Pyrimidines And Derivatives
Medchemexpress LLC AP1867-2-carboxymeth 250mg | 2230613-03-1 | 250 MG
AP1867-2-(carboxymethoxy) is a synthetic FKBP12(F36V)-directed ligand moiety used as the FKBP12-binding component in dTAG and PROTAC constructs. Supplied as a high-purity solid for research applications, it serves as a building block for targeted protein degradation synthesis and assay development.
- High purity solid (99.88%).
- Molecular weight 693.78 g/mol.
- Molecular formula C38H47NO11.
- Suitable for chemical synthesis of dTAG or PROTAC molecules.
- Available in multiple pack sizes, including 250 mg.
Medchemexpress LLC Thiamine hydrochloride | 67-03-8 | 337.27 | 1 ML
Thiamine hydrochloride is an essential micronutrient serving as a cofactor for many central metabolic enzymes. It activates NrF-2/HO-1 and inhibits TLR4, NF-κB, exhibiting neuroprotective and anti-inflammatory effects. It is utilized in studies concerning diabetic complications, neurological diseases, cancers, and colitis.
- Essential micronutrient and cofactor for central metabolic enzymes.
- Activates NrF-2/HO-1 and inhibits TLR4, NF-κB.
- Exhibits neuroprotective and anti-inflammatory effects.
- Used in studies of diabetic complications, neurological diseases, cancers, and colitis.
- Increases cellular PDH activities and oxygen consumption rate in breast cancer cells.
- Reduces proliferation in cancer cell lines.
- Ameliorates scopolamine-induced memory dysfunction in adult mice.
- Demonstrates anti-inflammatory and antihyperalgesic effects in adjuvant-induced arthritis rats.
Medchemexpress LLC Thiamine-d4 hydrochloride | 67-03-8 | 341.29 | 1 MG
Thiamine-d4 hydrochloride is a deuterium labeled form of Thiamine hydrochloride, an essential micronutrient and cofactor for many central metabolic enzymes. It is intended for research use only.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Deuteration may affect pharmacokinetic and metabolic profiles
eMolecules 2,6-Dichloro-N-methylpyrimidin-4-amine | 32998-03-1 | MFCD11520482 | 1g
Ambeed | 2,6-Dichloro-N-methylpyrimidin-4-amine | 1g | 525038192 | A132817 | | 32998-03-1 | MFCD11520482 | 178.020 | C5H5Cl2N3
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Medchemexpress LLC Pki 14-22 amide,myristoylated | 201422-03-9 | 99.7% | 1209.49 | 1 MG
PKI 14-22 amide, myristoylated, is a selective, cAMP-dependent, competitive PKA inhibitor with a Ki of approximately 36 nM. Its myristoylation modification enhances its permeability to cell membranes and blood-brain barriers. This compound can inhibit the phosphorylation of cAMP-dependent downstream targets like CREB and is suitable for research in opioid tolerance mechanisms and antiviral drugs.
- Selective, cAMP-dependent, competitive PKA inhibitor
- Myristoylation enhances cell membrane and blood-brain barrier permeability
- Inhibits phosphorylation of cAMP-dependent downstream targets (e.g., CREB)
- Prevents morphine analgesic tolerance in mice
- Inhibits Zika virus protein translation and RNA synthesis
eMolecules Ambeed 5-BDBD 250mg 879141033 A1209488 0 000 768404-03-1 MFCD18086878 355 191 C17H11BrN2O2
Ambeed 5-BDBD 250mg 879141033 A1209488 0 000 768404-03-1 MFCD18086878 355 191 C17H11BrN2O2
eMolecules Ambeed Bis(NHS)PEG5 250mg 682931190 A607408 0 000 756526-03-1 MFCD11041118 532 499 C22H32N2O13
Ambeed Bis(NHS)PEG5 250mg 682931190 A607408 0 000 756526-03-1 MFCD11041118 532 499 C22H32N2O13
Medchemexpress LLC 1-(2,6-dichlorophenyl)-3-(5-nitrothiophen-3-yl)urea | 672286-03-2 | 99.5% | 332.16 g/mol | C11H7Cl2N3O3S | 250MG
DFP00173 is a potent, selective small-molecule inhibitor of aquaporin-3 (AQP3) for research use. It inhibits mouse and human AQP3 with an IC50 of approximately 0.1-0.4 μM, is supplied as a high-purity solid, and is suitable for in vitro and in vivo research where AQP3 modulation is required.
- Potent and selective AQP3 inhibitor with IC50 ≈ 0.1-0.4 μM.
- High purity (≈99.5%).
- Molecular formula C11H7Cl2N3O3S; molecular weight 332.16 g/mol.
- Soluble in DMSO ≥ 100 mg/mL; clear solution in recommended in vivo formulations at ≥ 2.08 mg/mL.
- Stable as powder at -20°C for up to 3 years; in solution stable at -80°C for up to 6 months.
- Intended for research use only in cancer and inflammation/immunology studies.