Piperidines
Medchemexpress LLC Ropivacaine hydrochloride monohydrate | 132112-35-7 | 99.9% | 1 ML
Ropivacaine hydrochloride monohydrate is a potent sodium channel blocker that inhibits impulse conduction by reversibly blocking sodium ion influx in nerve fibers. It also acts as an inhibitor of K2P (two-pore domain potassium channel) TREK-1. This product is extensively used for regional anesthesia and the management of neuropathic pain in vivo.
- Potent sodium channel blocker
- Inhibits impulse conduction by blocking sodium ion influx
- Inhibitor of K2P (two-pore domain potassium channel) TREK-1
- Purity of 99.93%
- Appearance: white to off-white solid
- Recommended storage for solid: 4°C, sealed, away from moisture
- Recommended storage in solvent: -80°C for 6 months; -20°C for 1 month
Medchemexpress LLC Ropivacaine hydrochloride monohydrate | 132112-35-7 | 99.9% | 5 MG
Ropivacaine hydrochloride monohydrate | 132112-35-7 | 99.9% | 5 MG
Selleck Chemical LLC Mepivacaine S5392-25mg
Mepivacaine (Carbocaine) is a local anesthetic indicated for infiltration nerve block and epidural anesthesia
Medchemexpress LLC HY-B0670A 10mg Medchemexpress, Dihydroergotamine (mesylate) CAS:6190-39-2 Purity:>98%
Medchemexpress, HY-P7308 10ug TrkA (HEK293-expressed), Human CAS: Recombinant Human Tyrosine kinase receptor A (HEK293-expressed) is the high affinity catalytic receptor for the neurotrophin, nerve growth factor (NGF), and mediates the multiple effects of NGF, which include neuronal differentiation and avoidance of programmed cell death. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Apexbio Technology LLC Avibactam sodium 1192491-61-4 50mg
Avibactam sodium (1192491-61-4) is a small-molecule inhibitor targeting bacterial -lactamase enzymes including CTX-M-15 and TEM-1 It is designed to inhibit -lactamase activity thereby preventing the hydrolysis of -lactam antibiotics Avibactam sodium exerts its biological activity primarily through reversible covalent non- -lactam inhibition of its targets In in vitro studies avibactam sodium demonstrates inhibitory activity with IC50 values of 5 nM for CTX-M-15 and 8 nM for TEM-1 Based on these pharmacological properties avibactam sodium holds research potential in studies of combination therapy for bacterial infections involving -lactamase-producing Gram-negative pathogens
Aobchem Methanone (2 3-dichlorophenyl)-2-pyridinyl- | ≥95% | CAS 54523-80-7 | C12H7Cl2NO | 500mg
Methanone (2 3-dichlorophenyl)-2-pyridinyl- | ≥95% | CAS 54523-80-7 | C12H7Cl2NO | 500mg
Medchemexpress LLC Avibactam impurity 1 | 400626-71-3 | MFCD14635665 | 5g
Avibactam impurity 1 is an impurity of Avibactam (HY-14879)
![Medchemexpress LLC 1-[3-(2,3-dichlorophenyl)-2H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methylpiperidin-4-amine | 2160546-07-4 | 100.0% | C17H18Cl2N6 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000261615.png-250.jpg)
Medchemexpress LLC 1-[3-(2,3-dichlorophenyl)-2H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methylpiperidin-4-amine | 2160546-07-4 | 100.0% | C17H18Cl2N6 | 10MG
IACS-13909 is a selective, potent, orally active allosteric inhibitor of SHP2 (PTPN11) used as a research compound to probe MAPK pathway signaling and antitumor activity in RTK-dependent models. It provides defined potency, high supplied purity, and solubility/formulation data to support in vitro and in vivo pharmacology studies.
- Selective SHP2 allosteric inhibitor with IC50 15.7 nM and Kd 32 nM.
- High supplied purity (99.97%) suitable for biological assays.
- Soluble in DMSO at 10 mg/mL for in vitro use, with in vivo formulation options.
- Available in multiple solid and solution pack sizes for flexible dosing.
- Applicable to cellular and preclinical pharmacology studies of MAPK pathway signaling.
Medchemexpress LLC Nelfinavir mesylate | 159989-65-8 | C33H49N3O7S2 | 25 MG
Nelfinavir Mesylate, also known as AG 1343 Mesylate, is a potent and orally bioavailable HIV-1 protease inhibitor. It is also described as a broad-spectrum anticancer agent and an inhibitor of SARS-CoV 3CLpro.
- Potent HIV-1 protease inhibitor (Ki=2 nM)
- Inhibits proliferation of multiple myeloma cells (IC50 of 1-5 μM)
- Triggers apoptosis of myeloma cell lines
- Decreases phosphorylation of AKT, STAT-3, ERK1/2
- Activates the pro-apoptotic pathway of the unfolded protein response system
- Inhibits SARS-CoV 3CLpro (IC50 of 35.93 μM)
- Decreases multiple myeloma cell growth in animal models
Medchemexpress LLC Ropivacaine | 84057-95-4 | MFCD00078774 | 100.0% | 50 MG
Overview of Ropivacaine
Ropivacaine is a potent sodium channel blocker. It works by blocking impulse conduction through reversible inhibition of sodium ion influx in nerve fibers. Additionally, Ropivacaine acts as an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane. It is utilized in the research of neuropathic pain management.
Features and Benefits
- Potent sodium channel blocker.
- Blocks impulse conduction by inhibiting sodium ion influx.
- Inhibits K2P TREK-1 (IC50 of 402.7 μM).
- Used for neuropathic pain management research.
- Epidural administration blocks neuropathic pain and delays its development.
- Inhibits pressure-induced increases in filtration coefficient.
- Prevents pressure-induced lung edema and hyperpermeability.
- Inhibits pressure-induced NO production.