Oxazinanes
Cayman Chemical Fingolimod hydrochloride
An immune modulator and a prodrug form of FTY720 phosphate; decreases the number of circulating lymphocytes in mice at 1 mg/kg; increases skin allograft survival in rats from 0.3-3 mg/kg; prevents disease development in a rat model of EAE; inhibits S1P lyase from 0.3-30 µM
Medchemexpress LLC Mmpip hydrochloride | 1215566-78-1 | 99.1% | 369.80 g/mol | C19H16ClN3O3 | 1 ML
MMPIP hydrochloride is an allosteric metabotropic glutamate receptor 7 (mGluR7) selective antagonist supplied as a ready-to-use 10 mM solution in dimethyl sulfoxide (DMSO). It is intended for in vitro pharmacology and receptor modulation studies and is provided with high purity and characterized identity.
- Allosteric mGluR7 antagonist for receptor modulation studies.
- Provided as a 10 mM solution in DMSO for immediate use.
- High purity suitable for pharmacological assays.
- Available in multiple solid and solution pack sizes for flexibility.
- Characterized by CAS 1215566-78-1 and confirmed molecular weight of 369.80 g/mol.
Medchemexpress LLC 8-Azaadenine | 1123-54-2 | 99.9% | 136.12 | 250 MG
8-Azaadenine is an inhibitor of Xanthine Oxidase with an IC50 of 0.54 μM and a Ki of 0.66 μM. It is produced via the metabolism of 8-Azaadenosine and can be incorporated into polynucleotide chains alongside 8-Azaguanine to impact purine metabolism. This product is used in cancer studies and can also be synthesized into various derivatives through alkylation reactions, which demonstrate antiviral activity.
- Inhibits Xanthine Oxidase with an IC50 of 0.54 μM and a Kᵢ of 0.66 μM
- Produced via the metabolism of 8-Azaadenosine
- Incorporated into polynucleotide chains to affect purine metabolism
- Used in the study of cancer
- Can be synthesized into derivatives with antiviral activity
Cayman Chemical Amiodaroned4 hydrochloride
An internal standard for the quantification of amiodarone by GC- or LC-MS
Medchemexpress LLC (6S)-CP-470711 | 300552-09-4 | 98.8% | 358.44 | 1 MG
(6S)-CP-470711 (Compound 8) is an inhibitor for sorbitol dehydrogenase, inhibiting human and rat SDH with IC50 of 19 nM and 27 nM. It ameliorates Streptozotocin-induced diabetes in rat models. It is for research use only and not sold to patients.
- Inhibitor for sorbitol dehydrogenase (SDH)
- Inhibits human and rat SDH
- Ameliorates Streptozotocin-induced diabetes in rat models
- Appearance: Solid
- Color: White to off-white
- Molecular formula: C18H26N6O2
Cayman Chemical Oxybutynind10 hydrochloride
An internal standard for the quantification of oxybutynin by GC- or LC-MS
Cayman Chemical PIK75 hydrochloride
A selective inhibitor of p110α with an IC50 value of 5.8 nM; inhibits p110γ and p110β with IC50 values of 0.076 µM and 1.3 µM, respectively
Medchemexpress LLC S1ra (hydrochloride) | 1265917-14-3 | 99.9% | 373.88 | 250 MG
S1RA (E-52862) hydrochloride is an orally active and selective sigma-1 receptor (σ1R) antagonist with a Ki value of 17 nM. It demonstrates good selectivity against σ2R (Ki >1000 nM). This compound is also identified as a human 5-HT2B receptor antagonist with an IC50 value of 4.7 μM. S1RA hydrochloride has been shown to inhibit neuropathic pain and activity-induced spinal sensitization.
- Orally active and selective sigma-1 receptor (σ1R) antagonist
- High affinity for human and guinea pig σ1Rs
- Good selectivity against sigma-2 receptors (σ2R)
- Acts as a human 5-HT2B receptor antagonist
- Inhibits neuropathic pain
- Reduces activity-induced spinal sensitization
- Demonstrates analgesic effects on formalin-evoked nociceptive behaviors in mice
- Reverses capsaicin-induced mechanical hypersensitivity in mice
Selleck Chemical LLC Tenofovir alafenamide hemifumarate S4427-5mg
Tenofovir alafenamide (TAF GS-7340) hemifumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection