Lactams
Medchemexpress LLC 2,6-piperidinedione, 3-(1,3-dihydro-5-iodo-1-oxo-2H-isoindol-2-yl) | 2291364-01-5 | MFCD32853043 | 98.0% | 370.14 g·mol⁻¹ | C13H11IN2O3 | 1 G
Deoxy-thalidomide-5-iodine is a thalidomide analogue used as an E3 ligase ligand in PROTAC research and cereblon-targeting studies. Supplied as a high-purity solid, it is commonly used as a building block for synthesis of degraders and chemical probes.
- High purity suitable for research (98.0%).
- Chemical formula C13H11IN2O3.
- Molecular weight 370.14 g·mol⁻¹.
- Useful as an E3 ligase (cereblon) ligand in PROTAC design.
- Solid form for ease of handling and storage.
- Store protected from light at refrigerated temperatures; in solvent: -80°C (6 months), -20°C (1 month).
Medchemexpress LLC S-thalidomide-4-OH | 2357105-36-1 | MFCD03699892 | 98.0% | 274.23 | C13H10N2O5 | 25 MG
(S)-Thalidomide-4-OH is the S-enantiomer of thalidomide-4-OH, a thalidomide-based cereblon (CRBN) ligand used in chemical biology and proteolysis-targeting chimera (PROTAC) design. Supplied as a high-purity powder, it is intended for research use in CRBN recruitment studies and degrader synthesis.
- High purity (98.0%) for research applications.
- S-enantiomer for stereospecific biochemical studies.
- Useful cereblon ligand for PROTAC conjugation.
- Available in small milligram quantities for screening and synthesis.
- Stable when stored under recommended conditions.
Medchemexpress LLC Thalidomide-Piperazine-PEG2-NH2 (diTFA) | 99.7% | 701.57 | 25 MG
Thalidomide-Piperazine-PEG2-NH2 diTFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide-based cereblon ligand and a linker used in PROTAC technology. It is for research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide-based cereblon ligand
- Includes a linker used in PROTAC technology
- Targets Cereblon
- Utilizes the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Thalidomide 4-fluoride (Cereblon ligand 4) | 835616-60-9 | 99.83% | 276.22 | 25 G
Thalidomide 4-fluoride (Cereblon ligand 4) is a Thalidomide-based Cereblon ligand that is utilized in the recruitment of the CRBN protein. It can be linked to the ligand for IRAK4 protein via a linker to form PROTAC IRAK4 degrader-1. It is for research use only and not sold to patients.
- Purity: 99.83%
- Molecular weight: 276.22
- Formula: C13H9FN2O4
- CAS No.: 835616-60-9
- Appearance: Solid
- Color: Off-white to gray
- Solubility (in vitro): DMSO : 200 mg/mL (724.05 mM; requires ultrasonic; hygroscopic DMSO impacts solubility, use newly opened DMSO)
- Storage (powder): -20°C for 3 years, 4°C for 2 years
- Storage (in solvent): -80°C for 2 years, -20°C for 1 year
Cayman Chemical ThalIdomIde 25mg
An active enantiomer of (±)-thalidomide; enhances TPA-induced TNF-α production in HL-60 cells from 0.1-100 µM; preincubation of isolated RIR chicken donor blood reduces recipient chicken embryo splenomegaly in a model of graft versus host disease at 10 mg/ml; induces fetal malformations when administered to pregnant female rabbits at 150 mg/kg
Medchemexpress LLC Thalidomide-O-C8-Boc | 2225148-52-5 | 95.1% | 250 MG
Thalidomide-O-C8-Boc is a Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. It can be linked to a ligand for protein via a linker to create PROTACs. This product is a white to off-white solid, stable under recommended storage conditions, and intended for research use only.
- Cereblon ligand
- Utilized in CRBN protein recruitment
- Can be linked to a ligand for protein via a linker to create PROTACs
- Solid appearance
- White to off-white color
- Stable under recommended storage conditions
- Research use only
Medchemexpress LLC Vh 101 phenol-alkylc6-amine dihydrochloride | 2564467-16-7 | 704.72 | 50 MG
VH 101 phenol-alkylC6-amine dihydrochloride is a functionalized von-Hippel-Lindau (VHL) protein-ligand. This compound is suitable for PROTAC synthesis.
- Functionalized von-Hippel-Lindau (VHL) protein-ligand
- Can be used for PROTAC synthesis
Medchemexpress LLC 1H-isoindole-4-carboxylic acid, 2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo | 1547163-38-1 | MFCD32063448 | 98.0% | 302.24 g·mol-1 | C14H10N2O6 | 500 MG
Thalidomide acid is a thalidomide-derived cereblon (CRBN) ligand bearing a carboxylic acid functional group, supplied as a solid research reagent. It is intended for use as an E3 ligase recruiting moiety in PROTAC design and related chemical biology and synthetic applications.
- Ligand for E3 ligase (CRBN) used in targeted protein degradation research.
- Carboxylic acid handle enables amide coupling and linker attachment.
- High purity (98.0%) suitable for analytical and synthetic work.
- Solid powder form for convenient handling and formulation.
- Molecular weight 302.24 g·mol-1; formula C14H10N2O6.
- Identified by CAS number 1547163-38-1 for unambiguous chemical lookup.
