Piperazines
Apexbio Technology LLC Dexrazoxane 24584-09-6 100mg
Dexrazoxane is a cell-permeable iron chelator that suppresses intracellular superoxide radical generation via iron sequestration thereby exhibiting antioxidant activity Dexrazoxane exerts its biological effects primarily by modulating oxidative stress and ferroptosis pathways In cell-based studies including myocardial H9c2 cell models dexrazoxane inhibits ferroptosis by suppressing the HMGB1 pathway and induces DNA damage and apoptosis in various tumor cell lines Based on these pharmacological properties dexrazoxane holds research potential in the study of cardioprotective mechanisms tumor-related DNA damage responses ferroptosis and oxidative stress processes
Apexbio Technology LLC Dexrazoxane 24584-09-6 25mg
Dexrazoxane is a cell-permeable iron chelator that suppresses intracellular superoxide radical generation via iron sequestration thereby exhibiting antioxidant activity Dexrazoxane exerts its biological effects primarily by modulating oxidative stress and ferroptosis pathways In cell-based studies including myocardial H9c2 cell models dexrazoxane inhibits ferroptosis by suppressing the HMGB1 pathway and induces DNA damage and apoptosis in various tumor cell lines Based on these pharmacological properties dexrazoxane holds research potential in the study of cardioprotective mechanisms tumor-related DNA damage responses ferroptosis and oxidative stress processes
Medchemexpress LLC N-(Tert-Butoxycarbonyl)-L-neopentylglycine | 79777-82-5 | 98.5% | C12H23NO4 | 100 MG
N-(Tert-Butoxycarbonyl)-L-neopentylglycine is a glycine derivative intended for research use only. Amino acids and their derivatives, like this product, are recognized as beneficial ergogenic dietary substances, influencing anabolic hormone secretion, fuel supply during exercise, mental performance during stress-related tasks, and preventing exercise-induced muscle damage.
- High purity chemical compound
- Identified by CAS 79777-82-5
- Molecular formula C12H23NO4
- Beneficial as an ergogenic dietary substance
- Influences anabolic hormone secretion
- Supplies fuel during exercise
- Improves mental performance during stress-related tasks
- Prevents exercise-induced muscle damage
Apexbio Technology LLC Y-39983 dihydrochloride 173897-44-4 2mg
Y-39983 dihydrochloride (CAS 173897-44-4) is a selective inhibitor of Rho-associated coiled-coil containing protein kinase (ROCK) exhibiting an IC50 of 3 6 nM for ROCK inhibition It demonstrates substantially reduced inhibitory activity against protein kinase C (PKC IC50 0 42 M) and Ca2 /calmodulin-dependent protein kinase II (CaMKII IC50 0 81 M) In ex vivo studies Y-39983 dihydrochloride induces relaxation of pre-contracted rabbit ciliary arteries and has been shown to increase optic nerve head blood flow Furthermore dose-dependent reductions in intraocular pressure have been observed in both rabbit and monkey models These properties suggest its value for research on ROCK-related signaling in ocular physiology and vascular tone regulation
Medchemexpress LLC 2'-O-(2-methoxyethyl)adenosine | 168427-74-5 | 99.0% | 325.32 g·mol⁻¹ | C13H19N5O5 | 1 ML
2′-O-(2-methoxyethyl)adenosine is an adenosine analogue and ATP derivative used as a building block in nucleotide and oligonucleotide chemistry. It is offered as a solid and as a ready-to-use 10 mM solution in DMSO (1 mL), and is supplied at high purity for synthetic applications.
- Available as solid (multiple mass options) and 10 mM solution in DMSO.
- High purity: 99.0%.
- Molecular weight 325.32 g·mol⁻¹; chemical formula C13H19N5O5.
- CAS number 168427-74-5.
- Storage: room temperature for continental US shipping; store at 4°C protected from light. In solvent: -80°C up to 6 months, -20°C up to 1 month (protect from light).
Medchemexpress LLC 2'-O-(2-methoxyethyl)-cytidine | 223777-16-0 | 100.0% | 301.30 g/mol | C12H19N3O6 | 1 ML
2'-O-(2-methoxyethyl)-cytidine is a chemically modified cytidine nucleoside provided for research use and supplied as a 10 mM solution in DMSO or as solid material in multiple sizes. It is used as a nucleoside analog and an oligonucleotide building block in biochemical and cellular studies.
- modified cytidine nucleoside
- supplied as 10 mM solution in DMSO or solid material
- high reported purity suitable for research applications
- used as a nucleoside analog in biochemical studies
- available in multiple solid sizes for synthetic or analytical needs
Apexbio Technology LLC KX2-391 dihydrochloride 1038395-65-1 10mg
KX2-391 dihydrochloride (CAS 1038395-65-1) is an orally bioavailable small molecule that inhibits Src tyrosine kinase through selective interaction with the peptide substrate binding site rather than the ATP-binding site By blocking this non-catalytic domain KX2-391 disrupts Src kinase-mediated signaling pathways involved in tumor cell proliferation and metastatic processes Src kinases are frequently upregulated in various malignancies underscoring their importance in cancer biology KX2-391 is widely utilized in preclinical studies investigating Src-driven mechanisms of oncogenesis and tumor progression
Apexbio Technology LLC E-4031 dihydrochloride 113559-13-0 5mg
E-4031 dihydrochloride (CAS 113559-13-0) is a methanesulfonanilide compound classified as a class III antiarrhythmic agent It selectively inhibits ether- -go-go-related gene (ERG) family potassium channels including hERG (Kv11 1) with an IC50 of 29 nM and demonstrates binding affinities of 99 116 and 193 nM for ERG1 ERG2 and ERG3 respectively By blocking these voltage-gated K channels E-4031 dihydrochloride extends cardiac action potential duration and modulates inwardly rectifying potassium currents in myocardial and gastrointestinal cells This molecule is widely used to study ERG channel physiology arrhythmogenesis and pharmacological rescue of mutant hERG in long QT syndrome type 2
TARGETMOL CHEMICALS INC Pramipexole dihydrochloride hy
Also available in 1 mL, 10 mg, 25 mg, 100 mg, 200 mg, 500 mg and bulk. Please contact Fisher for quotes. Pramipexole dihydrochloride hydrate (Mirapex) is the hydrochloride salt of pramipexole, a benzothiazole derivative. As a nonergot dopamine agonist, pramipexole binds to D2 and D3 dopamine receptors in the striatum and substantia nigra of the brain. Purity 99.55%
Medchemexpress LLC Piperazine erastin | 1538593-71-3 | 99.1% | 645.19 g/mol | C35H41ClN6O4 | 1 ML
Piperazine erastin is a research reagent that induces ferroptosis, an iron-dependent form of non-apoptotic cell death. It is used in cellular and cancer research to investigate ferroptotic mechanisms; the piperazine substitution improves water solubility and metabolic stability relative to erastin.
- Induces ferroptosis in cell models.
- Improved water solubility and metabolic stability compared with erastin.
- Available as a ready-to-use 10 mM solution in DMSO (1 mL).
- Also available as a solid in multiple milligram quantities for flexibility.
- High purity, typically 99.12% as reported by the manufacturer.
- Useful for cancer research and studies of iron-dependent cell death pathways.