Oxazinanes
eMolecules Synthonix - Stock 2-(Tributylstannylmethylsulfanyl)ethanamine 500mg 525924737 T9181 1452829-00-3 MFCD23703162 380.220 C15H35NSSn
Synthonix - Stock 2-(Tributylstannylmethylsulfanyl)ethanamine 500mg 525924737 T9181 1452829-00-3 MFCD23703162 380.220 C15H35NSSn
Selleck Chemical LLC Epertinib hydrochloride
Epertinib hydrochloride (S-222611 hydrochloride) is a potent orally active reversible and selective tyrosine kinase inhibitor of EGFR HER2 and HER4 with IC50 of 1 48 nM 7 15 nM and 2 49 nM respectively Epertinib hydrochloride (S-222611 hydrochloride) exhibits antitumor activity
Selleck Chemical LLC Ellipticine hydrochloride
Ellipticine Hydrochloride (NSC 71795 PZE) is a potent inhibitor of DNA topoisomerase II and forms covalent DNA adducts mediated by its oxidation with cytochromes P450 (CYP) and peroxidases Ellipticine Hydrochloride is a natural product isolated from the Australian evergreen tree of the Apocynaceae family with antineoplastic activity
Sigma Aldrich Fine Chemicals Biosciences Ripasudil Hydrochloride 9825MG
Ripasudil Hydrochloride 9825MG
eMolecules 90902-84-4 | 2,5-Dibromopyridin-3-amine | ChemScene | MFCD09266224 | 251.909 | C5H4Br2N2 | 98.000 | Nc1cc(Br)cnc1Br | 25g | 572179909
2,5-Dibromopyridin-3-amine | ChemScene | 90902-84-4 | MFCD09266224 | 251.909 | C5H4Br2N2 | 98.000 | Nc1cc(Br)cnc1Br | 25g | 572179909
Apexbio Technology LLC Sotalol hydrochloride 959-24-0 10mM (in 1mL DMSO)
Sotalol hydrochloride (CAS 959-24-0) is a potent non-selective -adrenergic receptor antagonist and a potassium channel inhibitor In HEK cell models it exhibits an IC50 of approximately 1 2 mM for potassium channel inhibition As a class III antiarrhythmic agent sotalol hydrochloride increases the functional refractory period without reducing conduction velocity in ex vivo rabbit heart models of reentrant tachycardia In vivo studies in canine hearts demonstrate its ability to prolong atrial and ventricular monophasic action potential durations during constant atrial pacing Sotalol hydrochloride is frequently employed in research on arrhythmia mechanisms and rhythm control therapies particularly in the context of atrial fibrillation
Apexbio Technology LLC Sarpogrelate hydrochloride 135159-51-2 10mM (in 1mL DMSO)
Sarpogrelate hydrochloride (CAS 135159-51-2) is a selective antagonist of the 5-HT2A receptor exhibiting a binding affinity (Ki) of 8 39 nM comparable to ritanserin By inhibiting 5-HT2A receptor-mediated pathways sarpogrelate suppresses platelet aggregation thrombus formation and vascular smooth muscle cell proliferation In vitro its primary metabolite (M-1) blocks 5-HT-induced responses at the 5-HT2A receptor with minimal stereoselective difference Clinically oral administration of sarpogrelate in patients with peripheral arterial disease significantly enhances forearm and leg blood flow responses to reactive hyperemia indicating improved vascular function Sarpogrelate is employed in research on platelet function thrombosis and vascular disorders
Accela Chembio Inc 4-(4-nitrophenyl)morpholine | 100g | 10389-51-2 | MFCD00023317 | 97+% | Shelf Life: 1800 Days | Light Sensitive
4-(4-nitrophenyl)morpholine | 100g | 10389-51-2 | MFCD00023317 | 97+% | Shelf Life: 1800 Days | Light Sensitive
![eMolecules 719999-54-9 | (R)-tert-Butyl (pyrrolidin-2-ylmethyl)carbamate | ChemScene | MFCD03839886 | 200.282 | C10H20N2O2 | 95.000 | CC(C)(C)OC(=O)NC[C@H]1CCCN1 | 1g | 572245369](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502695670.jpg-250.jpg)
eMolecules 719999-54-9 | (R)-tert-Butyl (pyrrolidin-2-ylmethyl)carbamate | ChemScene | MFCD03839886 | 200.282 | C10H20N2O2 | 95.000 | CC(C)(C)OC(=O)NC[C@H]1CCCN1 | 1g | 572245369
