Oxazinanes
eMolecules 6-Ethylpicolinaldehyde | Combi-Blocks | 153646-82-3 | MFCD18256089 | 135.166 | C8H9NO | 95.000 | CCc1cccc(C=O)n1 | 250mg | 448003540
6-Ethylpicolinaldehyde | Combi-Blocks | 153646-82-3 | MFCD18256089 | 135.166 | C8H9NO | 95.000 | CCc1cccc(C=O)n1 | 250mg | 448003540
Medchemexpress LLC Quizartinib dihydrochloride | 1132827-21-4 | 99.8% | C29H34Cl2N6O4S | 25 MG
Quizartinib dihydrochloride (AC220 dihydrochloride) is the dihydrochloride salt form of Quizartinib. It is an orally active, highly selective, and potent second-generation type II FLT3 tyrosine kinase inhibitor. This compound inhibits wild-type FLT3 and FLT3-ITD autophosphorylation and induces apoptosis.
- Orally active, highly selective and potent second-generation type II FLT3 tyrosine kinase inhibitor
- Inhibits wild-type FLT3 and FLT3-ITD autophosphorylation
- Induces apoptosis
- Can be linked to the VHL ligand to form a PROTAC FLT3 degrader
Medchemexpress LLC Sapropterin dihydrochloride | 69056-38-8 | 99.96% | C9H17Cl2N5O3 | 50 MG
Sapropterin dihydrochloride is an analytical standard used for research and analytical applications. It functions as an orally active phenylalanine hydroxylase (PAH) cofactor, helping to reduce blood phenylalanine concentrations. This compound is suitable for studying phenylketonuria (PKU). It is an analytical standard grade, commonly employed in qualitative, quantitative, and methodological research experiments such as HPLC, GC, and MS.
- Analytical standard for research and analytical applications
- Orally active phenylalanine hydroxylase (PAH) cofactor
- Reduces blood phenylalanine concentrations
- Useful in the study of phenylketonuria (PKU)
- Suitable for HPLC, GC, and MS applications
Medchemexpress LLC C24:1 Dihydro 1-deoxyceramide (m18:0/24:1) | 1246298-60-1 | 99.0% | 634.11 | 1 MG
C24:1 Dihydro 1-deoxyceramide (m18:0/24:1) is a lipid molecule composed of a long-chain fatty acid (24:1) and a 1-deoxysphingoid backbone. Deoxyceramide accumulates under conditions of obesity and type 2 diabetes (T2D). It cannot be further metabolized to more complex sphingolipid and is toxic when it accumulates in the body. Deoxyceramide increases in differentiated adipocytes in vitro. This product is for research use only.
- Composed of a long-chain fatty acid (24:1) and a 1-deoxysphingoid backbone.
- Accumulates under conditions of obesity and type 2 diabetes (T2D).
- Cannot be metabolized to more complex sphingolipids and is toxic upon accumulation.
- Increases in differentiated adipocytes in vitro.
- For research use only.
Medchemexpress LLC Brilliant Black BN | 2519-30-4 | 25 MG
Brilliant Black BN (E151) is an azo dye and food colorant. It acts as a promising antiviral agent against EV71 infection by inhibiting the interaction between EV71 and its cellular uncoating factor cyclophilin A.
- Azo dye and food colorant
- Antiviral agent for EV71 infection
- Inhibits EV71 and cyclophilin A interaction
- IC50 of 10.1 μM against EV71-GFP in RD cells
- Effective against EV71, CVA16, and CVA6 strains
- IC50 for EV71 strains: 2.39-28.12 μM in rhabdomyosarcoma cells
- In vivo protection observed in EV71-challenged AG129 mice
Medchemexpress LLC ML204 hydrochloride | 2070015-10-8 | 99.7% | 1 ML
ML204 hydrochloride is a novel, potent, and selective TRPC4/TRPC5 channel inhibitor.
- Potent and selective TRPC4/TRPC5 channel inhibitor.
- Exhibits at least 19-fold selectivity against TRPC6.
- No appreciable effect on other TRP channels.
- Does not affect voltage-gated sodium, potassium, or Ca2+ channels.
Medchemexpress LLC 4-Phenyl-7,8-dihydroxycoumarin | 842-01-3 | 99.4% | 1 ML
4-Phenyl-7,8-dihydroxycoumarin is a coumarin derivative primarily used for bronchiectasis research. It is intended for research use only and not for medical applications.
