Oxazinanes
Medchemexpress LLC Rhodamine B isothiocyanate | 36877-69-7 | 95.7% | 536.09 | 25 MG
Rhodamine B isothiocyanate | 36877-69-7 | 95.7% | 536.09 | 25 MG
Medchemexpress LLC Elacestrant dihydrochloride | 1349723-93-8 | 99.5% | 531.56 | 1 ML
Elacestrant (RAD1901) dihydrochloride is an orally available and selective estrogen receptor degrader (SERD) with IC50s of 48 and 870 nM for ERα and ERβ, respectively. Elacestrant dihydrochloride also can inhibit growth of ER+ breast cancer cell lines in vitro and in vivo.
- Orally available and selective estrogen receptor degrader (SERD).
- Inhibits growth of ER+ breast cancer cell lines in vitro and in vivo.
- Demonstrates antitumor activity in breast cancer xenograft models.
- Induces complete tumor growth inhibition in mice.
- Tumor growth inhibition is maintained for 4 weeks after withdrawal.
Medchemexpress LLC Bersiporocin | 2241808-52-4 | 99.0% | C15H19Cl2N3O | 1 MG
Bersiporocin is a prolyl-tRNA synthetase inhibitor used in antifibrotic research. It exhibits an IC50 of ≤100 nM for phosphoribosylpyrophosphate synthetase (PRS) and is supplied as a white to off-white solid.
- Prolyl-tRNA synthetase inhibitor
- IC50 of ≤100 nM for phosphoribosylpyrophosphate synthetase (PRS)
- Suitable for antifibrotic research
- Ships at room temperature in continental US
- Store at 4°C, sealed, away from moisture and light
- For research use only
Medchemexpress LLC (6S,12aR)-Tadalafil (Tadalafil EP Impurity C) | 171596-28-4 | 99.5% | C22H19N3O4 | 50 MG
(6S,12aR)-Tadalafil (Tadalafil EP Impurity C) is a highly potent PDE5 inhibitor with an IC50 value of 5 nM and has blood pressure lowering activity. It is intended for research use only and is not sold to patients.
- Highly potent PDE5 inhibitor with an IC50 value of 5 nM.
- Has blood pressure lowering activity.
- Suitable for research applications only.
Apexbio Technology LLC TYRAMINE-HYDROCHLORIDE-250MG
Tyramine hydrochloride (CAS No 60-19-5) is a bioactive amine commonly used in biomedical research to study its interaction with trace amine-associated receptors (TAARs) and its involvement in neurotransmitter regulation It is derived from the decarboxylation of tyrosine which can occur naturally in fermented foods Tyramine primarily influences adrenergic dopaminergic and serotonergic pathways making it a valuable compound for investigating neurological and cardiovascular functions Its in vitro activity is observed in the nanomolar to low micromolar range Research applications include use in cell models and animal studies to explore its role in synaptic transmission and potential drug interactions It is also utilized in drug screening assays to evaluate biochemical pathways related to mood disorders and hypertension Experimental concentrations typically depend on the specific research design
Apexbio Technology LLC STACHYDRINE-HYDROCHLORIDE
Stachydrine (hydrochloride) (CAS No 4136-37-2) is an alkaloid found in plants such as Leonurus sibiricus It is studied in the category of cardiovascular and metabolic research due to its potential vasodilatory and cardioprotective effects The mechanism of action involves influencing pathways related to nitric oxide production and calcium channel modulation which can impact vascular smooth muscle relaxation In vitro activity is often observed in the nanomolar to low micromolar range indicating its potency in cellular assays Typical applications include studies in human endothelial cells rodent cardiac models and drug screening for cardiovascular benefits Experimental concentrations typically depend on the specific research design Stachydrine (hydrochloride) is integral to exploring therapeutic potentials for cardiovascular diseases contributing to the understanding of plant-derived bioactive compounds in modern pharmacology
eMolecules 2905-25-1 | 2-Bromobenzenesulphonyl chloride | Ambeed | MFCD00051971 | 255.510 | C6H4BrClO2S | 98.000 | ClS(=O)(=O)c1ccccc1Br | 1g | 531647901
2-Bromobenzenesulphonyl chloride | Ambeed | 2905-25-1 | MFCD00051971 | 255.510 | C6H4BrClO2S | 98.000 | ClS(=O)(=O)c1ccccc1Br | 1g | 531647901
Medchemexpress LLC Ipatasertib dihydrochloride | 1396257-94-5 | C24H34Cl3N5O2 | 1 G
Ipatasertib dihydrochloride is a highly selective and ATP-competitive pan-Akt inhibitor, demonstrating significant selectivity against Akt1, Akt2, and Akt3. It is intended for research use only.
- Highly selective and ATP-competitive pan-Akt inhibitor
- IC50s of 5, 18, and 8 nM for Akt1, Akt2, and Akt3, respectively
- Exhibits over 600-fold and over 100-fold selectivity for Akt1 against PKA and p70S6K
- Effective in xenograft models with Akt activation
- Achieves tumor growth delay, stasis, or regression in vivo
Medchemexpress LLC Ipatasertib dihydrochloride | 1396257-94-5 | C24H34Cl3N5O2 | 50 MG
Ipatasertib dihydrochloride | 1396257-94-5 | C24H34Cl3N5O2 | 50 MG
Medchemexpress LLC 5,6-dihydro-5-fluorouracil | 696-06-0 | MFCD00871150 | 99.9% | 132.09 g·mol⁻¹ | C4H5FN2O2 | 5 MG
5,6-Dihydro-5-fluorouracil (5-DHFU) is the active metabolite of the chemotherapy prodrug 5-fluorouracil. Supplied as a white to off-white solid for research use, it is used in metabolic profiling, enzyme assays, and studies of drug metabolism and pharmacokinetics. The material is suitable as a reference standard in biochemical and pharmacological investigations.
- High purity suitable for analytical and preparative studies.
- Available in small milligram quantities for early-stage research.
- Solid form facilitates weighing, storage, and transport.
- Documented chemical identifiers support traceability.
- Commonly used as a reference in metabolic and enzymatic assays.
Medchemexpress LLC RF9 hydrochloride | 00-00-0 | 99.9% | 519.08 | C26H39ClN6O3 | 1 ML
RF9 hydrochloride is a potent and selective antagonist of Neuropeptide FF (NPFF) receptors, with reported Ki values of 58 nM for hNPFF1R and 75 nM for hNPFF2R. It is supplied for research use as high-purity material, available as a 10 mM solution in DMSO or as dry powder in multiple vial sizes.
- Potent NPFF receptor antagonist (Ki = 58 nM for hNPFF1R; Ki = 75 nM for hNPFF2R).
- Molecular formula C26H39ClN6O3.
- Molecular weight 519.08.
- Purity >99.9%.
- Available as 10 mM solution in DMSO and as dry powders in multiple vial sizes.
- Intended for in vitro pharmacology and receptor binding studies.