Lactams
Medchemexpress LLC Thalidomide-o-amido-peg3-c2-nh2 (TFA) | 1957236-21-3 | MFCD31656717 | 99.6% | 620.53 g/mol | C25H31F3N4O11 | 50 MG
Thalidomide-O-amido-PEG3-C2-NH2 TFA is a Thalidomide-based cereblon E3 ligase ligand-linker conjugate provided as the trifluoroacetate salt. It contains a three-unit polyethylene glycol (PEG3) linker and a terminal C2 primary amine for conjugation, and is intended as a building block for PROTAC synthesis and cereblon recruitment studies.
- Cereblon-binding thalidomide ligand with a three-unit PEG linker.
- Terminal primary amine (C2) for facile conjugation to targeting ligands.
- Provided as a trifluoroacetate (TFA) salt for handling stability.
- High purity confirmed by LCMS (~99.6%).
- Molecular weight 620.53 g/mol and CAS 1957236-21-3 for unambiguous identification.
Medchemexpress LLC Thalidomide-piperazine-PEG1-COOH | 2731007-11-5 | 99.2% | 458.46 | 25 MG
Thalidomide-Piperazine-PEG1-COOH is a synthetic E3 ligase ligand-linker coupler containing a Thalidomide-based ligand and one linker. It acts as an E3 ligase ligand-linker conjugate.
- E3 ligase ligand-linker coupler
- Contains a Thalidomide-based ligand and one linker
Medchemexpress LLC Thalidomide-NH-C6-NH-Boc | 2093536-13-9 | 96.1% | 250 MG
Thalidomide-NH-C6-NH-Boc is a synthesized E3 ligase ligand-linker conjugate. It incorporates a Thalidomide-based cereblon ligand and a linker that was utilized in the synthesis of MI-389 (compound 22). MI-389 is recognized as a potent phthalimide PROTAC degrader, derived from the multi-targeted receptor tyrosine kinase inhibitor sunitinib (HY-10255A). This product is intended for research use only and is not sold to patients.
- E3 ligase ligand-linker conjugate: contains a Thalidomide-based cereblon ligand.
- PROTAC component: the linker is used in the synthesis of MI-389, a potent phthalimide PROTAC degrader.
- Research use only: exclusively for research purposes.
Medchemexpress LLC Thalidomide-iodo | 2509137-01-1 | MFCD31735039 | 98.0% | 384.13 g/mol | C13H9IN2O4 | 250 MG
Thalidomide-iodo is an iodinated derivative of thalidomide that functions as an E3 ligase activator for chemical biology and medicinal chemistry research. It is supplied as a solid research reagent and can be used as a synthetic building block for further derivatization via substitution of the iodine atom.
- Iodinated thalidomide derivative suitable for E3 ligase activation studies.
- Useful as a synthetic building block for iodine substitution and derivatization.
- High purity (≥98.0%) appropriate for research applications.
- Molecular weight 384.13 g/mol; formula C13H9IN2O4.
- CAS number 2509137-01-1 for unambiguous identification.
Medchemexpress LLC Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride | 2341841-02-7 | 99.3% | 410.81 | 25 MG
Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a linker. This compound is suitable for designing PROTACs.
- Incorporates a cereblon (CRBN) ligand for E3 ubiquitin ligase
- Contains a linker
- Suitable for designing PROTACs
- Relevant to cancer targeted therapy, cancer metabolism, and metastasis
- Related to PROTAC research
- Involved in autophagy studies
- Used in apoptosis research
- Applicable to E3 ligase ligand-linker conjugates
Medchemexpress LLC Thalidomide-Piperazine-PEG3-COOH | 2797619-63-5 | 99.89% | 546.57 | 25 MG
A synthesized ligand-linker conjugate is described as incorporating a cereblon ligand and a linker often employed in protein degradation technology. This conjugate is intended for research applications only and not for patient use.
- Synthesized conjugate.
- Incorporates a cereblon ligand.
- Utilizes a linker as part of protein degradation technology.
- Composed of two distinct ligands joined by a linker.
- One ligand targets an E3 ubiquitin ligase.
- The other ligand targets a specific protein.
- Leverages the intracellular ubiquitin-proteasome system.
- Aims for selective degradation of target proteins.