Medchemexpress LLC Thalidomide-piperazine-PEG1-NH2 diTFA | 00-00-0 | 99.4% | C25H29F6N5O9 | 10MG
Thalidomide-Piperazine-PEG1-NH2 diTFA is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-based cereblon ligand with a short PEG1/piperazine linker for PROTAC design. Intended for research use only, the compound is supplied as a solid (white to yellow) with characterized solubility and storage recommendations to support experimental workflows.
- High purity for research use (99.4%).
- Thalidomide-based cereblon ligand facilitates E3 ligase recruitment.
- Short PEG1/piperazine linker suitable for PROTAC assembly.
- DMSO solubility: 100 mg/mL; sonication recommended.
- In vivo formulation options reach ~2.5 mg/mL as suspended or clear solutions.
- Storage: sealed at 4°C; in solvent -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC (R)-(+)-thalidomide | 260939 | MFCD00210220 | 99.8% | C13H10N2O4 | 10MG
(R)-Thalidomide is the R-enantiomer of thalidomide supplied for research use. It is reported to have psychomotor stabilizing properties and is used as a ligand in studies of cereblon-mediated E3 ligase interactions and related cellular pathways. Provided as a high-purity research chemical for biochemical and cellular assays.
- R-enantiomer of thalidomide for stereospecific studies.
- High purity 99.8% suitable for analytical and biological assays.
- Useful for research on cereblon and E3 ligase interactions.
- Available in milligram scales for laboratory research.
- For research use only; not for human or clinical use.
Medchemexpress LLC Thalidomide 4-fluoride | 835616-60-9 | 99.8% | 276.22 | 100 G
Thalidomide 4-fluoride, also known as Cereblon ligand 4, is a Thalidomide-based Cereblon ligand. It is utilized in the recruitment of CRBN protein, a component of the cullin-4 E3 ubiquitin ligase complex. This compound mediates the ubiquitination and subsequent proteasomal degradation of target proteins, and can be connected to other ligands to form PROTAC degraders.
- Thalidomide-based cereblon ligand.
- Used in the recruitment of CRBN protein.
- Targets cereblon (CRBN), a part of the E3 ubiquitin ligase complex.
- Mediates ubiquitination and proteasomal degradation of target proteins.
- Can be used to form PROTAC degraders.
Medchemexpress LLC Vh 101 phenol-alkylC6-amine dihydrochloride | 2564467-16-7 | ≥95% | 704.72 | 250 MG
VH 101 phenol-alkylC6-amine dihydrochloride is a functionalized von-Hippel-Lindau (VHL) protein-ligand designed for optimal PROTAC (Proteolysis Targeting Chimeras) functionality. It binds the VHL protein, enabling ubiquitination of target proteins, and the terminal amine on its C6 linker allows conjugation to target ligands for PROTAC synthesis.
- Functionalized VHL protein-ligand.
- Designed for optimal PROTAC functionality.
- Binds VHL protein to recruit E3 ligase.
- Enables ubiquitination of target proteins.
- Terminal amine on C6 linker allows conjugation to target ligands.
- Used in PROTAC synthesis against various targets.
Medchemexpress LLC Thalidomide-O-COOH | 1061605-21-7 | MFCD31560477 | 99.9% | 332.26 g/mol | C15H12N2O7 | 5 G
Thalidomide-O-COOH is a thalidomide-derived carboxylic acid used as a cereblon (CRBN) ligand building block in PROTAC design and E3 ligase recruitment studies. It is supplied as a high-purity research chemical in small laboratory pack sizes for medicinal chemistry and chemical biology applications.
- Thalidomide-derived cereblon ligand for PROTAC design.
- Carboxylic acid functionality enables linker attachment and derivatization.
- Supplied as a solid suitable for standard laboratory storage.
- Provided in small research pack sizes for synthesis and assay development.
- High reported purity supports use in chemical biology experiments.
Medchemexpress LLC Thalidomide-piperazine 5-fluoride hydrochloride | 2222114-23-8 | MFCD32203462 | 98.9% | 396.80 g/mol | C17H18ClFN4O4 | 1 G
Thalidomide-piperazine 5-fluoride hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied as a hydrochloride salt for use in PROTAC synthesis and related cereblon-targeted chemical biology research. It is intended for research use and is provided with documented purity and stability data for handling and storage.
- Thalidomide-based cereblon ligand for PROTAC synthesis.
- Hydrochloride salt form for improved handling and solubility.
- High purity suitable for synthetic and analytical workflows.
- Documented stability under cold storage conditions.
- Provided in a small-scale research package for medicinal chemistry.
Medchemexpress LLC Thalidomide 5-fluoride | 835616-61-0 | MFCD30188075 | 100.0% | 276.22 g/mol | C13H9FN2O4 | 10 G
Thalidomide 5-fluoride is a thalidomide-derived cereblon ligand used as a building block in PROTAC degraders and other bifunctional molecules. It is supplied as a high-purity solid reagent intended for research and chemical biology applications.
- High purity solid (99.96%).
- Molecular weight 276.22 g/mol.
- Molecular formula C13H9FN2O4.
- Available in laboratory pack sizes, including 10 G.
- Storage: powder at -20°C for long-term, 4°C for shorter term; in solvent store at -80°C.