Piperidines
![Medchemexpress LLC 5'-benzyl-1'-butyl-N-(naphthalen-2-ylsulfonyl)-6'-oxo-1',6'-dihydro-[2,3'-bipyridine]-4-carboxamide | 2139330-34-8 | 99.5% | 551.66 g·mol⁻¹ | C32H29N3O4S | 5MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000235385.png-250.jpg)
Medchemexpress LLC 5'-benzyl-1'-butyl-N-(naphthalen-2-ylsulfonyl)-6'-oxo-1',6'-dihydro-[2,3'-bipyridine]-4-carboxamide | 2139330-34-8 | 99.5% | 551.66 g·mol⁻¹ | C32H29N3O4S | 5MG
SERCA2a activator 1 is a small-molecule activator of the sarco/endoplasmic reticulum Ca2+-dependent ATPase 2a (SERCA2a) used in preclinical cardiovascular research to attenuate phospholamban inhibition and enhance cardiac contractile function. Supplied for research use only.
- Activates SERCA2a and attenuates phospholamban inhibition.
- Used to enhance systolic and diastolic cardiac function in research models.
- Molecular formula C32H29N3O4S.
- Molecular weight 551.66 g·mol⁻¹.
- Available in milligram quantities suitable for in vitro and in vivo studies.
- Supplied for research use only; not for human or veterinary use.
Medchemexpress LLC HY-B2215 50mg Medchemexpress, Dimemorfan (phosphate) CAS:36304-84-4 Purity:>98%
Medchemexpress, HY-B2215 50mg Dimemorfan (phosphate) CAS:36304-84-4 Dimemorfan phosphate is a sigma 1 receptor agonist, used as a potent antitussive. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
eMolecules 1038915-64-8 | Medchem Express | Niraparib (hydrochloride) | 5mg | 415686568 | HY-10619A | MFCD20502397 | 356.85 | C19H21ClN4O
Ambeed | (11bR)-N-(26-Di([11-biphenyl]-4-yl)-4-oxidodinaphtho[21-d12-f][132]dioxaphosphepin-4-yl)-111-trifluoromethanesulfonamide | 50mg | 633658989 | A1006134 | 1071853-94-5 | 783.760 | C45H29F3NO5PS
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![Medchemexpress LLC 2-[(2-phenylethyl)thio]nicotinic acid | 496775-95-2 | MFCD03621206 | 99.8% | 259.32 g/mol | C14H13NO2S | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000237749.png-250.jpg)
Medchemexpress LLC 2-[(2-phenylethyl)thio]nicotinic acid | 496775-95-2 | MFCD03621206 | 99.8% | 259.32 g/mol | C14H13NO2S | 10MG
ML-099 (2-[(2-phenylethyl)thio]nicotinic acid) is a small-molecule pan Ras-family GTPase activator used in biochemical and cell-based research to activate Rac1, CDC42, Ras, Rab7, and Rab-2A. It is supplied for research use and is characterized by high purity and a molecular weight of 259.32 g/mol.
- Activates multiple Ras-family GTPases including Rac1 and CDC42.
- Useful for cell-based and biochemical assays probing GTPase signaling.
- High purity for research applications (reported 99.75%).
- Molecular formula C14H13NO2S and molecular weight 259.32 g/mol.
- Identified by CAS 496775-95-2 and PubChem CID 888706.
Medchemexpress LLC PI-103 | 371935-74-9 | 99.8% | 348.36 | 25 MG
PI-103 is a potent PI3K and mTOR inhibitor that also inhibits DNA-PK and induces autophagy. It shows antiproliferative effects in human cancer cell lines, leading to cell cycle arrest, inhibition of leukemic proliferation, and mitochondrial apoptosis. In vivo, it demonstrates therapeutic activity against human tumor xenografts, inhibiting angiogenesis, invasion, and metastasis.
- Potent PI3K and mTOR inhibitor
- Inhibits DNA-PK
- Induces autophagy
- Demonstrates antiproliferative properties in human cancer cell lines
- Induces cell cycle arrest in G1 phase
- Inhibits leukemic proliferation and mitochondrial apoptosis
- Exhibits therapeutic activity against human tumor xenografts
- Inhibits angiogenesis, invasion, and metastasis
- Provides direct antiproliferative effects
Medchemexpress LLC HY-10619D 5mg Medchemexpress, Niraparib R-enantiomer CAS:1038915-58-0 Purity:>98%
Medchemexpress, HY-10619D 5mg Niraparib R-enantiomer CAS:1038915-58-0 Niraparib R-enantiomer (MK-4827 R-enantiomer) is an excellent PARP1 inhibitor with IC50 of 2.4 nM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
eMolecules 3466-80-6 | Ambeed | 2-Phenylpiperidine | 1g | 491166965 | A118058 | MFCD00270125 | 161.248 | C11H15N
ChemScene | 4-(2-Bromophenyl)oxazole | 100mg | 712833151 | CS-0366275 | 850349-06-3 | MFCD08706070 | 224.057 | C9H6BrNO
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Medchemexpress LLC AMG-548 dihydrochloride | 2518299-32-4 | 99.9% | 534.48 | 50 MG
AMG-548 dihydrochloride is an orally active and selective inhibitor of p38α (Ki=0.5 nM), showing slight selectivity over p38β (Ki=36 nM) and more than 1000-fold selectivity against p38γ and p38δ. It is also highly potent in inhibiting whole blood LPS-stimulated TNFα (IC50=3 nM). Additionally, this compound inhibits Wnt signaling by directly targeting Casein kinase 1 isoforms δ and ε.
