Lactams
Selleck Chemical LLC Thalidomide S1193-1g
Thalidomide was introduced as a sedative drug immunomodulatory agent and also is investigated for treating symptoms of many cancers Thalidomide inhibits cereblon (CRBN) a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1
Medchemexpress LLC Acetamide, n-(4-azidobutyl)-thalidomide derivative | 2098488-36-7 | MFCD31560486 | 98.4% | 428.40 g/mol | C19H20N6O6 | 50 MG
Thalidomide-O-amido-C4-N3 is a thalidomide-derived E3 ligase (cereblon) ligand-linker conjugate containing an azide functional group for bioconjugation. It is used as a click-chemistry reagent and building block in targeted protein degradation (PROTAC) research. The compound has defined solubility profiles for in vitro and in vivo formulations and is supplied with storage recommendations for stability.
- Contains an azide group for CuAAc and SPAAC click reactions.
- Functions as a cereblon (CRBN) recruiter in PROTAC constructs.
- High purity verified by LCMS (98.36%).
- Good solubility in DMSO (≥ 41 mg/mL) and formulatable for in vivo use (≥ 2.5 mg/mL).
- Storage recommendations: 4°C under nitrogen; in solvent, -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Thalidomide-o-amido-c3-cooh | 2308035-51-8 | MFCD31560483 | >95.0% | 417.4 g/mol | C19H19N3O8 | 500 MG
Thalidomide-O-amido-C3-COOH is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon (CRBN) ligand with a three-carbon linker terminating in a carboxylic acid. It is intended for use in PROTAC synthesis and related chemical biology research, enabling conjugation to target-binding ligands for targeted protein degradation studies.
- Synthesized E3 ligase ligand-linker conjugate suitable for PROTAC design.
- Contains a thalidomide-derived cereblon ligand for CRBN recruitment.
- Features a C3 linker terminating in a carboxylic acid for conjugation.
- Available as a solid research-grade reagent in multiple package sizes.
- Recommended storage: 4°C under inert gas; in solvent store at -80°C for long term.
- Hazard: handle with appropriate personal protective equipment; may cause skin and eye irritation and is harmful if swallowed.
Medchemexpress LLC Thalidomide-O-amido-PEG3-C2-NH2 TFA | 1957236-21-3 | MFCD31560482 | 99.6% | 660.67 g/mol | C23H30F3N5O9 | 25 MG
Thalidomide-O-amido-PEG3-C2-NH2 TFA is a trifluoroacetate salt E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon ligand with a three-unit polyethylene glycol (PEG3) linker for use in PROTAC synthesis and related chemical biology research. It is supplied as a high-purity solid and is intended for research use only.
- Contains a thalidomide-based cereblon ligand for cereblon-mediated degradation studies.
- PEG3 linker provides flexibility and solubility for linker optimization in PROTAC design.
- Offered as a solid TFA salt for convenient handling and storage.
- High purity suitable for synthetic chemistry and biological probe development.
- Recommended storage: powder at -20°C; in solution, store at -80°C for long-term preservation.
Medchemexpress LLC Thalidomide-4-OH | 5054-59-1 | MFCD03699892 | 99.9% | 274.23 g/mol | C13H10N2O5 | 5 G
Thalidomide-4-OH is a 4-hydroxylated thalidomide derivative that serves as a cereblon (CRBN) ligand for targeted protein degradation research. It is commonly used as a building block in PROTAC design and medicinal chemistry studies and is supplied as a solid for laboratory research use only.
- Acts as a cereblon (CRBN) ligand suitable for PROTAC synthesis.
- 4-hydroxyl substitution enables linker attachment for conjugation.
- High purity supports reproducible conjugation and biological assays.
- Solid form allows convenient storage and handling.
- Useful for ligand optimization and E3 ligase recruitment studies.
TARGETMOL CHEMICALS INC ACY-957 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. ACY-957 (HDAC Inhibitor C001) is an orally active and selective inhibitor of HDAC1 and HDAC2 (IC50s 7 nM 18 nM and 1300 nM against HDAC1/2/3) and shows no inhibition on HDAC4/5/6/7/8/9. purity: 98%
![eMolecules rel-(1S,2S,5R)-3-azabicyclo[3.1.0]hexane-2-carboxylic acid;hydrochloride | 73804-69-0 | MFCD08457561 | 1g](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502136107.JPG-250.jpg)
eMolecules rel-(1S,2S,5R)-3-azabicyclo[3.1.0]hexane-2-carboxylic acid;hydrochloride | 73804-69-0 | MFCD08457561 | 1g
Pharmablock | rel-(1S,2S,5R)-3-azabicyclo[3.1.0]hexane-2-carboxylic acid;hydrochloride | 1g | 551143363 | PBN20122091-1 | | 73804-69-0 | MFCD08457561 | 163.600 | C6H10ClNO2
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