Lactams
Medchemexpress LLC S-thalidomide-4-OH | 2357105-36-1 | MFCD03699892 | 98.0% | 274.23 | C13H10N2O5 | 25 MG
(S)-Thalidomide-4-OH is the S-enantiomer of thalidomide-4-OH, a thalidomide-based cereblon (CRBN) ligand used in chemical biology and proteolysis-targeting chimera (PROTAC) design. Supplied as a high-purity powder, it is intended for research use in CRBN recruitment studies and degrader synthesis.
- High purity (98.0%) for research applications.
- S-enantiomer for stereospecific biochemical studies.
- Useful cereblon ligand for PROTAC conjugation.
- Available in small milligram quantities for screening and synthesis.
- Stable when stored under recommended conditions.
Medchemexpress LLC 1H-isoindole-4-carboxylic acid, 2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo | 1547163-38-1 | MFCD32063448 | 98.0% | 302.24 g·mol-1 | C14H10N2O6 | 500 MG
Thalidomide acid is a thalidomide-derived cereblon (CRBN) ligand bearing a carboxylic acid functional group, supplied as a solid research reagent. It is intended for use as an E3 ligase recruiting moiety in PROTAC design and related chemical biology and synthetic applications.
- Ligand for E3 ligase (CRBN) used in targeted protein degradation research.
- Carboxylic acid handle enables amide coupling and linker attachment.
- High purity (98.0%) suitable for analytical and synthetic work.
- Solid powder form for convenient handling and formulation.
- Molecular weight 302.24 g·mol-1; formula C14H10N2O6.
- Identified by CAS number 1547163-38-1 for unambiguous chemical lookup.
Medchemexpress LLC Thalidomide-4-Br | 2093536-12-8 | MFCD31730866 | 99.6% | 337.13 | C13H9BrN2O4 | 50 MG
Thalidomide-4-Br is a brominated thalidomide derivative used as a cereblon/bromodomain ligand in preclinical research on inflammation, oncology, and neurology. It is supplied as a solid, off-white to gray powder with characterized identity and stability data.
- High purity (reported ≈99.6%).
- Well characterized: CAS 2093536-12-8; formula C13H9BrN2O4; molecular weight 337.13.
- Available in multiple package sizes, including small (50 mg) and larger quantities.
- Defined storage and stability: powder -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months) or -20°C (1 month).
- Suitable for cereblon-targeting studies and use as a ligand in PROTAC development.
Medchemexpress LLC Thalidomide-5-OH | 64567-60-8 | 98.2% | 274.23 | 25 G
Thalidomide-5-OH is a thalidomide-based cereblon ligand. It is used in the recruitment of CRBN protein and can be connected to a target protein ligand via a linker to form PROTACs.
- Thalidomide-based cereblon ligand
- Recruits CRBN protein
- Connects to protein ligands via a linker to form PROTACs
- Targets cereblon
Medchemexpress LLC Thalidomide-5-O-C13-NH2 (hydrochloride) | 99.9% | 508.05 | 5 MG
Thalidomide-5-O-C13-NH2 hydrochloride is a cereblon ligand based on Thalidomide. It is utilized in the recruitment of CRBN protein and can be connected to a protein ligand by a linker to form PROTACs.
- Cereblon ligand
- Used in the recruitment of CRBN protein
- Can be connected to a protein ligand by a linker
- Forms PROTACs
Cayman Chemical AzIdo-ThalIdomIde 10mg
A PROTAC building block; contains thalidomide, which is a ligand for the E3 ubiquitin ligase cereblon, and can be conjugated to alkynylated ligands for target proteins via click chemistry; has been used in the synthesis of a SirReal-based PROTAC for the degradation of Sirt2 in cells
Medchemexpress LLC Thalidomide-pinacolborane | 2229725-98-6 | 97.0% | 384.19 g/mol | C19H21BN2O6 | 50 MG
Thalidomide-pinacolborane is a thalidomide analogue containing a pinacol boronate (Bpin) group, supplied as a research reagent for use in synthetic chemistry and chemical biology. It is suitable as a building block for cross-coupling reactions and as a probe to investigate E3 ligase-mediated ubiquitination in degradation studies.
- Contains a pinacol boronate functional group for cross-coupling chemistry.
- Useful as a synthetic intermediate in Suzuki-Miyaura reactions.
- Acts as a thalidomide analogue for studying E3 ligase activity.
- Supplied as a high-purity research chemical suitable for analytical and preparative use.
- Provided in small-quantity packaging for laboratory experiments.
Medchemexpress LLC Thalidomide-NH-C10-NH2 hydrochloride | 2460022-53-9 | 464.99 | C23H33ClN4O4 | 10 MG
Thalidomide-NH-C10-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied as a hydrochloride salt in solid form for research use. It is intended for incorporation into PROTACs and other E3 ligase recruiting conjugates for chemical biology and medicinal chemistry studies.
- Thalidomide-derived cereblon ligand for E3 ligase recruitment.
- Suitable for PROTAC construction and linker conjugation.
- Provided as a solid hydrochloride salt for stability and handling.
- Available in small milligram packages appropriate for synthesis and assays.
- Store sealed, away from moisture and light; follow supplier storage guidance.
![eMolecules Medchem Express / Thalidomide-4-O-C6-NH2 (hydrochloride) / 5mg / 599150703 / HY-135250B / / 2245697-88-3 / [null] / 409.870 / C19H24ClN3O5](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502484194.JPG-250.jpg)
eMolecules Medchem Express / Thalidomide-4-O-C6-NH2 (hydrochloride) / 5mg / 599150703 / HY-135250B / / 2245697-88-3 / [null] / 409.870 / C19H24ClN3O5
Medchem Express / Thalidomide-4-O-C6-NH2 (hydrochloride) / 5mg / 599150703 / HY-135250B / / 2245697-88-3 / [null] / 409.870 / C19H24ClN3O5
Medchemexpress LLC Thalidomide-4-O-C12-NH2 hydrochloride | 95.6% | 494.02 | C25H36ClN3O5 | 10 MG
Thalidomide-4-O-C12-NH2 hydrochloride is a thalidomide-derived cereblon ligand provided as the hydrochloride salt for use in chemical biology and medicinal chemistry applications. It functions as a CRBN E3 ligase recruiter for targeted protein degradation and is intended for use in PROTAC and ligand-linker conjugation studies. Store protected from light at recommended temperatures.
Medchemexpress LLC Thalidomide-4-O-C9-NH2 hydrochloride | >98.0% | 451.94 g/mol | C22H30ClN3O5 | 10 MG
Thalidomide-4-O-C9-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand intended for use in targeted protein degradation and PROTAC development. Supplied as the hydrochloride salt for conjugation chemistry, the compound is offered for research use and is commonly provided in small milligram quantities for medicinal chemistry and chemical biology applications.
- Acts as a cereblon (CRBN) ligand for E3 ligase recruitment.
- Designed for use in PROTAC and targeted protein degradation research.
- Provided as a hydrochloride salt suitable for conjugation chemistry.
- Reported purity ≥98% according to vendor listings.
- Molecular weight ~451.94 g/mol; formula C22H30ClN3O5.
- Store sealed at -20°C to maintain stability.