Piperidines
Medchemexpress LLC Avibactam free acid | 1192500-31-4 | 99.3% | 265.24 | 5 MG
Avibactam free acid is a covalent and reversible non-β-lactam β-lactamase inhibitor. It effectively inhibits β-lactamase TEM-1 and CTX-M-15, with IC50s of 8 nM and 5 nM respectively. This product exhibits minimal antibacterial activity but targets class A and C β-lactamases, excluding metallo types and Acinetobacter OXA carbapenemases. It is intended for research use only.
- Covalent and reversible non-β-lactam β-lactamase inhibitor
- Inhibits β-lactamase TEM-1 and CTX-M-15
- Targets class A and C β-lactamases
- Minimal antibacterial activity
- Suitable for research applications
Medchemexpress LLC Avibactam free acid | 1192500-31-4 | 99.3% | 265.24 | 100 MG
Avibactam free acid is a covalent and reversible non-β-lactam β-lactamase inhibitor that inhibits β-lactamase TEM-1 and CTX-M-15.
- Covalent and reversible non-β-lactam β-lactamase inhibitor.
- Inhibits β-lactamase TEM-1 and CTX-M-15 with IC50s of 8 nM and 5 nM, respectively.
- Exhibits little antibacterial activity.
- Inhibits class A and C β-lactamases, but not metallo types and Acinetobacter OXA carbapenemases.
Medchemexpress LLC Zidebactam | 1436861-97-0 | 98.6% | 50 MG
Zidebactam is a β-lactamase inhibitor and penicillin-binding protein 2 (PBP2) inhibitor used as a research compound and antibiotic adjuvant. CAS 1436861-97-0; molecular weight 391.40 g/mol; supplied as a white-to-yellow solid in a 50 mg vial. Reported activity includes PBP2 inhibition with an IC50 of 0.26 μg/mL. For research use only; not for human or clinical use.
- Beta-lactamase and PBP2 inhibitor; enhances β-lactam activity.
- Reported PBP2 IC50 of 0.26 μg/mL against P. aeruginosa PAO1.
- Molecular weight 391.40 g/mol; formula C13H21N5O7S.
- Purity 98.6% (reported) and supplied as a solid.
- Intended for laboratory research use only, not for human use.
Medchemexpress LLC Nelfinavir | 159989-64-7 | C32H45N3O4S | 1 ML
Nelfinavir is a potent, orally bioavailable HIV-1 protease inhibitor with a Ki of 2 nM for HIV infection. It is also recognized as a broad-spectrum anticancer agent. This product is supplied as a 10 mM solution in DMSO.
- Potent HIV-1 protease inhibitor (Ki=2 nM)
- Orally bioavailable
- Broad-spectrum anticancer agent
- For research use only
- Store in solvent at -80°C for 6 months or -20°C for 1 month
Medchemexpress LLC Avibactam sodium | 1192491-61-4 | 99.99% | 287.23 | 1 ML
Avibactam sodium (NXL-104) is a covalent and reversible non-β-lactam β-lactamase inhibitor. It inhibits β-lactamase TEM-1 and CTX-M-15 with IC50s of 8 nM and 5 nM, respectively. This molecule exhibits little antibacterial activity and effectively inhibits class A and C β-lactamases, but not metallo types and Acinetobacter OXA carbapenemases. It is intended for research use only.
- Covalent and reversible non-β-lactam β-lactamase inhibitor
- Inhibits β-lactamase TEM-1 and CTX-M-15
- Exhibits little antibacterial activity
- Inhibits class A and C β-lactamases
- Not effective against metallo types and Acinetobacter OXA carbapenemases
- Intended for research use only
Apexbio Technology LLC Nelfinavir Mesylate 159989-65-8 5mg
Nelfinavir Mesylate (CAS 159989-65-8) is a small-molecule inhibitor targeting HIV-1 protease It is designed to inhibit the enzymatic processing of gag and gag-pol precursor polyproteins thereby interfering with viral maturation Nelfinavir Mesylate exerts its biological activity primarily through inhibition of HIV-1 protease activity In cell-based antiviral assays using HIV-1-infected cells Nelfinavir Mesylate demonstrates inhibition of viral replication with EC50 values ranging from 14 nM to 43 nM Based on these pharmacological properties Nelfinavir Mesylate holds research potential in preclinical studies investigating HIV replication mechanisms therapeutic resistance profiles and combination antiretroviral drug strategies
Medchemexpress LLC Ropivacaine (hydrochloride) | 98717-15-8 | 99.5% | 1 ML
Ropivacaine hydrochloride is a potent sodium channel blocker that reversibly inhibits sodium ion influx in nerve fibers to block impulse conduction. It also acts as an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane. It is widely used for neuropathic pain management in vivo.
- Potent sodium channel blocker
- Reversibly inhibits sodium ion influx
- Inhibits K2P TREK-1 with an IC50 of 402.7 μM
- Used for neuropathic pain management in vivo
- Effectively blocks neuropathic pain via epidural administration
- Prevents pressure-induced lung edema and associated hyperpermeability
Medchemexpress LLC Nelfinavir mesylate | 159989-65-8 | C33H49N3O7S2 | 1 ML
Nelfinavir mesylate (AG 1343 Mesylate) is a potent and orally bioavailable HIV-1 protease inhibitor (Ki=2 nM) used for HIV infection. It also acts as a broad-spectrum anticancer agent.
- Potent HIV-1 protease inhibitor (Ki=2 nM)
- Broad-spectrum anticancer agent
- Inhibits proliferation of multiple myeloma cells
- Triggers apoptosis in myeloma cell lines
- Decreases phosphorylation of AKT
- Activates cleavage of caspase-3
- SARS-CoV 3CLpro inhibitor (IC50 = 35.93 μM)
Biotium Human Lambda Light Chain(ICO-106), CF594 conjugate, 0.1mg/mL
This MAb is specific to lambda light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of Kappa to Lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the lambda light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can
Biotium Involucrin(IVRN/827), CF647 conjugate, 0.1mg/mL
This antibody recognizes a protein of 66 kDa-170 kDa, identified as involucrin. In Western blotting of cultured human keratinocytes, this MAb reacts with a 120 kDa protein. Involucrin is expressed in a range of stratified squamous epithelia, including the cornea, which lacks a distinct cornified layer. In normal epidermis, it is first expressed in the upper spinous layers, and in keratinocyte cultures, all cells that have left the basal layer express it. Involucrin expression is altered in pathological conditions: in psoriasis and other benign epidermal hyperplasias, involucrin expression begins closer to the basal layer than normal; expression is abnormal in squamous cell carcinomas and premalignant lesions, and is reduced in severe dysplasias of the larynx and cervix.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like
Biotium Thyroglobulin(2H11), CF647 conjugate, 0.1mg/mL
MAb 2H11 reacts with a partially defined epitope of human thyroglobulin. This epitope is different form the epitope recognized by MAb 6E1. Thyroglobulin is a 660 kDa dimeric pre-protein with mutiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined