Lactams
Medchemexpress LLC Thalidomide-NH-PEG3-NH-Boc | 2204246-03-5 | 548.59 | 50 MG
Thalidomide-NH-PEG3-NH-Boc is a laboratory chemical intended for research use only. It is suitable for the manufacture of substances and should be handled by suitably qualified and experienced scientists in appropriately equipped and authorized facilities.
- For laboratory use
- For research purposes only
- To be handled by experienced personnel
- Requires appropriately equipped and authorized facilities
Medchemexpress LLC Thalidomide-NH-PEG3-propionic acid | 2138440-82-9 | 99.72% | 477.46 | 25 MG
Thalidomide-NH-PEG3-propionic acid is a synthesized E3 ligase ligand-linker conjugate used in PROTAC technology. It incorporates a thalidomide-based cereblon ligand and a 3-unit PEG linker.
- PROTACs contain two different ligands connected by a linker.
- One ligand is for an E3 ubiquitin ligase and the other is for the target protein.
- PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Stable under recommended storage conditions.
- Recommended storage temperature: 4°C, protect from light.
Selleck Chemical LLC Thalidomide-O-COOH
Thalidomide-O-COOH (Cereblon ligand 3 E3 ligase Ligand 3) a Thalidomide-based Cereblon (CRBN) ligand is used in the recruitment of CRBN protein Thalidomide-O-COOH (Cereblon ligand 3) can be connected to the ligand for protein by a linker to form PROTACs (Proteolysis Targeting Chimera)
Medchemexpress LLC Thalidomide-5-NH2-C8-NH2 TFA | 2097509-49-2 | >98.3% | 514.49 | 50 MG
Thalidomide-5-NH2-C8-NH2 TFA is a chemical compound suitable for synthesis applications.
- Used for compound synthesis
- Targeted as biochemical assay reagents
- Molecular formula: C23H29F3N4O6
Medchemexpress LLC Thalidomide 4-chloro | 244057-36-1 | MFCD30188071 | 96.0% | 292.68 g·mol⁻¹ | C13H9ClN2O4 | 1 G
Thalidomide 4-chloro is a chlorinated thalidomide derivative that functions as a cereblon (E3 ligase) ligand and E3 ligase activator. It is used in PROTAC development and as a synthetic building block for further derivatization via substitution at the 4-chloro position. The compound is supplied as a solid and is characterized for research applications.
- Molecular formula: C13H9ClN2O4.
- Molecular weight: 292.68 g·mol⁻¹.
- CAS number: 244057-36-1.
- Appearance: solid (powder).
- Purity: 96.0%.
- Intended use: E3 ligase (cereblon) ligand for PROTAC design and derivatization.
- Storage: powder -20 °C (3 years) or 4 °C (2 years); in solvent -80 °C (6 months) or -20 °C (1 month).
TARGETMOL CHEMICALS INC HKI-357 5MG
Also available in 1 mL, 1 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. HKI-357 is an irreversible dual inhibitor of EGFR and ERBB2 (IC50s 34 nM and 33 nM), effectively suppressing EGFR autophosphorylation (at Y1068), as well as AKT and MAPK phosphorylation. Purity 98.31%
Medchemexpress LLC Tetrazine tagged thalidomide | 2087490-42-2 | 98.6% | 571.58 g/mol | C29H29N7O6 | 1 ML
Tz-Thalidomide is a tetrazine-tagged thalidomide derivative supplied for research use as an E3 ligase ligand and chemical biology probe. It is offered as a ready-to-use 10 mM solution in DMSO (1 mL) and in solid quantities for synthesis and assay use, and is intended for applications in targeted protein degradation and PROTAC development.
- Tetrazine functional group enables rapid inverse electron demand Diels-Alder (iEDDA) click reactions.
- Supplied as a 10 mM solution in DMSO for immediate experimental use.
- High purity (98.6%) appropriate for biological testing and chemical biology workflows.
- Molecular weight 571.58 and formula C29H29N7O6 for accurate dosing and formulation.
- Available in solid amounts for synthetic chemistry and scale-up experiments.
Medchemexpress LLC Thalidomide-NH-PEG3-COOH | 2375283-62-6 | 98.9% | 477.46 | 100 MG
Thalidomide-NH-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate. It incorporates a thalidomide-based cereblon ligand and a linker utilized in PROTAC technology. This product is intended for research purposes only.
- Incorporates a thalidomide-based cereblon ligand
- Designed for use in PROTAC technology
- Targets cereblon
- Appears as a white to yellow solid
- Useful in cancer research applications
- Functions as an E3 ligase ligand-linker conjugate
- Involved in autophagy and apoptosis studies
- Acts as an inhibitor
Medchemexpress LLC Thalidomide-4-O-C5-NH2 hydrochloride | 2419145-66-5 | 96.9% | 395.84 | 25 MG
Thalidomide-4-O-C5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate. It incorporates a thalidomide-based cereblon ligand and a linker used in PROTAC technology. PROTACs (Proteolysis Targeting Chimeras) consist of two different ligands connected by a linker: one for an E3 ubiquitin ligase and the other for the target protein. They are utilized to exploit the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates thalidomide-based cereblon ligand
- Utilizes PROTAC technology for selective degradation of target proteins
- Exploits the intracellular ubiquitin-proteasome system
![Medchemexpress LLC 7-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}heptanoic acid | 2169266-69-5 | MFCD32063464 | 99.3% | C20H22N2O7 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000261970.png-250.jpg)
Medchemexpress LLC 7-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}heptanoic acid | 2169266-69-5 | MFCD32063464 | 99.3% | C20H22N2O7 | 10MG
Thalidomide-O-C6-COOH is a thalidomide-based cereblon (CRBN) E3 ligase ligand-linker conjugate terminating in a six-carbon carboxylic acid. It is used as a building block in PROTAC synthesis and chemical biology research, providing a convenient carboxylic acid handle for linker attachment and efficient recruitment of CRBN.
- Used in PROTAC design to recruit cereblon (CRBN) E3 ligase.
- Thalidomide-based ligand with a six-carbon carboxylic acid linker.
- High purity, 99.3% (reported).
- Soluble ≥100 mg/mL in DMSO.
- Off-white to light yellow solid suitable for synthesis.
- Molecular formula C20H22N2O7; molecular weight 402.40 g·mol⁻1.
- Storage recommendations provided for powder and solutions to maintain stability.