Oxazinanes
TARGETMOL CHEMICALS INC DASATINIB HYDROCHLORIDE 50MG
Also available in 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Dasatinib hydrochloride (BMS-354825 HCl) (BMS-354825) hydrochloride is a highly potent ATP competitive orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The Kis are 16 pM and 30 pM for Src and Bcr-Abl respectively. Dasatinib hydrochloride hydrochloride inhibits Bcr-Abl and Src with IC50s of <1.0 nM and 0.5 nM respectively. Dasatinib hydrochloride hydrochloride also induces Apoptosis and Autophagy. purity: 99%
TARGETMOL CHEMICALS INC SAR7334 HYDROCHLORIDE 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. SAR7334 hydrochloride is a potent and specific inhibitor of TRPC6(IC50 of 7.9 nM). purity: 98%
TARGETMOL CHEMICALS INC RIMONABANT HYDROCHLORIDE 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Rimonabant hydrochloride (SR 141716A) is a cannabinoid receptor antagonist binding selectively to central cannabinoid receptors (CB1) with high affinity. purity: 99%
TARGETMOL CHEMICALS INC ANAGRELIDE HYDROCHLORIDE 50MG
Also available in 5 mg 10 mg 25 mg 100 mg 200 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Anagrelide hydrochloride (BL4162A) is a drug used for the treatment of essential thrombocytosis. purity: 99%
Cayman Chemical GW 3965 hydrochloride
An orally-active agonist of LXRα and LXRβ, activating the human isoforms with EC50 values of 190 and 30 nM, respectively; alters LXR-regulated gene expression in mice and rats, affecting pathways related to glucose and lipid metabolism
Cayman Chemical Pargyline hydrochloride
An irreversible inhibitor of MAO (Kis = 15 and 1.8 μM for MAO-A and MAO-B, respectively); induces a moderate decrease of systolic blood pressure in unanaesthetized hypertensive rats but not normotensive WKR or Sprague-Dawley rats; prevents reactive oxygen species-mediated monocyte hypertrophy at a concentration of 10 µM
Cayman Chemical Trimidox hydrochloride
A specific ribonucleotide reductase inhibitor; inhibits growth of human promyelocytic leukemia HL-60 cells (IC50 = 35 µM)
Cayman Chemical Pargyline hydrochloride
An irreversible inhibitor of MAO (Kis = 15 and 1.8 μM for MAO-A and MAO-B, respectively); induces a moderate decrease of systolic blood pressure in unanaesthetized hypertensive rats but not normotensive WKR or Sprague-Dawley rats; prevents reactive oxygen species-mediated monocyte hypertrophy at a concentration of 10 µM
Selleck Chemical LLC Fipexide hydrochloride
Fipexide (hydrochloride) is a psychoactive drug of the piperazine class
Cayman Chemical Nefazodone hydrochloride
A serotonin, norepinephrine, and dopamine reuptake inhibitor (Kis = 137, 570, 2,380 nM, respectively); an antagonist of 5-HT2A, 5-HT1A, and histamine H1 receptors, as well as α1- and α2-ARs (Kis = 7.1, 52, 30, 5.5, and 84 nM, respectively); reduces immobility time in the tail suspension test in gerbils at 100 mg/kg; toxic to isolated human hepatocytes in a cultured sandwich hepatocyte preparation at 30 µM
Selleck Chemical LLC Olodaterol hydrochloride
Olodaterol hydrochloride (BI-1744) is the hydrochloride salt form of Olodaterol which is a long-acting beta2-adrenergic agonist
Sigma Aldrich Fine Chemicals Biosciences VILOXAZINE HYDROCHLORIDE 50MG
NC3843272 VILOXAZINE HYDROCHLORIDE 50MG
Cayman Chemical Y27632 hydrochloride
A potent, ATP-competitive inhibitor of ROCKs including p160ROCK (Ki = 140 nM) and ROCK2 (IC50 = 800 nM); also inhibits PRK2 with an IC50 value of 600 nM
Cayman Chemical Fingolimod hydrochloride
An immune modulator and a prodrug form of FTY720 phosphate; decreases the number of circulating lymphocytes in mice at 1 mg/kg; increases skin allograft survival in rats from 0.3-3 mg/kg; prevents disease development in a rat model of EAE; inhibits S1P lyase from 0.3-30 µM
Cayman Chemical H89 hydrochloride
A potent, non-selective inhibitor of PKA with an IC50 value of 0.14 µM (Ki = 48 nM) that is widely used to disrupt PKA signaling; inhibits S6K1, MSK1, ROCK2, PKBa, and MAPKAP-K1b with IC50 values of 0.08, 0.12, 0.27, 2.6, and 2.8 µM, respectively