Oxazinanes
eMolecules Combi-Blocks 2-(4-Chlorophenyl)ethylamine 5g 232334214 SS-3091 98.000 156-41-2 MFCD00008191 155.630 C8H10ClN
Combi-Blocks 2-(4-Chlorophenyl)ethylamine 5g 232334214 SS-3091 98.000 156-41-2 MFCD00008191 155.630 C8H10ClN
Apexbio Technology LLC SKF 525A (hydrochloride) 62-68-0 1g
SKF 525A (hydrochloride CAS 62-68-0) is a small-molecule inhibitor of cytochrome P450 (CYP) enzymes It modulates CYP-mediated metabolic pathways by inhibiting several isoforms including CYP2B6 CYP2C9 CYP2C19 CYP2D6 and CYP3A with limited impact on CYP1A2 CYP2A6 and CYP2E1 When assessed in human liver microsomes SKF 525A demonstrates CYP-dependent N-deethylation and exhibits inhibitory potency in the micromolar range In animal models it non-specifically disrupts sympathetic ganglia and adrenal medulla signaling possibly by stabilizing postsynaptic membranes SKF 525A is commonly used to study drug metabolism and CYP-mediated biotransformation in preclinical settings
TARGETMOL CHEMICALS INC PCLX-001 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. PCLX-001 is a small-molecule compound that acts as an orally active inhibitor of N-myristoyltransferase (NMT) specifically targeting NMT1 and NMT2 with IC50 values of 5 nM and 8 nM respectively. This compound demonstrates anti-tumor effects and effectively inhibits the early signaling of B-cell receptor (BCR). Consequently PCLX-001 is a valuable tool for researching B-cell malignancies [1] [2]. purity: 98%
TARGETMOL CHEMICALS INC MEDIFOXAMINE 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Medifoxamine (LG 152) is a selective non-monoamine oxidase inhibitor that exhibits antidepressant activity through inhibition of 5 HT reuptake.Medifoxamine preferentially inhibits dopamine reuptake. purity: 98%
Apexbio Technology LLC THZ1 Hydrochloride 1604810-83-4 (free base) 10mM (in 1mL DMSO)
THZ1 Hydrochloride is a covalent inhibitor targeting the cyclin-dependent kinase CDK7 with an IC50 of approximately 3 2 nM Mechanistically THZ1 modifies CDK7 by covalently binding to a cysteine residue located outside the kinase domain thereby inhibiting kinase-mediated phosphorylation events associated with the RNA Polymerase II C-terminal domain (CTD) It perturbs transcriptional regulation pathways mediated by CDK7-related signaling in cells including inhibition of phosphorylation essential for initiation and elongation processes THZ1 has demonstrated inhibitory activity in various cancer cell lines particularly in T-cell acute lymphoblastic leukemia (T-ALL) cell lines such as Jurkat and Loucy where sensitivity correlates with interference of RUNX1 transcriptional programs THZ1 is primarily used as a pharmacological tool to investigate CDK7-driven transcriptional regulation and tumor biology
TARGETMOL CHEMICALS INC ENDOXIFEN HYDROCHLORIDE 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Endoxifen hydrochloride is a key active metabolite of Tamoxifen (TAM) with higher affinity and specificity to estrogen receptor that also inhibits aromatase activity. Endoxifen hydrochloride has the potential for breast cancer study . purity: 99%
TARGETMOL CHEMICALS INC ALECTINIB HYDROCHLORIDE 100MG
Also available in 5 mg 10 mg 25 mg 50 mg 500 mg and bulk. Please contact Fisher for quotes. Alectinib hydrochloride (RO5424802 Hydrochloride) is a selective and orally available inhibitor of ALK( IC50 1.9 nM)purity: 99%
Apexbio Technology LLC 5,6-Dihydro-UTP(Synonyms: 5,6-Dihydrouridine-5'-triphosphate, DHU-TP, 5,6-DHUTP, Dihydrouridine triphosphate), 100ul (100 mM).
5 6-Dihydro-UTP is a base-modified ribonucleoside triphosphate utilized in biochemical research Acting primarily as an acceptor substrate during enzymatic synthesis of dinucleoside polyphosphates this compound participates in phosphorylation reactions catalyzed by nucleotide-utilizing enzymes Due to its altered nucleobase structure 5 6-Dihydro-UTP serves as a strategic molecular probe in studies examining nucleotide synthesis pathways enzyme specificity and nucleic acid biochemistry
Medchemexpress LLC Cholest-5-en-3-yl [(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]glycinate, trifluoroacetate | 1609010-59-4 | >95.0% | 886.1 g·mol⁻¹ | C43H73F6N5O7 | 5 MG
2H-Cho-Arg (trifluoroacetate) is a steroid-based cationic lipid that couples a 2H-cholesterol skeleton to an L-arginine head group. It forms complexes with plasmid DNA and is used to facilitate gene transfection in cultured cells.
- Steroid-based cationic lipid with a 2H-cholesterol skeleton and L-arginine head group.
- Forms stable complexes with plasmid DNA, reducing DNA migration in electrophoretic assays.
- Facilitates transfection of reporter genes in cell lines such as H1299.
- Cellular uptake involves lipid raft and caveolae-mediated endocytosis pathways.
- Supplied as the trifluoroacetate salt in solution; recommended storage -20 °C.
- Reported purity greater than 95%.
Medchemexpress LLC 3-Amino-2-oxazolidinone (AOZ) | 80-65-9 | 98.0% | 102.09 | 50 MG
3-Amino-2-oxazolidinone (AOZ) is a metabolite of Furazolidone and is used as an indicator for furazolidone residues in vivo. This orally active product inhibits monoamine oxidase (MAO) through its metabolite in rat brain and liver, increasing levels of monoamine neurotransmitters like norepinephrine and dopamine, and lowering blood pressure in renal hypertensive rats.
- Used as an indicator for furazolidone residues
- Orally active
- Increases levels of monoamine neurotransmitters
- Lowers blood pressure in renal hypertensive rats