azetidinone Hydrochloride | Accela ChemBio (ASD) | 17557-84-5 | MFCD01861742 | 107.540 | C3H6ClNO | 97.000 | Cl.O=C1CNC1 | 25g | 588340315
Apexbio Technology LLC Aztreonam 78110-38-0 100mg
Aztreonam (CAS 78110-38-0) is a synthetic monocyclic -lactam antibiotic targeting penicillin-binding protein 3 (PBP3) It is designed to bind to PBP3 thereby disrupting bacterial cell wall synthesis and inhibiting bacterial growth Aztreonam exerts its biological activity primarily through inhibition of cell wall synthesis in aerobic Gram-negative bacteria In in vitro studies Aztreonam demonstrates selective antibacterial activity with reported IC50 values ranging from 0 05 8 g/mL against sensitive Gram-negative bacterial strains depending on species and experimental conditions Based on these pharmacological properties Aztreonam holds research potential in studies of bacterial resistance mechanisms -lactamase susceptibility profiles and evaluation of antibiotic permeability
Apexbio Technology LLC Aztreonam 78110-38-0 10mM (in 1mL DMSO)
Aztreonam (CAS 78110-38-0) is a synthetic monocyclic -lactam antibiotic targeting penicillin-binding protein 3 (PBP3) It is designed to bind to PBP3 thereby disrupting bacterial cell wall synthesis and inhibiting bacterial growth Aztreonam exerts its biological activity primarily through inhibition of cell wall synthesis in aerobic Gram-negative bacteria In in vitro studies Aztreonam demonstrates selective antibacterial activity with reported IC50 values ranging from 0 05 8 g/mL against sensitive Gram-negative bacterial strains depending on species and experimental conditions Based on these pharmacological properties Aztreonam holds research potential in studies of bacterial resistance mechanisms -lactamase susceptibility profiles and evaluation of antibiotic permeability
Sigma Aldrich Fine Chemicals Biosciences 7-Aminodesacetoxycephalosporanic acid | 22252-43-3 | MFCD09750368 | 1G
7-Aminodesacetoxycephalosporanic acid | Mol Wt: 214.24 | 22252-43-3 | MFCD09750368 | 1G