- High purity (99.35%)
- Supplied as a 10 mM solution in DMSO
- Appearance: off-white to yellow solid
- Molecular weight: 254.24
- Demonstrates cytotoxicity against human A375 cells with an IC50 of 39 μM
- Demonstrates cytotoxicity against human MRC5 cells with an IC50 of 47 μM
- Powder storage: -20°C for 3 years, 4°C for 2 years
- Solution storage: -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC SAG (hydrochloride) | 2095432-58-7 | 99.91% | 1 MG
SAG hydrochloride is a potent Smoothened (Smo) receptor agonist with an EC50 of 3 nM and a Kd of 59 nM. It activates the Hedgehog signaling pathway and counteracts Cyclopamine inhibition of Smo.
- Induces firefly luciferase expression in Shh-LIGHT2 cells with an EC50 of 3 nM.
- Competes for the binding of BODIPY-cyclopamine to Smo-expressing Cos-1 cells, showing a dissociation constant (Kd) of 59 nM.
- Increases SMO mRNA and protein expression in MDAMB231 cells.
- Increases CAXII mRNA expression in MDAMB231 cells under normoxic and hypoxic conditions.
- Increases MDAMB231 cell migration.
- Promotes osteogenesis and significantly increases BV/TV in CD-1 mice.
- Induces pre-axial polydactyly and increases Gli1 and Gli2 mRNA expression in the limb bud in mice.
Medchemexpress LLC HADA hydrochloride | 2253733-10-5 | 98.0% | 1 ML
HADA hydrochloride is a blue (λem~450 nm) fluorescent D-amino acid (FDAA). FDAAs are efficiently incorporated into the peptidoglycans (PGs) of diverse bacterial species at the sites of PG biosynthesis, allowing specific and covalent probing of bacterial growth with minimal perturbation.
- Blue fluorescent D-amino acid
- Efficiently incorporated into peptidoglycans of diverse bacterial species
- Allows specific and covalent probing of bacterial growth
- Minimal perturbation during bacterial growth probing
- Suitable for laboratory research applications
Medchemexpress LLC 7,8-dihydro-2,5(1H,6H)-quinolinedione | 15450-69-8 | MFCD00766821 | 99.9% | 163.17 g/mol | C9H9NO2 | 1 G
7,8-Dihydro-2,5(1H,6H)-quinolinedione is a small-molecule research chemical used in biochemical and pharmacological studies. It is supplied as a light brown to light yellow solid, and the manufacturer's certificate of analysis reports high purity suitable for research applications.
- Small-molecule quinolinedione for biochemical and pharmacological research.
- High purity reported in supplier certificate of analysis.
- Light brown to light yellow solid, convenient for handling and storage.
- Molecular weight 163.17 g/mol; formula C9H9NO2.
- Documented as a positive inotropic agent in the literature.
- Provided with batch-specific certificate of analysis for traceability.
Medchemexpress LLC Tebanicline dihydrochloride | 209326-19-2 | 99.5% | C9H13Cl3N2O | 25 MG
Tebanicline dihydrochloride is a nAChR modulator with potent, orally effective analgesic activity. It inhibits the binding of cytisine to α4β2 neuronal nAChRs with a Ki of 37 pM. It is for research use only, and has shown antinociceptive effects in rat models of acute thermal, persistent chemical, and neuropathic pain.
- Potent, orally effective analgesic activity
- Inhibits binding of cytisine to α4β2 neuronal nAChRs with a Ki of 37 pM
- Antinociceptive effects in rat models of acute thermal, persistent chemical, and neuropathic pain
- Suitable for research use only
Medchemexpress LLC 3-Amino-2-oxazolidinone | 80-65-9 | MFCD00020871 | 98.0% | 102.09 | 1 ML
3-Amino-2-oxazolidinone (AOZ) is a metabolite of Furazolidone. It is consistently detected as an indicator of furazolidone residues in vivo. This compound is orally active.
- It is a metabolite of furazolidone.
- It is an indicator of furazolidone residues in vivo.
- The compound is orally active.
- It inhibits monoamine oxidase (MAO) via its metabolite in rats' brain and liver.
- It increases levels of monoamine neurotransmitters like norepinephrine and dopamine in the brain.
- It lowers blood pressure in renal hypertensive rats.