Piperidines
Medchemexpress LLC ERRα ligand-linker conjugates 1 | 00-00-0 | 98.8% | C24H20F9N3O5 | 10MG
ERRα ligand-linker conjugate combines an ERRα-targeting ligand with a PROTAC-compatible linker to serve as a building block for synthesis of ERRα-directed degraders and related conjugates. Supplied as a solid with documented purity, molecular properties, and recommended storage for research applications.
- Designed for use in PROTAC synthesis and conjugation.
- High purity: 98.8%.
- Molecular weight: 601.42 g·mol⁻¹.
- Molecular formula: C24H20F9N3O5.
- Soluble in DMSO up to 200 mg/mL; ultrasonic may be needed.
- Appearance: light yellow to yellow solid.
- Recommended storage: store under nitrogen at -20°C; in solution keep at -80°C for long-term.
Selleck Chemical LLC BSJ-4-116-5mg
BSJ-4-116 is a specific degrader of cyclin-dependent kinase 12 (CDK12). BSJ-4-116 exhibits potent antiproliferative effects.
Medchemexpress LLC BSJ-4-116 | 2519823-34-6 | 99.9% | 837.38 | 50 MG
BSJ-4-116 is a PROTAC (proteolysis-targeting chimera) designed to selectively degrade CDK12 (Cyclin-Dependent Kinase 12) with high potency, evidenced by an IC50 of 6 nM. It achieves its effect by linking ligands for Cereblon and CDK, leading to the downregulation of DNA damage response (DDR) genes through premature transcriptional termination and increased poly(adenylation). This compound exhibits significant antiproliferative capabilities, both as a standalone agent and in combination with the PARP inhibitor Olaparib. It has been shown to decrease CDK12 protein levels regardless of the cell line's mutational status and can overcome resistance due to specific CDK12 mutations.
- Highly potent and selective CDK12 degrader
- Downregulates DNA damage response genes
- Exhibits antiproliferative effects
- Can overcome resistance from specific CDK12 mutations
Medchemexpress LLC HY-103632 10mg Medchemexpress, PROTAC BRD9 Degrader-1 CAS:2097971-01-0 Purity:>98%
Medchemexpress, HY-103632 10mg PROTAC BRD9 Degrader-1 CAS:2097971-01-0 PROTAC BRD9 Degrader-1 is a lead PROTAC BRD9 chemical degrader (IC50=13.5 nM), which can be used as a selective probe useful for the study of BAF complex biology. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Pomalidomide-C12-NH2 hydrochloride | 2862774-02-3 | 97.1% | C25H37ClN4O4 | 50 MG
Pomalidomide-C12-NH2 hydrochloride is an E3 ligase ligand-linker conjugate of PROTAC KRAS G12C degrader-1. This is a Cereblon-based KRASG12C degrader.
- E3 ligase ligand-linker conjugate
- Cereblon-based degrader
- Intended for research use only
Medchemexpress LLC Pomalidomide-amino-PEG4-NH2 hydrochloride | 2331259-45-9 | >99.3% | 542.97 | 50 MG
Pomalidomide-amino-PEG4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate. This compound incorporates the Pomalidomide-based cereblon ligand and a linker, commonly utilized in PROTAC technology. PROTACs, or Proteolysis-targeting chimeras, are designed to selectively degrade target proteins by exploiting the intracellular ubiquitin-proteasome system through two distinct ligands connected by a linker: one targeting an E3 ubiquitin ligase and the other targeting the protein of interest.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Pomalidomide based cereblon ligand
- Used in PROTAC technology
- Target: E3 ligase ligand-linker conjugates
- Pathway: PROTAC
- Target: Cereblon
- Soluble in DMSO (250 mg/mL)
- Soluble in various in vivo solvent systems (≥ 6.25 mg/mL)
