Lactams
Medchemexpress LLC Thalidomide-NH-PEG3-COOH | 2375283-62-6 | 98.9% | C22H27N3O9 | 10MG
Thalidomide-NH-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate that links a thalidomide-derived cereblon (CRBN) ligand to a three-unit polyethylene glycol (PEG3) spacer terminated with a carboxylic acid. It is designed as a building block for PROTAC synthesis to recruit the CRBN E3 ligase and enable conjugation to target-binding ligands.
- High reported purity (98.9%).
- Includes a thalidomide-derived cereblon ligand for CRBN recruitment.
- PEG3 spacer provides flexible, hydrophilic linkage.
- Terminal carboxylic acid enables standard coupling chemistries.
- Soluble in DMSO for common assay and synthesis workflows.
- Supplied as a solid suitable for storage and handling in research labs.
Medchemexpress LLC Aztreonam E-isomer | 99341-02-3 | MFCD09028013 | 98.7% | C13H17N5O8S2 | 10MG
(E)-Aztreonam is the E-isomer of the monocyclic β-lactam antibiotic aztreonam, provided as a research-grade powder for in vitro studies of gram-negative bacterial infections and related assays. The material is characterized by a molecular weight of 435.43 and a reported purity of about 98.7%; follow recommended storage to preserve stability.
- Monocyclic β-lactam antibiotic, E-isomer
- Reported purity approximately 98.7%
- Intended for in vitro research on gram-negative pathogens
- Supplied as a powder with defined storage conditions
- Molecular formula C13H17N5O8S2; molecular weight 435.43
- Available in small milligram quantities suitable for analytical use
Medchemexpress LLC Thalidomide-5-PEG6-NH2 hydrochloride | 574.02 g/mol | C25H36ClN3O10 | 10 MG
Thalidomide-5-PEG6-NH2 hydrochloride is a thalidomide-derived cereblon ligand designed as a synthetic building block for targeted protein degradation research. The molecule includes a PEG6 linker terminating in a primary amine (hydrochloride salt) that enables conjugation to linkers or target ligands for PROTAC construction. Storage and handling conditions are provided to maintain stability.
Medchemexpress LLC Thalidomide-5-O-C3-NH2 hydrochloride | 2694727-94-9 | MFCD34475114 | 99.1% | 367.78 g/mol | C16H18ClN3O5 | 10 MG
Thalidomide-5-O-C3-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied as the hydrochloride salt for use as a building block in targeted protein degradation research and PROTAC design. It is provided as a solid with supporting analytical data for research use.
- Acts as a cereblon-binding ligand for CRBN recruitment.
- Enables linker conjugation for PROTAC assembly.
- Supplied with high purity (99.08%).
- Provided as a solid suitable for long-term storage under recommended conditions.
- Analytical data and COA available to support research use.
Medchemexpress LLC Thalidomide-NH-PEG1-NH2 hydrochloride | 2154342-56-8 | 99.2% | C17H21ClN4O5 | 10MG
Thalidomide-NH-PEG1-NH2 hydrochloride is a thalidomide-derived cereblon E3 ligase ligand-linker conjugate supplied as the hydrochloride salt and intended as a building block for PROTAC design and small-molecule degradation strategies. It couples a cereblon-recruiting moiety with a short PEG1 diamine linker to facilitate conjugation to target-binding ligands and streamline synthesis workflows.
- Provides thalidomide-based cereblon recruiting moiety.
- Includes a short PEG1 diamine linker for flexibility in conjugation.
- Supplied as hydrochloride salt for improved stability and handling.
- High purity suitable for synthetic applications (99.2%).
- Available in small milligram quantities for early-stage research.
Medchemexpress LLC Thalidomide-O-C8-COOH | 2225148-51-4 | 97.4% | C22H26N2O7 | 10MG
Thalidomide-O-C8-COOH is a thalidomide-derived cereblon (CRBN) ligand supplied as a solid research reagent for use in PROTAC design and chemical biology studies. It has molecular formula C22H26N2O7, molecular weight 430.45 g/mol, and a reported purity of 97.44%.
- Used as a cereblon E3 ligase recruiting moiety in PROTAC synthesis.
- White to off-white solid suitable for laboratory handling.
- Reported purity of 97.4% for research applications.
- Storage guidance provided for long-term and in-solvent conditions.
- Available in small research quantities for assay development.
- For research use only; not for human or clinical use.
Medchemexpress LLC Biotin-thalidomide | 2230857-87-9 | MFCD32851674 | 99.7% | C44H64N8O13S | 10MG
Biotin-thalidomide is a biotin-conjugated thalidomide derivative that binds the cereblon (CRBN) E3 ligase and is supplied as a high-purity reagent for use in PROTAC synthesis and biochemical assays.
- Binds cereblon (CRBN) E3 ligase
- Suitable for PROTAC synthesis and biochemical binding studies
- Facilitates affinity capture and pull-down assays via biotin tag
- Provided as a high-purity reagent for research use
- Characterized by molecular formula and SMILES for cheminformatics
Medchemexpress LLC Thalidomide-O-C8-Boc | 2225148-52-5 | MFCD32701934 | 95.1% | C26H34N2O7 | 10MG
Thalidomide-O-C8-Boc is a thalidomide-derived Cereblon (CRBN) ligand intended for use as the E3 ligase-recruiting moiety in PROTAC design. It features an O-linked eight-carbon spacer with a Boc-protected terminus to enable linker attachment. Manufacturer data report molecular formula C26H34N2O7, molecular weight 486.56, and typical purity ~95%.
- Provides an O-linked C8 spacer with a Boc-protected terminus for linker attachment.
- Suitable for recruiting Cereblon (CRBN) as the E3 ligase in degrader strategies.
- Reported purity approximately 95.1%.
- High solubility in DMSO (100 mg/mL); manufacturer lists example in vivo formulations.
- Recommended storage: solid at -20°C under nitrogen; in solution -80°C (6 months) or -20°C (1 month).
eMolecules 1061605-21-7 | Thalidomide-O-C1-acid | Broadpharm332.268 | C15H12N2O7 | 98.000 | OC(=O)COc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 | 1g | 550804650
Thalidomide-O-C1-acid | Broadpharm | 1061605-21-7332.268 | C15H12N2O7 | 98.000 | OC(=O)COc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 | 1g | 550804650
Medchemexpress LLC Thalidomide-5-methyl | 40313-92-6 | 99.9% | 272.26 | 50 MG
Thalidomide-5-methyl is a cereblon (CRBN) ligand, based on Thalidomide, used in the recruitment of CRBN protein. It can be utilized for the synthesis of PROTACs and is intended for research use only.
- Cereblon (CRBN) ligand
- Recruits CRBN protein
- Utilized for PROTAC synthesis
- Molecular weight: 272.26
- Solid appearance, gray to gray purple color
- Soluble in DMSO (50 mg/mL with warming)
- Recommended storage at 4°C, sealed, away from moisture
- In solvent, store at -80°C for 6 months or -20°C for 1 month
Medchemexpress LLC VH 101 phenol-alkylC6-amine dihydrochloride | 2564467-16-7 | 95% | 704.72 | 25 MG
VH 101 phenol-alkylC6-amine dihydrochloride is a functionalized von-Hippel-Lindau (VHL) protein-ligand that can be used for PROTAC synthesis.
- Target: E3 Ligase Ligand-Linker Conjugates
- Pathway: PROTAC
![Medchemexpress LLC 5,8,11-Trioxa-2-azatridecanoic acid, 13-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl)amino]-, 1,1-dimethylethyl ester | 2204246-03-5 | 97.2% | 548.59 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000403850-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 5,8,11-Trioxa-2-azatridecanoic acid, 13-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl)amino]-, 1,1-dimethylethyl ester | 2204246-03-5 | 97.2% | 548.59 | 5 MG
Thalidomide-NH-PEG3-NH-Boc is a chemical compound that appears as a light yellow to yellow oil. This product has been thoroughly tested and complies with the given specifications, ensuring its quality and suitability for research purposes.
- Molecular formula: C26H36N4O9
- Molecular weight: 548.59
- Purity (LCMS): 97.20%
- Storage for pure form: -20°C for 3 years; 4°C for 2 years
- Storage in solvent: -80°C for 6 months; -20°C for 1 month