(R)-tert-Butyl (pyrrolidin-2-ylmethyl)carbamate | ChemScene | 719999-54-9 | MFCD03839886 | 200.282 | C10H20N2O2 | 95.000 | CC(C)(C)OC(=O)NC[C@H]1CCCN1 | 1g | 572245369
![eMolecules 116183-83-6 | (S)-(+)-3-Aminopyrrolidine dihydrochloride | Combi-Blocks | MFCD00070605 | 159.050 | C4H12Cl2N2 | 97.000 | Cl.Cl.N[C@H]1CCNC1 | 5g | 528671160](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502696402.jpg-250.jpg)
eMolecules 116183-83-6 | (S)-(+)-3-Aminopyrrolidine dihydrochloride | Combi-Blocks | MFCD00070605 | 159.050 | C4H12Cl2N2 | 97.000 | Cl.Cl.N[C@H]1CCNC1 | 5g | 528671160
(S)-(+)-3-Aminopyrrolidine dihydrochloride | Combi-Blocks | 116183-83-6 | MFCD00070605 | 159.050 | C4H12Cl2N2 | 97.000 | Cl.Cl.N[C@H]1CCNC1 | 5g | 528671160
![eMolecules 1577233-70-5 | 3-[(Tributylstannyl)methoxy]-1-propanamine | Synthonix - Stock | MFCD28579830 | 378.188 | C16H37NOSn | 98.000 | CCCC[Sn](CCCC)(CCCC)COCCCN | 5g | 525924100](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502696550.jpg-250.jpg)
eMolecules 1577233-70-5 | 3-[(Tributylstannyl)methoxy]-1-propanamine | Synthonix - Stock | MFCD28579830 | 378.188 | C16H37NOSn | 98.000 | CCCC[Sn](CCCC)(CCCC)COCCCN | 5g | 525924100
3-[(Tributylstannyl)methoxy]-1-propanamine | Synthonix - Stock | 1577233-70-5 | MFCD28579830 | 378.188 | C16H37NOSn | 98.000 | CCCC[Sn](CCCC)(CCCC)COCCCN | 5g | 525924100
Apexbio Technology LLC Pitolisant hydrochloride 903576-44-3 10mM (in 1mL DMSO)
Pitolisant hydrochloride (CAS 903576-44-3) also known as BF2 649 or Ciproxidine is a potent and selective non-imidazole inverse agonist of the histamine H3 receptor exhibiting a Ki of 0 16 nM for the human recombinant receptor By targeting the H3 autoreceptor pitolisant modulates histaminergic neurotransmission and regulates the release of other neurotransmitters In vitro it demonstrates higher intrinsic activity than ciproxifan and an EC50 of 1 5 nM Pitolisant is orally bioavailable and increases brain tele-methylhistamine levels in rodents in a dose-dependent manner reflecting activation of histaminergic neurons It is widely applied in studies related to cognition epilepsy and models of neuropsychiatric disorders
![eMolecules 2168168-25-8 | TERT-BUTYL 3,3-DIFLUORO-OCTAHYDRO-1H-PYRROLO[2,3-C]PYRIDINE-6-CARBOXYLATE | AstaTech262.301 | C12H20F2N2O2 | 95.000 | CC(C)(C)OC(=O)N1CCC2C(C1)NCC2(F)F | 0.1g | 528990652](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502480947.JPG-250.jpg)
eMolecules 2168168-25-8 | TERT-BUTYL 3,3-DIFLUORO-OCTAHYDRO-1H-PYRROLO[2,3-C]PYRIDINE-6-CARBOXYLATE | AstaTech262.301 | C12H20F2N2O2 | 95.000 | CC(C)(C)OC(=O)N1CCC2C(C1)NCC2(F)F | 0.1g | 528990652
TERT-BUTYL 3,3-DIFLUORO-OCTAHYDRO-1H-PYRROLO[2,3-C]PYRIDINE-6-CARBOXYLATE | AstaTech | 2168168-25-8262.301 | C12H20F2N2O2 | 95.000 | CC(C)(C)OC(=O)N1CCC2C(C1)NCC2(F)F | 0.1g | 528990652
Apexbio Technology LLC Pazopanib Hydrochloride 635702-64-6 10mM (in 1mL DMSO)
Pazopanib Hydrochloride (CAS 635702-64-6) is a small-molecule receptor tyrosine kinase inhibitor that targets multiple kinases involved in tumor growth and angiogenesis including VEGFR1 (IC50 10 nM) VEGFR2 (30 nM) VEGFR3 (47 nM) PDGFR (84 nM) FGFR (74 nM) c-Kit (140 nM) and C-FMS (146 nM) By inhibiting these receptors pazopanib suppresses both tumor proliferation and neovascularization Preclinical studies have demonstrated its antitumor activity in various human xenograft models such as renal prostate colon lung melanoma head and neck and breast cancers Pazopanib is employed in research focusing on tumor biology angiogenesis and targeted therapy development