Oxazinanes
Cayman Chemical H89 hydrochloride
A potent, non-selective inhibitor of PKA with an IC50 value of 0.14 µM (Ki = 48 nM) that is widely used to disrupt PKA signaling; inhibits S6K1, MSK1, ROCK2, PKBa, and MAPKAP-K1b with IC50 values of 0.08, 0.12, 0.27, 2.6, and 2.8 µM, respectively
Cayman Chemical Y27632 hydrochloride
A potent, ATP-competitive inhibitor of ROCKs including p160ROCK (Ki = 140 nM) and ROCK2 (IC50 = 800 nM); also inhibits PRK2 with an IC50 value of 600 nM
Cayman Chemical Nefazodone hydrochloride
A serotonin, norepinephrine, and dopamine reuptake inhibitor (Kis = 137, 570, 2,380 nM, respectively); an antagonist of 5-HT2A, 5-HT1A, and histamine H1 receptors, as well as α1- and α2-ARs (Kis = 7.1, 52, 30, 5.5, and 84 nM, respectively); reduces immobility time in the tail suspension test in gerbils at 100 mg/kg; toxic to isolated human hepatocytes in a cultured sandwich hepatocyte preparation at 30 µM
Cayman Chemical GW 3965 hydrochloride
An orally-active agonist of LXRα and LXRβ, activating the human isoforms with EC50 values of 190 and 30 nM, respectively; alters LXR-regulated gene expression in mice and rats, affecting pathways related to glucose and lipid metabolism
Medchemexpress LLC GW3965 hydrochloride | 405911-17-3 | MFCD08276920 | 100.0% | 618.51 | C33H32Cl2F3NO3 | 1 ML
GW3965 hydrochloride is the hydrochloride salt of GW3965, a potent and selective liver X receptor (LXR) agonist used in biochemical and cell-based research. It activates human LXRα and LXRβ with reported EC50 values of 190 nM and 30 nM, respectively.
- Potent, selective LXR agonist with EC50s of 190 nM (hLXRα) and 30 nM (hLXRβ).
- Suitable for in vitro and in vivo studies involving LXR activation.
- Available as concentrated solution in DMSO and as solid for flexible dosing.
- High purity supporting reproducible biological activity.
- Soluble in DMSO and practically insoluble in water.
- Storage recommendations provided for both solid and solution to preserve stability.
Selleck Chemical LLC Cyclopentolate Hydrochloride
Cyclopentolate is an antagonist of muscarinic acetylcholine receptors with Ki values of 1 62 27 5 and 2 63 nM for M1 M2 and M3 receptors respectively
TARGETMOL CHEMICALS INC PROCATEROL HYDROCHLORIDE 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Short-acting (beta)2-adrenergic receptor agonist used to treat asthma. purity: 100%
TARGETMOL CHEMICALS INC PENTAGASTRIN 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Pentagastrin (ICI-50123) is a synthetic polypeptide that has effects like gastrin when given parenterally which can cause the secretion and synthesis of salivary proteins. purity: 99%
TARGETMOL CHEMICALS INC TIPIRACIL HYDROCHLORIDE 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 200 mg 500 mg and bulk. Please contact Fisher for quotes. Tipiracil hydrochloride (MA-1 hydrochloride) is a thymidine phosphorylase inhibitor (TPI). Tipiracil hydrochloride is one of the active components in TAS-102 which is an anticancer drug candidate currently in clinical trials. purity: 99%
TARGETMOL CHEMICALS INC FENEBRUTINIB 10MG
Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Fenebrutinib (GDC-0853) is a selective and noncovalent Btk inhibitor (Ki 0.91 nM). purity: 98%
TARGETMOL CHEMICALS INC ALISKIREN HEMIFUMARATE 100MG
Also available in 5 mg 10 mg 25 mg 50 mg 200 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Aliskiren hemifumarate (CGP60536B) is an orally active nonpeptide renin inhibitor with antihypertensive activity. purity: 99%
TARGETMOL CHEMICALS INC DONITRIPTAN HYDROCHLORID 25MG
Also available in 1 mg 2 mg 5 mg 10 mg 50 mg 100 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Donitriptan hydrochloride (Donitriptan monohydrochloride) is a potent high efficacy agonist of 5-HT1B/1D receptors with pKis of 9.4 and 9.3 respectivelypurity: 99%
Apexbio Technology LLC PRE-084 hydrochloride 75136-54-8 10mM (in 1mL DMSO)
PRE-084 hydrochloride (CAS 75136-54-8) is a selective agonist of the sigma-1 receptor ( 1R) demonstrating high affinity and specificity over sigma-2 receptors (Ki values 2 2 nM for 1R 13091 nM for 2R) and negligible activity at PCP and other receptor systems (IC50 100 000 nM) In neuronal cell models expressing mutant huntingtin PRE-084 enhances NF- B pathway activation improving antioxidant responses and cell survival In vivo it reverses cognitive impairment induced by CO or trimethyltin and reduces cough response in guinea pig models highlighting PRE-084 as a relevant tool for neurological and respiratory research
Cayman Chemical Methedrone hydrochloride
A phenethylamine, amphetamine, and cathinone derivative that acts as a triple reuptake/release/reversible MAO inhibitor; intended for use as a standard for the forensic analysis of samples that may contain this compound
Cayman Chemical GW 3965 hydrochloride
An orally-active agonist of LXRα and LXRβ, activating the human isoforms with EC50 values of 190 and 30 nM, respectively; alters LXR-regulated gene expression in mice and rats, affecting pathways related to glucose and lipid metabolism