Lactams
Medchemexpress LLC Vh 101 phenol-alkylC6-amine dihydrochloride | 2564467-16-7 | ≥95% | 704.72 | 250 MG
VH 101 phenol-alkylC6-amine dihydrochloride is a functionalized von-Hippel-Lindau (VHL) protein-ligand designed for optimal PROTAC (Proteolysis Targeting Chimeras) functionality. It binds the VHL protein, enabling ubiquitination of target proteins, and the terminal amine on its C6 linker allows conjugation to target ligands for PROTAC synthesis.
- Functionalized VHL protein-ligand.
- Designed for optimal PROTAC functionality.
- Binds VHL protein to recruit E3 ligase.
- Enables ubiquitination of target proteins.
- Terminal amine on C6 linker allows conjugation to target ligands.
- Used in PROTAC synthesis against various targets.
![Medchemexpress LLC 6H-Thieno[3,2-f]triazolo[4,3-a]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, cyclopropyl ester, (6S)- | 3077900-08-1 | 98.3% | 440.95 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000384892-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 6H-Thieno[3,2-f]triazolo[4,3-a]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, cyclopropyl ester, (6S)- | 3077900-08-1 | 98.3% | 440.95 | 25 MG
DDL-357 is a potent secreted clusterin enhancer. It reduces phospho-tau in the brain and improves memory in the murine 3xTg-AD model. It is for research use only.
- Potent secreted clusterin enhancer.
- Reduces phospho-tau in the brain.
- Improves memory in the murine 3xTg-AD model.
Medchemexpress LLC Thalidomide-4-O-C6-NH2 hydrochloride | 2245697-88-3 | 98.5% | 409.86 | C19H24ClN3O5 | 5 MG
Thalidomide-4-O-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate supplied as the hydrochloride salt for research use. It is used as a building block in PROTAC dTAG-13, a degrader of FKBP12F36V and BET proteins, and is provided with supporting analytical data and handling documentation.
- Provided as the hydrochloride salt suitable for synthetic applications.
- High purity (98.5% by HPLC) with supporting analytical data.
- Analytical files include data sheet, COA, H NMR, and LCMS.
- Available in multiple pack sizes from milligrams to grams.
- Intended for research use only; not for human or therapeutic use.
Medchemexpress LLC Thalidomide-5-PEG4-NH2 hydrochloride | 2743434-24-2 | 95.2% | 485.92 g/mol | C21H28ClN3O8 | 5 MG
Thalidomide-5-PEG4-NH2 hydrochloride is a thalidomide-derived E3 ligase ligand-linker conjugate that combines a cereblon-binding thalidomide moiety with a four-unit PEG linker. It is intended as a research reagent for PROTAC design and targeted protein degradation studies and is supplied as a light yellow to yellow oil with reported high purity.
- Designed as an E3 ligase ligand-linker conjugate for PROTAC synthesis.
- Contains a cereblon-binding thalidomide moiety with a PEG4 linker for linker flexibility.
- High reported purity suitable for research applications (95.2%).
- Soluble in DMSO at 100 mg/mL; ultrasonic agitation recommended.
- Light yellow to yellow oil; easy to handle in synthetic workflows.
- Store sealed away from moisture; recommended storage at -20°C (in solvent: -80°C for long term).
Selleck Chemical LLC Sulbactam S1958-10mg
Sulbactam(CP45899) is a beta-lactamase inhibitor with an average IC50 of 0 8 M
Medchemexpress LLC DDL-357 | 3077900-08-1 | 98.3% | 440.95 | 100 MG
DDL-357 is a potent secreted clusterin enhancer that reduces phospho-tau in the brain and improves memory in the murine 3xTg-AD model. It is for research use only and not sold to patients.
- Potent secreted clusterin enhancer
- Reduces phospho-tau in brain
- Improves memory in the murine 3xTg-AD model
- For research use only
Medchemexpress LLC Thalidomide-o-amido-C3-COOH | 2308035-51-8 | 98.4% | 417.37 | C19H19N3O8 | 2 G
Thalidomide-O-amido-C3-COOH is an E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon ligand with a short C3 linker terminating in a carboxylic acid. It is intended for use as a CRBN-recruiting building block in PROTAC synthesis and related targeted protein degradation research.
- used as a cereblon (CRBN) recruiting building block in PROTAC synthesis
- terminates in a carboxylic acid for conjugation to target ligands
- reported purity 98.43% by LCMS
- molecular weight 417.37; formula C19H19N3O8
- storage: 4°C under nitrogen; in solution store at -80°C (6 months) or -20°C (1 month)
Medchemexpress LLC CD23/Fc epsilon RII 5ug
CD23/Fc epsilon RII Protein a low-affinity receptor for IgE and CR2/CD21 regulates IgE production and B cell differentiation On B cells it initiates IgE-dependent antigen uptake and presentation to T cells On macrophages IgE binding induces intracellular killing of parasites through the L-Arginine-nitric oxide pathway CD23/Fc epsilon RII homotrimer interacts with IGHE to regulate IgE homeostasis and with CR2/CD21 for binding CD23/Fc epsilon RII Protein Mouse (HEK293 His) is the recombinant mouse-derived CD23/Fc epsilon RII protein expressed by HEK293 with N-His labeled tag
Medchemexpress LLC Thalidomide-O-amido-C8-NH2 (TFA) | 1950635-16-1 | MFCD31560485 | >=95.0% | 572.53 g/mol | C25H31F3N4O8 | 25 MG
Thalidomide-O-amido-C8-NH2 (TFA) is a thalidomide-derived cereblon ligand-linker conjugate supplied as the trifluoroacetic acid salt. It is intended for use as a building block in PROTAC synthesis and other E3 ligase ligand-linker research in chemical biology.
- Chemical form: TFA salt.
- Chemical formula: C25H31F3N4O8.
- CAS number: 1950635-16-1.
- Molecular weight: 572.53 g/mol.
- Appearance: solid.
- Typical use: building block for PROTAC and E3 ligase ligand-linker conjugate synthesis.
- Purity: high (≥95%).