Lactones
Selleck Chemical LLC GA-017-E1145-10MM/1ML
GA-017 inhibits the serine/threonine protein kinases large tumor suppressor kinase 1/2 (LATS1/2) which exerts inhibitory with IC50s against LATS1 and 2 of 4 10 0 79 and 3 92 0 42 nM respectively and competitively inhibits LATS1 and 2 against ATP with Ki (inhibition constant) values of 0 58 0 11 and 0 25 0 03 nM respectively
Medchemexpress LLC IFN-gamma R1/CD119 50ug
IFN-gamma R1 (CD119) one of the subunit of IFN-gamma receptor is a receptor for IFN-gamma IFN-gamma R1 forms the functional receptor with IFN-gamma R2 Upon binding with IFN-gamma IFN-gamma R1 and IFN-gamma R2 oligomerize and transphosphorylate[1] Then JAK1 and JAK2 are phosphorylated and activated and STAT1 is recruited to the receptor complex Phosphorylated STAT1 translocates to the nucleus where it regulates the expression of IFN-responsive genes (e g CD54)[2] IFN-gamma R1/CD119 Protein Mouse (HEK293 His) is a recombinant mouse IFN-gamma R1 with C-terminal 6 His tag which is produced in HEK293 cells
Medchemexpress LLC Interleukin-36 gamma | 50 UG
Recombinant human interleukin-36 gamma (IL-36γ, IL-1F9) is an animal-free, E. coli-expressed cytokine supplied as a lyophilized His-tagged protein. It activates NF-κB and MAPK signaling and induces chemokine expression; biological activity in A431 cells shows an ED50 <5 ng/mL. The product is formulated in PBS with trehalose, has low endotoxin, and is intended for cell-culture research use.
- Lyophilized His-tagged recombinant human IL-36γ.
- Expressed in Escherichia coli to provide animal-free material.
- Approximate molecular weight ~19 kDa by SDS-PAGE.
- Low endotoxin level (<0.1 EU per μg).
- Demonstrated biological activity: ED50 <5 ng/mL (IL-8 induction in A431 cells).
- Formulated in PBS, pH 8.0, with trehalose for stability.
- Reconstitute to 100-200 μg/mL and aliquot to avoid freeze-thaw cycles.
- For research use only; not for therapeutic or human use.
Medchemexpress LLC IFN-gamma Canine 100ug | 100ug
IFN-gamma (interferon-gamma) is a type II interferon produced by immune cells such as T cells and NK cells and plays a key role in activating antibacterial antiviral and antitumor responses Through the JAK-STAT pathway its interaction with the receptor IFNGR1 triggers gene regulation IFN-gamma Protein Canine is the recombinant canine-derived IFN-gamma protein expressed by E coli with tag free
![Medchemexpress LLC 8-benzyl-4-oxo-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid | 960201-81-4 | 99.1% | 329.35 g/mol | C18H19NO5 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000241614.png-250.jpg)
Medchemexpress LLC 8-benzyl-4-oxo-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid | 960201-81-4 | 99.1% | 329.35 g/mol | C18H19NO5 | 5 MG
SD-1008 is a small-molecule JAK inhibitor (CAS 960201-81-4) used in research to block tyrosyl phosphorylation of STAT3, JAK2, and Src and to enhance apoptosis in sensitive cell lines. It is supplied as a high-purity, solid reagent for biochemical and cellular studies.
- Potent inhibition of JAK/STAT3 signaling, reducing phosphorylation of STAT3, JAK2, and Src.
- High purity suitable for biochemical and cellular assays.
- Molecular weight 329.35 g/mol and formula C18H19NO5 for accurate dosing.
- Light yellow solid appearance, convenient for handling and dissolution.
- Multiple package sizes available to support assay development and screening.
- Storage recommendations: protect from light, store under inert gas, and maintain cold storage for solutions.
Medchemexpress LLC AMP-activated protein kinase gamma-1/beta-2/alpha-1 heterotrimer, human recombinant (His-GST) | 96.3% | 5 UG
Recombinant human AMPK heterotrimer containing γ1, β2, and α1 subunits, expressed in Sf9 insect cells and affinity-tagged with His-GST. This purified complex is provided for biochemical and cell-free assays requiring the intact AMPK enzyme complex.
- Purity 96.3% by supplier analysis.
- Expressed in Sf9 insect cells (baculovirus expression).
- His-GST tag enables affinity purification and detection.
- Approximate subunit molecular weights: ~35 kDa, ~37 kDa, ~95 kDa.
- Supplied as a 5 μg quantity suitable for assay development.
- Intended for biochemical and in vitro functional assays.
Medchemexpress LLC Fc gamma RIIA/CD32a protein, human (H167R), Fc tag | 20 UG
Recombinant human Fc gamma receptor IIa (CD32a), H167R variant, is a C-terminal Fc-tagged protein expressed in HEK293 cells. Supplied as a 0.22 μm-filtered PBS solution with endotoxin <1 EU/μg, it is designed for in vitro biochemical and cell-based assays that probe Fc-IgG interactions and immune complex binding. Store at -80 °C and avoid repeated freeze-thaw cycles.
- C-terminal Fc tag for enhanced stability and dimerization
- Produced in HEK293 cells for mammalian post-translational modifications
- H167R variant suitable for functional and binding studies
- Supplied in filtered PBS, pH 7.4, ready for assay use
- Low endotoxin level (<1 EU/μg) compatible with cell assays
- Stable at -80 °C; aliquot to avoid repeated freeze-thaw cycles
Medchemexpress LLC Interferon gamma receptor 1 (IFN-gamma R1) Fc-fusion protein | >95.0% | 5 UG
Recombinant human interferon-γ receptor 1 extracellular domain fused to a human Fc tag, expressed in HEK293 cells and supplied lyophilized for research use. The protein is intended for use in binding studies, biochemical characterization, and immunoassays requiring a soluble Fc-fusion receptor fragment.
- Recombinant extracellular domain of IFN-γ receptor 1 fused to hFc.
- Produced in HEK293 cells for human-like glycosylation.
- Purity >95% as determined by reducing SDS-PAGE.
- Molecular weight ~60-75 kDa.
- Lyophilized from 0.22 μm filtered PBS, pH 7.4 for stability.
- Recommended storage at -20°C; reconstituted stability at 4°C for 1 week.
- Suitable for binding assays and biochemical characterization.
C[C@@H]1CO | 1g | 233627353](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502171786.JPG-250.jpg)
eMolecules 1279038-50-4 | (2R,4R)-1-BOC-2-HYDROXYMETHYL-4-AMINOPYRROLIDINE HYDROCHLORIDE | AstaTech | MFCD11101163 | 252.740 | C10H21ClN2O3 | 95.000 | Cl.CC(C)(C)OC(=O)N1C[C@H](N)C[C@@H]1CO | 1g | 233627353
(2R,4R)-1-BOC-2-HYDROXYMETHYL-4-AMINOPYRROLIDINE HYDROCHLORIDE | AstaTech | 1279038-50-4 | MFCD11101163 | 252.740 | C10H21ClN2O3 | 95.000 | Cl.CC(C)(C)OC(=O)N1C[C@H](N)C[C@@H]1CO | 1g | 233627353
Medchemexpress LLC CEBP gamma/CEBPG Hu 5ug
CEBP gamma/CEBPG protein is a transcription factor that regulates genes by binding to their promoter and enhancer regions It targets IL-4 and immunoglobulin heavy chains binding to enhancer elements PRE-I and GPE1 in the G-CSF gene promoter CEBP gamma/CEBPG Protein Human (His) is the recombinant human-derived CEBP gamma/CEBPG protein expressed by E coli with N-His labeled tag
![eMolecules 1630907-13-9 | tert-butyl rel-(3aR,5s,6aS)-5-amino-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-2-carboxylate;hydrochloride | Pharmablock262.780 | C12H23ClN2O2 | 97.000 | Cl.CC(C)(C)OC(=O)N1C[C@@H]2C[C@@H](N)C[C@@H]2C1 | 1g | 551074236](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502157691.JPG-250.jpg)
eMolecules 1630907-13-9 | tert-butyl rel-(3aR,5s,6aS)-5-amino-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-2-carboxylate;hydrochloride | Pharmablock262.780 | C12H23ClN2O2 | 97.000 | Cl.CC(C)(C)OC(=O)N1C[C@@H]2C[C@@H](N)C[C@@H]2C1 | 1g | 551074236
tert-butyl rel-(3aR,5s,6aS)-5-amino-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-2-carboxylate;hydrochloride | Pharmablock | 1630907-13-9262.780 | C12H23ClN2O2 | 97.000 | Cl.CC(C)(C)OC(=O)N1C[C@@H]2C[C@@H](N)C[C@@H]2C1 | 1g | 551074236