- Selective p38α inhibitor with high potency.
- Potent inhibition of whole blood LPS-stimulated TNFα and IL1β.
- Inhibits Wnt signaling through direct targeting of Casein kinase 1 isoforms δ and ε.
- Good oral bioavailability in vivo.
![Medchemexpress LLC 2-[(2-phenylethyl)thio]nicotinic acid | 496775-95-2 | MFCD03621206 | 99.8% | 259.32 g/mol | C14H13NO2S | 50MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000235232.png-250.jpg)
Medchemexpress LLC 2-[(2-phenylethyl)thio]nicotinic acid | 496775-95-2 | MFCD03621206 | 99.8% | 259.32 g/mol | C14H13NO2S | 50MG
ML-099 (CID-888706) is a small-molecule pan activator of Ras-related GTPases provided for research use. It enhances GTPase activity by increasing affinity for guanine nucleotides and activates multiple small GTPases relevant to cytoskeletal dynamics and signaling pathways. The compound is supplied as a solid in several pack sizes and as a DMSO solution for cell-based and biochemical assays.
![Medchemexpress LLC 6-[[4-(cyclopropylmethyl)-1-piperazinyl]methyl]-2-(5-fluoro-indol-4-yl)-4-(4-morpholinyl)-thieno-pyrimidine | 955977-50-1 | 99.0% | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000230705.png-250.jpg)
Medchemexpress LLC 6-[[4-(cyclopropylmethyl)-1-piperazinyl]methyl]-2-(5-fluoro-indol-4-yl)-4-(4-morpholinyl)-thieno-pyrimidine | 955977-50-1 | 99.0% | 50 MG
PI-3065 is a selective small-molecule inhibitor of PI3K p110δ used for research applications. It potently inhibits p110δ (IC50 5 nM; Ki 1.5 nM) and shows substantially lower activity against other PI3K isoforms, and is supplied as a solid for in vitro and in vivo studies.
- Potent p110δ inhibition (IC50 5 nM; Ki 1.5 nM).
- Reduced activity against p110α (IC50 910 nM), p110β (IC50 600 nM), p110γ (>10,000 nM).
- Purity approximately 98.97%.
- Chemical formula C27H31FN6OS; molecular weight 506.64 g/mol.
- Appearance: white to off-white solid.
- Soluble in DMSO (25 mg/mL) and formulatable for in vivo dosing.
- Storage: powder -20°C (up to 3 years) or 4°C (up to 2 years).
- Available in small-mass pack sizes (for example 50 mg).
eMolecules 3466-80-6 | 2-Phenylpiperidine | Ambeed | MFCD00270125 | 161.248 | C11H15N | 98.000 | C1CCC(NC1)c1ccccc1 | 5g | 552543121
2-Phenylpiperidine | Ambeed | 3466-80-6 | MFCD00270125 | 161.248 | C11H15N | 98.000 | C1CCC(NC1)c1ccccc1 | 5g | 552543121
Apexbio Technology LLC AT7867 857531-00-1 5mg
AT7867 (CAS 857531-00-1) is a small molecule ATP-competitive inhibitor that targets Akt1 Akt2 Akt3 p70S6 kinase (p70S6K) and protein kinase A (PKA) with reported IC50 values of 32 nM 17 nM 47 nM 85 nM and 20 nM respectively Akt or protein kinase B is a serine/threonine kinase involved in cellular pathways such as glucose metabolism apoptosis proliferation transcription and migration AT7867 suppresses proliferation across various human tumor cell lines including MES-SA MDA-MB-468 MCF-7 HCT116 and HT29 with IC50 values ranging from 0 9 to 3 M Additionally it inhibits GSK3 within these lines (IC50 2 4 M) and induces apoptosis in U87MG glioblastoma cells via dose- and time-dependent Akt pathway inhibition In PTEN-deficient tumor xenograft models AT7867 reduces phosphorylation of Akt/p70S6K substrates and impedes tumor growth supporting its use in cancer research
eMolecules 340-07-8 | 1-Trifluoroacetyl piperidine | Oakwood Chemical | MFCD00466213 | 181.158 | C7H10F3NO | 99.000 | FC(F)(F)C(=O)N1CCCCC1 | 25g | 537704748
1-Trifluoroacetyl piperidine | Oakwood Chemical | 340-07-8 | MFCD00466213 | 181.158 | C7H10F3NO | 99.000 | FC(F)(F)C(=O)N1CCCCC1 | 25g | 537704748
Apexbio Technology LLC Piperine 94-62-2 5g
Piperine (CAS 94-62-2) is an alkaloid primarily found in black pepper (Piper nigrum) that has demonstrated diverse pharmacological activities It modulates several signaling pathways including inhibition of drug-metabolizing enzymes such as CYP3A4 and P-glycoprotein and affects cellular processes through regulation of MAPK and Akt phosphorylation Piperine has been studied for its potential to enhance the bioavailability of various therapeutic agents and for its anti-inflammatory anti-tumor and neuroprotective properties This compound is utilized in biomedical research to investigate drug-drug interactions signal transduction mechanisms and its impact on cellular proliferation and apoptosis