STA PHARMACEUTICAL US LLC Fmoc-DL-hPro-OH | 10 g | CAS 105751-19-7 | MDL MFCD01823265
Fmoc-DL-hPro-OH is a Amino Acid reagent (Subcategory: Homo-natural AA) sold by WuXi TIDES. Offered in 10 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 105751-19-7
- MDL: MFCD01823265
- InChIKey: CKLAZLINARHOTG-UHFFFAOYSA-N
- Molecular Weight: 351.402
- Molecular Formula: C21H21NO4
- Purity: ≥95%
- Container Type: 60 mL HDPE
- Pack Size: 10 g
- Net Weight: 10 g
- Gross Weight: 25 g
- Commodity Code: 29333999
- Country Of Origin: China
- IUPAC: 1-(((9H-fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid
- SMILES: O=C(N1CCCCC1C(O)=O)OCC2C3=CC=CC=C3C4=CC=CC=C42
![eMolecules 1160246-89-8 | tert-butyl 3-oxo-1-oxa-7-azaspiro[4.5]decane-7-carboxylate | MFCD12198527 | 1g](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502136177.JPG-250.jpg)
eMolecules 1160246-89-8 | tert-butyl 3-oxo-1-oxa-7-azaspiro[4.5]decane-7-carboxylate | MFCD12198527 | 1g
Ambeed | N-Isopropyl-5-(4455-tetramethyl-132-dioxaborolan-2-yl)pyrimidin-2-amine | 100mg | 526403774 | A231920 | 1218791-46-8 | MFCD12546556 | 263.150 | C13H22BN3O2
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![eMolecules 99027-90-4 | TERT-BUTYL 2-OXA-3-AZABICYCLO[2.2.1]HEPT-5-ENE-3-CARBOXYLATE | MFCD24465569 | 5g](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502182654.JPG-250.jpg)
eMolecules 99027-90-4 | TERT-BUTYL 2-OXA-3-AZABICYCLO[2.2.1]HEPT-5-ENE-3-CARBOXYLATE | MFCD24465569 | 5g
AstaTech | TERT-BUTYL 2-OXA-3-AZABICYCLO[2.2.1]HEPT-5-ENE-3-CARBOXYLATE | 5g | 449789920 | W12230 | 95.000 | 99027-90-4 | MFCD24465569 | 197.234 | C10H15NO3
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Medchemexpress LLC Thiophene-3-carboxylic acid triazaspiro nonan derivative | 509083-77-6 | 99.4% | 25 MG
Small-molecule LFA-1 antagonist (CAS 509083-77-6) supplied as a high-purity research reagent for in vitro and in vivo pharmacology studies.
- High purity: 99.4% (LCMS, rounded).
- Molecular weight: 555.43 g/mol.
- Chemical formula: C26H20Cl2N4O4S.
- Suitable for pharmacology and preclinical inflammation models.
- Available in small laboratory pack sizes for research use.
Accela Chembio Inc Methyl N-boc-piperidine-4-carboxylate | 25g | 124443-68-1 | MFCD02183584 | 97+% | D: 1.07 | Shelf Life: 1800 Days | Light Sensitive/moisture Sensitive/n2
Methyl N-boc-piperidine-4-carboxylate | 25g | 124443-68-1 | MFCD02183584 | 97+% | D: 1.07 | Shelf Life: 1800 Days | Light Sensitive/moisture Sensitive/n2
eMolecules 91600-19-0 | 1-Benzyl-3-methyl-piperidin-4-ol | J & W PharmLab, LLC | MFCD09701317 | 205.301 | C13H19NO | 96.000 | CC1CN(Cc2ccccc2)CCC1O | 1g | 249985328
1-Benzyl-3-methyl-piperidin-4-ol | J & W PharmLab, LLC | 91600-19-0 | MFCD09701317 | 205.301 | C13H19NO | 96.000 | CC1CN(Cc2ccccc2)CCC1O | 1g | 249985328
STA PHARMACEUTICAL US LLC Fmoc-DL-hPro-OH | 1 g | CAS 105751-19-7 | MDL MFCD01823265
Fmoc-DL-hPro-OH is a Amino Acid reagent (Subcategory: Homo-natural AA) sold by WuXi TIDES. Offered in 1 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 105751-19-7
- MDL: MFCD01823265
- InChIKey: CKLAZLINARHOTG-UHFFFAOYSA-N
- Molecular Weight: 351.402
- Molecular Formula: C21H21NO4
- Purity: ≥95%
- Container Type: 15 mL HDPE
- Pack Size: 1 g
- Net Weight: 1 g
- Gross Weight: 7.8 g
- Commodity Code: 29333999
- Country Of Origin: China
- IUPAC: 1-(((9H-fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid
- SMILES: O=C(N1CCCCC1C(O)=O)OCC2C3=CC=CC=C3C4=CC=CC=C42