- For research purposes only.
eMolecules 1061605-21-7 | Thalidomide-O-C1-acid | Broadpharm332.268 | C15H12N2O7 | 98.000 | OC(=O)COc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 | 1g | 550804650
Thalidomide-O-C1-acid | Broadpharm | 1061605-21-7332.268 | C15H12N2O7 | 98.000 | OC(=O)COc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 | 1g | 550804650
Medchemexpress LLC Thalidomide-NH-C5-NH2 hydrochloride | 2375194-03-7 | 99.9% | 394.85 | 250 MG
Thalidomide-NH-C5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. It is for research use only and not sold to patients.
- Targets cereblon.
- Utilizes PROTAC technology for selective degradation of target proteins.
- Soluble in DMSO at 250 mg/mL (633.15 mM) with ultrasonication.
- In vivo dissolution protocols available for clear solutions.
- Ships at room temperature in continental US.
- Solid storage at -20°C, sealed, away from moisture and light.
- Storage in solvent at -80°C for 6 months or -20°C for 1 month.
Sigma Aldrich Fine Chemicals Biosciences Pomalidomide >=98% (HPLC) | 19171-19-8 | MFCD12756407 | 25MG
Pomalidomide >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 273.24 | 19171-19-8 | MFCD12756407 | 25MG
Medchemexpress LLC Thalidomide-O-amido-PEG4-azide | 2411681-89-3 | 99.19% | C25H32N6O10 | 100 MG
Thalidomide-O-amido-PEG4-azide is a PEG-based PROTAC linker designed for the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an Azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. It also participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. PROTACs utilizing this linker are engineered to selectively degrade target proteins by exploiting the intracellular ubiquitin-proteasome system.
- PEG-based PROTAC linker
- Click chemistry reagent with Azide group
- Enables CuAAc reactions with alkyne groups
- Facilitates SPAAC reactions with DBCO or BCN groups
- Used in the synthesis of PROTACs
Medchemexpress LLC Thalidomide-5-O-CH2-COOH | 2467425-53-0 | MFCD34186095 | 95.0% | 332.26 g/mol | C15H12N2O7 | 50 MG
Thalidomide-5-O-CH2-COOH is an E3 ligase ligand-linker conjugate used as a cereblon (CRBN) ligand and an intermediate for the synthesis of PROTAC molecules. Supplied as a solid with supplier-characterized purity, it is intended for research applications in targeted protein degradation.
- Acts as a cereblon ligand for targeted protein degradation research.
- Suitable intermediate for PROTAC synthesis and conjugation chemistry.
- Approximately 95.0% purity, characterized by supplier analytical data.
- Solid form, light yellow to brown appearance for easy handling.
- Good solubility in DMSO for in vitro formulation and assays.
- Stable when stored under recommended conditions for long-term use.
Medchemexpress LLC Thalidomide-5-o-c9-nh2 hydrochloride | 99.6% | 451.94 g·mol⁻1 | C22H30ClN3O5 | 10 MG
Thalidomide-5-O-C9-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand intended for chemical biology research. Supplied as the hydrochloride salt, it is used as an E3 ligase recruiting moiety in PROTACs and related conjugates. The product is reported with molecular formula C22H30ClN3O5 and molecular weight 451.94 g·mol⁻1.
- High purity: 99.6%.
- Hydrochloride salt form for improved handling and solubility.
- Designed for recruitment of cereblon (CRBN) in PROTAC construction.
- Suitable for synthesis, assay development, and linker conjugation.
- Available in small research pack sizes for laboratory use.
Medchemexpress LLC Thalidomide-5-PEG3-NH2 hydrochloride | 2761385-81-1 | 97% | 441.86 | 1 MG
Thalidomide-5-PEG3-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. It has an IC 50 of Cereblon.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide-based cereblon ligand
- Used in PROTAC technology
- Solid form
- White to off-white color
Medchemexpress LLC Thalidomide-O-C6-NHBoc | 2509093-23-4 | 95.99% | C24H31N3O7 | 50 MG
Thalidomide-O-C6-NHBoc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. It is for research use only and not sold to patients. The product appears as an off-white to light yellow solid with a molecular weight of 473.52.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide based cereblon ligand
- Linker used in PROTAC technology
- For research use only
- Appears as an off-white to light yellow solid
- Molecular weight of 473.52
Medchemexpress LLC Thalidomide-5-PEG6-NH2 hydrochloride | 574.02 g/mol | C25H36ClN3O10 | 10 MG
Thalidomide-5-PEG6-NH2 hydrochloride is a thalidomide-derived cereblon ligand designed as a synthetic building block for targeted protein degradation research. The molecule includes a PEG6 linker terminating in a primary amine (hydrochloride salt) that enables conjugation to linkers or target ligands for PROTAC construction. Storage and handling conditions are provided to maintain stability.